Wolfram Doehner

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Uric acid in cachectic and noncachectic patients with chronic heart failure: relationship to leg vascular resistance
    W Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Am Heart J 141:792-9. 2001
  2. ncbi Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia
    W Doehner
    Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Endocrinol 145:727-35. 2001
  3. ncbi Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY, UK
    Int J Cardiol 83:73-81. 2002
  4. ncbi Cardiac cachexia in early literature: a review of research prior to Medline
    Wolfram Doehner
    Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Int J Cardiol 85:7-14. 2002
  5. ncbi The relationship between age and production of tumour necrosis factor-alpha in healthy volunteers and patients with chronic heart failure
    Stephan von Haehling
    Department of Clinical Cardiology, National Heart and Lung Institute, London SW3 6LY, UK
    Int J Cardiol 90:197-204. 2003
  6. ncbi Whole blood endotoxin responsiveness in patients with chronic heart failure: the importance of serum lipoproteins
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, Dovehouse Street, SW3 6LY, London, UK
    Eur J Heart Fail 7:479-84. 2005
  7. ncbi Cellular endotoxin desensitization in patients with severe chronic heart failure
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Heart Fail 7:865-8. 2005
  8. ncbi Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity
    Constantinos H Davos
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    J Card Fail 9:29-35. 2003
  9. ncbi Heat shock protein 70 in patients with chronic heart failure: relation to disease severity and survival
    Sabine Genth-Zotz
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Int J Cardiol 96:397-401. 2004
  10. ncbi The relationship between cholesterol and survival in patients with chronic heart failure
    Mathias Rauchhaus
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    J Am Coll Cardiol 42:1933-40. 2003

Detail Information

Publications35

  1. ncbi Uric acid in cachectic and noncachectic patients with chronic heart failure: relationship to leg vascular resistance
    W Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Am Heart J 141:792-9. 2001
    ..We aimed to study the relationship between serum uric acid levels and leg vascular resistance in patients with CHF with and without cachexia and in healthy control subjects...
  2. ncbi Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia
    W Doehner
    Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Endocrinol 145:727-35. 2001
    ..This study aimed to examine the influence of leptin on GHBP in CHF patients with and without cardiac cachexia compared with healthy control subjects...
  3. ncbi Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY, UK
    Int J Cardiol 83:73-81. 2002
    ..The purpose of this study was to examine in patients with CHF and in comparison to healthy controls subjects whether norepinephrine, TNFalpha or leptin relate to insulin sensitivity...
  4. ncbi Cardiac cachexia in early literature: a review of research prior to Medline
    Wolfram Doehner
    Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Int J Cardiol 85:7-14. 2002
    ..This review presents an overview of early thoughts and milestone studies on metabolic abnormalities and cachexia in chronic heart failure...
  5. ncbi The relationship between age and production of tumour necrosis factor-alpha in healthy volunteers and patients with chronic heart failure
    Stephan von Haehling
    Department of Clinical Cardiology, National Heart and Lung Institute, London SW3 6LY, UK
    Int J Cardiol 90:197-204. 2003
    ..Elevated plasma levels of tumour necrosis factor-alpha (TNF-alpha) are present in patients with advanced chronic heart failure (CHF). However, the relationship between age and the immune response in CHF is unknown...
  6. ncbi Whole blood endotoxin responsiveness in patients with chronic heart failure: the importance of serum lipoproteins
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, Dovehouse Street, SW3 6LY, London, UK
    Eur J Heart Fail 7:479-84. 2005
    ..We sought to investigate the relationship between whole blood endotoxin responsiveness and serum lipoprotein concentrations. It is not known if low-dose LPS is sufficient to stimulate immune activation...
  7. ncbi Cellular endotoxin desensitization in patients with severe chronic heart failure
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Heart Fail 7:865-8. 2005
    ..It is not known if LPS desensitization occurs in CHF...
  8. ncbi Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity
    Constantinos H Davos
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    J Card Fail 9:29-35. 2003
    ..Cachexia in chronic heart failure carries a poor prognosis, but little is known about the influence of body mass on the prognosis of noncachectic heart failure patients...
  9. ncbi Heat shock protein 70 in patients with chronic heart failure: relation to disease severity and survival
    Sabine Genth-Zotz
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Int J Cardiol 96:397-401. 2004
    ..We hypothesised that circulating Hsp70 levels are elevated in patients with CHF, more so in cachechtic patients, and that Hsp70 levels would relate to mortality...
  10. ncbi The relationship between cholesterol and survival in patients with chronic heart failure
    Mathias Rauchhaus
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    J Am Coll Cardiol 42:1933-40. 2003
    ..We sought to describe the relationship between cholesterol and survival in patients with chronic heart failure (CHF)...
  11. ncbi Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Am Coll Cardiol 46:1019-26. 2005
    ..The aim of this study was to determine the significance of insulin resistance as an independent risk factor for impaired prognosis in patients with chronic heart failure (CHF)...
  12. ncbi Clinical characteristics and survival of patients with chronic heart failure and prolonged QRS duration
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Int J Cardiol 86:225-31. 2002
    ..Whilst resynchronisation of ventricular conduction may benefit patients with QRS>150 ms, this has yet to be determined for patients with moderate QRS prolongation...
  13. ncbi The cardiac component of cardiac cachexia
    Viorel G Florea
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Heart J 144:45-50. 2002
    ..This study sought to assess the cardiac dimensions, mass, and function and changes in these parameters over time in patients with chronic heart failure with and without cachexia...
  14. ncbi Effect of interleukin-10 on the production of tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with chronic heart failure
    Aidan P Bolger
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Cardiol 90:384-9. 2002
    ..IL-10 is, therefore, a potential therapy for use in chronic HF associated with inflammatory immune activation...
  15. ncbi Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies
    Wolfram Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 105:2619-24. 2002
    ..We therefore studied the effects of XO inhibition with allopurinol on endothelial function and peripheral blood flow in CHF patients after intra-arterial infusion and after oral administration in 2 independent placebo-controlled studies...
  16. ncbi Wasting of the left ventricle in patients with cardiac cachexia: a cardiovascular magnetic resonance study
    Viorel G Florea
    Department of Clinical Cardiology, Imperial College of Science, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Int J Cardiol 97:15-20. 2004
    ..Cardiovascular magnetic resonance (CMR) has high reproducibility and is more sensitive than other techniques...
  17. ncbi Association of deranged adrenal steroid metabolism with anemia in chronic heart failure
    Darlington O Okonko
    Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, UK
    Am J Cardiol 96:101-3. 2005
    ..The cortisol/DHEA ratio was independently and inversely associated with hemoglobin concentrations, suggesting that alterations of the steroid milieu may play a role in the pathogenesis of anemia in CHF...
  18. ncbi Nutrition, metabolism, and the complex pathophysiology of cachexia in chronic heart failure
    Stephan von Haehling
    Department of Clinical Cardiology, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Cardiovasc Res 73:298-309. 2007
    ..Finally, therapeutic approaches are discussed. These include dietary advice, ongoing studies, and future possibilities...
  19. ncbi Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging
    Stefan D Anker
    Applied Cachexia Research Unit, Charite, Campus Virchow Klinikum, Berlin, Germany
    Circulation 107:1991-7. 2003
    ..Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF)...
  20. ncbi Meeting report from the 74th annual scientific sessions of the American Heart Association (AHA). Anaheim, CA, USA, November 11-14, 2001
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Heart Fail Monit 2:104-7. 2002
  21. ncbi Prognostic utility of growth differentiation factor-15 in patients with chronic heart failure
    Tibor Kempf
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    J Am Coll Cardiol 50:1054-60. 2007
    ..We explored the prognostic utility of growth differentiation factor (GDF)-15 in patients with chronic heart failure (CHF)...
  22. ncbi Comparison of midregional pro-atrial natriuretic peptide with N-terminal pro-B-type natriuretic peptide in predicting survival in patients with chronic heart failure
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany
    J Am Coll Cardiol 50:1973-80. 2007
    ..Our aim was assess the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) using a new immunoassay in patients with chronic heart failure (HF)...
  23. ncbi Anorexia in chronic obstructive pulmonary disease--association to cachexia and hormonal derangement
    Friedrich Koehler
    Department of Cardiology, Charite University Hospital, Campus Mitte, Berlin, Germany
    Int J Cardiol 119:83-9. 2007
    ..Anorexia may importantly contribute to weight loss in COPD, however, the association between immune and hormonal derangement and altered appetite has not been studied in detail...
  24. ncbi Uric acid as a prognostic marker in acute heart failure--new expectations from an old molecule
    Wolfram Doehner
    Eur J Heart Fail 9:437-9. 2007
  25. ncbi Prediction of mortality in chronic heart failure from peak oxygen consumption adjusted for either body weight or lean tissue
    Mariantonietta Cicoira
    Divisione Clinicizzata di Cardiologia, Universita degli Studi di Verona, Italy
    J Card Fail 10:421-6. 2004
    ..We hypothesized that correcting pVO2 for lean tissue rather than total body weight would improve the prediction of prognosis in patients with chronic heart failure (CHF)...
  26. ncbi Uric acid in CHF: marker or player in a metabolic disease?
    Wolfram Doehner
    Int J Cardiol 115:156-8. 2007
  27. ncbi Uric acid in chronic heart failure
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Humboldt University, D 13353 Berlin, Germany
    Semin Nephrol 25:61-6. 2005
    ..In this article, the significance of the xanthine oxidase metabolic pathway in CHF is discussed. Data on xanthine oxidase inhibition are reviewed, which suggest a beneficial effect of therapeutically targeting this enzymatic pathway...
  28. ncbi Anemia and inflammation in COPD
    Matthias John
    Department of Pneumology, University Hospital Charite, Campus Mitte, Schumannstr 20 21, 10098 Berlin, Germany
    Chest 127:825-9. 2005
    ..Anemia in patients with COPD and its pathophysiology is an understudied issue...
  29. ncbi Questions in cardiac resynchronization therapy: metabolic implications
    Tim Karhausen
    J Am Coll Cardiol 48:591-2; author reply 592. 2006
  30. ncbi Altered intestinal function in patients with chronic heart failure
    Anja Sandek
    Department of Gastroenterology, Charite, Campus Mitte, Berlin, Germany
    J Am Coll Cardiol 50:1561-9. 2007
    ..We evaluated morphology and function of the gut in patients with chronic heart failure (CHF)...
  31. ncbi Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Eur Heart J 28:821-8. 2007
    ....
  32. ncbi Heart failure therapy: testosterone replacement and its implications
    Mathias Rauchhaus
    Eur Heart J 27:10-2. 2006
  33. ncbi Metabolic disturbances in chronic heart failure: a case for the "macho" approach with testosterone?!
    Mitja Lainscak
    Eur J Heart Fail 9:2-3. 2007
    ..We discuss this study in detail. Further studies are needed to substantiate this link and to generally explore the value of testosterone therapy in CHF patients...
  34. ncbi Survival and body fat in hemodialysis patients: true association or effects of concomitant therapy?
    Anja Sandek
    Am J Clin Nutr 84:663-4; author reply 634. 2006
  35. doi Insulin resistance in chronic heart failure
    Wolfram Doehner
    J Am Coll Cardiol 52:239; author reply 239-40. 2008