Gerhard Paul Diller

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Detrimental impact of socioeconomic status on exercise capacity in adults with congenital heart disease
    Gerhard Paul Diller
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London, UK National Heart and Lung Institute, Imperial College School of Medicine, London, UK Electronic address
    Int J Cardiol 165:80-6. 2013
  2. ncbi B-type natriuretic peptide concentrations in contemporary Eisenmenger syndrome patients: predictive value and response to disease targeting therapy
    Gerhard Paul Diller
    Adult Congenital Heart Disease Centre and, National Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Heart 98:736-42. 2012
  3. ncbi Endothelial progenitor cells in pulmonary arterial hypertension
    Gerhard Paul Diller
    Adult Congenital Heart Center and Center for Pulmonary Hypertension, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College of Science and Medicine, SW3 6NP London, UK
    Trends Cardiovasc Med 20:22-9. 2010
  4. ncbi A modelling study of atrial septostomy for pulmonary arterial hypertension, and its effect on the state of tissue oxygenation and systemic blood flow
    Gerhard Paul Diller
    National Heart and Lung Institute, Imperial College of Science and Medicine, London, UK
    Cardiol Young 20:25-32. 2010
  5. ncbi Predictors of morbidity and mortality in contemporary Fontan patients: results from a multicenter study including cardiopulmonary exercise testing in 321 patients
    Gerhard Paul Diller
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital and the National Heart and Lung Institute, Imperial College of Science and Medicine, Sydney Street, SW3 6NP London, UK
    Eur Heart J 31:3073-83. 2010
  6. ncbi Evidence of improved regional myocardial function in patients with chronic stable angina and apparent normal ventricular function--a tissue Doppler study before and after percutaneous coronary intervention
    Gerhard Paul Diller
    International Centre for Circulatory Health, St Mary s Hospital and National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Am Soc Echocardiogr 22:177-82. 2009
  7. ncbi Effect of coronary artery bypass surgery on myocardial function as assessed by tissue Doppler echocardiography
    Gerhard Paul Diller
    International Centre for Circulatory Health, St Mary s Hospital and National Heart and Lung Institute, Imperial College, London, UK
    Eur J Cardiothorac Surg 34:995-9. 2008
  8. ncbi Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension
    Gerhard Paul Diller
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Circulation 117:3020-30. 2008
  9. ncbi Impaired heart rate response to exercise in adult patients with a systemic right ventricle or univentricular circulation: prevalence, relation to exercise, and potential therapeutic implications
    Gerhard Paul Diller
    Adult Congenital Heart Program, Department of Cardiology, Royal Brompton, Hospital, Sydney Street, London, UK
    Int J Cardiol 134:59-66. 2009
  10. ncbi Cardiac resynchronization therapy for adult congenital heart disease patients with a systemic right ventricle: analysis of feasibility and review of early experience
    Gerhard Paul Diller
    Adult Congenital Heart Programme, Royal Brompton Hospital, Sydney Street, SW3 6NP London, UK
    Europace 8:267-72. 2006

Detail Information

Publications35

  1. ncbi Detrimental impact of socioeconomic status on exercise capacity in adults with congenital heart disease
    Gerhard Paul Diller
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London, UK National Heart and Lung Institute, Imperial College School of Medicine, London, UK Electronic address
    Int J Cardiol 165:80-6. 2013
    ..To evaluate the relationship between socioeconomic status (SES), access to physical activity resources, urban-rural dwelling, levels of pollution and exercise capacity in adult congenital heart disease (ACHD) patients...
  2. ncbi B-type natriuretic peptide concentrations in contemporary Eisenmenger syndrome patients: predictive value and response to disease targeting therapy
    Gerhard Paul Diller
    Adult Congenital Heart Disease Centre and, National Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Heart 98:736-42. 2012
    ..To assess the relationship between elevated levels of B-type natriuretic peptide (BNP) and outcome in patients with Eisenmenger syndrome...
  3. ncbi Endothelial progenitor cells in pulmonary arterial hypertension
    Gerhard Paul Diller
    Adult Congenital Heart Center and Center for Pulmonary Hypertension, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College of Science and Medicine, SW3 6NP London, UK
    Trends Cardiovasc Med 20:22-9. 2010
    ....
  4. ncbi A modelling study of atrial septostomy for pulmonary arterial hypertension, and its effect on the state of tissue oxygenation and systemic blood flow
    Gerhard Paul Diller
    National Heart and Lung Institute, Imperial College of Science and Medicine, London, UK
    Cardiol Young 20:25-32. 2010
    ..Our data suggest that the clinically observed beneficial effects of atrial septostomy are the result of improved flow of blood rather than augmented tissue oxygenation, provided that right ventricular function is adequate...
  5. ncbi Predictors of morbidity and mortality in contemporary Fontan patients: results from a multicenter study including cardiopulmonary exercise testing in 321 patients
    Gerhard Paul Diller
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital and the National Heart and Lung Institute, Imperial College of Science and Medicine, Sydney Street, SW3 6NP London, UK
    Eur Heart J 31:3073-83. 2010
    ..We aimed to clarify if exercise intolerance is associated with poor outcome in Fontan patients and to identify risk factors for mortality, transplantation, and cardiac-related hospitalization...
  6. ncbi Evidence of improved regional myocardial function in patients with chronic stable angina and apparent normal ventricular function--a tissue Doppler study before and after percutaneous coronary intervention
    Gerhard Paul Diller
    International Centre for Circulatory Health, St Mary s Hospital and National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Am Soc Echocardiogr 22:177-82. 2009
    ..The aim of this study was to determine the impact of percutaneous coronary intervention (PCI) on myocardial function assessed by tissue Doppler echocardiography...
  7. ncbi Effect of coronary artery bypass surgery on myocardial function as assessed by tissue Doppler echocardiography
    Gerhard Paul Diller
    International Centre for Circulatory Health, St Mary s Hospital and National Heart and Lung Institute, Imperial College, London, UK
    Eur J Cardiothorac Surg 34:995-9. 2008
    ..Coronary artery bypass graft (CABG) surgery may induce myocardial stunning and thereby affect cardiac function. We aimed to assess whether myocardial function is affected by CABG in patients with preserved preoperative systolic function...
  8. ncbi Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension
    Gerhard Paul Diller
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Circulation 117:3020-30. 2008
    ..We speculated that PAH patients are deficient in circulating endothelial progenitor cells (EPCs), potentially contributing to endothelial dysfunction and disease progression...
  9. ncbi Impaired heart rate response to exercise in adult patients with a systemic right ventricle or univentricular circulation: prevalence, relation to exercise, and potential therapeutic implications
    Gerhard Paul Diller
    Adult Congenital Heart Program, Department of Cardiology, Royal Brompton, Hospital, Sydney Street, London, UK
    Int J Cardiol 134:59-66. 2009
    ..We aimed to investigate the association of CI with exercise capacity, and evaluate whether CI is causally related to exercise intolerance...
  10. ncbi Cardiac resynchronization therapy for adult congenital heart disease patients with a systemic right ventricle: analysis of feasibility and review of early experience
    Gerhard Paul Diller
    Adult Congenital Heart Programme, Royal Brompton Hospital, Sydney Street, SW3 6NP London, UK
    Europace 8:267-72. 2006
    ..We aimed to assess the proportion of unselected patients with a systemic RV eligible for CRT and to review available data on the effect of CRT in congenital heart disease patients...
  11. ncbi Analytical identification of ideal pulmonary-systemic flow balance in patients with bidirectional cavopulmonary shunt and univentricular circulation: oxygen delivery or tissue oxygenation?
    Gerhard Paul Diller
    National Heart and Lung Institute, Imperial College of Science and Medicine, Dovehouse St, SW3 6LY London, United Kingdom
    Circulation 114:1243-50. 2006
    ..We set out to determine which of these descriptors best represents the overall tissue oxygenation. We also introduce a new descriptor, SO2min, defined as the lower of the superior and inferior vena cava oxygen saturations...
  12. ncbi Systemic right ventricular longitudinal strain is reduced in adults with transposition of the great arteries, relates to subpulmonary ventricular function, and predicts adverse clinical outcome
    Gerhard Paul Diller
    Adult Congenital Heart Disease Programme, Royal Brompton Hospital, London, United Kingdom
    Am Heart J 163:859-66. 2012
    ....
  13. ncbi Echocardiographic predictors of outcome in eisenmenger syndrome
    Pamela Moceri
    Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, United Kingdom
    Circulation 126:1461-8. 2012
    ..We sought to assess the relationship between the echocardiographic characteristics of patients with Eisenmenger syndrome and mortality...
  14. ncbi Comprehensive use of cardiopulmonary exercise testing identifies adults with congenital heart disease at increased mortality risk in the medium term
    Ryo Inuzuka
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney St, SW3 6NP, London, UK
    Circulation 125:250-9. 2012
    ..We hypothesized that combinations of cardiopulmonary exercise testing parameters may provide optimal prognostic information on midterm survival in this population...
  15. ncbi Quality of life and functional capacity can be improved in patients with Eisenmenger syndrome with oral sildenafil therapy
    Edgar L W Tay
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, UK
    Int J Cardiol 149:372-6. 2011
    ..While patients may survive to middle adulthood, the burden of disease is disabling. Sildenafil seems to improve exercise tolerance and hemodynamics, but there is no data to date on its impact on QoL...
  16. ncbi Reference values for exercise limitations among adults with congenital heart disease. Relation to activities of daily life--single centre experience and review of published data
    Aleksander Kempny
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London, UK
    Eur Heart J 33:1386-96. 2012
    ..We aimed to investigate the distribution of exercise capacity across the spectrum of adult congenital heart disease (ACHD) using own data and the published experience and to provide diagnosis, gender-, and age- specific reference values...
  17. ncbi Effect of pregnancy on clinical status and ventricular function in women with heart disease
    Anselm Uebing
    Adult Congenital Heart Disease Unit, Royal Brompton and Harefield NHS Trust, and the National Heart and Lung Institute at Imperial College, London SW3 6NP, UK
    Int J Cardiol 139:50-9. 2010
    ..However, the effect of pregnancy on clinical status and ventricular function in women with HD has not been examined in a controlled study...
  18. ncbi Long-term safety, tolerability and efficacy of bosentan in adults with pulmonary arterial hypertension associated with congenital heart disease
    Gerhard Paul Diller
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, and the National Heart and Lung Institute, Imperial College of Science and Medicine, London, UK
    Heart 93:974-6. 2007
    ..To examine long-term safety and efficacy of bosentan--an oral dual endothelin receptor antagonist--in patients with pulmonary hypertension associated with congenital heart disease or Eisenmenger's syndrome...
  19. ncbi Peak oxygen uptake correlates with disease severity and predicts outcome in adult patients with Ebstein's anomaly of the tricuspid valve
    Jelena Radojevic
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, UK
    Int J Cardiol 163:305-8. 2013
    ..Ebstein's anomaly of the tricuspid valve often results in biventricular dysfunction and functional deterioration. Little is known about the relation between exercise capacity, disease severity and outcome in adults with Ebstein's anomaly...
  20. ncbi Anemia in adults with congenital heart disease relates to adverse outcome
    Konstantinos Dimopoulos
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, United Kingdom
    J Am Coll Cardiol 54:2093-100. 2009
    ..To assess the relation of anemia in noncyanotic adults with congenital heart disease (ACHD) to functional capacity and mortality...
  21. ncbi Exercise intolerance in adults with congenital heart disease
    Konstantinos Dimopoulos
    Adult Congenital Heart Programme, Department of Cardiology, Royal Brompton Hospital, Sydney Street, London, UK
    Cardiol Clin 24:641-60, vii. 2006
    ..It also discusses the likely pathogenesis of exercise intolerance in ACHD, the similarities between ACHD and acquired heart failure, and potential therapeutic options...
  22. ncbi Comparison of 6-min walk test distance and cardiopulmonary exercise test performance in children with pulmonary hypertension
    Astrid E Lammers
    Department of Paediatric Cardiology, Great Ormond Street Hospital for Children, London, UK
    Arch Dis Child 96:141-7. 2011
    ..To assess the relationship between 6-min walk test (6MWT) distance and variables of cardiopulmonary exercise testing (CPET) in children with pulmonary arterial hypertension (PAH)...
  23. ncbi Abnormal lung function in adults with congenital heart disease: prevalence, relation to cardiac anatomy, and association with survival
    Rafael Alonso-González
    Adult Congenital Heart Disease Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital, NIHR Cardiovascular Biomedical Research Unit, London, UK
    Circulation 127:882-90. 2013
    ..We investigated the prevalence of abnormal lung function, its relation to severity of underlying cardiac defect, its surgical history, and its impact on outcome across the spectrum of adult congenital heart disease...
  24. ncbi Optimised rate-responsive pacing does not improve either right ventricular haemodynamics or exercise capacity in adults with a systemic right ventricle
    Anselm Uebing
    Adult Congenital Heart Centre, Royal Brompton Hospital and the National Heart and Lung Institute at Imperial College, London, United Kingdom
    Cardiol Young 20:485-94. 2010
    ..We aimed to assess the relationship between heart rate increase, oxygen consumption, and timing of the right ventricular cardiac cycle in this cohort...
  25. ncbi Hyponatraemia: A strong predictor of mortality in adults with congenital heart disease
    Konstantinos Dimopoulos
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, UK
    Eur Heart J 31:595-601. 2010
    ..We studied the prevalence of hyponatraemia and its prognostic implications in a large population of adult patients with congenital heart disease (ACHD)...
  26. ncbi Value of tissue Doppler echocardiography in children with pulmonary hypertension
    Astrid E Lammers
    Paediatric Cardiology and the UK Pulmonary Hypertension Service for Children, Great Ormond Street Hospital for Children, London, United Kingdom
    J Am Soc Echocardiogr 25:504-10. 2012
    ....
  27. ncbi Prevalence, predictors, and prognostic value of renal dysfunction in adults with congenital heart disease
    Konstantinos Dimopoulos
    Adult Congenital Heart Centre, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College School of Medicine, London SW3 6NP, United Kingdom
    Circulation 117:2320-8. 2008
    ..We studied the prevalence of renal dysfunction in adult patients with congenital heart disease (ACHD) and its relation to outcome...
  28. ncbi Burden of coronary artery disease in adults with congenital heart disease and its relation to congenital and traditional heart risk factors
    Georgios Giannakoulas
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, United Kingdom
    Am J Cardiol 103:1445-50. 2009
    ..Traditional cardiovascular risk factors for CAD also applied to adult patients with CHD, in whom primary prevention of CAD was as important as in the general population...
  29. ncbi Pulmonary vascular disease in adults with congenital heart disease
    Gerhard Paul Diller
    Adult Congenital Heart Center, Royal Brompton Hospital, Sydney St, London, SW3 6NP, UK
    Circulation 115:1039-50. 2007
    ..In addition, we discuss the numerous complications associated with Eisenmenger syndrome, representing a multisystem disorder. Finally, we present general management strategies and emerging disease-targeting therapies...
  30. ncbi Atrial septostomy in patients with pulmonary hypertension: should it be recommended?
    Astrid E Lammers
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, London SW3 6NP, UK
    Expert Rev Respir Med 5:363-76. 2011
    ..We review pathophysiologic data and the published clinical experience and discuss the rationale, indication and potential pitfalls of AS in patients with severe PH...
  31. ncbi Selective right ventricular impairment following coronary artery bypass graft surgery
    Hemang Yadav
    International Centre for Circulatory Health, Imperial College NHS Trust, St Mary s Hospital and National Heart and Lung Institute, London W2 1LA, UK
    Eur J Cardiothorac Surg 37:393-8. 2010
    ..We tested this hypothesis in two study parts: a prospective cohort undergoing CABG, and a retrospective cross-sectional cohort of heart-failure patients with and without a history of CABG...
  32. ncbi Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival
    Konstantinos Dimopoulos
    Adult Congenital Heart Programme, Department of Cardiology, Royal Brompton Hospital, Sydney St, London, SW3 6NP, United Kingdom
    Circulation 113:2796-802. 2006
    ..Increased V(E)/V(CO2) slope is the strongest exercise predictor of death in noncyanotic ACHD patients...
  33. ncbi Heart rate response during exercise predicts survival in adults with congenital heart disease
    Gerhard-Paul Diller
    Adult Congenital Heart Program, Department of Cardiology, Royal Brompton Hospital, London, United Kingdom
    J Am Coll Cardiol 48:1250-6. 2006
    ..Heart rate reserve is a simple and inexpensive way to identify ACHD patients at higher mortality risk...
  34. ncbi Presentation, survival prospects, and predictors of death in Eisenmenger syndrome: a combined retrospective and case-control study
    Gerhard-Paul Diller
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Heart J 27:1737-42. 2006
    ..Markers of heart failure and parameters associated with arrhythmia are of prognostic value in terms of mortality and may guide clinicians caring for Eisenmenger patients...
  35. ncbi Exercise intolerance in adult congenital heart disease: comparative severity, correlates, and prognostic implication
    Gerhard-Paul Diller
    Adult Congenital Heart Program, Department of Cardiology, Royal Brompton Hospital, London, UK
    Circulation 112:828-35. 2005
    ..Poor exercise capacity identifies ACHD patients at risk for hospitalization or death...