Andrew J deMello

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Precise temperature control in microfluidic devices using Joule heating of ionic liquids
    Andrew J de Mello
    Imperial College London, Exhibition Road, South Kensington, London, UK SW7 2AZ
    Lab Chip 4:417-9. 2004
  2. ncbi request reprint Control and detection of chemical reactions in microfluidic systems
    Andrew J deMello
    Electronic Materials Group, Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK
    Nature 442:394-402. 2006
  3. doi request reprint Passive self-synchronized two-droplet generation
    Jongin Hong
    Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK
    Lab Chip 10:2702-9. 2010
  4. doi request reprint Lab-chip HPLC with integrated droplet-based microfluidics for separation and high frequency compartmentalisation
    Jin Young Kim
    Department of Bioengineering, Imperial College London, London SW7 2AZ, UK
    Chem Commun (Camb) 48:9144-6. 2012
  5. doi request reprint Analysis of protein-protein interactions by using droplet-based microfluidics
    Monpichar Srisa-art
    Department of Chemistry, Imperial College London, Exhibition Road, London, UK
    Chembiochem 10:1605-11. 2009
  6. pmc Opportunities for microfluidic technologies in synthetic biology
    Shelly Gulati
    Department of Chemistry, Imperial College London, London, UK
    J R Soc Interface 6:S493-506. 2009
  7. doi request reprint Mapping of fluidic mixing in microdroplets with 1 micros time resolution using fluorescence lifetime imaging
    Xavier Casadevall i Solvas
    Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, United Kingdom
    Anal Chem 82:3950-6. 2010
  8. doi request reprint Dielectric cell response in highly conductive buffers
    Fabrice Gielen
    Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, United Kingdom
    Anal Chem 84:1849-53. 2012
  9. doi request reprint Novel technologies for the formation of 2-D and 3-D droplet interface bilayer networks
    Yuval Elani
    Department of Chemistry, Imperial College London, Exhibition Road South Kensington, London, UK
    Lab Chip 12:3514-20. 2012
  10. doi request reprint Thermoset polyester droplet-based microfluidic devices for high frequency generation
    Jin Young Kim
    Department of Bioengineering, Imperial College London, London, United Kingdom
    Lab Chip 11:4108-12. 2011

Collaborators

  • Xavier Casadevall I Solvas
  • Danny O'Hare
  • Andrew Williams
  • Suwan N Jayasinghe
  • Ali Salehi-Reyhani
  • Richard H Templer
  • Tim Albrecht
  • Hyun Park
  • Molly M Stevens
  • Joshua B Edel
  • Monpichar Srisa-art
  • Jongin Hong
  • Fabrice Gielen
  • Xize Niu
  • Oliver Hofmann
  • John C deMello
  • Guillaume A T Chansin
  • Jin Young Kim
  • Donal D C Bradley
  • Xavier Casadevall i Solvas
  • Xuhua Wang
  • Gihan Ryu
  • Soo Ik Chang
  • Shelly Gulati
  • Miriam S Goyder
  • Oscar Ces
  • Yuval Elani
  • Mikihide Yamazaki
  • Dong Ku Kang
  • Nigel P Beard
  • Richard K P Benninger
  • Andrew J de Mello
  • Soong Won Cho
  • David R Klug
  • Keith R Willison
  • Jonathan Dusting
  • Gareth D McClean
  • Jake G Bundy
  • Alan Mosley
  • Armand M Leroi
  • Tai Kyu Lee
  • Jasmine Y Y Sze
  • Li Xiaoe
  • Florian M Geier
  • Jingsong Huang
  • Simon J Rattle
  • Claire A Walshe
  • Fiona Pereira
  • Minsuk Choi
  • James Chappell
  • Robin J Leatherbarrow
  • Richard I Kitney
  • Tony Cass
  • Vincent Rouilly
  • Ian C Bonzani
  • Paul S Freemont
  • Yoonjae Lee
  • Emily C Dyson
  • Edward M Barrett
  • Min Jun Kim
  • Anthony E G Cass
  • Pedro Lahoud
  • Rupa Das
  • Rafael Mulero
  • Mark A A Neil
  • Stephen Beecher
  • Yasemin Koç
  • Paul M W French
  • Amal Raja
  • Jose Requejo-Isidro
  • Alastair Cornwell
  • Matthew Habgood
  • Tom Welton
  • Robert C R Wootton
  • N Llewellyn Lancaster
  • Chao Xuan Zhang

Detail Information

Publications38

  1. ncbi request reprint Precise temperature control in microfluidic devices using Joule heating of ionic liquids
    Andrew J de Mello
    Imperial College London, Exhibition Road, South Kensington, London, UK SW7 2AZ
    Lab Chip 4:417-9. 2004
    ..2 degrees C. Ionic liquids held in co-running channels are Joule heated with an a.c. current. The nature of the devices means that the internal temperature can be directly assessed in a facile manner...
  2. ncbi request reprint Control and detection of chemical reactions in microfluidic systems
    Andrew J deMello
    Electronic Materials Group, Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK
    Nature 442:394-402. 2006
    ..Such systems define new operational paradigms and provide predictions about how molecular synthesis might be revolutionized in the fields of high-throughput synthesis and chemical production...
  3. doi request reprint Passive self-synchronized two-droplet generation
    Jongin Hong
    Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK
    Lab Chip 10:2702-9. 2010
    ..We study droplet generation and self-synchronization in a quantitative fashion by using high-speed image analysis...
  4. doi request reprint Lab-chip HPLC with integrated droplet-based microfluidics for separation and high frequency compartmentalisation
    Jin Young Kim
    Department of Bioengineering, Imperial College London, London SW7 2AZ, UK
    Chem Commun (Camb) 48:9144-6. 2012
    ..This describes the use of droplet-based microfluidics for the preservation of chromatographic separations, and its potential application as a high frequency fraction collector...
  5. doi request reprint Analysis of protein-protein interactions by using droplet-based microfluidics
    Monpichar Srisa-art
    Department of Chemistry, Imperial College London, Exhibition Road, London, UK
    Chembiochem 10:1605-11. 2009
    ..Importantly, the use of fluorophores does not affect the activity of ANG or the binding of anti-ANG antibodies to ANG. Such an experimental platform could be applied to the high-throughput analysis of protein-protein interactions...
  6. pmc Opportunities for microfluidic technologies in synthetic biology
    Shelly Gulati
    Department of Chemistry, Imperial College London, London, UK
    J R Soc Interface 6:S493-506. 2009
    ..Recent advances in the field of microfluidics are reviewed and the potential of such a technological platform to support the rapid development of synthetic biology solutions is discussed...
  7. doi request reprint Mapping of fluidic mixing in microdroplets with 1 micros time resolution using fluorescence lifetime imaging
    Xavier Casadevall i Solvas
    Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, United Kingdom
    Anal Chem 82:3950-6. 2010
    ..Importantly, such exquisite resolution is only possible as a result of the large number of droplets sampled and their high structural reproducibility...
  8. doi request reprint Dielectric cell response in highly conductive buffers
    Fabrice Gielen
    Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, United Kingdom
    Anal Chem 84:1849-53. 2012
    ..Herein, we demonstrate that at 40 MHz, we are able to statistically distinguish between live and dead cell populations...
  9. doi request reprint Novel technologies for the formation of 2-D and 3-D droplet interface bilayer networks
    Yuval Elani
    Department of Chemistry, Imperial College London, Exhibition Road South Kensington, London, UK
    Lab Chip 12:3514-20. 2012
    ..Both approaches allow individual droplet position and composition to be controlled, paving the way for complex on-chip functional network synthesis...
  10. doi request reprint Thermoset polyester droplet-based microfluidic devices for high frequency generation
    Jin Young Kim
    Department of Bioengineering, Imperial College London, London, United Kingdom
    Lab Chip 11:4108-12. 2011
    ..The improved resistance of TPE to high pressures enabled investigation of high frequency droplet generation as a function of a wide range of flow-rates with three different oils as continuous phase...
  11. doi request reprint Non-emissive colour filters for fluorescence detection
    Mikihide Yamazaki
    Department of Chemistry, Imperial College London, South Kensington, London, United Kingdom
    Lab Chip 11:1228-33. 2011
    ....
  12. doi request reprint Identification of rare progenitor cells from human periosteal tissue using droplet microfluidics
    Monpichar Srisa-art
    Department of Chemistry, Imperial College London, South Kensington, London, UK SW7 2AZ
    Analyst 134:2239-45. 2009
    ..Accordingly, this study demonstrates the biological capacity of droplet-based microfluidics for cellular analysis and provides a necessary first step towards the development of a novel cell sorting technology...
  13. doi request reprint Bio-electrospraying and droplet-based microfluidics: control of cell numbers within living residues
    Jongin Hong
    Department of Chemistry, Imperial College London, UK
    Biomed Mater 5:21001. 2010
    ..In this communication, we address this issue by demonstrating the coupling of BES with droplet-based microfluidics for controlling live cell numbers within droplets and residues...
  14. doi request reprint High-resolution local imaging of temperature in dielectrophoretic platforms
    Fabrice Gielen
    Institute of Biomedical Engineering, Imperial College London, South Kensington, London, SW7 2AZ, United Kingdom
    Anal Chem 82:7509-14. 2010
    ..Such measurements are shown to provide a novel calibration tool for screening temperature-mediated processes with high resolution...
  15. doi request reprint Increasing the trapping efficiency of particles in microfluidic planar platforms by means of negative dielectrophoresis
    Fabrice Gielen
    Department of Chemistry, Institute of Biomedical Engineering, and Chemical Biology Centre, Imperial College London, South Kensington, London, SW7 2AZ, United Kingdom
    J Phys Chem B 113:1493-500. 2009
    ..This trapping configuration results in improved trapping yields and a decrease in overall reagent consumption. Particles are trapped dynamically while flowing in a microfluidic channel...
  16. doi request reprint Pillar-induced droplet merging in microfluidic circuits
    Xize Niu
    Department of Chemistry, Imperial College London, South Kensington, London, UKSW7 2AZ
    Lab Chip 8:1837-41. 2008
    ..Finally, we note that the merging of droplet interfaces occurs within both compressing and the decompressing regimes...
  17. doi request reprint Resizing metal-coated nanopores using a scanning electron microscope
    Guillaume A T Chansin
    Department of Chemistry, Imperial College London, London, SW7 2AZ, UK
    Small 7:2736-41. 2011
    ..Shrinkage is observed on the Al side of the pore as well as on the Si(3) N(4) side, while the shrinkage rate is observed to be dependent on a variety of factors...
  18. doi request reprint Micro- and nanofluidic systems for high-throughput biological screening
    Jongin Hong
    Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom
    Drug Discov Today 14:134-46. 2009
    ..We review recent advances in both arraying strategies based on nano/microfluidics and novel nano/microfluidic devices with high analytical throughput rates...
  19. doi request reprint A microdroplet dilutor for high-throughput screening
    Xize Niu
    Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London SW72AZ, UK
    Nat Chem 3:437-42. 2011
    ..As a proof of concept, we used the dilutor to perform a high-throughput homogeneous DNA-binding assay using only nanolitres of sample...
  20. doi request reprint Highly sensitive fluorescence detection system for microfluidic lab-on-a-chip
    Gihan Ryu
    Molecular Vision Ltd BioIncubator Unit, Bessemer Building, Imperial College London, London, SW7 2BP, UK
    Lab Chip 11:1664-70. 2011
    ..6 × 10(4) beads µl(-1) which can be equated to ∼3 nM fluorescein equivalent concentration. The LOD for the human plasma immunoassays is measured as 1.5 ng ml(-1) for both myoglobin and CK-MB...
  21. ncbi request reprint Single-molecule spectroscopy using nanoporous membranes
    Guillaume A T Chansin
    Institute of Biomedical Engineering, Imperial College London, South Kensington, SW7 2AZ, United Kingdom
    Nano Lett 7:2901-6. 2007
    ..Single-pore translocation events are also successfully detected using single-point confocal spectroscopy...
  22. ncbi request reprint Fluorescence lifetime imaging of mixing dynamics in continuous-flow microdroplet reactors
    Monpichar Srisa-art
    Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom
    Phys Rev Lett 101:014502. 2008
    ..Herein, we demonstrate that fluorescence lifetime imaging can be used to reconstruct mixing patterns within a droplet with a time resolution of 5 micros...
  23. doi request reprint Monitoring of real-time streptavidin-biotin binding kinetics using droplet microfluidics
    Monpichar Srisa-art
    Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, United Kingdom
    Anal Chem 80:7063-7. 2008
    ..The binding rate constant of streptavidin and biotin was found to be in a range of 3.0 x 10 (6)-4.5 x 10 (7) M (-1) s (-1)...
  24. doi request reprint High-throughput age synchronisation of Caenorhabditis elegans
    Xavier Casadevall i Solvas
    Department of Chemistry, Imperial College London, London, UK
    Chem Commun (Camb) 47:9801-3. 2011
    ..In brief, the microfluidic device allows worms to sort themselves in a passive manner...
  25. ncbi request reprint Design of a solid-state nanopore-based platform for single-molecule spectroscopy
    Jongin Hong
    Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK
    Nanotechnology 19:165205. 2008
    ..The cut-off behavior for Al/SiN membranes with varying pore diameters was investigated in terms of light propagation, distribution of electromagnetic fields, and light attenuation characteristics...
  26. doi request reprint Electro-coalescence of digitally controlled droplets
    Xize Niu
    Department of Chemistry, and Institute of Biomedical Engineering, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, United Kingdom
    Anal Chem 81:7321-5. 2009
    ..This brings adjacent droplets into close proximity. At this point, an electric field applied to the electrodes breaks up the thin oil film surrounding the droplets resulting in merging...
  27. doi request reprint A first step towards practical single cell proteomics: a microfluidic antibody capture chip with TIRF detection
    Ali Salehi-Reyhani
    Single Cell Proteomics Project, Institute of Chemical Biology, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Lab Chip 11:1256-61. 2011
    ..These results suggest that this is a viable method for measuring relative protein levels in single cells...
  28. ncbi request reprint Integrated thin-film polymer/fullerene photodetectors for on-chip microfluidic chemiluminescence detection
    Xuhua Wang
    Experimental Solid State Physics Group, Blackett Laboratory, Imperial College London, UK
    Lab Chip 7:58-63. 2007
    ....
  29. doi request reprint High-efficiency single-molecule detection within trapped aqueous microdroplets
    Monpichar Srisa-art
    Department of Chemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330 Thailand
    J Phys Chem B 114:15766-72. 2010
    ..This circulation phenomenon allows a given molecule to be detected multiple times during an experiment and can therefore be used for performing time-dependent single-molecule analysis...
  30. ncbi request reprint Affinity chromatography and capillary electrophoresis for analysis of the yeast ribosomal proteins
    Miriam S Goyder
    The Single Cell Proteomics Group, Institute of Chemical Biology, Department of Chemistry, Imperial College London, South Kensington, London, UK
    BMB Rep 45:233-8. 2012
    ..This method is a remarkably quick route from cell to separation that has the potential to be coupled to high throughput readout platforms for studies of the ribosomal proteome...
  31. ncbi request reprint High-throughput DNA droplet assays using picoliter reactor volumes
    Monpichar Srisa-art
    Department of Chemistry and Institute of Biomedical Engineering, Imperial College London, South Kensington, London, UK
    Anal Chem 79:6682-9. 2007
    ..FRET efficiency for this FRET pair was also investigated from the binding results. Efficiency results show that this detection system can precisely measure FRET even at low FRET efficiencies...
  32. ncbi request reprint Quantitative 3D mapping of fluidic temperatures within microchannel networks using fluorescence lifetime imaging
    Richard K P Benninger
    Department of Physics and Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, United Kingdom
    Anal Chem 78:2272-8. 2006
    ..This technique allows optimization of the chip design for miniaturized processes, such as on-chip PCR, for which precise temperature control is important...
  33. ncbi request reprint Thin-film polymer light emitting diodes as integrated excitation sources for microscale capillary electrophoresis
    Joshua B Edel
    Department of Chemistry, Imperial College London, South Kensington, London, UKSW7 2AZ
    Lab Chip 4:136-40. 2004
    ..The drive voltages required to generate sufficient emission from the polymer diode device are as low as 3.7 V...
  34. ncbi request reprint In-column field-amplified sample stacking of biogenic amines on microfabricated electrophoresis devices
    Nigel P Beard
    Department of Chemistry, Imperial College of Science, Technology and Medicine, South Kensington, London, UK
    Electrophoresis 24:732-9. 2003
    ..This design feature radically reduces the complexity in chip structures and associated chip operation. The approach is applied to the analysis of fluorescently labelled biogenic amines affording detection at concentrations down to 20 pM...
  35. ncbi request reprint Discrimination between single Escherichia coli cells using time-resolved confocal spectroscopy
    Joshua B Edel
    Institute of Biomedical Engineering, Department of Chemistry, South Kensington, London, SW7 2AZ, United Kingdom
    J Phys Chem B 111:1129-34. 2007
    ..The simplicity of the approach for obtaining well-defined burst width distributions is expected to be extremely valuable for single-cell sorting experiments...
  36. ncbi request reprint Microfluidics: DNA amplification moves on
    Andrew J deMello
    Nature 422:28-9. 2003
  37. ncbi request reprint Towards microalbuminuria determination on a disposable diagnostic microchip with integrated fluorescence detection based on thin-film organic light emitting diodes
    Oliver Hofmann
    Molecular Vision Ltd, 90 Fetter Lane, London, EC4A 1JP, United Kingdom
    Lab Chip 5:863-8. 2005
    ..This sensitivity is sufficient for the determination of microalbuminuria (MAU), an increased urinary albumin excretion indicative of renal disease (clinical cut-off levels: 15-40 mg L(-1))...
  38. ncbi request reprint Monolithically integrated dye-doped PDMS long-pass filters for disposable on-chip fluorescence detection
    Oliver Hofmann
    Molecular Vision Ltd, 90 Fetter Lane, London EC4A 1JP, UK
    Lab Chip 6:981-7. 2006
    ..The provision of low cost high quality integrated filters represents a key step towards the development of high-sensitivity disposable microfluidic devices for point-of-care diagnostics...