Michael J Delves

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Laboratory maintenance of rodent malaria parasites
    Chandra Ramakrishnan
    The Malaria Centre, Department of Life Sciences, Imperial College, London, UK
    Methods Mol Biol 923:51-72. 2013
  2. pmc Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs
    Michael J Delves
    Department of Life Sciences, Imperial College, London, United Kingdom
    Antimicrob Agents Chemother 57:3268-74. 2013
  3. doi request reprint Plasmodium cell biology should inform strategies used in the development of antimalarial transmission-blocking drugs
    Michael J Delves
    Cell and Molecular Biology, Imperial College, South Kensington, London, SW7 2AZ, UK
    Future Med Chem 4:2251-63. 2012
  4. doi request reprint A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines
    Michael J Delves
    Department of Life Sciences, Imperial College, London, UK
    Int J Parasitol 42:999-1006. 2012
  5. pmc A semi-automated method for counting fluorescent malaria oocysts increases the throughput of transmission blocking studies
    Michael J Delves
    Division of Cell and Molecular Biology, Imperial College London, London, UK
    Malar J 9:35. 2010
  6. ncbi request reprint Assessing transmission blockade in Plasmodium spp
    Andrew M Blagborough
    The Malaria Centre, Department of Life Sciences, Imperial College, London, UK
    Methods Mol Biol 923:577-600. 2013
  7. doi request reprint The design and interpretation of laboratory assays measuring mosquito transmission of Plasmodium
    Robert E Sinden
    The Malaria Centre, Imperial College London, South Kensington, London SW7 2AZ, UK
    Trends Parasitol 28:457-65. 2012
  8. doi request reprint Plasmodium male development gene-1 (mdv-1) is important for female sexual development and identifies a polarised plasma membrane during zygote development
    Kalpana Lal
    The Division of Cell and Molecular Biology, Imperial College London, London, UK
    Int J Parasitol 39:755-61. 2009

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Laboratory maintenance of rodent malaria parasites
    Chandra Ramakrishnan
    The Malaria Centre, Department of Life Sciences, Imperial College, London, UK
    Methods Mol Biol 923:51-72. 2013
    ..The descriptions given illustrate methods routinely used for the maintenance of P. berghei; where critical, we note important differences when transmitting other parasite species...
  2. pmc Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs
    Michael J Delves
    Department of Life Sciences, Imperial College, London, United Kingdom
    Antimicrob Agents Chemother 57:3268-74. 2013
    ..Both assays reported here are being scaled up to at least medium throughput and will permit identification of key transmission-blocking molecules that have been overlooked by other screening campaigns...
  3. doi request reprint Plasmodium cell biology should inform strategies used in the development of antimalarial transmission-blocking drugs
    Michael J Delves
    Cell and Molecular Biology, Imperial College, South Kensington, London, SW7 2AZ, UK
    Future Med Chem 4:2251-63. 2012
    ..The most recent knowledge of the transmission-blocking properties of current antimalarial classes is also summarized and, underdeveloped targets for transmission-stage drug discovery are highlighted...
  4. doi request reprint A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines
    Michael J Delves
    Department of Life Sciences, Imperial College, London, UK
    Int J Parasitol 42:999-1006. 2012
    ..This assay may greatly accelerate the development of malaria transmission-blocking interventions...
  5. pmc A semi-automated method for counting fluorescent malaria oocysts increases the throughput of transmission blocking studies
    Michael J Delves
    Division of Cell and Molecular Biology, Imperial College London, London, UK
    Malar J 9:35. 2010
    ..is important for many of assays investigating transmission. However, current assays are very time-consuming, manually demanding and patently subject to observer-observer variation...
  6. ncbi request reprint Assessing transmission blockade in Plasmodium spp
    Andrew M Blagborough
    The Malaria Centre, Department of Life Sciences, Imperial College, London, UK
    Methods Mol Biol 923:577-600. 2013
    ..The selection of method to be used is determined by the purpose of the experiment, which can include the determination of the site/time of activity, and/or the potential reduction in transmission achieved...
  7. doi request reprint The design and interpretation of laboratory assays measuring mosquito transmission of Plasmodium
    Robert E Sinden
    The Malaria Centre, Imperial College London, South Kensington, London SW7 2AZ, UK
    Trends Parasitol 28:457-65. 2012
    ..However, the diverse readouts of these assays are not directly comparable. Here we attempt to identify the utility of each assay and provide rational frameworks by which to compare the impacts recorded by the diverse methodologies...
  8. doi request reprint Plasmodium male development gene-1 (mdv-1) is important for female sexual development and identifies a polarised plasma membrane during zygote development
    Kalpana Lal
    The Division of Cell and Molecular Biology, Imperial College London, London, UK
    Int J Parasitol 39:755-61. 2009
    ..In the fully developed ookinete MDV-1 is localised to the posterior pole. In vivo, the knock-out parasites demonstrate a phenotype in which there is a 90% reduction of parasite transmission to oocysts in mosquitoes...