Charlotte H Dean
Affiliation: Imperial College
Goggolidou P, Hadjirin N, Bak A, Papakrivopoulou E, Hilton H, Norris D, et al
. Atmin mediates kidney morphogenesis by modulating Wnt signaling. Hum Mol Genet. 2014;23:5303-16 pubmed publisher
..The identification of a novel modulator of Wnt signaling has important implications for understanding the pathobiology of renal disease. ..
Akram K, Yates L, Mongey R, Rothery S, Gaboriau D, Sanderson J, et al
. Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour. Nat Commun. 2019;10:1178 pubmed publisher
..This study reveals important novel information about lung biology and provides a new system in which to manipulate alveologenesis genetically and pharmacologically. ..
Henderson D, Long D, Dean C. Planar cell polarity in organ formation. Curr Opin Cell Biol. 2018;55:96-103 pubmed publisher
..In this review we discuss the increasingly prominent role of the PCP pathway in organogenesis, focusing on the lungs, kidneys and heart. We also highlight emerging evidence that PCP gene mutations are associated with adult diseases. ..
Poobalasingam T, Salman D, Li H, Alçada J, Dean C. Imaging the lung: the old ways and the new. Histol Histopathol. 2017;32:325-337 pubmed publisher
..In this review we assess some of the most commonly-used and novel imaging techniques available for lung research today. ..
Poobalasingam T, Yates L, Walker S, Pereira M, Gross N, Ali A, et al
. Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. Dis Model Mech. 2017;10:409-423 pubmed publisher
..Our data reveal an important novel role for the PCP pathway in adult lung homeostasis and repair and shed new light on the genetic factors which may modify destructive lung diseases such as emphysema. ..
Dean C, Lloyd C. Lung Alveolar Repair: Not All Cells Are Equal. Trends Mol Med. 2017;23:871-873 pubmed publisher
..In turn, these result in either normal or aberrant alveolar repair. Thus, a key question in lung regenerative medicine is how to maintain a 'Goldilocks zone' of repair. ..