J C Davies

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Modifier genes in cystic fibrosis
    Jane C Davies
    Department of Gene Therapy Royal Brompton Hospital and Imperial College, Sydney Street, London, SW3 6NP, UK
    Pediatr Pulmonol Suppl 26:86-7. 2004
  2. pmc Cystic fibrosis
    Jane C Davies
    Department of Gene Therapy, Imperial College, London
    BMJ 335:1255-9. 2007
  3. ncbi request reprint Ion transport in lung disease
    Jane C Davies
    Department of Gene Therapy Royal Brompton Hospital and Imperial College, Sydney Street, London, SW3 6NT, UK
    Pediatr Pulmonol Suppl 26:147-8. 2004
  4. ncbi request reprint Research applications of bronchoscopy
    Jane Davies
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, SW3 6NP, London, UK
    Paediatr Respir Rev 4:230-6. 2003
  5. pmc Cystic fibrosis presenting as acute upper airway obstruction
    J Davies
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London SW3 6LR, UK
    Thorax 61:92. 2006
  6. ncbi request reprint Emerging and unusual gram-negative infections in cystic fibrosis
    Jane C Davies
    Department of Pediatric Respiratory Medicine, Royal Brompton Hospital, and Department of Gene Therapy, Imperial College, London, United Kingdom
    Semin Respir Crit Care Med 28:312-21. 2007
  7. ncbi request reprint Gene therapy for cystic fibrosis
    J C Davies
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    J Gene Med 3:409-17. 2001
  8. pmc New therapeutic approaches for cystic fibrosis lung disease
    Jane C Davies
    Royal Brompton Hospital, Sydney Street, London SW3 6NT, UK
    J R Soc Med 95:58-67. 2002
  9. ncbi request reprint Bone marrow stem cells do not repopulate the healthy upper respiratory tract
    Jane C Davies
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    Pediatr Pulmonol 34:251-6. 2002
  10. ncbi request reprint Prospects for gene therapy in lung disease
    J C Davies
    Imperial College at the National Heart and Lung Institute, London, UK
    Curr Opin Pharmacol 1:272-7. 2001

Detail Information

Publications44

  1. ncbi request reprint Modifier genes in cystic fibrosis
    Jane C Davies
    Department of Gene Therapy Royal Brompton Hospital and Imperial College, Sydney Street, London, SW3 6NP, UK
    Pediatr Pulmonol Suppl 26:86-7. 2004
  2. pmc Cystic fibrosis
    Jane C Davies
    Department of Gene Therapy, Imperial College, London
    BMJ 335:1255-9. 2007
  3. ncbi request reprint Ion transport in lung disease
    Jane C Davies
    Department of Gene Therapy Royal Brompton Hospital and Imperial College, Sydney Street, London, SW3 6NT, UK
    Pediatr Pulmonol Suppl 26:147-8. 2004
  4. ncbi request reprint Research applications of bronchoscopy
    Jane Davies
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, SW3 6NP, London, UK
    Paediatr Respir Rev 4:230-6. 2003
    ..Collaboration between centres should be encouraged to maximise the use of samples obtained...
  5. pmc Cystic fibrosis presenting as acute upper airway obstruction
    J Davies
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London SW3 6LR, UK
    Thorax 61:92. 2006
  6. ncbi request reprint Emerging and unusual gram-negative infections in cystic fibrosis
    Jane C Davies
    Department of Pediatric Respiratory Medicine, Royal Brompton Hospital, and Department of Gene Therapy, Imperial College, London, United Kingdom
    Semin Respir Crit Care Med 28:312-21. 2007
    ..cepacia complex, are clearly linked to an adverse prognosis, and both treatment and infection control issues can pose a real challenge...
  7. ncbi request reprint Gene therapy for cystic fibrosis
    J C Davies
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    J Gene Med 3:409-17. 2001
    ..We highlight the problems encountered, and likely future directions of the field...
  8. pmc New therapeutic approaches for cystic fibrosis lung disease
    Jane C Davies
    Royal Brompton Hospital, Sydney Street, London SW3 6NT, UK
    J R Soc Med 95:58-67. 2002
  9. ncbi request reprint Bone marrow stem cells do not repopulate the healthy upper respiratory tract
    Jane C Davies
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    Pediatr Pulmonol 34:251-6. 2002
    ..In the absence of such conditions, whole bone marrow transplantation is unlikely to provide a route for correction of the CF airway...
  10. ncbi request reprint Prospects for gene therapy in lung disease
    J C Davies
    Imperial College at the National Heart and Lung Institute, London, UK
    Curr Opin Pharmacol 1:272-7. 2001
    ..Recently, progress has been made in both laboratory and clinical studies of gene therapy for cystic fibrosis, alpha1-antitrypsin deficiency and lung cancer...
  11. ncbi request reprint Inflammation in cystic fibrosis airways: relationship to increased bacterial adherence
    P Scheid
    Dept. of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    Eur Respir J 17:27-35. 2001
    ..The authors conclude that the stimulus produced by Pseudomonas aeruginosa is the predominant inflammatory trigger in their models...
  12. doi request reprint Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism
    K J Fidler
    Infectious Diseases and Microbiology Unit, Institute of Child Health, London, UK
    Thorax 64:150-5. 2009
    ..The mechanism is uncertain, and could relate either to systemic or local effects. The aim of this study was to determine, in a large cohort of children, whether MBL is present on the airway surface in health or disease...
  13. doi request reprint Cystic fibrosis and survival to 40 years: a study of cystic fibrosis transmembrane conductance regulator function
    N J Simmonds
    Dept of Cystic Fibrosis, Royal Brompton Hospital, London, SW3 6NP, UK
    Eur Respir J 37:1076-82. 2011
    ..5 (80.0-113.5) mmol·L⁻¹; young/mild). Δ Amil is associated with FEV₁ but our findings indicate that long-term survival cannot be explained by residual CFTR function when measurements are taken in later life...
  14. ncbi request reprint Normal nasal mucociliary clearance in CF children: evidence against a CFTR-related defect
    D McShane
    Dept of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    Eur Respir J 24:95-100. 2004
    ..Studies to explore this mechanism in the distal, more sparsely-ciliated airways could aid an understanding of pathogenesis and the development of new treatments...
  15. ncbi request reprint Modifier genes in cystic fibrosis
    J C Davies
    Department of Gene Therapy, National Lung and Heart Institute, Faculty of Medicine, Imperial College, London, UK
    Pediatr Pulmonol 39:383-91. 2005
    ..This review will summarize the field to date and discuss some of the methodological issues important in the design and interpretation of such studies...
  16. ncbi request reprint Safety of endobronchial biopsy in children with cystic fibrosis
    A Molina-Teran
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, United Kingdom
    Pediatr Pulmonol 41:1021-4. 2006
    ..Studies of such samples would allow us to determine the early pathological changes in the CF airway and possibly find new treatments to prevent the progression to bronchiectasis and end stage airway destruction...
  17. doi request reprint Pseudomonas aeruginosa, cyanide accumulation and lung function in CF and non-CF bronchiectasis patients
    B Ryall
    Dept of Life Sciences, Division of Biology, Faculty of Natural Sciences, Imperial College London, Sir Alexander Fleming Building, London, SW7 2AZ, UK
    Eur Respir J 32:740-7. 2008
    ..4+/-4.9 versus 60.1+/-7.7%). Cyanide is detectable in sputum from cystic fibrosis and non-cystic fibrosis bronchiectasis patients infected with Pseudomonas aeruginosa, and is also associated with impaired lung function...
  18. ncbi request reprint Multiresistant Pseudomonas aeruginosa in a pediatric cystic fibrosis center: natural history and implications for segregation
    G Davies
    Department of Paediatric Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, UK
    Pediatr Pulmonol 35:253-6. 2003
    ..The variability with time in isolation of MR strains from individuals demonstrates the potential difficulties in designing segregation policies based on antibiotic sensitivity patterns...
  19. ncbi request reprint Tumour necrosis factor gene polymorphisms and childhood wheezing
    H Bilolikar
    Dept of Paediatric Respiratory Medicine, Royal BromptonHospital, Sydney Street, London SW3 6NP, UK
    Eur Respir J 26:637-46. 2005
    ..In conclusion, these findings may have implications for future early intervention studies by helping to identify infants at increased risk for wheezing and childhood asthma...
  20. pmc Computed tomography and cystic fibrosis: promises and problems
    Z A Aziz
    Department of Radiology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Thorax 62:181-6. 2007
    ..This review summarises current concepts relating to the research applications of CT in CF, with particular emphasis on the evidence supporting the use of CT as a surrogate outcome measure in clinical trials...
  21. ncbi request reprint Impaired pulmonary status in cystic fibrosis adults with two mutated MBL-2 alleles
    J C Davies
    Dept of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney St, London, SW3 6NP, UK
    Eur Respir J 24:798-804. 2004
    ....
  22. ncbi request reprint Airway surface pH in subjects with cystic fibrosis
    D McShane
    Dept of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    Eur Respir J 21:37-42. 2003
    ....
  23. doi request reprint Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung
    E W F W Alton
    1 UK CF Gene Therapy Consortium, London, Oxford and Edinburgh, UK 2 Department of Gene Therapy, Imperial College, London, UK
    Gene Ther 21:89-95. 2014
    ..This study supports progression into the first non-viral multidose lung trial in CF patients. ..
  24. ncbi request reprint Novel antipseudomonal treatment approaches
    J C Davies
    Dept of Gene Therapy, National Heart and Lung Institute, Imperial College, Emmanuel Kaye Building, Manresa Rd, London SW3 6LR
    Arch Pediatr 13:S51-4. 2006
    ....
  25. ncbi request reprint Early detection of lung disease in preschool children with cystic fibrosis
    Andrew Bush
    Imperial School of Medicine at National Heart and Lung Institute, Royal Brompton Hospital, London, United Kingdom
    Curr Opin Pulm Med 11:534-8. 2005
    ..This is particularly urgent to select groups of children for new, phenotype-specific therapies, and monitor their effects...
  26. ncbi request reprint Wheezing in infants and pre-school children accounts for a considerable proportion of acute hospital admissions
    Jane Davies
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Paediatr Respir Rev 4:267, 270. 2003
  27. ncbi request reprint Exploring the mechanisms of macrolides in cystic fibrosis
    Amanda C Equi
    Department of Gene Therapy, National Heart and Lung Institute, Imperial College, London, UK
    Respir Med 100:687-97. 2006
    ..aeruginosa did not decrease. We conclude that these are unlikely to be significant contributing mechanisms accounting for the consistent beneficial results observed in clinical trials of macrolides in CF...
  28. ncbi request reprint Increased incidence and severity of the systemic inflammatory response syndrome in patients deficient in mannose-binding lectin
    Katy J Fidler
    Infectious Diseases and Microbiology Unit, Institute of Child Health, 30 Guilford Street, London, WC1 N 1EH, UK
    Intensive Care Med 30:1438-45. 2004
    ..To determine whether pediatric PICU patients with mannose-binding lectin (MBL) gene polymorphisms associated with low levels of the functional protein have an increased risk of developing sepsis and SIRS...
  29. ncbi request reprint Pseudomonas aeruginosa in cystic fibrosis: pathogenesis and persistence
    Jane C Davies
    Department of Gene Therapy, Imperial College School of Medicine, London, UK
    Paediatr Respir Rev 3:128-34. 2002
    ..Understanding the steps involved in both initial infection and in establishing chronicity may help in the development of new treatment strategies...
  30. ncbi request reprint Quality, size, and composition of pediatric endobronchial biopsies in cystic fibrosis
    Nicolas Regamey
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Chest 131:1710-7. 2007
    ..We prospectively assessed how the quality of biopsy specimens obtained from children with CF compare with those from children with other airway diseases...
  31. pmc Bronchoscopy following diagnosis with cystic fibrosis
    Tom N Hilliard
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Arch Dis Child 92:898-9. 2007
    ..Lavage culture was positive in eight of 18 children without respiratory symptoms. This highlights the potential of bronchoscopy following diagnosis, even in asymptomatic children...
  32. ncbi request reprint Potential difference measurements in the lower airway of children with and without cystic fibrosis
    Jane C Davies
    Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, UK
    Am J Respir Crit Care Med 171:1015-9. 2005
    ..Potential difference measurements could form a useful functional endpoint assay for future studies of either the CFTR gene or protein-based therapies in future trials in the pediatric age group...
  33. ncbi request reprint New tests for cystic fibrosis
    Jane C Davies
    Department of Gene Therapy, Imperial College, London, UK
    Paediatr Respir Rev 7:S141-3. 2006
    ..Nasal PD can also be helpful in the latter group, although there are a number of caveats to its use and interpretation...
  34. ncbi request reprint Airway gene therapy
    Jane C Davies
    Department of Gene Therapy, Imperial College London, London SW3 6LR, United Kingdom
    Adv Genet 54:291-314. 2005
    ..This chapter reviews these issues, strategies aimed at overcoming them, and progress into clinical trials with non-viral vectors in a variety of pulmonary diseases...
  35. doi request reprint CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression
    Stephen C Hyde
    Gene Medicine Research Group, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK
    Nat Biotechnol 26:549-51. 2008
    ..Using a CpG-free pDNA expression vector, we achieved sustained (>or=56 d) in vivo transgene expression in the absence of lung inflammation...
  36. doi request reprint Lung clearance index in CF: a sensitive marker of lung disease severity
    Jane C Davies
    Thorax 63:96-7. 2008
  37. doi request reprint Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis
    Nicolas Regamey
    Department of Gene Therapy, National Heart and Lung Institute, 1B Manresa Road, London SW3 6LR, UK
    Am J Respir Crit Care Med 177:837-43. 2008
    ..Structural alterations to airway smooth muscle (ASM) are a feature of asthma and cystic fibrosis (CF) in adults...
  38. doi request reprint Endobronchial biopsy in childhood
    Nicolas Regamey
    Chest 133:312; author reply 313. 2008
  39. pmc Airway remodelling in children with cystic fibrosis
    Tom N Hilliard
    Department of Gene Therapy, National Heart and Lung Institute, Imperial College, London, UK
    Thorax 62:1074-80. 2007
    ..A study was undertaken to determine changes in airway remodelling in children with CF compared with appropriate disease and healthy controls...
  40. ncbi request reprint Detection of antibodies to Pseudomonas aeruginosa in serum and oral fluid from patients with cystic fibrosis
    Abbie M Weisner
    Laboratory of Healthcare Associated Infections, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Med Microbiol 56:670-4. 2007
    ..All serum samples from the CF patients were positive by both methods. Thus this is a sensitive procedure for the detection of antibodies to A-band LPS of P. aeruginosa in oral fluid and serum from patients with CF...
  41. ncbi request reprint Biomarkers for cystic fibrosis: are we progressing?
    Eric W F W Alton
    Am J Respir Crit Care Med 175:750-1. 2007
  42. ncbi request reprint Measurement of tobramycin and gentamicin in saliva is not suitable for therapeutic drug monitoring of patients with cystic fibrosis
    Helen Spencer
    J Cyst Fibros 4:209. 2005
  43. ncbi request reprint Gene and cell therapy for cystic fibrosis
    Jane C Davies
    Departments of Gene Therapy and Paediatric Respiratory Medicine, Imperial College, National Heart and Lung Institute, Manresa Road, London, SW3 6LR, UK
    Paediatr Respir Rev 7:S163-5. 2006
    ..Whether this approach will be able to achieve clinical success remains to be seen...
  44. doi request reprint Nasal abnormalities in cystic fibrosis mice independent of infection and inflammation
    Tom N Hilliard
    Department of Gene Therapy, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, UK
    Am J Respir Cell Mol Biol 39:19-25. 2008
    ..There are significant histologic changes in the nasal mucosa of adult CF mice, not associated with increased lumenal inflammation or bacterial content, and which are not present perinatally. These may be novel therapeutic targets...