J Cuzick

Summary

Affiliation: Imperial Cancer Research Fund
Country: UK

Publications

  1. ncbi request reprint A brief review of the International Breast Cancer Intervention Study (IBIS), the other current breast cancer prevention trials, and proposals for future trials
    J Cuzick
    Department of Mathematics, Statistics, and Epidemiology, Imperial Cancer Research Fund, London, United Kingdom
    Ann N Y Acad Sci 949:123-33. 2001
  2. ncbi request reprint Screening for cancer: future potential
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, U K
    Eur J Cancer 35:1925-32. 1999
  3. ncbi request reprint Once-only sigmoidoscopy
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Ann Oncol 10:65-9. 1999
  4. ncbi request reprint Screening for cancer: future potential
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, U K
    Eur J Cancer 35:685-92. 1999
  5. ncbi request reprint Electropotential measurements as a new diagnostic modality for breast cancer
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Lancet 352:359-63. 1998
  6. ncbi request reprint A brief review of the current breast cancer prevention trials and proposals for future trials
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, 61 Lincoln s Inn Fields, WC2A 3PX, London, UK
    Eur J Cancer 36:1298-302. 2000
  7. pmc HPV testing in primary screening of older women
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Br J Cancer 81:554-8. 1999
  8. pmc Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: a sub-protocol of the 'Arimidex and tamoxifen alone or in combination' (ATAC) trial
    M Dowsett
    CRC and UCL Cancer Trials Centre, University College London, Stephenson House, 158 160 N Gower Street, London, NW1 2ND, UK
    Br J Cancer 85:317-24. 2001
  9. pmc Type-specific human papillomavirus DNA in abnormal smears as a predictor of high-grade cervical intraepithelial neoplasia
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Br J Cancer 69:167-71. 1994
  10. ncbi request reprint Use of luteinising-hormone-releasing hormone agonists as adjuvant treatment in premenopausal patients with hormone-receptor-positive breast cancer: a meta-analysis of individual patient data from randomised adjuvant trials
    J Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    Lancet 369:1711-23. 2007

Collaborators

Detail Information

Publications36

  1. ncbi request reprint A brief review of the International Breast Cancer Intervention Study (IBIS), the other current breast cancer prevention trials, and proposals for future trials
    J Cuzick
    Department of Mathematics, Statistics, and Epidemiology, Imperial Cancer Research Fund, London, United Kingdom
    Ann N Y Acad Sci 949:123-33. 2001
    ..Continued follow-up of these trials is crucial for resolving these issues...
  2. ncbi request reprint Screening for cancer: future potential
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, U K
    Eur J Cancer 35:1925-32. 1999
    ..Less certainty exists about screening for other major cancers such as lung, prostate and ovary, but a range of potential approaches merit investigation...
  3. ncbi request reprint Once-only sigmoidoscopy
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Ann Oncol 10:65-9. 1999
    ..The rationale for infrequent screening for colorectal cancers by sigmoidoscopy of the general population around age 60 is reviewed. A progress report for a trial to evaluate this approach is also presented...
  4. ncbi request reprint Screening for cancer: future potential
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, U K
    Eur J Cancer 35:685-92. 1999
    ..Less certainty exists about screening for other major cancers such as lung, prostate and ovary, but a range of potential approaches merit investigation...
  5. ncbi request reprint Electropotential measurements as a new diagnostic modality for breast cancer
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Lancet 352:359-63. 1998
    ..Diagnostic information might be obtained from a non-imaging and non-invasive test based on skin-surface electropotentials...
  6. ncbi request reprint A brief review of the current breast cancer prevention trials and proposals for future trials
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, 61 Lincoln s Inn Fields, WC2A 3PX, London, UK
    Eur J Cancer 36:1298-302. 2000
    ..Continued follow-up of these trials is crucial for resolving these issues...
  7. pmc HPV testing in primary screening of older women
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Br J Cancer 81:554-8. 1999
    ..A combined screening test offers the possibility of greater protection and/or longer screening intervals, which could reduce the overall cost of the screening programme...
  8. pmc Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: a sub-protocol of the 'Arimidex and tamoxifen alone or in combination' (ATAC) trial
    M Dowsett
    CRC and UCL Cancer Trials Centre, University College London, Stephenson House, 158 160 N Gower Street, London, NW1 2ND, UK
    Br J Cancer 85:317-24. 2001
    ....
  9. pmc Type-specific human papillomavirus DNA in abnormal smears as a predictor of high-grade cervical intraepithelial neoplasia
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Br J Cancer 69:167-71. 1994
    ..In particular, HPV testing appears to be helpful in determining which women with mildly abnormal smears have high-grade underlying lesions in need of immediate referral for colposcopy...
  10. ncbi request reprint Use of luteinising-hormone-releasing hormone agonists as adjuvant treatment in premenopausal patients with hormone-receptor-positive breast cancer: a meta-analysis of individual patient data from randomised adjuvant trials
    J Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    Lancet 369:1711-23. 2007
    ..Several trials have been done to assess treatment of premenopausal breast cancer with luteinising-hormone-releasing hormone (LHRH) agonists, but results have been inconclusive, especially for patients with hormone-receptor-positive cancer...
  11. doi request reprint Does trauma or an intercurrent surgical intervention lead to a short-term increase in breast cancer recurrence rates?
    Z Allawi
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Ann Oncol 23:866-9. 2012
    ..To test this, we examined if accidental trauma or surgery, unrelated to the original cancer, might stimulate the growth of dormant micrometastases and be related to an increase in the recurrence rate in the period after the event...
  12. ncbi request reprint The use of cervicography in a primary screening service
    A Szarewski
    Department of Epidemiology and Statistics, Imperial Cancer Research Fund, Lincoln s Inn Fields, London
    Br J Obstet Gynaecol 98:313-7. 1991
    ..The false positive rate for cervicography was 26%. Even after adjustment, this difference was highly significant (P less than 0.0001)...
  13. pmc Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer
    J Cuzick
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, EC1M 6BQ, UK
    Br J Cancer 108:2582-9. 2013
    ..We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 men with conservatively managed prostate cancer diagnosed by transurethral resection of the prostate...
  14. pmc Association between DNA methylation of HSPB1 and death in low Gleason score prostate cancer
    N Vasiljevic
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    Prostate Cancer Prostatic Dis 16:35-40. 2013
    ..To gain insight into the mechanism regulating its expression, we tested the hypothesis that differential methylation of CpG islands within HSPB1 controls transcription and subsequent translation of the gene...
  15. pmc Predicted impact of vaccination against human papillomavirus 16/18 on cancer incidence and cervical abnormalities in women aged 20-29 in the UK
    J Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK
    Br J Cancer 102:933-9. 2010
    ..In the UK, vaccination for girls aged 12-13 with catch-up for girls up to age 18 was introduced in 2008, using the bivalent GSK vaccine (Cervarix)...
  16. pmc Future possibilities in the prevention of breast cancer: breast cancer prevention trials
    J Cuzick
    Department of Methematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Breast Cancer Res 2:258-63. 2000
    ..Continued follow up of these trials is crucial for resolving these issues...
  17. pmc Ki-67 and outcome in clinically localised prostate cancer: analysis of conservatively treated prostate cancer patients from the Trans-Atlantic Prostate Group study
    D M Berney
    The Orchid Tissue Laboratory, Centre for Molecular Oncology, Barts and the London School of Medicine and Dentistry, London, UK
    Br J Cancer 100:888-93. 2009
    ..As it is already in widespread use in routine pathology, it is confirmed as the most promising biomarker to be applied into routine practice...
  18. pmc Association between high-risk HPV types, HLA DRB1* and DQB1* alleles and cervical cancer in British women
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Br J Cancer 82:1348-52. 2000
    ..05), associated with HPV16-positive cervical cancers. Taking all cancers together, a marginally significant protective effect was found for DQB1*0501 (2P = 0.03) but no protective effect could be seen for DRB1*1301...
  19. ncbi request reprint Breast density and breast cancer risk factors in a high-risk population
    J Warwick
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London WC2A 3PX, UK
    Breast 12:10-6. 2003
    ....
  20. ncbi request reprint Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update ana
    M Baum
    University College London, London, United Kingdom
    Cancer 98:1802-10. 2003
    ..9 months)...
  21. pmc A systematic review of the role of human papilloma virus (HPV) testing within a cervical screening programme: summary and conclusions
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Br J Cancer 83:561-5. 2000
    ..A range of issues including the age to start and stop screening, the appropriate screening interval, the role of self-sampling for HPV testing and the choice of primary test (HPV and/or cytology) require further evaluation...
  22. ncbi request reprint Neuroendocrine differentiation does not have independent prognostic value in conservatively treated prostate cancer
    S S Jeetle
    Department of Molecular Oncology, Barts Cancer Institute, Charterhouse Square, London, EC1M 6BQ, UK
    Virchows Arch 461:103-7. 2012
    ..083). Determination of neuroendocrine differentiation does not appear to have any bearing on the outcome of prostatic carcinoma and does not add to the established prognostic model...
  23. pmc A case-control study of cervix cancer in Singapore
    J Cuzick
    Imperial Cancer Research Fund, London, UK
    Br J Cancer 60:238-43. 1989
    ..Biopsies were available for HPV DNA analysis in 38 cases and 37% were positive, mostly for HPV type 16. All these factors gave similar risks in invasive and preinvasive disease...
  24. ncbi request reprint Overview of the main outcomes in breast-cancer prevention trials
    J Cuzick
    Cancer Research UK, London, UK
    Lancet 361:296-300. 2003
    ..Early findings on the use of tamoxifen or raloxifene as prophylaxis against breast cancer have been mixed; we update available data and overview the combined results...
  25. ncbi request reprint Management of women who test positive for high-risk types of human papillomavirus: the HART study
    J Cuzick
    Cancer Research UK, London, UK
    Lancet 362:1871-6. 2003
    ..We aimed to compare the detection rate and positive predictive values of HPV assay with cytology and to determine the best management strategy for HPV-positive women...
  26. pmc The association between naevi and melanoma in populations with different levels of sun exposure: a joint case-control study of melanoma in the UK and Australia
    V Bataille
    Imperial Cancer Research Fund Skin Tumour Laboratory, London, UK
    Br J Cancer 77:505-10. 1998
    ....
  27. pmc Significant differences in UK and US female bone density reference ranges
    E Noon
    Osteoporosis Research Unit, Division of Imaging Sciences, King s College London, London, UK
    Osteoporos Int 21:1871-80. 2010
    ..6 standard deviation higher than their US counterparts...
  28. ncbi request reprint Psychosocial influences on older adults' interest in participating in bowel cancer screening
    J Wardle
    ICRF Health Behaviour Unit, Department of Epidemiology and Public Health, University College, London, United Kingdom
    Prev Med 31:323-34. 2000
    ..As part of a multicenter, randomized controlled trial of the efficacy of flexible sigmoidoscopy for the prevention of bowel cancer, an investigation of the predictors of screening interest was carried out in a subsample of older adults...
  29. pmc The identification of chromosomal translocation, t(4;6)(q22;q15), in prostate cancer
    L Shan
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Prostate Cancer Prostatic Dis 13:117-25. 2010
    ..0628). The potential role of this translocation in the development of human prostate cancer is discussed...
  30. pmc Multiple myeloma--a case-control study
    J Cuzick
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Br J Cancer 57:516-20. 1988
    ..001), but most of the excess cases occurred within 10 years of diagnosis, suggesting this was a preclinical manifestation of disease rather than a cause of it...
  31. ncbi request reprint The effect of stopping smoking on cervical Langerhans' cells and lymphocytes
    A Szarewski
    Margaret Pyke Centre, London, UK
    BJOG 108:295-303. 2001
    ....
  32. ncbi request reprint Development of a protocol for evaluation of mammographic surveillance services in women under 50 with a family history of breast cancer
    J Mackay
    North East Thames Regional Genetics Service, Institute of Child Health, London, UK
    J Epidemiol Biostat 6:365-9; discussion 371-5. 2001
    ..Incremental cost-effectiveness ratios of implementing the standardised mammography strategy compared with no screening will be presented in terms of the additional cost per cancer detected, per life saved and per life-year saved...
  33. doi request reprint Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial
    Wendy S Atkin
    Department of Surgery and Cancer, Imperial College London, London, UK
    Lancet 375:1624-33. 2010
    ..We tested the hypothesis that only one flexible sigmoidoscopy screening between 55 and 64 years of age can substantially reduce colorectal cancer incidence and mortality...
  34. ncbi request reprint Pitfalls in the diagnosis of prostatic cancer: retrospective review of 1791 cases with clinical outcome
    D M Berney
    Department of Histopathology, St Bartholomew s Hospital, London, UK
    Histopathology 51:452-7. 2007
    ..To assess the possible reasons for error in the diagnosis of prostatic cancer with available follow-up data...
  35. pmc Estimating the efficacy of screening by auditing smear histories of women with and without cervical cancer. The National Co-ordinating Network for Cervical Screening Working Group
    P D Sasieni
    Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK
    Br J Cancer 73:1001-5. 1996
    ..These data suggest that full adherence to current guidelines could perhaps have prevented another 1250 cases, but additional steps would have been required to prevent some of the 2300 remaining cases in women under the age of 70...
  36. doi request reprint A placebo-controlled trial of oral cladribine for relapsing multiple sclerosis
    Gavin Giovannoni
    Queen Mary University London, the Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    N Engl J Med 362:416-26. 2010
    ..Cladribine provides immunomodulation through selective targeting of lymphocyte subtypes. We report the results of a 96-week phase 3 trial of a short-course oral tablet therapy in patients with relapsing-remitting multiple sclerosis...