Paul Cullinan

..Patients with occupational asthma, and their medical advisers, need valid information about the prognosis of their disease...

..To estimate the incidence of specific IgE sensitization and allergic respiratory symptoms among UK bakery and flour mill workers; and to examine the roles of flour aeroallergen and total dust exposures in determining these outcomes...

..There are, however, few prospective data in support. We aimed to examine this relationship in a representative cohort of children born in Ashford, Kent (UK)...

..It is frequently asserted that antibiotic prescriptions in childhood are associated with the development of allergic disease, especially asthma. A study was undertaken to establish the direction of this relationship...

..The findings support the suggestion that the "sibling effect" in atopy may not simply reflect protection by early infection...

..Considerably more cooperation between scientists in the field, regulatory authorities and industry is required...

..Specific IgG(4) produced together with specific IgE may reduce the risk of developing work-related chest symptoms compared with when specific IgE is produced alone...

..We compared different definitions of childhood asthma, identified characteristics that might have influenced their accuracy and an acquisition of an 'asthma' label in wheezy and treated children...

..Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease...

..It is suggested that the inverse relationship between allergic disease and family size reflects reduced exposure to early life infections, and that antibiotic treatment in childhood diminishes any protective effect of such infection...

..Occupational asthma is a disease that is potentially preventable and often curable; positive outcomes are dependent more on changes in the workplace than on pharmacological therapy...

..To date the 'hygiene hypothesis' offers the most efficient explanation for the distribution of the disease in time and place although convincing evidence for it remains elusive...

..We surveyed a population of long-term CF survivors to assess their burden of illness and profile their disease characteristics...

..There has been much debate as to whether this is due to diisocyanate-induced asthma being mediated by non-IgE mechanisms or whether it is the result of using inappropriate conjugates...

..We investigated the effects of short-term exposure to diesel traffic in people with asthma in an urban, roadside environment...

..Laboratory animal allergy is a common occupational health problem affecting between 11% and 44% of exposed researchers. Allergy to rats and mice is most common, probably because these are the animals most frequently used...

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..To examine the association of adult onset asthma with lifetime exposure to occupations and occupational exposures...

..Here we review one approach to prevention: the routine use of health surveillance in exposed workforces...

..A study was undertaken to examine whether this discrepancy could be attributed to a high consumption of fresh fruit and vegetables or adherence to a traditional Mediterranean diet...

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..Additionally, allergen reduction measures related to indoor sources must be specific to each location...

..To examine smoking habits before and during pregnancy, as well as factors associated with smoking cessation, in three European settings...

..To investigate the levels of agreement between expert respiratory physicians when making a diagnosis of occupational asthma...

..77; 95% confidence interval = 1.19-6.46). Our data support the idea that several patterns of wheezing with different risk profiles exist among young children. The effect of Fel d1 exposure varied according to age and maternal asthma...

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..DDE was not associated with atopy alone. Prenatal exposure to DDE residues may contribute to development of asthma...

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..Seasonal allergic rhinitis is common globally, and symptoms have been shown to impair learning ability in children in laboratory conditions. Critical examinations in children are often held in the summer during the peak grass pollen season...

..04). The results show that total exposure weighted for distance has met the criteria for a successful index by being associated with most respiratory symptoms as well as FEF(25-75), features of obstructive airways disease...