Genomes and Genes
Affiliation: Imperial College
- Outcome of occupational asthma after cessation of exposure: a systematic reviewGeorge Rachiotis
Department of Occupational and Environmental Medicine, Imperial College NHLI, 1B Manresa Road, London SW3 6LR, UK
Thorax 62:147-52. 2007..Patients with occupational asthma, and their medical advisers, need valid information about the prognosis of their disease...
- Allergen and dust exposure as determinants of work-related symptoms and sensitization in a cohort of flour-exposed workers; a case-control analysisP Cullinan
Department of Occupational and Environmental Medicine, Imperial College, NHLI, SW3 6LR, London, UK
Ann Occup Hyg 45:97-103. 2001..To estimate the incidence of specific IgE sensitization and allergic respiratory symptoms among UK bakery and flour mill workers; and to examine the roles of flour aeroallergen and total dust exposures in determining these outcomes...
- Early allergen exposure, skin prick responses, and atopic wheeze at age 5 in English children: a cohort studyP Cullinan
Department of Occupational and Environmental Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, Manresa Road, London SW3 6LR, UK
Thorax 59:855-61. 2004..There are, however, few prospective data in support. We aimed to examine this relationship in a representative cohort of children born in Ashford, Kent (UK)...
- Epidemiological assessment of health effects from chemical incidentsPaul Cullinan
Department of Occupational and Environmental Medicine, National Heart and Lung Institute, London, UK
Occup Environ Med 59:568-72; quiz 572,516. 2002
- Occupational asthmaPaul Cullinan
Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College, 1B Manresa Road, London SW3 6LR, UK
Occup Environ Med 65:151. 2008
- The prevention of occupational asthmaP Cullinan
Dept of Occupational and Environmental Medicine, Imperial College NHLI, London, UK
Eur Respir J 22:853-60. 2003..Considerably more cooperation between scientists in the field, regulatory authorities and industry is required...
- Can early infection explain the sibling effect in adult atopy?P Cullinan
Dept of Occupational and Environmental Medicine, Imperial College School of Medicine NHLI, London, UK
Eur Respir J 22:956-61. 2003..The findings support the suggestion that the "sibling effect" in atopy may not simply reflect protection by early infection...
- Early prescriptions of antibiotics and the risk of allergic disease in adults: a cohort studyP Cullinan
Department of Occupational and Environmental Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, UK
Thorax 59:11-5. 2004..It is frequently asserted that antibiotic prescriptions in childhood are associated with the development of allergic disease, especially asthma. A study was undertaken to establish the direction of this relationship...
- Modified Th2 responses at high-dose exposures to allergen: using an occupational modelHayley Jeal
Department of Occupational and Environmental Medicine, Faculty of Medicine, Imperial College NHLI, London, United Kingdom
Am J Respir Crit Care Med 174:21-5. 2006..quot; Attenuation of risk of allergy and asthma at high exposure levels has been reported in longitudinal studies of both childhood and occupational asthma...
- Epidemiological measures of childhood asthma: cross-sectional and longitudinal consistencyCristina Canova
MRC HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Emmanuel Kaye Building, Manresa Road, Imperial College, London SW3 6LR, UK
Respir Med 106:1226-35. 2012..We compared different definitions of childhood asthma, identified characteristics that might have influenced their accuracy and an acquisition of an 'asthma' label in wheezy and treated children...
- A large-scale, consortium-based genomewide association study of asthmaMiriam F Moffatt
National Heart and Lung Institute, Imperial College, London, United Kingdom
N Engl J Med 363:1211-21. 2010..Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease...
- Recorded infections and antibiotics in early life: associations with allergy in UK children and their parentsJessica M Harris
Occupational and Environmental Medicine, Imperial College School of Medicine NHLI, Manresa Road, London SW3 6LR, UK
Thorax 62:631-7. 2007..It is suggested that the inverse relationship between allergic disease and family size reflects reduced exposure to early life infections, and that antibiotic treatment in childhood diminishes any protective effect of such infection...
- Asthma and occupation in the 1958 birth cohortRebecca Elisabeth Ghosh
Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London and MRC HPA Centre for Environment and Health, Imperial College, London, UK
Thorax 68:365-71. 2013..To examine the association of adult onset asthma with lifetime exposure to occupations and occupational exposures...
- Occupational asthmaJoanna Szram
Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom
Semin Respir Crit Care Med 33:653-65. 2012..Occupational asthma is a disease that is potentially preventable and often curable; positive outcomes are dependent more on changes in the workplace than on pharmacological therapy...
- 0148 Using the UK Biobank study to estimate occupational causes of chronic disease: comparability with the UK national population and adjustment for biasSally Hutchings
Imperial College London, London, UK
Occup Environ Med 71:A79. 2014..As part of a project to investigate the causes of COPD and estimate the UK occupational burden, we have assessed the sample's representativeness with respect to the UK national population, with a view to accounting for potential biases...
- Asthma: environmental and occupational factorsPaul Cullinan
Department of Occupational and Environmental Lung Disease, Imperial College, London, UK
Br Med Bull 68:227-42. 2003..To date the 'hygiene hypothesis' offers the most efficient explanation for the distribution of the disease in time and place although convincing evidence for it remains elusive...
- Obliterative bronchiolitis in fibreglass workers: a new occupational disease?Paul Cullinan
Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College London, London, UK
Occup Environ Med 70:357-9. 2013..Obliterative bronchiolitis (OB) is a rare disease with a small number of established occupational aetiologies. We describe a case series of severe OB in workers making glass-reinforced plastics...
- Is occupational asthma to diisocyanates a non-IgE-mediated disease?Meinir G Jones
Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
J Allergy Clin Immunol 117:663-9. 2006..There has been much debate as to whether this is due to diisocyanate-induced asthma being mediated by non-IgE mechanisms or whether it is the result of using inappropriate conjugates...
- Growing old with cystic fibrosis - the characteristics of long-term survivors of cystic fibrosisNicholas J Simmonds
Department of Cystic Fibrosis, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK
Respir Med 103:629-35. 2009..We surveyed a population of long-term CF survivors to assess their burden of illness and profile their disease characteristics...
- Occupation and chronic obstructive pulmonary disease (COPD)Paul Cullinan
Occupational and Environmental Medicine, Imperial College NHLI, London, UK
Br Med Bull 104:143-61. 2012..There is growing interest in preventable, non-smoking causes of chronic obstructive pulmonary disease (COPD), among which are chronic exposures to respiratory irritants in the workplace...
- Respiratory effects of exposure to diesel traffic in persons with asthmaJames McCreanor
National Heart and Lung Institute, Imperial College, and Royal Brompton Hospital, London, United Kingdom
N Engl J Med 357:2348-58. 2007..We investigated the effects of short-term exposure to diesel traffic in people with asthma in an urban, roadside environment...
- HLA associations with occupational sensitization to rat lipocalin allergens: a model for other animal allergies?Hayley Jeal
Department of Occupational and Environmental Medicine, Imperial College NHLI, London, United Kingdom
J Allergy Clin Immunol 111:795-9. 2003..Laboratory animal allergy is a common occupational health problem affecting between 11% and 44% of exposed researchers. Allergy to rats and mice is most common, probably because these are the animals most frequently used...
- Urban air pollution and children's asthma: what do parents and health professionals think?Emma Stevens
Department of Environmental Science and Technology, Imperial College London, London, UK
Pediatr Pulmonol 37:530-6. 2004....
- 0154 A new, efficient web-based tool to collect and code lifetime job histories in large population-based studies: the COPD project in the UK Biobank cohortSara De Matteis
Imperial College, London, UK
Occup Environ Med 71:A19. 2014..We aimed to develop a new web-based tool to automatically collect and code individual lifetime job histories in the UK Biobank cohort for investigating the causes and burden of work-related COPD in the UK...
- Reliability and validity of 4-metre gait speed in COPDSamantha S C Kon
Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK
Eur Respir J 42:333-40. 2013..The 4MGS is reliable in COPD, correlates with exercise capacity, dyspnoea and health-related quality of life, and has potential as a simple assessment tool in COPD. ..
- Oral contraceptives do not appear to affect cystic fibrosis disease severityNatalie G Kernan
Dept of Gene Therapy, Imperial College London, London, UK
Eur Respir J 41:67-73. 2013..Our data suggests that the use of OCs does not affect CF disease severity...
- Occupational asthma often goes unrecognisedPaul Cullinan
Royal Brompton Hospital, London, UK
Practitioner 256:15-8, 2. 2012..Patients should routinely be asked whether their symptoms improve when they are not at work...
- Medical surveillance for prevention of occupational asthmaJoanna Szram
Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College London, London, UK
Curr Opin Allergy Clin Immunol 13:138-44. 2013..Here we review one approach to prevention: the routine use of health surveillance in exposed workforces...
- Protective effect of fruits, vegetables and the Mediterranean diet on asthma and allergies among children in CreteLeda Chatzi
Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece
Thorax 62:677-83. 2007..A study was undertaken to examine whether this discrepancy could be attributed to a high consumption of fresh fruit and vegetables or adherence to a traditional Mediterranean diet...
- Early-life domestic aeroallergen exposure and IgE sensitization at age 4 yearsMatias Torrent
Menorca Health Area, Ib Salut, Menorca, Spain
J Allergy Clin Immunol 118:742-8. 2006....
- Occupational asthma: an assessment of diagnostic agreement between physiciansDavid Fishwick
Centre for Workplace Health, Health and Safety Laboratory, Harpur Hill, Buxton, Derbyshire SK17 9JN, UK
Occup Environ Med 64:185-90. 2007..To investigate the levels of agreement between expert respiratory physicians when making a diagnosis of occupational asthma...
- Prenatal dichlorodiphenyldichloroethylene (DDE) and asthma in childrenJordi Sunyer
Unitat Recerca Respiratòria i Ambiental, Institut Municipal d Investigacio Medica, Barcelona, Spain
Environ Health Perspect 113:1787-90. 2005..DDE was not associated with atopy alone. Prenatal exposure to DDE residues may contribute to development of asthma...
- Smoking cessation and associated factors during pregnancyMatias Torrent
Area de Salut de Menorca ib salut, Spain
Gac Sanit 18:184-9. 2004..To examine smoking habits before and during pregnancy, as well as factors associated with smoking cessation, in three European settings...
- Domestic aeroallergen levels in Barcelona and Menorca (Spain)Xavier Basagana
Respiratory and Environmental Health Research Unit, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
Pediatr Allergy Immunol 13:412-7. 2002..Additionally, allergen reduction measures related to indoor sources must be specific to each location...
- Bhopal prioritiesV Ramana Dhara
Int J Occup Environ Health 10:107. 2004
- Early-life allergen exposure and atopy, asthma, and wheeze up to 6 years of ageMatias Torrent
Menorca Health Area, ib salut Menorca, Institute Universitary d Investigacio en Ciencies de la Salut, Menorca, Spain
Am J Respir Crit Care Med 176:446-53. 2007....
- A prospective study of Fel d1 and Der p1 exposure in infancy and childhood wheezingSarah Polk
Unitat Recerca Respiratòria i Ambietal, Institut Municipal Investigacio Medica, Barcelona, Spain
Am J Respir Crit Care Med 170:273-8. 2004..77; 95% confidence interval = 1.19-6.46). Our data support the idea that several patterns of wheezing with different risk profiles exist among young children. The effect of Fel d1 exposure varied according to age and maternal asthma...
- Peanuts in pregnancy: what is a mother to do?Seif O Shaheen
Am J Respir Crit Care Med 178:113-4. 2008
- Chemical respiratory allergy: opportunities for hazard identification and characterisation. The report and recommendations of ECVAM workshop 60Ian Kimber
Syngenta Central Toxicology Laboratory, Macclesfield, UK
Altern Lab Anim 35:243-65. 2007
- Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: case-control studySamantha Walker
Education for Health, Warwick, United Kingdom
J Allergy Clin Immunol 120:381-7. 2007..Seasonal allergic rhinitis is common globally, and symptoms have been shown to impair learning ability in children in laboratory conditions. Critical examinations in children are often held in the summer during the peak grass pollen season...
- Personal exposure and long-term health effects in survivors of the union carbide disaster at bhopalV Ramana Dhara
Emory Eastside Occupational Health Center, Snellville, Georgia, USA
Environ Health Perspect 110:487-500. 2002..04). The results show that total exposure weighted for distance has met the criteria for a successful index by being associated with most respiratory symptoms as well as FEF(25-75), features of obstructive airways disease...
- The incidence of cancer in patients with idiopathic pulmonary fibrosis and sarcoidosis in the UKIvan Le Jeune
Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham NG5 1PB, UK
Respir Med 101:2534-40. 2007....