Valerie F Crepin

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo
    Valerie F Crepin
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, UK
    Mol Microbiol 75:308-23. 2010
  2. pmc The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals
    Richard Bulgin
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom
    PLoS Pathog 5:e1000683. 2009
  3. pmc Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors
    Richard Bulgin
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College, London SW7 2AZ, United Kingdom
    Infect Immun 78:1417-25. 2010
  4. ncbi request reprint Structural and functional studies of the enteropathogenic Escherichia coli type III needle complex protein EscJ
    Valerie F Crepin
    Centres for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK
    Mol Microbiol 55:1658-70. 2005
  5. pmc Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut
    Cordula Hemrajani
    Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom
    Infect Immun 76:4804-13. 2008
  6. pmc Polarity of enteropathogenic Escherichia coli EspA filament assembly and protein secretion
    Valerie F Crepin
    Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London, London SW7 2AZ, UK
    J Bacteriol 187:2881-9. 2005
  7. pmc The mechanisms used by enteropathogenic Escherichia coli to control filopodia dynamics
    Cedric N Berger
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    Cell Microbiol 11:309-22. 2009
  8. pmc Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH
    Eric Martinez
    Centre for Molecular Microbiology and Infection, Imperial College London, UK
    Cell Microbiol 12:1718-31. 2010
  9. doi request reprint The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP)
    Alexander R C Wong
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    Cell Microbiol 14:1051-70. 2012
  10. ncbi request reprint The enteropathogenic Escherichia coli type III secretion system effector Map binds EBP50/NHERF1: implication for cell signalling and diarrhoea
    Nandi Simpson
    Division of Cell and Molecular Biology, Flowers Building, Imperial College London, London SW7 2AZ, UK
    Mol Microbiol 60:349-63. 2006

Collaborators

Detail Information

Publications17

  1. pmc Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo
    Valerie F Crepin
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, UK
    Mol Microbiol 75:308-23. 2010
    ..Importantly, wild-type C. rodentium out-competed the tir tyrosine mutants during mixed infections. These results uncouple the Tir:Nck and Tir:IRTKS pathways from A/E lesion formation in vivo but assign them an important in vivo role...
  2. pmc The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals
    Richard Bulgin
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom
    PLoS Pathog 5:e1000683. 2009
    ..Moreover, our data breaks the dogma of EPEC as an extracellular pathogen and defines a new category of invasive EPEC...
  3. pmc Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors
    Richard Bulgin
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College, London SW7 2AZ, United Kingdom
    Infect Immun 78:1417-25. 2010
    ..In this minireview, we summarize contemporary findings related to the SopE and WxxxE GEFs in the context of their role in subverting general host cell signaling pathways and infection...
  4. ncbi request reprint Structural and functional studies of the enteropathogenic Escherichia coli type III needle complex protein EscJ
    Valerie F Crepin
    Centres for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK
    Mol Microbiol 55:1658-70. 2005
    ..In contrast, periplasmic overexpression of EscJ(D1) and EscJ(D2) in the same wild-type bacterium had a dominant-negative phenotype suggesting defective assembly of the TTSS and protein translocation...
  5. pmc Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut
    Cordula Hemrajani
    Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom
    Infect Immun 76:4804-13. 2008
    ..Consistent with this, we found that the nleH mutant triggered a significantly lower tumor necrosis factor alpha response than the wild-type strain...
  6. pmc Polarity of enteropathogenic Escherichia coli EspA filament assembly and protein secretion
    Valerie F Crepin
    Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London, London SW7 2AZ, UK
    J Bacteriol 187:2881-9. 2005
    ..Finally, we provide direct evidence that EspA filaments are hollow conduits through which effector proteins are delivered to the extremity of the bacterial cell (and subsequently into the host cell)...
  7. pmc The mechanisms used by enteropathogenic Escherichia coli to control filopodia dynamics
    Cedric N Berger
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    Cell Microbiol 11:309-22. 2009
    ..These results show that EPEC effectors modulate actin dynamics by temporal subverting the Rho GTPases and other actin polymerization pathways for the benefit of the adherent pathogen...
  8. pmc Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH
    Eric Martinez
    Centre for Molecular Microbiology and Infection, Imperial College London, UK
    Cell Microbiol 12:1718-31. 2010
    ..Our data suggest that NHERF2 may act as a plasma membrane sorting site, providing a novel regulatory mechanism to control the intracellular spatial and temporal effector protein activity...
  9. doi request reprint The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP)
    Alexander R C Wong
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    Cell Microbiol 14:1051-70. 2012
    ..Our study reveals the intricacies of Tir and EspH-mediated actin signalling pathways that comprise of distinct, convergent and synergistic signalling cascades...
  10. ncbi request reprint The enteropathogenic Escherichia coli type III secretion system effector Map binds EBP50/NHERF1: implication for cell signalling and diarrhoea
    Nandi Simpson
    Division of Cell and Molecular Biology, Flowers Building, Imperial College London, London SW7 2AZ, UK
    Mol Microbiol 60:349-63. 2006
    ..We report significantly greater diarrhoea following infections with wild-type C. rodentium compared with C. rodentiumDeltamap. These results provide new insights into the mechanisms of EPEC diarrhoea...
  11. ncbi request reprint Molecular basis of antigenic polymorphism of EspA filaments: development of a peptide display technology
    Valerie F Crepin
    Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London, London SW7 2AZ, UK
    J Mol Biol 350:42-52. 2005
    ..Accordingly, EspA filaments have a potential to be developed into a novel epitope display system...
  12. doi request reprint The WxxxE effector EspT triggers expression of immune mediators in an Erk/JNK and NF-κB-dependent manner
    Benoit Raymond
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College, London SW7 2AZ, UK
    Cell Microbiol 13:1881-93. 2011
    ..e. NleC, NleD, NleE, NleH) that inhibit inflammation, a subset of strains, which encode EspT, employ an infection strategy that also involves upregulation of immune mediators...
  13. doi request reprint Structural and functional properties of chimeric EspA-FliCi filaments of EPEC
    Valerie F Crepin
    Division of Cell and Molecular Biology, Flowers Building, Imperial College London, London SW7 2AZ, UK
    J Mol Biol 378:243-50. 2008
    ....
  14. pmc Subversion of actin dynamics by EspM effectors of attaching and effacing bacterial pathogens
    Ana Arbeloa
    Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    Cell Microbiol 10:1429-41. 2008
    ..These results suggest that the EspM effectors modulate actin dynamics by activating the RhoA signalling pathway...
  15. ncbi request reprint Subversion of actin dynamics by EPEC and EHEC
    Emmanuelle Caron
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    Curr Opin Microbiol 9:40-5. 2006
    ..A recent highlight is the unravelling of functions for effector proteins (particularly Tir, TccP, Map and EspG/EspG2) that are injected into the host cell by a type III secretion system...
  16. ncbi request reprint Use of biophotonic imaging as a training aid for administration of substances in laboratory rodents
    Siouxsie Wiles
    Division of Cell and Molecular Biology, Natural Sciences, Imperial College London, London SW7 2AZ, UK
    Lab Anim 41:321-8. 2007
    ..The data presented suggest that this technology is ideal for use as a teaching aid and may also prove valuable in assessing the effectiveness of 'complex' and novel administration routes in 'realtime'...
  17. pmc Transcriptome of enterohemorrhagic Escherichia coli O157 adhering to eukaryotic plasma membranes
    Sivan Dahan
    Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College London, London SW7 2AZ, United Kingdom
    Infect Immun 72:5452-9. 2004
    ..Analysis of the complete transcriptomes of the bound bacteria revealed increased levels of stress-associated mRNAs and decreased levels of mRNA encoding proteins involved in translation and type III secretion...