J T B Crawley

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint The haemostatic role of tissue factor pathway inhibitor
    James T B Crawley
    Department of Hematology, Imperial College London, 5th Floor Commonwealth Building, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Arterioscler Thromb Vasc Biol 28:233-42. 2008
  2. pmc Further characterization of ADAMTS-13 inactivation by thrombin
    J K Lam
    Department of Haematology, Imperial College London, London, UK
    J Thromb Haemost 5:1010-8. 2007
  3. ncbi request reprint Multiple roles of the endothelial cell protein C receptor
    J T B Crawley
    Department of Haematology, Imperial College London, London, UK
    J Thromb Haemost 5:1813-6. 2007
  4. pmc Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack
    J T B Crawley
    Department of Haematology, Imperial College London, London, UK
    J Thromb Haemost 6:583-8. 2008
  5. doi request reprint Cytoprotective effect of activated protein C: specificity of PAR-1 signaling
    J T B Crawley
    Department of Haematology, Imperial College London, London, UK
    J Thromb Haemost 6:951-3. 2008
  6. ncbi request reprint Proteolytic inactivation of ADAMTS13 by thrombin and plasmin
    James T B Crawley
    Haematology Department, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, 5th Fl, Commonwealth Bldg, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, United Kingdom
    Blood 105:1085-93. 2005
  7. ncbi request reprint ADAMTS13 substrate recognition of von Willebrand factor A2 domain
    Sara Zanardelli
    Department of Haematology, Imperial College London, London W12 ONN, United Kingdom
    J Biol Chem 281:1555-63. 2006
  8. ncbi request reprint The central role of thrombin in hemostasis
    J T B Crawley
    Department of Haematology, Imperial College London, London, UK
    J Thromb Haemost 5:95-101. 2007
  9. doi request reprint Essential role of the disintegrin-like domain in ADAMTS13 function
    Rens de Groot
    Department of Haematology, Imperial College London, London, United Kingdom
    Blood 113:5609-16. 2009
  10. pmc The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function
    Brenda M Luken
    Department of Haematology, Imperial College London, London, UK
    Blood 115:4910-3. 2010

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The haemostatic role of tissue factor pathway inhibitor
    James T B Crawley
    Department of Hematology, Imperial College London, 5th Floor Commonwealth Building, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Arterioscler Thromb Vasc Biol 28:233-42. 2008
    ..This review article focuses on the major physiological regulator of tissue factor-induced coagulation, tissue factor pathway inhibitor, its expression, anticoagulant function, and its role in normal hemostasis...
  2. pmc Further characterization of ADAMTS-13 inactivation by thrombin
    J K Lam
    Department of Haematology, Imperial College London, London, UK
    J Thromb Haemost 5:1010-8. 2007
    ..In vitro ADAMTS-13 is susceptible to proteolytic inactivation by thrombin...
  3. ncbi request reprint Multiple roles of the endothelial cell protein C receptor
    J T B Crawley
    Department of Haematology, Imperial College London, London, UK
    J Thromb Haemost 5:1813-6. 2007
  4. pmc Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack
    J T B Crawley
    Department of Haematology, Imperial College London, London, UK
    J Thromb Haemost 6:583-8. 2008
    ..Moreover, ADAMTS-13 influences hemostatic plug formation in mouse models. We therefore studied their associations in the Glasgow MI Study (GLAMIS)...
  5. doi request reprint Cytoprotective effect of activated protein C: specificity of PAR-1 signaling
    J T B Crawley
    Department of Haematology, Imperial College London, London, UK
    J Thromb Haemost 6:951-3. 2008
  6. ncbi request reprint Proteolytic inactivation of ADAMTS13 by thrombin and plasmin
    James T B Crawley
    Haematology Department, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, 5th Fl, Commonwealth Bldg, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, United Kingdom
    Blood 105:1085-93. 2005
    ..This study demonstrates the susceptibility of ADAMTS13 to proteolytic inactivation and suggests possible roles for thrombin and plasmin at sites of vascular injury...
  7. ncbi request reprint ADAMTS13 substrate recognition of von Willebrand factor A2 domain
    Sara Zanardelli
    Department of Haematology, Imperial College London, London W12 ONN, United Kingdom
    J Biol Chem 281:1555-63. 2006
    ..3 microM), compared with VWF115 (KD 20 nM). These results demonstrate an important role for Asp1614 and surrounding charged residues in the binding and cleavage of the VWFA2 domain by ADAMTS13...
  8. ncbi request reprint The central role of thrombin in hemostasis
    J T B Crawley
    Department of Haematology, Imperial College London, London, UK
    J Thromb Haemost 5:95-101. 2007
    ..Thereafter, we develop the concept of cofactor competition as a means by which the activities of thrombin are controlled...
  9. doi request reprint Essential role of the disintegrin-like domain in ADAMTS13 function
    Rens de Groot
    Department of Haematology, Imperial College London, London, United Kingdom
    Blood 113:5609-16. 2009
    ....
  10. pmc The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function
    Brenda M Luken
    Department of Haematology, Imperial College London, London, UK
    Blood 115:4910-3. 2010
    ..Mutagenesis of C1669/C1670 in full-length VWF resulted in markedly increased susceptibility to cleavage by ADAMTS13, confirming the important role of the paired vicinal cysteines in VWF A2 domain stabilization...
  11. doi request reprint A functional calcium-binding site in the metalloprotease domain of ADAMTS13
    Michelle D Gardner
    Department of Haematology, Imperial College London, London, United Kingdom
    Blood 113:1149-57. 2009
    ..Together, our results demonstrate that a major influence of Ca(2+) upon ADAMTS13 function is mediated through binding to a high-affinity site adjacent to its active site cleft...
  12. pmc The ADAMTS13 metalloprotease domain: roles of subsites in enzyme activity and specificity
    Rens de Groot
    Department of Haematology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
    Blood 116:3064-72. 2010
    ..It is concluded that 2 subsites, D187-R193 and D252-P256, in the metalloprotease domain play an important role in cleavage efficiency and site specificity...
  13. ncbi request reprint Role of a 5'-enhancer in the transcriptional regulation of the human endothelial cell protein C receptor gene
    Luigina R Mollica
    Department of Haematology, Imperial College London, UK
    Blood 108:1251-9. 2006
    ....
  14. ncbi request reprint Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis
    James S O'Donnell
    Haematology Dept, Imperial College London, 5th Floor, Commonwealth Building, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom
    Blood 106:1988-91. 2005
    ..We conclude that reduction in the number of terminal sugars on N-linked glycan increases susceptibility of globular VWF to ADAMTS13 proteolysis and is associated with reduced plasma VWF:Ag and VWF:CB levels...
  15. ncbi request reprint Prevalence of the ADAMTS-13 missense mutation R1060W in late onset adult thrombotic thrombocytopenic purpura
    R S Camilleri
    Haemostasis Research Unit, Department of Haematology, University College London School of Medicine, London, UK
    J Thromb Haemost 6:331-8. 2008
    ..ADAMTS-13 mutations and polymorphisms have been reported in childhood congenital TTP, but their significance in adult onset TTP remains unclear...
  16. ncbi request reprint ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men
    Chan K N K Chion
    Department of Haematology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
    Blood 109:1998-2000. 2007
    ..5-1.6). If confirmed, the association of ADAMTS13 with MI may suggest an unexpected mechanistic action of ADAMTS13...
  17. pmc Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain
    Helena M Andersson
    Department of Haematology, Faculty of Medicine, Imperial College London, London, UK
    Blood 115:4878-85. 2010
    ..It is concluded that residue Asp95 within EGF1 is critical for APC cofactor function of protein S and could define a principal functional interaction site for APC...
  18. ncbi request reprint Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality
    Jian Ming Gu
    Cardiovascular Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Biol Chem 277:43335-43. 2002
    ..We conclude that EPCR is essential for normal embryonic development. Moreover, EPCR plays a key role in preventing thrombosis at the maternal-embryonic interface...
  19. ncbi request reprint Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development
    James T B Crawley
    Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, OK, USA
    Thromb Haemost 88:259-66. 2002
    ..However, not until postnatal day 7 did the intensity and distribution of EPCR staining mimic that observed in adult mice...