J Collinge

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint The same prion strain causes vCJD and BSE
    A F Hill
    Nature 389:448-50, 526. 1997
  2. ncbi request reprint Human prion diseases and bovine spongiform encephalopathy (BSE)
    J Collinge
    Prion Disease Group, Neurogenetics Unit, Imperial College School of Medicine at St Mary s, London, UK
    Hum Mol Genet 6:1699-705. 1997
  3. ncbi request reprint Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
    J Collinge
    Neurogenetics Unit, Department of Biochemistry and Molecular Genetics, Imperial College School of Medicine at St Mary s, London, UK
    Nature 383:685-90. 1996
  4. ncbi request reprint Prion diseases of humans and animals: their causes and molecular basis
    J Collinge
    MRC Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St Mary s, London, United Kingdom
    Annu Rev Neurosci 24:519-50. 2001
  5. ncbi request reprint Variant Creutzfeldt-Jakob disease
    J Collinge
    Department of Neurogenetics, Imperial College School of Medicine at St Mary s, London, UK
    Lancet 354:317-23. 1999
  6. ncbi request reprint Early onset familial Alzheimer's disease: Mutation frequency in 31 families
    J C Janssen
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurology 60:235-9. 2003
  7. ncbi request reprint Inherited prion disease with 5-OPRI: phenotype modification by repeat length and codon 129
    S Mead
    MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London, UK
    Neurology 69:730-8. 2007
  8. pmc Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series
    T E F Webb
    Department of Neurodegenerative Disease and MRC Prion Unit, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Brain 131:2632-46. 2008
  9. doi request reprint Age of onset and death in inherited prion disease are heritable
    T E F Webb
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Am J Med Genet B Neuropsychiatr Genet 150:496-501. 2009
  10. pmc Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease
    J A Beck
    MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK
    J Med Genet 45:813-7. 2008

Collaborators

Detail Information

Publications59

  1. ncbi request reprint The same prion strain causes vCJD and BSE
    A F Hill
    Nature 389:448-50, 526. 1997
  2. ncbi request reprint Human prion diseases and bovine spongiform encephalopathy (BSE)
    J Collinge
    Prion Disease Group, Neurogenetics Unit, Imperial College School of Medicine at St Mary s, London, UK
    Hum Mol Genet 6:1699-705. 1997
    ..Such molecular analysis of prion strains suggests that new variant Creutzfeldt-Jakob disease is caused by BSE exposure. The novel biology of prion propagation may not be unique to these rare degenerative brain diseases...
  3. ncbi request reprint Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
    J Collinge
    Neurogenetics Unit, Department of Biochemistry and Molecular Genetics, Imperial College School of Medicine at St Mary s, London, UK
    Nature 383:685-90. 1996
    ..Strain characteristics revealed here suggest that the prion protein may itself encode disease phenotype...
  4. ncbi request reprint Prion diseases of humans and animals: their causes and molecular basis
    J Collinge
    MRC Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St Mary s, London, United Kingdom
    Annu Rev Neurosci 24:519-50. 2001
    ..It is unclear if a large epidemic of variant CJD will occur in the years ahead...
  5. ncbi request reprint Variant Creutzfeldt-Jakob disease
    J Collinge
    Department of Neurogenetics, Imperial College School of Medicine at St Mary s, London, UK
    Lancet 354:317-23. 1999
    ..The theoretical possibility that BSE prions might have transferred to other species and continue to present a risk to human health cannot be excluded at present...
  6. ncbi request reprint Early onset familial Alzheimer's disease: Mutation frequency in 31 families
    J C Janssen
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurology 60:235-9. 2003
    ..Three causative genes have been identified for autosomal dominant AD...
  7. ncbi request reprint Inherited prion disease with 5-OPRI: phenotype modification by repeat length and codon 129
    S Mead
    MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London, UK
    Neurology 69:730-8. 2007
    ..An individual inherited prion disease offers an opportunity to study the determinants of this clinicopathologic heterogeneity among individuals with the same causal mutation...
  8. pmc Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series
    T E F Webb
    Department of Neurodegenerative Disease and MRC Prion Unit, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Brain 131:2632-46. 2008
    ..These data allow an appreciation of the range of clinical phenotype, modern imaging and molecular investigation and should inform genetic counselling of at-risk individuals, with the identification of two genetic modifiers...
  9. doi request reprint Age of onset and death in inherited prion disease are heritable
    T E F Webb
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Am J Med Genet B Neuropsychiatr Genet 150:496-501. 2009
    ....
  10. pmc Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease
    J A Beck
    MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK
    J Med Genet 45:813-7. 2008
    ..The gene SPRN, encodes Shadoo (Sho, shadow of prion protein) which has protein homology and possible functional links with the prion protein...
  11. ncbi request reprint A novel presenilin 1 deletion (p.L166del) associated with early onset familial Alzheimer's disease
    W D Knight
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    Eur J Neurol 14:829-31. 2007
    ..They are, however, consistent with the reported clinical phenotype in the majority of PSEN1 exon 6 mutations so far reported...
  12. pmc The molecular biology of prion propagation
    A R Clarke
    Medical Research Council Prion Unit, Department of Neurogenetics, Imperial College School of Medicine at St Mary's, London W2 1NY, UK
    Philos Trans R Soc Lond B Biol Sci 356:185-95. 2001
    ..These and other advances in the fundamental biology of prion propagation are leading to strategies for the development of rational therapeutics...
  13. ncbi request reprint Pathogenic presenilin 1 mutations (P436S & I143F) in early-onset Alzheimer's disease in the UK. Mutations in brief no. 223. Online
    M S Palmer
    Molecular Genetics, Biomedical Sciences Division, Imperial College School of Medicine, London, UK
    Hum Mutat 13:256. 1999
    ..I143F shows incomplete penetration within the affected family. P436S is the most carboxy-terminal presenilin 1 mutation reported to date...
  14. ncbi request reprint A presenilin 1 R278I mutation presenting with language impairment
    A K Godbolt
    Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, London, UK
    Neurology 63:1702-4. 2004
    ..Screening for PSEN1 mutations may be appropriate in cases of familial dementia even where the clinical phenotype is not typical of AD...
  15. ncbi request reprint Prion protein is necessary for normal synaptic function
    J Collinge
    Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, Imperial College, London, UK
    Nature 370:295-7. 1994
    ....
  16. ncbi request reprint Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay
    J D Wadsworth
    MRC Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St Mary s, Norfolk Place, W2 1PG, London, UK
    Lancet 358:171-80. 2001
    ..We aimed to improve immunoblotting methods for high sensitivity detection of PrP(Sc) to investigate the distribution of PrP(Sc) in a range of vCJD tissues...
  17. ncbi request reprint Mossy fibre reorganization in the hippocampus of prion protein null mice
    S B Colling
    Department of Physiology and Biophysics, Imperial College School of Medicine at St Mary s, London, UK
    Brain Res 755:28-35. 1997
    ..We propose that reorganization of neuronal circuity is a feature of PrP-null mice...
  18. ncbi request reprint Familial Alzheimer's disease and inherited prion disease in the UK are poorly ascertained
    J C Stevens
    Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 82:1054-7. 2011
    ..By comparison with frequencies predicted from published population studies, to estimate the proportion of patients with these conditions who are being accurately diagnosed...
  19. pmc The molecular pathology of CJD: old and new variants
    G S Jackson
    MRC Prion Unit, Department of Neurogenetics, Imperial College School of Medicine at St Mary s, Norfolk Place, Paddington, London W2 1NY, UK
    Mol Pathol 54:393-9. 2001
    ..Concomitantly, advances in the fundamental biology of prion disease have done much to reinforce the protein only hypothesis of prion replication...
  20. doi request reprint Distinct neuropsychological profiles correspond to distribution of cortical thinning in inherited prion disease caused by insertional mutation
    K Alner
    National Prion Clinic, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 83:109-14. 2012
    ..Here we report for the first time the neuropsychological and clinical assessments in these two groups...
  21. pmc Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1
    S Mead
    MRC Prion Unit and Department of Neurogenetics, Imperial College, St Mary s Hospital, London, United Kingdom
    Am J Hum Genet 69:1225-35. 2001
    ..In addition, there was no evidence of a PRNP founder effect in the first reported geographical cluster of vCJD...
  22. ncbi request reprint Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein
    M A Whittington
    Department of Physiology and Biophysics, St Mary s Hospital Medical School, Imperial College, London, UK
    Nat Genet 9:197-201. 1995
    ....
  23. pmc Brain-water diffusion coefficients reflect the severity of inherited prion disease
    H Hyare
    National Prion Clinic, Box 98, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK, WC1N 3BG
    Neurology 74:658-65. 2010
    ..We wished to assess the potential of diffusion-weighted MRI as a biomarker of disease severity in inherited prion diseases...
  24. ncbi request reprint Hippocampal slices from prion protein null mice: disrupted Ca(2+)-activated K+ currents
    S B Colling
    Department of Physiology and Biophysics, St Mary s Hospital Medical School, Imperial College, London, UK
    Neurosci Lett 209:49-52. 1996
    ..The PrP-null group differed in having lower input resistances, a lack of the late AHP and of a charybdotoxin-sensitive summated AHP. We propose that CA(2+)-activated K+ currents, in particular IAHP, are disrupted in PrP-null mice...
  25. pmc Review: contribution of transgenic models to understanding human prion disease
    J D F Wadsworth
    MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, University College London, National Hospital for Neurology and Neurosurgery, London, UK
    Neuropathol Appl Neurobiol 36:576-97. 2010
    ....
  26. ncbi request reprint Two-octapeptide repeat deletion of prion protein associated with rapidly progressive dementia
    J A Beck
    MRC Prion Unit, Department of Neurogenetics, Imperial College School of Medicine at St. Mary's, London, UK
    Neurology 57:354-6. 2001
    ..This mutation was absent from more than 3,000 individuals and may be causally related to prion disease and represent a novel disease mechanism...
  27. ncbi request reprint Phenotypic variability in the brains of a family with a prion disease characterized by a 144-base pair insertion in the prion protein gene
    A King
    Department of Neuropathology, Institute of Psychiatry, Kings College London, London, UK
    Neuropathol Appl Neurobiol 29:98-105. 2003
    ..They also reveal that the relationship between PrP deposition and cerebral or cerebellar damage might be complex...
  28. ncbi request reprint Isolation and functional characterisation of the promoter region of the human prion protein gene
    S P Mahal
    MRC Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St. Mary's, W2 1PG, London, UK
    Gene 268:105-14. 2001
    ..7 kb genomic fragment driving a luciferase reporter gene, demonstrate an active promoter within a 273 bp region (-148 to +125, relative to the cap site)...
  29. ncbi request reprint Mutations and polymorphisms in the prion protein gene
    M S Palmer
    Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, Norfolk Place, London, UK
    Hum Mutat 2:168-73. 1993
    ..The identification of mutations in this gene has lead to a broadening of the spectrum of clinical phenotypes that can be classified as prion diseases and have provided an important tool in the diagnosis of familial dementias...
  30. ncbi request reprint Molecular genetic characterisation of frontotemporal dementia on chromosome 3
    A Ashworth
    Department of Neurogenetics, Imperial College School of Medicine at St Mary s, London, UK
    Dement Geriatr Cogn Disord 10:93-101. 1999
    ..We also outline our strategies to clone the mutant gene via its putative associated trinucleotide repeat sequence...
  31. ncbi request reprint Regional brain metabolite abnormalities in inherited prion disease and asymptomatic gene carriers demonstrated in vivo by quantitative proton magnetic resonance spectroscopy
    A D Waldman
    Dementia Research Group, Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London, WC1 3BG, UK
    Neuroradiology 48:428-33. 2006
    ....
  32. pmc Identification of multiple quantitative trait loci linked to prion disease incubation period in mice
    S E Lloyd
    Medical Research Council Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St Mary s, Norfolk Place, London W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 98:6279-83. 2001
    ..However, the demonstration of other major genetic effects on incubation period suggests the need for extreme caution in interpreting estimates of variant Creutzfeldt-Jakob disease epidemic size utilizing existing epidemiological models...
  33. ncbi request reprint ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)
    N Parkinson
    MRC Prion Unit, Institute of Neurology, University College London, London, UK
    Neurology 67:1074-7. 2006
    ..Neuropathology of the Q206H case showed lower motor neuron predominant disease with ubiquitylated inclusions in motor neurons. Antibodies to p62 (sequestosome 1) showed novel oligodendroglial inclusions in the motor cortex...
  34. doi request reprint High-b-value diffusion MR imaging and basal nuclei apparent diffusion coefficient measurements in variant and sporadic Creutzfeldt-Jakob disease
    H Hyare
    National Prion Clinic, National Hospital for Neurology and Neurosurgery, London, United Kingdom
    AJNR Am J Neuroradiol 31:521-6. 2010
    ....
  35. pmc PRION-1 scales analysis supports use of functional outcome measures in prion disease
    S Mead
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, and National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCLH NHS Trust, Queen Square, London, UK
    Neurology 77:1674-83. 2011
    ..Although there are several limitations to the usefulness of survival as an outcome measure, there have been no comprehensive studies of alternatives...
  36. ncbi request reprint Prion disease--the propagation of infectious protein topologies
    G S Jackson
    MRC Prion Unit, Department of Neurogenetics, Imperial College School of Medicine at St Mary s, W2 1PG, London, UK
    Microbes Infect 2:1445-9. 2000
    ..Concomitantly, advances in the analysis of the abnormal isoform, PrP(Sc), have expanded our knowledge on the molecular basis of prion strains and have done much to reinforce the protein-only hypothesis of prion replication...
  37. ncbi request reprint Expression pattern of a mini human PrP gene promoter in transgenic mice
    E A Asante
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, University College, Queen Square, London, WCIN 3BG, United Kingdom
    Neurobiol Dis 10:1-7. 2002
    ....
  38. pmc Neuroimaging findings in human prion disease
    R G MacFarlane
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 78:664-70. 2007
    ..This paper reviews the current knowledge of imaging appearances in human prion disease...
  39. pmc Location and properties of metal-binding sites on the human prion protein
    G S Jackson
    Medical Research Council Prion Unit, Department of Neurogenetics, Imperial College School of Medicine at St. Mary's, London W2 1NY, United Kingdom
    Proc Natl Acad Sci U S A 98:8531-5. 2001
    ..A role for prion protein (PrP) in copper metabolism or transport seems likely and disturbance of this function may be involved in prion-related neurotoxicity...
  40. ncbi request reprint Prion diseases
    J Collinge
    Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, London, UK
    Curr Opin Genet Dev 2:448-54. 1992
    ..The conundrum of how a disease can both be inherited as an autosomal dominant condition and also be experimentally transmissible by inoculation is beginning to make sense...
  41. ncbi request reprint Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease
    M S Palmer
    Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, London, UK
    Nature 352:340-2. 1991
    ..We argue that homozygosity predisposes towards sporadic CJD and that this directly supports the hypothesis that interaction between prion protein molecules underlies the disease process...
  42. pmc Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene
    R J Harvey
    Dementia Research Group, The National Hospital for Neurology and Neurosurgery and Imperial College School of Medicine at St Mary s, London, UK
    J Neurol Neurosurg Psychiatry 64:44-9. 1998
    ....
  43. pmc Transmission of scrapie by steel-surface-bound prions
    E Flechsig
    Department of Neurogenetics, Imperial College School of Medicine at St Mary's, London, UK
    Mol Med 7:679-84. 2001
    ..This system mimics contaminated surgical instruments and will allow an assessment of sterilisation procedures...
  44. ncbi request reprint An improved protocol for the analysis of SOD1 gene mutations, and a new mutation in exon 4
    I G Yulug
    Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, Imperial College, London, UK
    Hum Mol Genet 4:1101-4. 1995
  45. ncbi request reprint Familial non-specific dementia maps to chromosome 3
    J Brown
    Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, London, UK
    Hum Mol Genet 4:1625-8. 1995
    ..Like a number of other late onset neurodegenerative diseases, the disease presents at an earlier age when paternally inherited...
  46. pmc The neuropsychology of variant CJD: a comparative study with inherited and sporadic forms of prion disease
    R J Cordery
    Dementia Research Group, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 76:330-6. 2005
    ....
  47. ncbi request reprint An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease
    F Owen
    Division of Psychiatry, Clinical Research Centre, Harrow, Middlesex, U K
    Brain Res Mol Brain Res 7:273-6. 1990
    ..The possibility that this mutation may prove relevant to elucidating the mechanism of horizontal transmission of the spongiform encephalopathies is discussed...
  48. ncbi request reprint Inherited prion disease with 144 base pair gene insertion. 1. Genealogical and molecular studies
    M Poulter
    Division of Psychiatry, Clinical Research Centre, Harrow, UK
    Brain 115:675-85. 1992
    ..The clinical features which were very variable and the neuropathological findings, which sometimes included spongiform encephalopathy, but which often did not, are described fully in the accompanying article (Collinge et al., 1992)...
  49. ncbi request reprint Diagnosis of Gerstmann-Sträussler syndrome in familial dementia with prion protein gene analysis
    J Collinge
    Division of Psychiatry, Clinical Research Centre, Harrow, Middlesex, UK
    Lancet 2:15-7. 1989
    ..GSS may be more common than is currently realised; PrP gene analysis is potentially useful for diagnosis and genetic counselling in familial dementias and ataxias...
  50. pmc Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration
    G R Mallucci
    MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    EMBO J 21:202-10. 2002
    ..Furthermore, they show that acute depletion of PrP does not affect neuronal survival in this model, ruling out loss of PrP function as a pathogenic mechanism in prion disease and validating therapeutic approaches targeting PrP...
  51. ncbi request reprint Questionnaire to reduce the risk of iatrogenic prion disease transmission
    S Mead
    J Hosp Infect 60:378-9. 2005
  52. pmc Lack of TAR-DNA binding protein-43 (TDP-43) pathology in human prion diseases
    A M Isaacs
    MRC Prion Unit, UCL Institute of Neurology, London, U K
    Neuropathol Appl Neurobiol 34:446-56. 2008
    ..We therefore aimed to determine whether there is TDP-43 pathology in human prion diseases, which are characterised by variable deposition of prion protein (PrP) aggregates in the brain as amyloid plaques or more diffuse deposits...
  53. ncbi request reprint Lymphocyte contamination of laryngoscope blades--a possible vector for transmission of variant Creutzfeldt-Jakob disease
    N Hirsch
    Department of Neuroanaesthesia, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Anaesthesia 60:664-7. 2005
    ..As prions resist routine sterilisation procedures, the use of non-disposable laryngoscope blades poses a risk of transmitting vCJD from patient to patient. The use of such instruments should be abandoned and disposable alternatives used...
  54. pmc Familial prion disease in a Hungarian family with a novel 144-base pair insertion in the prion protein gene
    T Kovacs
    Department of Neurology, Semmelweis University, Budapest, Balassa u 6, H 1083 Hungary
    J Neurol Neurosurg Psychiatry 78:321-3. 2007
    ..In addition to the cerebellar and parahippocampal pathological changes already described, we also found deposits of pathological prion protein in the olfactory system...
  55. pmc Molecular neurology of prion disease
    J Collinge
    MRC Prion Unit and National Prion Clinic, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 76:906-19. 2005
    ....
  56. pmc Irregular presence of abnormal prion protein in appendix in variant Creutzfeldt-Jakob disease
    S Joiner
    J Neurol Neurosurg Psychiatry 73:597-8. 2002
  57. pmc Prion infectivity in variant Creutzfeldt-Jakob disease rectum
    J D F Wadsworth
    MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, University College London, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Gut 56:90-4. 2007
    ..To date PrP(Sc):prion infectivity ratios have not been determined in vCJD, and it is unknown whether vCJD prions are similar to experimental rodent prions, where PrP(Sc) concentration typically reflects infectious prion titre...
  58. ncbi request reprint XAFS study of the high-affinity copper-binding site of human PrP(91-231) and its low-resolution structure in solution
    S S Hasnain
    CCLRC Daresbury Laboratory, Daresbury, Warrington, Cheshire, UK
    J Mol Biol 311:467-73. 2001
    ..The restored molecular envelope is consistent with the picture where the N-terminal segment, residues 91-120, extends out from the previously known globular domain containing residues 121-231...
  59. pmc High levels of disease related prion protein in the ileum in variant Creutzfeldt-Jakob disease
    S Joiner
    Gut 54:1506-8. 2005