J Cohen

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Superantigen antagonist peptides
    M Llewelyn
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Crit Care 5:53-5. 2001
  2. ncbi request reprint New strategies for clinical trials in patients with sepsis and septic shock
    J Cohen
    Department of Infectious Diseases, Imperial College School of Medicine, London, England
    Crit Care Med 29:880-6. 2001
  3. ncbi request reprint Mechanisms of tissue injury in sepsis: contrasts between gram positive and gram negative infection
    J Cohen
    Dept of Infectious Diseases and Microbiology, Imperial College School of Medicine, Hammersmith Hospital, London, England, UK
    J Chemother 13:153-8. 2001
  4. ncbi request reprint The detection and interpretation of endotoxaemia
    J Cohen
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Intensive Care Med 26:S51-6. 2000
  5. ncbi request reprint Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice
    S Sriskandan
    Department of Infectious Diseases, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Infect Dis 184:166-73. 2001
  6. ncbi request reprint Mitogenic factor (MF) is the major DNase of serotype M89 Streptococcus pyogenes
    S Sriskandan
    Department of Infectious Diseases, Imperial College School of Medicine, London W12 0NN, UK
    Microbiology 146:2785-92. 2000
  7. ncbi request reprint Contact activation in shock caused by invasive group A Streptococcus pyogenes
    S Sriskandan
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Crit Care Med 28:3684-91. 2000
  8. ncbi request reprint Kallikrein-kinin system activation in streptococcal toxic shock syndrome
    S Sriskandan
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    Clin Infect Dis 30:961-2. 2000
  9. ncbi request reprint Complementation of a speA negative Streptococcus pyogenes with speA: effects on virulence and production of streptococcal pyrogenic exotoxin A
    M Unnikrishnan
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, Du Can Road, London W12 0NN, UK
    Microb Pathog 31:109-14. 2001
  10. ncbi request reprint Microbiologic findings and correlations with serum tumor necrosis factor-alpha in patients with severe sepsis and septic shock
    J Cohen
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Infect Dis 180:116-21. 1999

Collaborators

Detail Information

Publications16

  1. pmc Superantigen antagonist peptides
    M Llewelyn
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Crit Care 5:53-5. 2001
    ..In this article, we review the first published data to address one such strategy in the context of other recognised and experimental treatments...
  2. ncbi request reprint New strategies for clinical trials in patients with sepsis and septic shock
    J Cohen
    Department of Infectious Diseases, Imperial College School of Medicine, London, England
    Crit Care Med 29:880-6. 2001
    ..The United Kingdom Medical Research Council convened an International Working Party to address these issues...
  3. ncbi request reprint Mechanisms of tissue injury in sepsis: contrasts between gram positive and gram negative infection
    J Cohen
    Dept of Infectious Diseases and Microbiology, Imperial College School of Medicine, Hammersmith Hospital, London, England, UK
    J Chemother 13:153-8. 2001
    ..These differences will assume greater importance in developing targeted therapeutic interventions to severe sepsis...
  4. ncbi request reprint The detection and interpretation of endotoxaemia
    J Cohen
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Intensive Care Med 26:S51-6. 2000
    ..It may be that the LAL assay, or one of the newer developments, may be more useful in excluding Gram negative infection, but that remains to be shown...
  5. ncbi request reprint Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice
    S Sriskandan
    Department of Infectious Diseases, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Infect Dis 184:166-73. 2001
    ..Lymphoid activation was undetectable in HLA-DQ mice infected with an isogenic SPEA(-) strain, which proves that a single superantigen can play a role in sepsis pathogenesis...
  6. ncbi request reprint Mitogenic factor (MF) is the major DNase of serotype M89 Streptococcus pyogenes
    S Sriskandan
    Department of Infectious Diseases, Imperial College School of Medicine, London W12 0NN, UK
    Microbiology 146:2785-92. 2000
    ..Despite loss of DNase activity, the virulence of S. pyogenes in a mouse model of necrotizing fasciitis and myositis was unaffected...
  7. ncbi request reprint Contact activation in shock caused by invasive group A Streptococcus pyogenes
    S Sriskandan
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Crit Care Med 28:3684-91. 2000
    ....
  8. ncbi request reprint Kallikrein-kinin system activation in streptococcal toxic shock syndrome
    S Sriskandan
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    Clin Infect Dis 30:961-2. 2000
    ..We speculate that bradykinin release following activation of the kallikrein-kinin system in streptococcal toxic shock may underlie the features of pain, capillary leaking, and severe hypotension characteristic of this syndrome...
  9. ncbi request reprint Complementation of a speA negative Streptococcus pyogenes with speA: effects on virulence and production of streptococcal pyrogenic exotoxin A
    M Unnikrishnan
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, Du Can Road, London W12 0NN, UK
    Microb Pathog 31:109-14. 2001
    ..SPEA production was quantitated from muscle tissue of infected mice. However, H361 did not produce more SPEA than H305 in vivo. We conclude that SPEA does not play a key role in invasive murine streptococcal infection...
  10. ncbi request reprint Microbiologic findings and correlations with serum tumor necrosis factor-alpha in patients with severe sepsis and septic shock
    J Cohen
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Infect Dis 180:116-21. 1999
    ..6, 64.0, and 52.8 pg/mL, respectively, P=.004). These results provide further support for the concept that patients with sepsis are a heterogeneous group that require more precise definition...
  11. ncbi request reprint High-throughput sequence typing of T-cell epitope polymorphisms in Plasmodium falciparum circumsporozoite protein
    A Alloueche
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Mol Biochem Parasitol 106:273-82. 2000
    ..PCR-SSOP could be used to determine the allelic frequencies of other parasite antigens and their geographical distribution...
  12. ncbi request reprint Stimulation of cytokine release and adhesion molecule expression by products of Viridans streptococci
    W P Hanage
    Department of Infectious Diseases and Microbiology, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, Hammersmith Hospital, London, United Kingdom w hanageic ac uk
    J Infect Dis 185:357-67. 2002
    ..This up-regulation was blocked by IL-1 receptor antagonist but not neutralizing antibody against TNF-alpha. These data may help explain the pathogenesis of the viridans streptococcal shock syndrome in neutropenic patients...
  13. ncbi request reprint Development of a time-to-positivity assay as a tool in the antibiotic management of septic patients
    P Kaltsas
    Department of Microbiology and Infectious Diseases, Hammersmith Hospital, London, UK
    Clin Microbiol Infect 11:109-14. 2005
    ..The T(pos) assay might offer a quick and convenient way to improve the efficacy of antibiotic therapy in septic patients, and further prospective large-scale studies are now warranted...
  14. ncbi request reprint Observations on the role of tumor necrosis factor-alpha in a murine model of shock due to Streptococcus pyogenes
    J Wayte
    Department of Infectious Diseases and Bacteriology, Hammersmith Hospital, London, UK
    Crit Care Med 21:1207-12. 1993
    ..To examine the effect of a monoclonal antibody to tumor necrosis factor-alpha (TNF-alpha) in a murine model of shock due to Streptococcus pyogenes...
  15. ncbi request reprint Complete genomic characterization and antigenic relatedness of genogroup III, genotype 2 bovine noroviruses
    S L Oliver
    Department of Pathology and Infectious Diseases, Royal Veterinary College, London, UK
    Arch Virol 152:257-72. 2007
    ..A close antigenic relationship was demonstrated by ELISA between the genotype 2 viruses, which will allow their serological diagnosis...
  16. ncbi request reprint Immunization against the murine malaria parasite Plasmodium yoelii using a recombinant protein with adjuvants developed for clinical use
    I T Ling
    National Institute for Medical Research, Mill Hill, London, UK
    Vaccine 15:1562-7. 1997
    ..Mice passively immunized with serum or purified IgG from vaccinated mice had delayed onset of parasitemia and were able to control the infection...