Research Topics
Species | Nish ChaturvediSummaryAffiliation: Imperial College Country: UK Publications
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Publications
Markers of insulin resistance are strong risk factors for retinopathy incidence in type 1 diabetesN Chaturvedi
EURODIAB Prospective Complications Study, University College London, UK
Diabetes Care 24:284-9. 2001..To determine the incidence of retinopathy and the relative importance of its risk factors in type 1 diabetes...
Differing aspects of insulin resistance in diabetes complications: the shape of things to come. RD Lawrence Lecture 2000N Chaturvedi
International Centre for Circulatory Health, Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College of Science, Technology and Medicine at St Mary s, London, UK
Diabet Med 19:973-7. 2002..This indicates novel targets for the prevention and treatment of diabetes complications...
The DIabetic Retinopathy Candesartan Trials (DIRECT) Programme, rationale and study designNish Chaturvedi
International Centre for Circulatory Health Department of Epidemiology and Public Health, Imperial College at St Mary s, London, W2 1PG, UK
J Renin Angiotensin Aldosterone Syst 3:255-61. 2002..The main secondary endpoint for each study is change in urinary albumin excretion rate. A positive outcome of the DIRECT Programme would be an important step forward in the clinical management of patients with diabetes...
Misleading meta-analysis: a need to look beyond the headlinesN Chaturvedi
International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, UK
Diabet Med 24:587-91. 2007
Circulating and urinary transforming growth factor beta1, Amadori albumin, and complications of type 1 diabetes: the EURODIAB prospective complications studyNish Chaturvedi
Department of Epidemiology and Public Health, Imperial College of Medicine at St Mary s, London, UK
Diabetes Care 25:2320-7. 2002..We sought to examine the role of both urinary and circulating TGF-beta1 and its promoter Amadori albumin in the vascular complications of type 1 diabetes...
Risk of diabetes-related amputation in South Asians vs. Europeans in the UKN Chaturvedi
EURODIAB, University College London, London, UK
Diabet Med 19:99-104. 2002..To compare the risk of and risk factors for diabetes-related amputation in South Asians and Europeans...
Indian Asian men have less peripheral arterial disease than European men for equivalent levels of coronary diseaseNish Chaturvedi
NHLI Division, Faculty of Medicine, Imperial College London, UK
Atherosclerosis 193:204-12. 2007..This paradox, and reasons for it, have not been explored. We compared ethnic differences in peripheral arterial disease for a given level of coronary disease...
Differing associations of lipid and lipoprotein disturbances with the macrovascular and microvascular complications of type 1 diabetesN Chaturvedi
EURODIAB, Department of Epidemiology and Public Health, University College London, London, UK
Diabetes Care 24:2071-7. 2001..In contrast, nephropathy is associated with an adverse distribution. We compared the associations and predictive power of lipid and lipoprotein disturbances with these complications...
Circulating plasma vascular endothelial growth factor and microvascular complications of type 1 diabetes mellitus: the influence of ACE inhibitionN Chaturvedi
EURODIAB, Department of Epidemiology and Public Health, University College London, London, UK
Diabet Med 18:288-94. 2001....
Microalbuminuria in type 1 diabetes: rates, risk factors and glycemic thresholdN Chaturvedi
EURODIAB, University College London, London, England, United Kingdom
Kidney Int 60:219-27. 2001..We determined the incidence and risk factors for microalbuminuria [albumin excretion rate (AER) 20 to 200 microg/min] in the EURODIAB Prospective Complications Study...
Determinants of retinal microvascular architecture in normal subjectsAlun D Hughes
Clinical Pharmacology, NHLI Division, International Centre for Circulatory Health, Faculty of Medicine, Imperial College London, UK
Microcirculation 16:159-66. 2009....
Increased arterial stiffness in Europeans and African Caribbeans with type 2 diabetes cannot be accounted for by conventional cardiovascular risk factorsW David Strain
International Centre for Circulatory Health, National Heart and Lung Institute, Faculty of Medicine, Imperial College London at St Mary s, Hammersmith Hospital, London, UK
Am J Hypertens 19:889-96. 2006..We hypothesized that arterial stiffness, an independent cardiovascular risk factor, would be more prevalent with diabetes and in African Caribbeans with diabetes than Europeans...
Measurement of pulse wave velocity: site mattersTherese Tillin
International Centre for Circulatory Health, St Mary s Hospital, Hammersmith Hospital and Imperial College, London, UK
J Hypertens 25:383-9. 2007..However, a comparison of associations between PWV measured at different sites and atherosclerosis in coronary, carotid and femoral arteries has not been made...
Differential effects of antihypertensive treatment on the retinal microcirculation: an anglo-scandinavian cardiac outcomes trial substudySimon Thom
International Centre for Circulatory Health, 59 61 North Wharf Rd, Paddington, London W2 1NY, United Kingdom
Hypertension 54:405-8. 2009..Photographic assessment of the retinal vascular network may be a useful approach to evaluating microvascular structural responses in clinical trials of antihypertensive therapy...
Microalbuminuria and coronary heart disease risk in an ethnically diverse UK population: a prospective cohort studyTherese Tillin
National Heart and Lung Institute, Imperial College at St Mary s, Norfolk Place, London W2 IPG, UK
J Am Soc Nephrol 16:3702-10. 2005..These differences suggest that the pathogenesis of kidney disease and its link with CHD differ by ethnicity and gender...
Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudyAndrew S P Sharp
Department of Cardiology, International Centre for Circulatory Health, St Mary s Hospital and Imperial College London, 59 61 North Wharf Road, Paddington, London W2 1LA, UK
Eur Heart J 31:747-52. 2010....
Soluble vascular cell adhesion molecule-1 and soluble E-selectin are associated with micro- and macrovascular complications in Type 1 diabetic patientsSabita S Soedamah-Muthu
Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, UK, and Department of Internal Medicine, University Hospital Maastricht, The Netherlands
J Diabetes Complications 20:188-95. 2006..Therefore, the main objective is to examine the relationship between soluble (s) vascular cell adhesion molecule-1 (sVCAM-1) and sE-selectin and retinopathy, albuminuria, and cardiovascular disease (CVD) in Type 1 diabetic patients...
Comparison of the retinal microvasculature in European and African-Caribbean people with diabetesSharleet Mahal
International Centre for Circulatory Health, NHLI Division, Faculty of Medicine, Imperial College London and Imperial College Healthcare NHS Trust, London, U K
Clin Sci (Lond) 117:229-36. 2009..African-Caribbean people with diabetes have wider retinal arterioles and this could contribute to enhanced microvascular damage in this ethnic group...
Ethnic differences in vascular stiffness and relations to hypertensive target organ damageNish Chaturvedi
Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London at St Mary s, Norfolk Place, London, UK
J Hypertens 22:1731-7. 2004..People of Black African descent have greater risks of hypertensive target organ damage than would be anticipated for given levels of blood pressure. Arterial stiffness may further account for ethnic differences in risk...
Ethnicity and left ventricular diastolic function in hypertension an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudyAndrew Sharp
International Centre for Circulatory Health, St Mary s Hospital and Imperial College London, London, United Kingdom
J Am Coll Cardiol 52:1015-21. 2008..We investigated whether diastolic function differs between hypertensive patients of African-Caribbean or white European origin and established whether differences could be explained by confounding variables...
Ethnic differences in skin microvascular function and their relation to cardiac target-organ damageWilliam D Strain
International Centre for Circulatory Health, Faculty of Medicine, Imperial College London at St Mary s, London, UK
J Hypertens 23:133-40. 2005..People of Black African descent have increased risks of vascular target-organ damage not explained by greater blood pressures...
South Asian men have different patterns of coronary artery disease when compared with European menTherese Tillin
International Centre for Circulatory Health, St Mary s Hospital, Hammersmith Hospital and Imperial College, 59 North Wharf Road, London W2 1LA, UK
Int J Cardiol 129:406-13. 2008..To compare patterns of coronary artery disease in British South Asian and White European men...
Risk factors for coronary heart disease in type 1 diabetic patients in Europe: the EURODIAB Prospective Complications StudySabita S Soedamah-Muthu
Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, UK
Diabetes Care 27:530-7. 2004..The goal of the study was to examine risk factors in the prediction of coronary heart disease (CHD) and differences in men and women in the EURODIAB Prospective Complications Study...
Ethnic differences in cardiovascular diseaseNish Chaturvedi
International Centre for Circulatory Health and Department of Epidemiology and Public Health, Faculty of Medicine at St Mary's, Imperial College London, Norfolk Place, London W2 1PG, UK
Heart 89:681-6. 2003
Ethnicity and risk of diabetes-related lower extremity amputation: a population-based, case-control study of African Caribbeans and Europeans in the United kingdomSandra Leggetter
Department of Epidemiology and Public Health, University College London, London, England
Arch Intern Med 162:73-8. 2002..This was wholly accounted for by low smoking, neuropathy, and peripheral vascular disease rates...
South Asians have adverse cerebrovascular haemodynamics, despite equivalent blood pressure, compared with Europeans. This is due to their greater hyperglycaemiaRajaram Bathula
National Heart and Lung Institute, Imperial College Academic Health Sciences Centre, London, UK
Int J Epidemiol 40:1490-8. 2011..We hypothesized that it is the greater hyperglycaemia in South Asians that increases stroke risk, by adversely affecting cerebrovascular haemodynamics...
Impact of size at birth on the microvasculature: the Avon Longitudinal Study of Parents and ChildrenRobyn J Tapp
International Centre for Circulatory Health, NHLI, Imperial College London, St Mary s Campus, London W2 1LA, United Kingdom
Pediatrics 120:e1225-8. 2007..The impact of early life factors on the microvasculature is relatively unknown...
Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trialsNish Chaturvedi
International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK
Lancet 372:1394-402. 2008..We therefore designed the DIabetic REtinopathy Candesartan Trials (DIRECT) Programme to assess whether candesartan could reduce the incidence and progression of retinopathy in type 1 diabetes...
South Asians have elevated postexercise blood pressure and myocardial oxygen consumption compared to Europeans despite equivalent resting pressureNish Chaturvedi
National Heart and Lung Institute, Imperial College Academic Health Sciences Centre, London, UK
J Am Heart Assoc 1:e000281. 2012..Elevated recovery BP after exercise predicts stroke, independently of resting values. We hypothesized that South Asians would have adverse postexercise hemodynamics and sought explanations for this...
The role of antihypertensive therapy in reducing vascular complications of type 2 diabetes. Findings from the DIabetic REtinopathy Candesartan Trials-Protect 2 studyTherese Tillin
International Centre for Circulatory Health, Imperial College London, London, UK
J Hypertens 29:1457-62. 2011..Recent trials question previously accepted low blood pressure targets in type 2 diabetes to reduce complication risk. We explored this question in the DIabetic REtinopathy Candesartan Trials-Protect 2 clinical trial...
Ethnic differences in heart rate: can these be explained by conventional cardiovascular risk factors?Rajaram Bathula
Department of Clinical Pharmacology, Imperial College London, St Mary s Campus, London, UK
Clin Auton Res 18:90-5. 2008..This study investigated ethnic differences in heart rate, sympathovagal balance, and baroreflex sensitivity (BRS) to establish if they were explained by dysglycaemia/insulin resistance...
Abnormalities of retinal microvascular structure and risk of mortality from ischemic heart disease and strokeNicholas Witt
National Heart and Lung Institute Division, Department of Clinical Pharmacology, International Centre for Circulatory Health, Faculty of Medicine, Imperial College London, United Kingdom
Hypertension 47:975-81. 2006..A detailed assessment of the retinal microvascular network from digitized photographs may be useful in the noninvasive assessment of target organ damage and cardiovascular risk...
The renin-angiotensin-aldosterone system and the eye in diabetesW David Strain
Faculty of Medicine, Imperial College at St Mary s, London, W2 1PG, UK
J Renin Angiotensin Aldosterone Syst 3:243-6. 2002..This may be due to antagonism of activation of mitogen-activated protein kinase, which is a potent cellular proliferation stimulator, by Ang II, although this needs further evaluation...
Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urateMark A Peterzan
International Centre for Circulatory Health, National Heart and Lung Institute, Faculty of Medicine, Imperial College London and Imperial College Healthcare National Health Service Trust, London, United Kingdom
Hypertension 59:1104-9. 2012..Hydrochlorothiazide, chlorthalidone, and bendroflumethiazide have markedly different potency. This may account for differences in the antihypertensive effect between hydrochlorothiazide and chlorthalidone using standard dose ranges...
The burden of diabetes and its complications: trends and implications for interventionNish Chaturvedi
International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College at St Mary s, Norfolk Place, London, UK
Diabetes Res Clin Pract 76:S3-12. 2007..However, more information is required about the long-term sustainability of these changes, and programmes also need to be adapted to meet the needs of developing countries...
Insulin resistance and truncal obesity as important determinants of the greater incidence of diabetes in Indian Asians and African Caribbeans compared with Europeans: the Southall And Brent REvisited (SABRE) cohortTherese Tillin
International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, UK
Diabetes Care 36:383-93. 2013..To determine the extent of, and reasons for, ethnic differences in type 2 diabetes incidence in the U.K...
Electrocardiographic left ventricular hypertrophy in type 1 diabetes: prevalence and relation to coronary heart disease and cardiovascular risk factors: the Eurodiab IDDM Complications StudySara Giunti
Department of Internal Medicine, University of Turin, 14, C.so A.M. Dogliotti, I-10126, Torino, Italy
Diabetes Care 28:2255-7. 2005
Ethnic subgroup differences in hypertension in PakistanTazeen H Jafar
Department of Community Health Sciences, Tufts University Medical School, Boston, Massachusetts, USA
J Hypertens 21:905-12. 2003..Further study would provide valuable etiological and therapeutic clues...
Relationship between risk factors and mortality in type 1 diabetic patients in Europe: the EURODIAB Prospective Complications Study (PCS)Sabita S Soedamah-Muthu
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Diabetes Care 31:1360-6. 2008..The purpose of this study was to examine risk factors for mortality in patients with type 1 diabetes...
Serum heat shock protein 27 and diabetes complications in the EURODIAB prospective complications study: a novel circulating marker for diabetic neuropathyGabriella Gruden
Department of Internal Medicine, University of Turin, Turin, Italy
Diabetes 57:1966-70. 2008..We investigated whether sHSP27 levels were associated with micro- and macrovascular complications in type 1 diabetic patients...
Vascular risk factors and diabetic neuropathySolomon Tesfaye
Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom
N Engl J Med 352:341-50. 2005..We studied risk factors for the development of distal symmetric neuropathy in 1172 patients with type 1 diabetes mellitus from 31 centers participating in the European Diabetes (EURODIAB) Prospective Complications Study...
Explanations for the high risk of diabetes-related amputation in a Caribbean population of black african descent and potential for preventionAnselm J M Hennis
Chronic Disease Research Centre, Tropical Medicine Research Institute, University of the West Indies, Jemmott s Lane, Bridgetown, Barbados, West Indies
Diabetes Care 27:2636-41. 2004..S., but are lower in African Caribbeans in the U.K., whereas anecdotal reports suggest high rates in the Caribbean. We aimed to establish the incidence and risk factors for diabetes-related LEA in a Caribbean population...
Pulse pressure is associated with age and cardiovascular disease in type 1 diabetes: the Eurodiab Prospective Complications StudyMiranda T Schram
Institute for Cardiovascular Research and Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands
J Hypertens 21:2035-44. 2003..These findings support the concept of early vascular ageing in type 1 diabetes, especially in the presence of microvascular complications...
Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trialAnne Katrin Sjølie
Department of Ophthalmology, Odense University Hospital, Odense, Denmark
Lancet 372:1385-93. 2008..Diabetic retinopathy remains a leading cause of visual loss in people of working age. We examined whether candesartan treatment could slow the progression and, secondly, induce regression of retinopathy in people with type 2 diabetes...
Adiponectin is inversely associated with renal function in type 1 diabetic patientsCasper G Schalkwijk
Department of Clinical Chemistry, Institute for Cardiovascular Research, Vrije Universiteit, 1007 MB Amsterdam, The Netherlands
J Clin Endocrinol Metab 91:129-35. 2006..We examined the relation of adiponectin with several cardiovascular risk factors and with micro- and macrovascular outcomes in type 1 diabetic patients...
Ethnic differences and determinants of proteinuria among South Asian subgroups in PakistanTazeen H Jafar
Department of Medicine, Aga Khan University, Karachi, Pakistan
Kidney Int 64:1437-44. 2003..Prevalence of proteinuria is high in South Asians. However, ethnic subgroup differences and determinants of proteinuria within the South Asian population have not been explored...
Children in South Asia have higher body mass-adjusted blood pressure levels than white children in the United States: a comparative studyTazeen H Jafar
Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, PO Box 3500, Stadium Road, Karachi, Pakistan
Circulation 111:1291-7. 2005....
Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the EURODIAB Prospective Complications StudyMiranda T Schram
Institute for Cardiovascular Research, and Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
Diabetes Care 26:2165-73. 2003....
Heart disease epidemic in Pakistan: women and men at equal riskTazeen H Jafar
Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
Am Heart J 150:221-6. 2005..We conducted this study to determine the prevalence of coronary artery disease (CAD) and its risk factors in Karachi, Pakistan...
Ethnic differences in microvascular structure and functionWilliam D Strain
J Hypertens 23:1434-5; author reply 1435-6. 2005
The role of diabetes and components of the metabolic syndrome in stroke and coronary heart disease mortality in U.K. white and African-Caribbean populationsTherese Tillin
National Heart and Lung Institute, Imperial College at St. Mary's, Norfolk Place, London W2 1PG, U.K
Diabetes Care 29:2127-9. 2006
Prevalence of overweight and obesity and their association with hypertension and diabetes mellitus in an Indo-Asian populationTazeen H Jafar
Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
CMAJ 175:1071-7. 2006....
Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications StudyMiranda T Schram
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Hypertension 46:232-7. 2005..These findings suggest that the formation of advanced glycation end products is an important pathway in the development of arterial stiffness in young type 1 diabetic individuals...
Use of albumin creatinine ratio and urine albumin concentration as a screening test for albuminuria in an Indo-Asian populationTazeen H Jafar
Section of Nephrology, Department of Medicine, The Aga Khan University, PO Box 3500, Stadium Road, Karachi, Pakistan
Nephrol Dial Transplant 22:2194-200. 2007..We compared the use of spot urine albumin concentration and urine albumin to creatinine excretion ratio for detection of albuminuria in this population...
Incidence and risk factors of prolonged QTc interval in type 1 diabetes: the EURODIAB Prospective Complications StudySara Giunti
Department of Internal Medicine, University of Torino, I 10126 Torino, Italy
Diabetes Care 30:2057-63. 2007..As part of the EURODIAB Prospective Complication Study, we have assessed the 7-year incidence and risk factors of prolonged QTc in people with type 1 diabetes...
Diabetic retinopathy is associated with mortality and cardiovascular disease incidence: the EURODIAB prospective complications studyManon V Van Hecke
Department of Ophthalmology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, Netherlands
Diabetes Care 28:1383-9. 2005....
Rationale and design of the AdRem study: evaluating the effects of blood pressure lowering and intensive glucose control on vascular retinal disorders in patients with type 2 diabetes mellitusNish Chaturvedi
Contemp Clin Trials 28:780. 2007
Does microalbuminuria predict diabetic nephropathy?Han Henrik Parving
Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
Diabetes Care 25:406-7. 2002
Ethnicity, socio-economic position and gender--do they affect reported health-care seeking behaviour?Joy Adamson
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, BS8 2PR Bristol, UK
Soc Sci Med 57:895-904. 2003....
General practitioners' approach to hypertension in urban Pakistan: disturbing trends in practiceTazeen H Jafar
Section of Nephrology, Department of Medicine, Aga Khan University, PO Box 3500, Stadium Road, Karachi, 74800, Pakistan
Circulation 111:1278-83. 2005..Control of blood pressure (BP) remains suboptimal worldwide. The objective of this study was to determine whether (primary) general practitioners' (GPs) approach to high BP is in accordance with international guidelines...
Albumin excretion rate and cardiovascular risk: could the association be explained by early microvascular dysfunction?W David Strain
Clinical Microvascular Research, Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Rd, Exeter EX2 5AX, UK
Diabetes 54:1816-22. 2005..This may represent shared mechanistic pathways and causative or con-sequential changes in the microvasculature and supports the hypothesis that microvascular dysfunction may contribute to large vessel pathophysiology...
Prevalence and predictors of smoking in Pakistan: results of the National Health Survey of PakistanKhabir Ahmad
Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
Eur J Cardiovasc Prev Rehabil 12:203-8. 2005..CONCLUSIONS: One out of every two to three middle-aged men in Pakistan smoke cigarettes. Our findings suggest that ethnically sensitive smoking control programmes that include measures for improving literacy rates are needed in Pakistan...
Knowledge of modifiable risk factors of heart disease among patients with acute myocardial infarction in Karachi, Pakistan: a cross sectional studyMuhammad S Khan
Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
BMC Cardiovasc Disord 6:18. 2006....
Effect of general practitioner education on adherence to antihypertensive drugs: cluster randomised controlled trialNudrat Noor Qureshi
Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, P O Box 3500, Stadium Road, Karachi, 74800, Pakistan
BMJ 335:1030. 2007..To determine the impact of a simple educational package for general practitioners on adherence to antihypertensive drugs...
