John C Chambers

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Genetic variation in SCN10A influences cardiac conduction
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, UK
    Nat Genet 42:149-52. 2010
  2. pmc Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
    John C Chambers
    Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
    Nat Genet 43:1131-8. 2011
  3. pmc Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Nat Genet 41:1170-2. 2009
  4. pmc Genetic loci influencing kidney function and chronic kidney disease
    John C Chambers
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK
    Nat Genet 42:373-5. 2010
  5. ncbi request reprint Common genetic variation near MC4R is associated with waist circumference and insulin resistance
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Pl, London W2 1PG, UK
    Nat Genet 40:716-8. 2008
  6. pmc Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, London, U K
    Diabetes 58:2703-8. 2009
  7. pmc Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
    Jaspal S Kooner
    National Heart and Lung Institute NHLI, Imperial College London, Hammersmith Hospital, London, UK
    Nat Genet 43:984-9. 2011
  8. doi request reprint Ethnic and gender differences in the relationship between hostility and metabolic and autonomic risk factors for coronary heart disease
    Emily D Williams
    Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London, United Kingdom
    Psychosom Med 73:53-8. 2011
  9. ncbi request reprint Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    Jaspal S Kooner
    National Heart and Lung Institute, Imperial College London, UK
    Nat Genet 40:149-51. 2008
  10. pmc Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease
    Paul Elliott
    Faculty of Medicine, Imperial College London, London, United Kingdom
    JAMA 302:37-48. 2009

Detail Information

Publications12

  1. ncbi request reprint Genetic variation in SCN10A influences cardiac conduction
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, UK
    Nat Genet 42:149-52. 2010
    ..05) and a lower risk of ventricular fibrillation (P = 0.01). Our findings provide new insight into the pathogenesis of cardiac conduction, heart block and ventricular fibrillation...
  2. pmc Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
    John C Chambers
    Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
    Nat Genet 43:1131-8. 2011
    ..Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function...
  3. pmc Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Nat Genet 41:1170-2. 2009
    ..13 (95% CI 0.09-0.17) g/dl lower per copy of allele A (P = 1.6 x 10(-13)). Our findings suggest that TMPRSS6, a regulator of hepcidin synthesis and iron handling, is crucial in hemoglobin level maintenance...
  4. pmc Genetic loci influencing kidney function and chronic kidney disease
    John C Chambers
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK
    Nat Genet 42:373-5. 2010
    ..0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease...
  5. ncbi request reprint Common genetic variation near MC4R is associated with waist circumference and insulin resistance
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Pl, London W2 1PG, UK
    Nat Genet 40:716-8. 2008
    ..Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance...
  6. pmc Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, London, U K
    Diabetes 58:2703-8. 2009
    ..Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians...
  7. pmc Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
    Jaspal S Kooner
    National Heart and Lung Institute NHLI, Imperial College London, Hammersmith Hospital, London, UK
    Nat Genet 43:984-9. 2011
    ..001, respectively). Our findings provide additional insight into mechanisms underlying T2D and show the potential for new discovery from genetic association studies in South Asians, a population with increased susceptibility to T2D...
  8. doi request reprint Ethnic and gender differences in the relationship between hostility and metabolic and autonomic risk factors for coronary heart disease
    Emily D Williams
    Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London, United Kingdom
    Psychosom Med 73:53-8. 2011
    ..To examine the relationship between hostility and biological risk factors for coronary heart disease (CHD) in a population of white European and South Asian men and women living in the United Kingdom...
  9. ncbi request reprint Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    Jaspal S Kooner
    National Heart and Lung Institute, Imperial College London, UK
    Nat Genet 40:149-51. 2008
    ..4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'...
  10. pmc Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease
    Paul Elliott
    Faculty of Medicine, Imperial College London, London, United Kingdom
    JAMA 302:37-48. 2009
    ..Plasma levels of C-reactive protein (CRP) are independently associated with risk of coronary heart disease, but whether CRP is causally associated with coronary heart disease or merely a marker of underlying atherosclerosis is uncertain...
  11. ncbi request reprint Arrhythmogenic cardiomyopathy: etiology, diagnosis, and treatment
    Srijita Sen-Chowdhry
    Imperial College, London, UK
    Annu Rev Med 61:233-53. 2010
    ..Development of a prospectively validated risk-stratification algorithm for the full disease spectrum remains the foremost clinical challenge...
  12. pmc The South asian genome
    John C Chambers
    Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom Imperial College Healthcare NHS Trust, London, United Kingdom MRC HPA Centre for Environment and Health, Imperial College London, Norfolk Place, London, United Kingdom Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom
    PLoS ONE 9:e102645. 2014
    ..Our results will accelerate the search for the genetic variants underlying susceptibility to disorders such as type-2 diabetes and cardiovascular disease which are highly prevalent amongst South Asians. ..