Genomes and Genes
John C Chambers
Affiliation: Imperial College
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasmaJohn C Chambers
Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
Nat Genet 43:1131-8. 2011..Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function...
- Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levelsJohn C Chambers
Department of Epidemiology and Public Health, Imperial College London, London, UK
Nat Genet 41:1170-2. 2009..13 (95% CI 0.09-0.17) g/dl lower per copy of allele A (P = 1.6 x 10(-13)). Our findings suggest that TMPRSS6, a regulator of hepcidin synthesis and iron handling, is crucial in hemoglobin level maintenance...
- Genetic variation in SCN10A influences cardiac conductionJohn C Chambers
Department of Epidemiology and Public Health, Imperial College London, UK
Nat Genet 42:149-52. 2010..05) and a lower risk of ventricular fibrillation (P = 0.01). Our findings provide new insight into the pathogenesis of cardiac conduction, heart block and ventricular fibrillation...
- Genetic loci influencing kidney function and chronic kidney diseaseJohn C Chambers
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK
Nat Genet 42:373-5. 2010..0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease...
- Common genetic variation near MC4R is associated with waist circumference and insulin resistanceJohn C Chambers
Department of Epidemiology and Public Health, Imperial College London, Norfolk Pl, London W2 1PG, UK
Nat Genet 40:716-8. 2008..Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance...
- Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European CaucasiansJohn C Chambers
Department of Epidemiology and Public Health, Imperial College London, London, U K
Diabetes 58:2703-8. 2009..Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians...
- Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility lociJaspal S Kooner
National Heart and Lung Institute NHLI, Imperial College London, Hammersmith Hospital, London, UK
Nat Genet 43:984-9. 2011..001, respectively). Our findings provide additional insight into mechanisms underlying T2D and show the potential for new discovery from genetic association studies in South Asians, a population with increased susceptibility to T2D...
- Ethnic and gender differences in the relationship between hostility and metabolic and autonomic risk factors for coronary heart diseaseEmily D Williams
Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London, United Kingdom
Psychosom Med 73:53-8. 2011..To examine the relationship between hostility and biological risk factors for coronary heart disease (CHD) in a population of white European and South Asian men and women living in the United Kingdom...
- Genome-wide scan identifies variation in MLXIPL associated with plasma triglyceridesJaspal S Kooner
National Heart and Lung Institute, Imperial College London, UK
Nat Genet 40:149-51. 2008..4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'...
- Genetic Loci associated with C-reactive protein levels and risk of coronary heart diseasePaul Elliott
Faculty of Medicine, Imperial College London, London, United Kingdom
JAMA 302:37-48. 2009..Plasma levels of C-reactive protein (CRP) are independently associated with risk of coronary heart disease, but whether CRP is causally associated with coronary heart disease or merely a marker of underlying atherosclerosis is uncertain...
- Arrhythmogenic cardiomyopathy: etiology, diagnosis, and treatmentSrijita Sen-Chowdhry
Imperial College, London, UK
Annu Rev Med 61:233-53. 2010..Development of a prospectively validated risk-stratification algorithm for the full disease spectrum remains the foremost clinical challenge...