Sarah Burl

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Optimisation of a functional mycobacterial growth-inhibition assay to improve its suitability for infant TB vaccine studies
    S Burl
    Department of Paediatrics, St Mary s Campus, Imperial College London, Norfolk Place, London W2 1PG, UK
    J Immunol Methods 394:121-4. 2013
  2. pmc Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants
    Sarah Burl
    Infant Immunology, Medical Research Council UK The Gambia, Fajara, The Gambia
    PLoS ONE 6:e18185. 2011
  3. doi request reprint Delaying bacillus Calmette-Guérin vaccination from birth to 4 1/2 months of age reduces postvaccination Th1 and IL-17 responses but leads to comparable mycobacterial responses at 9 months of age
    Sarah Burl
    Medical Research Council United Kingdom, The Gambia, Fajara, The Gambia, West Africa
    J Immunol 185:2620-8. 2010
  4. pmc The tuberculin skin test (TST) is affected by recent BCG vaccination but not by exposure to non-tuberculosis mycobacteria (NTM) during early life
    Sarah Burl
    Infant Immunology, Medical Research Council UK The Gambia, Fajara, The Gambia
    PLoS ONE 5:e12287. 2010
  5. pmc Vitamin D in early childhood and the effect on immunity to Mycobacterium tuberculosis
    Anna Jane Battersby
    Academic Department of Paediatrics, Imperial College London, St Mary s Campus, Wright Fleming Building, Norfolk Place, London W2 1PG, UK
    Clin Dev Immunol 2012:430972. 2012
  6. pmc The challenge of assessing infant vaccine responses in resource-poor settings
    Katie L Flanagan
    Medical Research Council UK The Gambia, Fajara, The Gambia
    Expert Rev Vaccines 9:665-74. 2010
  7. doi request reprint The effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth
    Katie L Flanagan
    MRC Laboratories, Fajara, The Gambia
    Eur J Immunol 40:1062-72. 2010

Detail Information

Publications7

  1. pmc Optimisation of a functional mycobacterial growth-inhibition assay to improve its suitability for infant TB vaccine studies
    S Burl
    Department of Paediatrics, St Mary s Campus, Imperial College London, Norfolk Place, London W2 1PG, UK
    J Immunol Methods 394:121-4. 2013
    ..These results confirm the suitability of the BCG-lux assay for functional studies of vaccine immunogenicity and immunopathogenesis in young children and could play a role in late-phase TB vaccine trials of novel candidates...
  2. pmc Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants
    Sarah Burl
    Infant Immunology, Medical Research Council UK The Gambia, Fajara, The Gambia
    PLoS ONE 6:e18185. 2011
    ..These observations provide fresh insights into the ontogeny of innate immunity in African children, and may inform development of age-specific adjuvanted vaccine formulations important for global health...
  3. doi request reprint Delaying bacillus Calmette-Guérin vaccination from birth to 4 1/2 months of age reduces postvaccination Th1 and IL-17 responses but leads to comparable mycobacterial responses at 9 months of age
    Sarah Burl
    Medical Research Council United Kingdom, The Gambia, Fajara, The Gambia, West Africa
    J Immunol 185:2620-8. 2010
    ..The evidence did not suggest that mycobacterial specific naturally occurring Tregs accounted for this attenuated immunogenicity...
  4. pmc The tuberculin skin test (TST) is affected by recent BCG vaccination but not by exposure to non-tuberculosis mycobacteria (NTM) during early life
    Sarah Burl
    Infant Immunology, Medical Research Council UK The Gambia, Fajara, The Gambia
    PLoS ONE 5:e12287. 2010
    ..Collectively these data provide further insights into how the TST is regulated in early life, and how a positive response might be interpreted...
  5. pmc Vitamin D in early childhood and the effect on immunity to Mycobacterium tuberculosis
    Anna Jane Battersby
    Academic Department of Paediatrics, Imperial College London, St Mary s Campus, Wright Fleming Building, Norfolk Place, London W2 1PG, UK
    Clin Dev Immunol 2012:430972. 2012
    ..Where much of the attention has been paid by past reviews to the role of vitamin D in adult TB patients, this paper, where possible, focuses on research in paediatric populations...
  6. pmc The challenge of assessing infant vaccine responses in resource-poor settings
    Katie L Flanagan
    Medical Research Council UK The Gambia, Fajara, The Gambia
    Expert Rev Vaccines 9:665-74. 2010
    ..In this article, we will review immunity to vaccines in early life, discuss the many challenges associated with assessing immunogenicity and provide practical tips...
  7. doi request reprint The effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth
    Katie L Flanagan
    MRC Laboratories, Fajara, The Gambia
    Eur J Immunol 40:1062-72. 2010
    ..The findings might explain some of the adverse effects on the health of babies born to women with PM...