Anne Burke-Gaffney

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor
    Susannah K Leaver
    Unit of Critical Care, Respiratory Science, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW3 6LY, UK
    Intensive Care Med 36:336-41. 2010
  2. pmc PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells
    M E Callister
    Critical Care, Pulmonary Vascular and Sleep Science, Respiratory Science, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK
    Br J Pharmacol 155:661-72. 2008
  3. pmc Differences in lipopolysaccharide- and lipoteichoic acid-induced cytokine/chemokine expression
    Simon J Finney
    Unit of Critical Care, Respiratory Science, NHLI, Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Intensive Care Med 38:324-32. 2012
  4. ncbi request reprint Thioredoxin: friend or foe in human disease?
    Anne Burke-Gaffney
    Unit of Critical Care, National Heart and Lung Institute Division, Imperial College Faculty of Medicine, Dovehouse Street, London SW3 6LY, UK
    Trends Pharmacol Sci 26:398-404. 2005
  5. ncbi request reprint Butanol-extracted lipoteichoic acid induces in vivo leukocyte adhesion
    Simon J Finney
    Unit of Critical Care, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Dovehouse Street, London, SW3 6LY, United Kingdom
    Biochem Biophys Res Commun 364:831-7. 2007
  6. pmc Association between preoperative plasma sRAGE levels and recovery from cardiac surgery
    Benedict C Creagh-Brown
    Unit of Critical Care, Respiratory Science, National Heart and Lung Institute Division NHLI, Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UK NIHR Respiratory Disease Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London SW3 6NP, UK
    Mediators Inflamm 2013:496031. 2013
  7. ncbi request reprint Sepsis since the discovery of Toll-like receptors: disease concepts and therapeutic opportunities
    Susannah K Leaver
    Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Crit Care Med 35:1404-10. 2007
  8. ncbi request reprint Severe sepsis and Toll-like receptors
    Hongmei Gao
    Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Semin Immunopathol 30:29-40. 2008
  9. ncbi request reprint Persistently low plasma thioredoxin is associated with meningococcal septic shock in children
    Matthew E Callister
    Unit of Critical Care, National Heart and Lung Institute Division, Imperial College Faculty of Medicine, Royal Brompton Hospital, SW3 6 lY, London, UK
    Intensive Care Med 33:364-7. 2007
  10. ncbi request reprint TNF-alpha potentiates C5a-stimulated eosinophil adhesion to human bronchial epithelial cells: a role for alpha 5 beta 1 integrin
    Anne Burke-Gaffney
    Applied Pharmacology and Unit of Critical Care, National Heart and Lung Institute Division, Imperial College of Science, Technology and Medicine, Dovehouse Street, London, SW3 6LY, United Kingdom
    J Immunol 168:1380-8. 2002

Collaborators

Detail Information

Publications13

  1. pmc Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor
    Susannah K Leaver
    Unit of Critical Care, Respiratory Science, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW3 6LY, UK
    Intensive Care Med 36:336-41. 2010
    ..To establish the relationship between plasma levels of thioredoxin (Trx) and macrophage migration inhibitory factor (MIF) in systemic inflammatory stress syndrome (SIRS)/sepsis...
  2. pmc PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells
    M E Callister
    Critical Care, Pulmonary Vascular and Sleep Science, Respiratory Science, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK
    Br J Pharmacol 155:661-72. 2008
    ..The aim of this work was to investigate whether PMX464 inhibited NF-kappaB-mediated proinflammatory activation of human type II alveolar epithelial cells (A549)...
  3. pmc Differences in lipopolysaccharide- and lipoteichoic acid-induced cytokine/chemokine expression
    Simon J Finney
    Unit of Critical Care, Respiratory Science, NHLI, Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Intensive Care Med 38:324-32. 2012
    ..To investigate differences in cytokine/chemokine release in response to lipoteichoic acid (LTA) or lipopolysaccharide (LPS) and contributing cellular mechanisms, in order to improve understanding of the pathogenesis of sepsis...
  4. ncbi request reprint Thioredoxin: friend or foe in human disease?
    Anne Burke-Gaffney
    Unit of Critical Care, National Heart and Lung Institute Division, Imperial College Faculty of Medicine, Dovehouse Street, London SW3 6LY, UK
    Trends Pharmacol Sci 26:398-404. 2005
    ..In this article, we review the role of Trx in human disease and relate this to its redox activity and biological properties, and discuss the development and use of therapies that either inhibit or augment Trx activity...
  5. ncbi request reprint Butanol-extracted lipoteichoic acid induces in vivo leukocyte adhesion
    Simon J Finney
    Unit of Critical Care, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Dovehouse Street, London, SW3 6LY, United Kingdom
    Biochem Biophys Res Commun 364:831-7. 2007
    ..01) increased leukocyte adhesion measured at 60 min. In conclusion, Bu-LTA with intact alanine residues promotes beta2-integrin-dependent leukocyte adhesion in vivo...
  6. pmc Association between preoperative plasma sRAGE levels and recovery from cardiac surgery
    Benedict C Creagh-Brown
    Unit of Critical Care, Respiratory Science, National Heart and Lung Institute Division NHLI, Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UK NIHR Respiratory Disease Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London SW3 6NP, UK
    Mediators Inflamm 2013:496031. 2013
    ....
  7. ncbi request reprint Sepsis since the discovery of Toll-like receptors: disease concepts and therapeutic opportunities
    Susannah K Leaver
    Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Crit Care Med 35:1404-10. 2007
    ..This review describes these advances...
  8. ncbi request reprint Severe sepsis and Toll-like receptors
    Hongmei Gao
    Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Semin Immunopathol 30:29-40. 2008
    ..TLR agonists may augment the innate response and are being investigated...
  9. ncbi request reprint Persistently low plasma thioredoxin is associated with meningococcal septic shock in children
    Matthew E Callister
    Unit of Critical Care, National Heart and Lung Institute Division, Imperial College Faculty of Medicine, Royal Brompton Hospital, SW3 6 lY, London, UK
    Intensive Care Med 33:364-7. 2007
    ..To compare plasma levels of thioredoxin (Trx), TNF-alpha and IL-1 beta in children during the acute phase of meningococcal septic shock (MSS) and in convalescence...
  10. ncbi request reprint TNF-alpha potentiates C5a-stimulated eosinophil adhesion to human bronchial epithelial cells: a role for alpha 5 beta 1 integrin
    Anne Burke-Gaffney
    Applied Pharmacology and Unit of Critical Care, National Heart and Lung Institute Division, Imperial College of Science, Technology and Medicine, Dovehouse Street, London, SW3 6LY, United Kingdom
    J Immunol 168:1380-8. 2002
    ..Fibronectin, associated with HBEC, may act as a ligand for alpha(5)beta(1) integrin. Dual regulation of eosinophil priming may prevent inappropriate activation of eosinophils in the circulation...
  11. doi request reprint The RAGE axis in systemic inflammation, acute lung injury and myocardial dysfunction: an important therapeutic target?
    Benedict C Creagh-Brown
    Unit of Critical Care, Respiratory Science, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College, London, UK
    Intensive Care Med 36:1644-56. 2010
    ..More recent approaches have therefore attempted to identify pathways that could offer a wider therapeutic window, such as the receptor for advanced glycation end-products (RAGE) and its ligands...
  12. pmc Lest we forget the endothelial glycocalyx in sepsis
    Anne Burke-Gaffney
    Unit of Critical Care, Respiratory Science, National Heart and Lung Institute Division, Faculty of Medicine Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Crit Care 16:121. 2012
    ....
  13. ncbi request reprint Regulation of chemokine expression in atherosclerosis
    Anne Burke-Gaffney
    Unit of Critical Care, National Heart and Lung Institute Division, Imperial College of Science, Technology and Medicine, Dovehouse Street, London SW3 6LY, UK
    Vascul Pharmacol 38:283-92. 2002
    ..Understanding the mechanisms controlling chemokine expression is essential for the design of specific therapeutic interventions in atherosclerosis...