Anne Burke-Gaffney

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Differences in lipopolysaccharide- and lipoteichoic acid-induced cytokine/chemokine expression
    Simon J Finney
    Unit of Critical Care, Respiratory Science, NHLI, Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Intensive Care Med 38:324-32. 2012
  2. ncbi Thioredoxin: friend or foe in human disease?
    Anne Burke-Gaffney
    Unit of Critical Care, National Heart and Lung Institute Division, Imperial College Faculty of Medicine, Dovehouse Street, London SW3 6LY, UK
    Trends Pharmacol Sci 26:398-404. 2005
  3. ncbi Butanol-extracted lipoteichoic acid induces in vivo leukocyte adhesion
    Simon J Finney
    Unit of Critical Care, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Dovehouse Street, London, SW3 6LY, United Kingdom
    Biochem Biophys Res Commun 364:831-7. 2007
  4. ncbi TNF-alpha potentiates C5a-stimulated eosinophil adhesion to human bronchial epithelial cells: a role for alpha 5 beta 1 integrin
    Anne Burke-Gaffney
    Applied Pharmacology and Unit of Critical Care, National Heart and Lung Institute Division, Imperial College of Science, Technology and Medicine, Dovehouse Street, London, SW3 6LY, United Kingdom
    J Immunol 168:1380-8. 2002
  5. ncbi Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor
    Susannah K Leaver
    Unit of Critical Care, Respiratory Science, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW3 6LY, UK
    Intensive Care Med 36:336-41. 2010
  6. ncbi The RAGE axis in systemic inflammation, acute lung injury and myocardial dysfunction: an important therapeutic target?
    Benedict C Creagh-Brown
    Unit of Critical Care, Respiratory Science, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College, London, UK
    Intensive Care Med 36:1644-56. 2010
  7. ncbi Regulation of chemokine expression in atherosclerosis
    Anne Burke-Gaffney
    Unit of Critical Care, National Heart and Lung Institute Division, Imperial College of Science, Technology and Medicine, Dovehouse Street, London SW3 6LY, UK
    Vascul Pharmacol 38:283-92. 2002
  8. ncbi Persistently low plasma thioredoxin is associated with meningococcal septic shock in children
    Matthew E Callister
    Unit of Critical Care, National Heart and Lung Institute Division, Imperial College Faculty of Medicine, Royal Brompton Hospital, SW3 6 lY, London, UK
    Intensive Care Med 33:364-7. 2007

Collaborators

  • Simon J Finney
  • Simon Nadel
  • Hajime Nakamura
  • Gregory J Quinlan
  • Timothy W Evans
  • Benedict C Creagh-Brown
  • Susannah K Leaver
  • Matthew E Callister
  • Niall S MacCallum
  • Vasisht Pingle
  • Matthew B Hacking
  • Anne Burke Gaffney
  • Helen Betts

Detail Information

Publications8

  1. ncbi Differences in lipopolysaccharide- and lipoteichoic acid-induced cytokine/chemokine expression
    Simon J Finney
    Unit of Critical Care, Respiratory Science, NHLI, Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Intensive Care Med 38:324-32. 2012
    ..To investigate differences in cytokine/chemokine release in response to lipoteichoic acid (LTA) or lipopolysaccharide (LPS) and contributing cellular mechanisms, in order to improve understanding of the pathogenesis of sepsis...
  2. ncbi Thioredoxin: friend or foe in human disease?
    Anne Burke-Gaffney
    Unit of Critical Care, National Heart and Lung Institute Division, Imperial College Faculty of Medicine, Dovehouse Street, London SW3 6LY, UK
    Trends Pharmacol Sci 26:398-404. 2005
    ..In this article, we review the role of Trx in human disease and relate this to its redox activity and biological properties, and discuss the development and use of therapies that either inhibit or augment Trx activity...
  3. ncbi Butanol-extracted lipoteichoic acid induces in vivo leukocyte adhesion
    Simon J Finney
    Unit of Critical Care, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Dovehouse Street, London, SW3 6LY, United Kingdom
    Biochem Biophys Res Commun 364:831-7. 2007
    ..01) increased leukocyte adhesion measured at 60 min. In conclusion, Bu-LTA with intact alanine residues promotes beta2-integrin-dependent leukocyte adhesion in vivo...
  4. ncbi TNF-alpha potentiates C5a-stimulated eosinophil adhesion to human bronchial epithelial cells: a role for alpha 5 beta 1 integrin
    Anne Burke-Gaffney
    Applied Pharmacology and Unit of Critical Care, National Heart and Lung Institute Division, Imperial College of Science, Technology and Medicine, Dovehouse Street, London, SW3 6LY, United Kingdom
    J Immunol 168:1380-8. 2002
    ..Fibronectin, associated with HBEC, may act as a ligand for alpha(5)beta(1) integrin. Dual regulation of eosinophil priming may prevent inappropriate activation of eosinophils in the circulation...
  5. ncbi Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor
    Susannah K Leaver
    Unit of Critical Care, Respiratory Science, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW3 6LY, UK
    Intensive Care Med 36:336-41. 2010
    ..To establish the relationship between plasma levels of thioredoxin (Trx) and macrophage migration inhibitory factor (MIF) in systemic inflammatory stress syndrome (SIRS)/sepsis...
  6. ncbi The RAGE axis in systemic inflammation, acute lung injury and myocardial dysfunction: an important therapeutic target?
    Benedict C Creagh-Brown
    Unit of Critical Care, Respiratory Science, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College, London, UK
    Intensive Care Med 36:1644-56. 2010
    ..More recent approaches have therefore attempted to identify pathways that could offer a wider therapeutic window, such as the receptor for advanced glycation end-products (RAGE) and its ligands...
  7. ncbi Regulation of chemokine expression in atherosclerosis
    Anne Burke-Gaffney
    Unit of Critical Care, National Heart and Lung Institute Division, Imperial College of Science, Technology and Medicine, Dovehouse Street, London SW3 6LY, UK
    Vascul Pharmacol 38:283-92. 2002
    ..Understanding the mechanisms controlling chemokine expression is essential for the design of specific therapeutic interventions in atherosclerosis...
  8. ncbi Persistently low plasma thioredoxin is associated with meningococcal septic shock in children
    Matthew E Callister
    Unit of Critical Care, National Heart and Lung Institute Division, Imperial College Faculty of Medicine, Royal Brompton Hospital, SW3 6 lY, London, UK
    Intensive Care Med 33:364-7. 2007
    ..To compare plasma levels of thioredoxin (Trx), TNF-alpha and IL-1 beta in children during the acute phase of meningococcal septic shock (MSS) and in convalescence...