Julia C Buckingham

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Integrating pharmacology and clinical pharmacology in universities
    Julia C Buckingham
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Br J Clin Pharmacol 73:861-5. 2012
  2. pmc Annexin 1, glucocorticoids, and the neuroendocrine-immune interface
    Julia C Buckingham
    Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Campus, London W12 0NN, UK
    Ann N Y Acad Sci 1088:396-409. 2006
  3. pmc Glucocorticoids: exemplars of multi-tasking
    Julia C Buckingham
    Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Hammersmith W12 0NN
    Br J Pharmacol 147:S258-68. 2006
  4. pmc Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue
    James P Warne
    Dept of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Campus, London, W12 0NN, UK
    Am J Physiol Endocrinol Metab 291:E1264-73. 2006
  5. ncbi request reprint Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system
    Julia C Buckingham
    Department of Neuroendocrinology, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, UK
    Cell Biochem Funct 21:217-21. 2003
  6. doi request reprint Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1-FPR2/ALX anti-inflammatory system
    Felicity N E Gavins
    Division of Brain Sciences, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Burlington Danes Bldg, Du Cane Rd, London W12 0NN, UK
    FASEB J 26:4977-89. 2012
  7. ncbi request reprint Expression, subcellular localization and phosphorylation status of annexins 1 and 5 in human pituitary adenomas and a growth hormone-secreting carcinoma
    Abeda Mulla
    Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Commonwealth Building, Hammersmith Hospital Campus, Du Cane Road, London, UK
    Clin Endocrinol (Oxf) 60:107-19. 2004
  8. doi request reprint Annexin A1 and the formyl peptide receptor family: neuroendocrine and metabolic aspects
    Christopher D John
    Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Campus, London, UK
    Curr Opin Pharmacol 8:765-76. 2008
  9. ncbi request reprint Annexin 1 and the regulation of endocrine function
    Christopher D John
    Cellular and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W120NN, UK
    Trends Endocrinol Metab 15:103-9. 2004
  10. ncbi request reprint Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, phosphatidylinositol 3-kinase, and
    Egle Solito
    Department of Neuroendocrinology, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London W12 ONN, United Kingdom
    Endocrinology 144:1164-74. 2003

Collaborators

Detail Information

Publications28

  1. pmc Integrating pharmacology and clinical pharmacology in universities
    Julia C Buckingham
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Br J Clin Pharmacol 73:861-5. 2012
    ....
  2. pmc Annexin 1, glucocorticoids, and the neuroendocrine-immune interface
    Julia C Buckingham
    Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Campus, London W12 0NN, UK
    Ann N Y Acad Sci 1088:396-409. 2006
    ..In addition, the role of ANXA1 in the perinatal programming of the HPA axis is discussed...
  3. pmc Glucocorticoids: exemplars of multi-tasking
    Julia C Buckingham
    Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Hammersmith W12 0NN
    Br J Pharmacol 147:S258-68. 2006
    ..In addition, consideration is given to the irreversible 'organisational' actions of glucocorticoids in perinatal life and to the potential role of the steroids in the aetiology of disease...
  4. pmc Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue
    James P Warne
    Dept of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Campus, London, W12 0NN, UK
    Am J Physiol Endocrinol Metab 291:E1264-73. 2006
    ..Collectively, these studies suggest that ANXA1 supports aspects of adipose tissue mass and alters the sensitivity of epididymal adipose tissue to catecholamines, glucocorticoids, and LPS, thereby modulating lipolysis and IL-6 release...
  5. ncbi request reprint Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system
    Julia C Buckingham
    Department of Neuroendocrinology, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, UK
    Cell Biochem Funct 21:217-21. 2003
    ..This brief review outlines this work and describes molecular and cellular studies which have provided insight into the mechanism of annexin 1-dependent GC signalling in the neuroendocrine system...
  6. doi request reprint Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1-FPR2/ALX anti-inflammatory system
    Felicity N E Gavins
    Division of Brain Sciences, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Burlington Danes Bldg, Du Cane Rd, London W12 0NN, UK
    FASEB J 26:4977-89. 2012
    ..In summary, our novel results demonstrate that the AnxA1/FPR2 system has an important role in effecting the resolution of cerebral inflammation in sepsis and may, therefore, provide a novel therapeutic target...
  7. ncbi request reprint Expression, subcellular localization and phosphorylation status of annexins 1 and 5 in human pituitary adenomas and a growth hormone-secreting carcinoma
    Abeda Mulla
    Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Commonwealth Building, Hammersmith Hospital Campus, Du Cane Road, London, UK
    Clin Endocrinol (Oxf) 60:107-19. 2004
    ....
  8. doi request reprint Annexin A1 and the formyl peptide receptor family: neuroendocrine and metabolic aspects
    Christopher D John
    Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Campus, London, UK
    Curr Opin Pharmacol 8:765-76. 2008
    ..In addition, we discuss evidence that ANXA1 contributes to the regulation of other aspects of endocrine and metabolic function and to the aetiology of sexual dimorphisms...
  9. ncbi request reprint Annexin 1 and the regulation of endocrine function
    Christopher D John
    Cellular and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W120NN, UK
    Trends Endocrinol Metab 15:103-9. 2004
    ....
  10. ncbi request reprint Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, phosphatidylinositol 3-kinase, and
    Egle Solito
    Department of Neuroendocrinology, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London W12 ONN, United Kingdom
    Endocrinology 144:1164-74. 2003
    ....
  11. ncbi request reprint Macrophage migration inhibitory factor is released from pituitary folliculo-stellate-like cells by endotoxin and dexamethasone and attenuates the steroid-induced inhibition of interleukin 6 release
    Tanya Tierney
    Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College London, London W12 0NN, United Kingdom
    Endocrinology 146:35-43. 2005
    ....
  12. ncbi request reprint In vitro and in vivo studies on CCR10 regulation by Annexin A1
    Flavia Cristina Rodrigues-Lisoni
    Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    FEBS Lett 580:1431-8. 2006
    ..Moreover the reduction in CCR10 expression induced by ANXA1 gene deletion was rescued by intravenous treatment with low doses of ANXA1. These findings provide new evidence that ANXA1 modulates gene expression...
  13. doi request reprint Annexin A1 in the brain--undiscovered roles?
    Egle Solito
    Imperial College London, Commonwealth Building, Hammersmith Hospital, DuCane Road, London, UK
    Trends Pharmacol Sci 29:135-42. 2008
    ..We suggest that ANXA1, its small peptide mimetics and its receptors might be exciting new therapeutic targets in the management of a wide range of neuroinflammatory diseases, including stroke and neurodegenerative conditions...
  14. ncbi request reprint Correlation between the antiinflammatory protein annexin 1 (lipocortin 1) and serum cortisol in subjects with normal and dysregulated adrenal function
    Abeda Mulla
    Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 90:557-62. 2005
    ..They also reveal a correlation between ANXA1 and the serum gonadotrophins, LH and FSH, and an age-related reduction in ANXA1 expression in lymphocytes...
  15. pmc Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic-pituitary-adrenal axis in rats
    Saadia Basharat
    Division of Diabetes, Endocrinology and Metabolism, Department of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, 6th Floor, Commonwealth Building, Du Cane Road, London W12 0NN, UK University College London, Institute of Neurology, Queen Square House, Queen Square, London WC1N 3BG, UK Brunel University, Wilfred Brown Building, Kingston Lane, Uxbridge UB8 3PH, UK
    J Endocrinol 221:229-34. 2014
    ....
  16. pmc Role and interactions of annexin A1 and oestrogens in the manifestation of sexual dimorphisms in cerebral and systemic inflammation
    Ellen L Hughes
    Wolfson Neuroscience Laboratories, Imperial College London, London, UK
    Br J Pharmacol 169:539-53. 2013
    ....
  17. ncbi request reprint A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils
    Egle Solito
    Department of Neuroendocrinology, Imperial College London, Hammersmith Campus, Commonwealth Building, Du Cane Rd, London W12 ONN, London, UK E mail
    FASEB J 17:1544-6. 2003
    ..In conclusion, exogenous ANXA1 displayed selective actions on human PMN. We propose that the new proapoptotic effect reported here may be part of the spectrum of ANXA1-mediated events involved in the resolution of acute inflammation...
  18. ncbi request reprint Cytokines: regulation of the hypothalamo-pituitary-adrenocortical axis
    Christopher D John
    Department of Neuroendocrinology, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Curr Opin Pharmacol 3:78-84. 2003
    ..The mechanisms by which cytokines cause glucocorticoid release are complex and can be affected by repeated or sustained cytokine exposure, gender and age, or counter-regulatory mechanisms...
  19. ncbi request reprint Annexin 1 (lipocortin 1) mimics inhibitory effects of glucocorticoids on testosterone secretion and enhances effects of interleukin-1beta
    Patricia O Cover
    Faculty of Medicine, Department of Neuroendocrinology, Imperial College of Science Technology and Medicine, Hammersmith Hospital, London, UK
    Endocrine 18:33-9. 2002
    ....
  20. ncbi request reprint Externalization of annexin I from a folliculo-stellate-like cell line
    Lee Chapman
    Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    Endocrinology 143:4330-8. 2002
    ..These data support our hypothesis that annexin I is released by FS cells in response to glucocorticoids to mediate glucocorticoid inhibitory actions on pituitary hormone release via a juxtacrine mechanism...
  21. ncbi request reprint Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis
    Yuan H Yang
    Centre for Inflammatory Diseases, Monash University, Clayton, Victoria, Australia
    Arthritis Rheum 50:976-84. 2004
    ..This study investigated the role of Anx-1 in experimental arthritis and in GC-mediated inhibition of inflammation, using antigen-induced arthritis (AIA) in Anx-1 knockout (Anx-1(-/-)) mice...
  22. ncbi request reprint Evidence for a role of the adenosine 5'-triphosphate-binding cassette transporter A1 in the externalization of annexin I from pituitary folliculo-stellate cells
    Lee P Chapman
    Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    Endocrinology 144:1062-73. 2003
    ..We conclude that ANXA1, which mediates the early delayed feedback of glucocorticoids in the anterior pituitary, is externalized from FS cells by an ABC transporter and that the ABCA1 transporter is a likely candidate...
  23. ncbi request reprint Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse
    Robert Hannon
    Department of Biochemical Pharmacology, William Harvey Research Institute, Queen Mary, University of London, Charterhouse Square, EC1M 6BQ, UK
    FASEB J 17:253-5. 2003
    ..There are also gender differences in activated leukocyte behavior in the Anx-1-/- mice that are not seen in the wild-type animals, suggesting an interaction between sex hormones and inflammation in Anx-1-/- animals...
  24. pmc Attenuation of glucocorticoid functions in an Anx-A1-/- cell line
    Jamie D Croxtall
    Department of Biochemical Pharmacology, William Harvey Research Institute, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
    Biochem J 371:927-35. 2003
    ..Taken together, these observations suggest strongly that Anx-A1 functions as an inhibitor of signal-transduction pathways that lead to cell proliferation and may help to explain how glucocorticoids regulate these processes...
  25. ncbi request reprint Chemokines as modulators of neuroendocrine functions
    William Rostene
    INSERM U732, Universitó Pet M Curie, Hopital St Antoine, Paris Cedex 12, France
    J Mol Endocrinol 38:351-3. 2007
    ....
  26. ncbi request reprint Expression and externalization of annexin 1 in the adrenal gland: structure and function of the adrenal gland in annexin 1-null mutant mice
    Evelyn Davies
    Department of Physiology, Anatomy, and Genetics, University of Oxford, South Parks Road, Oxford, United Kingdom
    Endocrinology 148:1030-8. 2007
    ..These results suggest ANXA1 is a regulator of adrenocortical size and corticosterone secretion...
  27. pmc Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages
    Simon Yona
    Department of Biochemical Pharmacology, William Harvey Research Institute, Queen Mary, University of London, Charterhouse Square, EC1 M 6BQ
    Br J Pharmacol 142:890-8. 2004
    ..In conclusion, these results suggest that participation of endogenous annexin 1 during zymosan phagocytosis is critical and that this protein plays a tonic inhibitory role during macrophage activation...
  28. ncbi request reprint Macrophage biology in the Anx-A1-/- mouse
    S Yona
    Biochemical Pharmacology Group, William Harvey Research Institute, Queen Mary Charterhouse Square, University of London, London EC1M 6BQ, UK
    Prostaglandins Leukot Essent Fatty Acids 72:95-103. 2005
    ..Anx-A1 is also apparently important in the tonic down-regulation of other macrophage functions such as COX-2 induction, PGE(2) release and the production of reactive oxygen species...