Robert Brown

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Review of processing and analysis methods for DNA methylation array data
    C S Wilhelm-Benartzi
    Epigenetics Unit, Division of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Ovarian Cancer Action Research Centre, Imperial College London, 4th Floor IRDB, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Br J Cancer 109:1394-402. 2013
  2. pmc Cytokeratin 18 in plasma of patients with gastrointestinal adenocarcinoma as a biomarker of tumour response
    L C Scott
    Centre for Oncology and Applied Pharmacology, University of Glasgow, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Br J Cancer 101:410-7. 2009
  3. pmc Aberrant DNA methylation at genes associated with a stem cell-like phenotype in cholangiocarcinoma tumors
    Ruethairat Sriraksa
    Department of Surgery and Cancer, Imperial College London, IRDB Building, Hammersmith Hospital Campus, London W12 0NN, United Kingdom Phone 44 0 2075 941804 Fax 44 0 2075 942129 and Temduang Limpaiboon, Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
    Cancer Prev Res (Phila) 6:1348-55. 2013
  4. pmc Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands
    Wei Dai
    Ovarian Cancer Action Centre and Section of Epigenetics, Department of Oncology, Imperial College, Hammersmith Hospital, London, UK
    BMC Bioinformatics 9:337. 2008
  5. ncbi request reprint Promoter CpG island methylation of genes in key cancer pathways associates with clinical outcome in high-grade serous ovarian cancer
    Wei Dai
    Authors Affiliations Epigenetics Unit, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London Section of Molecular Pathology, Institute for Cancer Research, Sutton Department of Gynaecology, Glasgow Royal Infirmary and Cancer Research UK Clinical Trials Unit, Glasgow University, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
    Clin Cancer Res 19:5788-97. 2013
  6. ncbi request reprint DNA methylation as a long-term biomarker of exposure to tobacco smoke
    Natalie S Shenker
    Department of Surgery and Cancer, Epigenetics Unit, Imperial College London, London, United Kingdom
    Epidemiology 24:712-6. 2013
  7. ncbi request reprint The DNA methylomes of serous borderline tumors reveal subgroups with malignant- or benign-like profiles
    Constanze Zeller
    Epigenetics Unit, Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, London, United Kingdom
    Am J Pathol 182:668-77. 2013
  8. ncbi request reprint Prospects for epigenetic compounds in the treatment of autoimmune disease
    Nadine Chapman-Rothe
    Department of Surgery and Cancer Hammersmith Hospital Campus, Imperial College London, London, UK
    Adv Exp Med Biol 711:150-61. 2011
  9. ncbi request reprint CpG island methylator phenotype (CIMP) in cancer: causes and implications
    Jens M Teodoridis
    Department of Oncology, Imperial College, Hammersmith Campus, London, UK
    Cancer Lett 268:177-86. 2008
  10. doi request reprint Approaches to target the genome and its epigenome in cancer
    Nadine Chapman-Rothe
    Department of Oncology, Hammersmith Hospital Campus, Imperial College London, UK
    Future Med Chem 1:1481-95. 2009

Detail Information

Publications18

  1. pmc Review of processing and analysis methods for DNA methylation array data
    C S Wilhelm-Benartzi
    Epigenetics Unit, Division of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Ovarian Cancer Action Research Centre, Imperial College London, 4th Floor IRDB, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Br J Cancer 109:1394-402. 2013
    ....
  2. pmc Cytokeratin 18 in plasma of patients with gastrointestinal adenocarcinoma as a biomarker of tumour response
    L C Scott
    Centre for Oncology and Applied Pharmacology, University of Glasgow, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Br J Cancer 101:410-7. 2009
    ..Measurement of caspase-cleaved (CK18-Asp396) or total cytokeratin 18 (CK18) from epithelial-derived tumours could be a simple, non-invasive way to monitor or predict responses to treatment...
  3. pmc Aberrant DNA methylation at genes associated with a stem cell-like phenotype in cholangiocarcinoma tumors
    Ruethairat Sriraksa
    Department of Surgery and Cancer, Imperial College London, IRDB Building, Hammersmith Hospital Campus, London W12 0NN, United Kingdom Phone 44 0 2075 941804 Fax 44 0 2075 942129 and Temduang Limpaiboon, Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
    Cancer Prev Res (Phila) 6:1348-55. 2013
    ..These data have implications for cholangiocarcinogenesis, as well as possible novel treatment options using histone methyltransferase inhibitors...
  4. pmc Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands
    Wei Dai
    Ovarian Cancer Action Centre and Section of Epigenetics, Department of Oncology, Imperial College, Hammersmith Hospital, London, UK
    BMC Bioinformatics 9:337. 2008
    ..We have therefore developed a novel algorithm tailored to this type of data, Methylation Linear Discriminant Analysis (MLDA)...
  5. ncbi request reprint Promoter CpG island methylation of genes in key cancer pathways associates with clinical outcome in high-grade serous ovarian cancer
    Wei Dai
    Authors Affiliations Epigenetics Unit, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London Section of Molecular Pathology, Institute for Cancer Research, Sutton Department of Gynaecology, Glasgow Royal Infirmary and Cancer Research UK Clinical Trials Unit, Glasgow University, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
    Clin Cancer Res 19:5788-97. 2013
    ..We aimed to identify DNA methylation biomarkers of progression-free survival (PFS) to platinum-based chemotherapy in high-grade serous ovarian cancer (HGSOC) within biologically relevant ovarian cancer-associated pathways...
  6. ncbi request reprint DNA methylation as a long-term biomarker of exposure to tobacco smoke
    Natalie S Shenker
    Department of Surgery and Cancer, Epigenetics Unit, Imperial College London, London, United Kingdom
    Epidemiology 24:712-6. 2013
    ..Most biomarkers of exposure tend to have short half-lives. This includes cotinine, a metabolite of nicotine widely used to assess smoke exposure. Cotinine is thus unsuitable as a determinant of past exposure to cigarette smoke...
  7. ncbi request reprint The DNA methylomes of serous borderline tumors reveal subgroups with malignant- or benign-like profiles
    Constanze Zeller
    Epigenetics Unit, Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, London, United Kingdom
    Am J Pathol 182:668-77. 2013
    ..A subgroup of SBOTs can be classified into tumors with a benign- or a malignant-like methylation profile that may help in identifying tumors more likely to progress into LGSCs...
  8. ncbi request reprint Prospects for epigenetic compounds in the treatment of autoimmune disease
    Nadine Chapman-Rothe
    Department of Surgery and Cancer Hammersmith Hospital Campus, Imperial College London, London, UK
    Adv Exp Med Biol 711:150-61. 2011
    ....
  9. ncbi request reprint CpG island methylator phenotype (CIMP) in cancer: causes and implications
    Jens M Teodoridis
    Department of Oncology, Imperial College, Hammersmith Campus, London, UK
    Cancer Lett 268:177-86. 2008
    ..Therefore, further clinical testing of the diagnostic and prognostic value of the current CIMP markers, as well as increasing our understanding of the molecular causes underlying CIMP are required...
  10. doi request reprint Approaches to target the genome and its epigenome in cancer
    Nadine Chapman-Rothe
    Department of Oncology, Hammersmith Hospital Campus, Imperial College London, UK
    Future Med Chem 1:1481-95. 2009
    ..Ultimately, improved specificity of epigenetic therapies will require increased mapping of the aberrant epigenetic landscape in cancer and cancer-specific target validation using chemical epigenetic approaches...
  11. doi request reprint WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis
    Adam J W Paige
    Ovarian cancer action HHMT Research Centre and Section of Molecular Therapeutics, Department of Oncology, Imperial College London Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom
    Eur J Cancer 46:818-25. 2010
    ..While these results may suggest that the associations are false positives, differences between the two populations cannot be excluded, and thus highlight the challenges in validation studies...
  12. ncbi request reprint Pharmaco(epi)genomics in ovarian cancer
    Adam J W Paige
    Department of Oncology, Imperial College, Hammersmith Hospital Campus, London W12 8EE, UK
    Pharmacogenomics 9:1825-34. 2008
    ..Integrated approaches that identify stable pharmacogenomic and epigenomic patterns and their relationship with expression patterns and gene function will be increasingly necessary...
  13. pmc Ovarian cancer stem cell-like side populations are enriched following chemotherapy and overexpress EZH2
    Sian Rizzo
    Section of Medicine, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Mol Cancer Ther 10:325-35. 2011
    ..As such, EZH2 is an important target for anticancer drug development...
  14. pmc Systematic CpG islands methylation profiling of genes in the wnt pathway in epithelial ovarian cancer identifies biomarkers of progression-free survival
    Wei Dai
    Epigenetics Unit Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London, United Kingdom
    Clin Cancer Res 17:4052-62. 2011
    ..We aimed to evaluate DNA methylation at promoter CpG islands (CGI) of Wnt pathway genes in ovarian tumors at presentation and identify biomarkers of patient progression-free survival (PFS)...
  15. ncbi request reprint Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking
    Natalie S Shenker
    Epigenetics Unit, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK
    Hum Mol Genet 22:843-51. 2013
    ..These data show that smoking has a direct effect on the epigenome in lung tissue, which is also detectable in peripheral blood DNA and may contribute to cancer risk...
  16. pmc Common variants at 19p13 are associated with susceptibility to ovarian cancer
    Kelly L Bolton
    Department of Oncology, University of Cambridge, Cambridge, UK
    Nat Genet 42:880-4. 2010
    ..Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development...
  17. doi request reprint The promises and pitfalls of epigenetic therapies in solid tumours
    Janet S Graham
    Department of Oncology and Ovarian Cancer Action Centre, Imperial College, Hammersmith Campus, Du Cane Road, W120NN London, UK
    Eur J Cancer 45:1129-36. 2009
    ..Such trials already suggest that improved tumour delivery and specificity, with decreased normal tissue toxicity, will be required to take full advantage of this class of agents in solid tumours...
  18. pmc HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer
    Euan A Stronach
    Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, Edinburgh, United Kingdom
    Cancer Res 71:4412-22. 2011
    ..Together, our findings identify HDAC4 as a novel, therapeutically tractable target to counter platinum resistance in ovarian cancer...