Mark Bower

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Does HIV adversely influence the outcome in advanced non-small-cell lung cancer in the era of HAART?
    T Powles
    Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Br J Cancer 89:457-9. 2003
  2. pmc HIV-associated anal cancer
    Thomas Newsom-Davis
    Department of Oncology, Chelsea and Westminster Hospital NHS Foundation Trust 369 Fulham Road, London SW10 9NH UK
    F1000 Med Rep 2:85. 2010
  3. pmc HIV-associated bladder cancer: a case series evaluating difficulties in diagnosis and management
    Elizabeth M Gaughan
    Department of Medicine Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    BMC Urol 9:10. 2009
  4. doi request reprint How I treat HIV-associated multicentric Castleman disease
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    Blood 116:4415-21. 2010
  5. doi request reprint The effect of HAART in 254 consecutive patients with AIDS-related Kaposi's sarcoma
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    AIDS 23:1701-6. 2009
  6. doi request reprint Clinical Features and Outcome in HIV-Associated Multicentric Castleman's Disease
    Mark Bower
    Department of Oncology, Imperial College School of Medicine, The Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, UK
    J Clin Oncol 29:2481-6. 2011
  7. ncbi request reprint A prognostic index for systemic AIDS-related non-Hodgkin lymphoma treated in the era of highly active antiretroviral therapy
    Mark Bower
    The Chelsea and Westminster Hospital, London, United Kingdom
    Ann Intern Med 143:265-73. 2005
  8. doi request reprint Immunologic recovery in survivors following chemotherapy for AIDS-related non-Hodgkin lymphoma
    Mark Bower
    Department of Oncology, Imperial College School of Medicine, London, UK
    Blood 111:3986-90. 2008
  9. ncbi request reprint Protease inhibitors potentiate chemotherapy-induced neutropenia
    Mark Bower
    Department of Oncology, The Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    Blood 104:2943-6. 2004
  10. doi request reprint Cytokine changes during rituximab therapy in HIV-associated multicentric Castleman disease
    Mark Bower
    Department of Oncology, HIV Medicine and Immunology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    Blood 113:4521-4. 2009

Collaborators

Detail Information

Publications95

  1. pmc Does HIV adversely influence the outcome in advanced non-small-cell lung cancer in the era of HAART?
    T Powles
    Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Br J Cancer 89:457-9. 2003
    ..This suggests that the survival of patients with HIV-related NSCLC may have improved since the introduction of HAART, and this may be due to a decrease in HIV-related deaths...
  2. pmc HIV-associated anal cancer
    Thomas Newsom-Davis
    Department of Oncology, Chelsea and Westminster Hospital NHS Foundation Trust 369 Fulham Road, London SW10 9NH UK
    F1000 Med Rep 2:85. 2010
    ..The development of cost-effective national screening programs for HIV-associated anal cancer remains a challenge...
  3. pmc HIV-associated bladder cancer: a case series evaluating difficulties in diagnosis and management
    Elizabeth M Gaughan
    Department of Medicine Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    BMC Urol 9:10. 2009
    ..To date, only a limited number of cases of bladder cancer have been linked with HIV infection. We sought to describe the clinical characteristics of HIV-associated bladder cancer...
  4. doi request reprint How I treat HIV-associated multicentric Castleman disease
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    Blood 116:4415-21. 2010
    ..The success of antiherpesvirus agents in controlling active disease is limited, but valganciclovir may have a role as maintenance therapy in the future...
  5. doi request reprint The effect of HAART in 254 consecutive patients with AIDS-related Kaposi's sarcoma
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    AIDS 23:1701-6. 2009
    ..A prospective cohort study was performed to evaluate the clinical outcomes of patients with histologically confirmed AIDS-related Kaposi's sarcoma diagnosed since the introduction of HAART...
  6. doi request reprint Clinical Features and Outcome in HIV-Associated Multicentric Castleman's Disease
    Mark Bower
    Department of Oncology, Imperial College School of Medicine, The Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, UK
    J Clin Oncol 29:2481-6. 2011
    ..To describe clinical features, treatment outcomes and relapse rates in HIV-associated multicentric Castleman's disease (MCD) in a sizeable mature cohort...
  7. ncbi request reprint A prognostic index for systemic AIDS-related non-Hodgkin lymphoma treated in the era of highly active antiretroviral therapy
    Mark Bower
    The Chelsea and Westminster Hospital, London, United Kingdom
    Ann Intern Med 143:265-73. 2005
    ..The established International Prognostic Index for lymphomas has not included patients with systemic AIDS-related non-Hodgkin lymphoma...
  8. doi request reprint Immunologic recovery in survivors following chemotherapy for AIDS-related non-Hodgkin lymphoma
    Mark Bower
    Department of Oncology, Imperial College School of Medicine, London, UK
    Blood 111:3986-90. 2008
    ..Chemotherapy and concomitant HAART for AIDS-related NHL does not cause prolonged suppression of lymphocyte subsets. These data should provide reassurance regarding the long-term consequences of chemotherapy in these individuals...
  9. ncbi request reprint Protease inhibitors potentiate chemotherapy-induced neutropenia
    Mark Bower
    Department of Oncology, The Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    Blood 104:2943-6. 2004
    ..PI-based HAART appears to significantly potentiate the myelotoxicity of CDE chemotherapy. This potentiation may be a consequence of microsomal enzyme inhibition reducing the metabolism of cytotoxics in this regimen...
  10. doi request reprint Cytokine changes during rituximab therapy in HIV-associated multicentric Castleman disease
    Mark Bower
    Department of Oncology, HIV Medicine and Immunology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    Blood 113:4521-4. 2009
    ..Therapies that reduce the inflammatory cytokine response are likely to be successful in a range of diseases, including HIV-MCD, and in the future may be used to guide therapeutic strategies...
  11. ncbi request reprint Prognostic significance of immune subset measurement in individuals with AIDS-associated Kaposi's sarcoma
    Justin Stebbing
    Imperial College of Science, Medicine, and Technology, Department of Oncology, The Chelsea and Westminster Hospital, London, United Kingdom
    J Clin Oncol 25:2230-5. 2007
    ..Because immune subset measurement is often performed in HIV-positive individuals, we examined whether these were predictive of mortality independently of the prognostic index, or could predict time to progression of KS...
  12. ncbi request reprint Adherence to trizivir and tenofovir as a simplified salvage regimen is associated with suppression of viraemia and a decreased cholesterol
    Victoria Latham
    The St Stephen s Centre, The Chelsea and Westminster Hospital, London, UK
    J Antimicrob Chemother 56:186-9. 2005
    ..Trizivir (zidovudine/lamivudine/abacavir) and tenofovir disoproxil fumarate may improve adherence and enhance virological suppression in individuals who have failed previous regimens...
  13. ncbi request reprint A randomized study comparing a three- and four-drug HAART regimen in first-line therapy (QUAD study)
    Chloe Orkin
    The St Stephen s Centre, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH
    J Antimicrob Chemother 55:246-51. 2005
    ..Research is required on the effectiveness of quadruple therapy in comparison to this and the relative effectiveness of specific highly active antiretroviral therapy (HAART) combinations...
  14. ncbi request reprint Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients
    Justin Stebbing
    The Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Cell Res 14:251-6. 2004
    ..These findings are compatible with results of prior clinical studies that found no evidence that HCV co-infection altered HIV disease progression and has implications for immunotherapeutic approaches in co-infected individuals...
  15. ncbi request reprint The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Int J Cancer 108:631-3. 2004
    ..This is consistent with data suggesting that regression of KS is mediated by an overall improvement in immune function and not by the effects of specific antiretrovirals...
  16. doi request reprint HIV status does not influence outcome in patients with classical Hodgkin lymphoma treated with chemotherapy using doxorubicin, bleomycin, vinblastine, and dacarbazine in the highly active antiretroviral therapy era
    Silvia Montoto
    Centre for Haemato Oncology, Barts Cancer Institute, Queen Mary University of London, Chelsea and Westminster Hospital, 45 Little Britain, EC1A 7BE, London, United Kingdom
    J Clin Oncol 30:4111-6. 2012
    ..We analyzed the outcome of patients with Hodgkin lymphoma (HL) treated with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) in the HAART era according to HIV serostatus to establish whether this also holds true for HL...
  17. ncbi request reprint A comparison of regimens based on non-nucleoside reverse transcriptase inhibitors or protease inhibitors in preventing Kaposi's sarcoma
    Simon Portsmouth
    Department of Immunology, Chelsea and Westminster Hospital, London, UK
    AIDS 17:F17-22. 2003
    ....
  18. ncbi request reprint Hepatitis C virus infection in HIV type 1-infected individuals does not accelerate a decrease in the CD4+ cell count but does increase the likelihood of AIDS-defining events
    Justin Stebbing
    Department of HIV Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    Clin Infect Dis 41:906-11. 2005
    ..In conclusion, there was an increased number of adverse events in coinfected individuals, compared with individuals infected with HIV-1 alone...
  19. doi request reprint The risks and incidence of K65R and L74V mutations and subsequent virologic responses
    Laura Waters
    Department of HIV Medicine, Chelsea and Westminster Hospital and Imperial College School of Medicine, London, United Kingdom
    Clin Infect Dis 46:96-100. 2008
    ..If suboptimal HAART was used, patients with K65R experienced significantly higher rates of virologic suppression than did those with L74V (P = .01)...
  20. ncbi request reprint Antiretroviral treatment regimens and immune parameters in the prevention of systemic AIDS-related non-Hodgkin's lymphoma
    Justin Stebbing
    Department of Oncology, The Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    J Clin Oncol 22:2177-83. 2004
    ..As there are no data demonstrating that specific antiretroviral regimens are effective at protecting from NHL, we compared different HAART regimens...
  21. ncbi request reprint A prognostic index for AIDS-associated Kaposi's sarcoma in the era of highly active antiretroviral therapy
    Justin Stebbing
    Department of Oncology, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Lancet 367:1495-502. 2006
    ..We developed a simple model for predicting mortality on the basis of clinical characteristics present at the time of diagnosis of Kaposi's sarcoma...
  22. ncbi request reprint HIV-associated anal cancer: has highly active antiretroviral therapy reduced the incidence or improved the outcome?
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, United Kingdom
    J Acquir Immune Defic Syndr 37:1563-5. 2004
    ..We wished to evaluate its effects on incidence and survival in HIV-associated anal cancer...
  23. doi request reprint Use of antidepressants and risk of cancer in individuals infected with HIV
    Justin Stebbing
    Imperial College, Imperial Healthcare NHS Trust, Charing Cross Hospital, Department of Medical Oncology, London, UK
    J Clin Oncol 26:2305-10. 2008
    ..We aimed to assess whether different classes of antidepressants were associated with changes in cancer incidence in a population of HIV-1 infected individuals, based on duration of exposure...
  24. ncbi request reprint Resolution of AIDS-related Castleman's disease with anti-CD20 monoclonal antibodies is associated with declining IL-6 and TNF-alpha levels
    Tom Newsom-Davis
    Departments of Oncology and HIV Medicine, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Leuk Lymphoma 45:1939-41. 2004
    ..This highlights the close association between circulating cytokines such as IL-6 and virally-induced malignancy...
  25. ncbi request reprint Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor
    Justin Stebbing
    Department of Immunology, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    Blood 102:1806-14. 2003
    ..These results have important implications for the etiopathogenesis of KS and for the development and design of any compounds, including vaccines, derived from cellular lysates...
  26. doi request reprint A retrospective, multi-center analysis of treatment intensification for human immunodeficiency virus-positive patients with high-risk diffuse large B-cell lymphoma
    Shireen Kassam
    Royal Free Hospital, London, UK
    Leuk Lymphoma 54:1921-7. 2013
    ..In our cohort, the outcome for HIV-positive patients with high-risk DLBCL is favorable. Treatment intensification is feasible, but demonstrated no advantage over R-CHOP...
  27. ncbi request reprint Effects of combination chemotherapy and highly active antiretroviral therapy on immune parameters in HIV-1 associated lymphoma
    Tom Powles
    Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    AIDS 16:531-6. 2002
    ....
  28. doi request reprint Plasma HHV8 DNA predicts relapse in individuals with HIV-associated multicentric Castleman disease
    Justin Stebbing
    Department of HIV Medicine, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom
    Blood 118:271-5. 2011
    ..Rising levels predicted an attack (hazard ratio = 2.9; 95% confidence interval, 1.3-6.7), and maintenance therapy with rituximab should be considered in these individuals...
  29. ncbi request reprint Highly active antiretroviral therapy and human immunodeficiency virus-associated primary cerebral lymphoma
    Mark Bower
    Department of Oncology and HIV Medicine, The Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    J Natl Cancer Inst 98:1088-91. 2006
    ..013), and patients were more likely to have the diagnosis of PCL confirmed histologically or by polymerase chain reaction (77% versus 26%; P<.001). Exposure to specific antiretroviral agents was not associated with risk for PCL...
  30. ncbi request reprint Hepatitis C infection is not associated with systemic HIV-associated non-Hodgkin's lymphoma: a cohort study
    Laura Waters
    Department of HIV Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Int J Cancer 116:161-3. 2005
    ..1 of 10(4) patient years during HIV alone (p = 0.9). In this immunocompromised patient population, there was no association between HCV infection and an increased risk of lymphoma...
  31. doi request reprint Follicular dendritic cells in multicentric Castleman disease present human herpes virus type 8 (HHV8)-latent nuclear antigen 1 (LANA1) in a proportion of cases and is associated with an enhanced T-cell response
    Hesham El-Daly
    Department of Histopathology, Hammersmith Hospital and Imperial College, London, UK
    Eur J Haematol 84:133-6. 2010
    ..Our findings show, for the first time, possible 'presentation' of an HHV8 antigen by FDCs in MCD...
  32. ncbi request reprint Nadir B cell counts are significantly correlated with the risk of Kaposi's sarcoma
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Int J Cancer 108:473-4. 2004
    ..015). These data highlight a potential role for B cells and therefore the humoral immune system in KS aetiopathogenesis...
  33. ncbi request reprint A randomized trial to investigate the recycling of stavudine and didanosine with and without hydroxyurea in salvage therapy (RESTART)
    Justin Stebbing
    The St Stephen s Centre, The Chelsea and Westminster Hospital, London, UK
    J Antimicrob Chemother 53:501-5. 2004
    ....
  34. ncbi request reprint Transmission of hepatitis C virus among HIV-positive homosexual men and response to a 24-week course of pegylated interferon and ribavirin
    Yvonne C Gilleece
    St Stephen s Centre, Chelsea and Westminster Hospital, London, UK
    J Acquir Immune Defic Syndr 40:41-6. 2005
    ..To evaluate treatment outcome of acute hepatitis C virus (HCV) in HIV-positive individuals...
  35. doi request reprint The nucleoside backbone affects durability of efavirenz- or nevirapine-based highly active antiretroviral therapy in antiretroviral-naive individuals
    Naa Torshie Annan
    Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom
    J Acquir Immune Defic Syndr 51:140-6. 2009
    ....
  36. ncbi request reprint Virological failure and subsequent resistance profiles in individuals exposed to atazanavir
    Justin Stebbing
    Department of HIV Medicine, The Chelsea and Westminster Hospital, Imperial College School of Science, Technology and Medicine, London, UK
    AIDS 21:1826-8. 2007
    ..This is particularly important because of the increasing use of atazanavir monotherapy, and implies that treatment failure is caused by lack of potency...
  37. doi request reprint FDG-PET/CT imaging in the management of HIV-associated multicentric Castleman's disease
    Rob Barker
    Department of Radiology, Imperial College School of Medicine, The Chelsea and Westminster Hospital, London, UK
    Eur J Nucl Med Mol Imaging 36:648-52. 2009
    ..To evaluate the role of FDG-PET/CT scanning in the management of HIV-associated multicentric Castleman's disease (MCD) a rare lymphoproliferative disorder associated with infection by human herpesvirus 8 (HHV8)...
  38. doi request reprint Ritonavir-boosted atazanavir exposure is associated with an increased rate of renal stones compared with efavirenz, ritonavir-boosted lopinavir and ritonavir-boosted darunavir
    Neesha Rockwood
    Department of HIV Medicine, Chelsea and Westminster Hospital, London, UK
    AIDS 25:1671-3. 2011
    ..When choosing a boosted protease inhibitor, ATZ/r renal stones should be considered as a potential comorbidity...
  39. pmc CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK
    Mark Bower
    Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    Haematologica 94:875-80. 2009
    ..Earlier highly active anti-retroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma...
  40. ncbi request reprint Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcoma
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London SW10 9NH, UK
    AIDS 17:1998-2000. 2003
    ..KS-associated herpesvirus replication was not demonstrated in vivo or in vitro within NK cells, suggesting that NK cells do not contribute to the resolution of KS. Their role appears limited to events occurring during early infection...
  41. ncbi request reprint Antibody-targeted MHC complex-directed expansion of HIV-1- and KSHV-specific CD8+ lymphocytes: a new approach to therapeutic vaccination
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Blood 103:1791-5. 2004
    ..This approach, which offers an easy and effective protocol for the amplification of specific antiviral and antitumor CTLs, may offer significant advances for in vivo T-cell immunotherapeutic protocols...
  42. ncbi request reprint The heat-shock protein receptor CD91 is up-regulated in monocytes of HIV-1-infected "true" long-term nonprogressors
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Blood 101:4000-4. 2003
    ..The ability of CD91 to internalize alpha-defensins and to cross-present exogenous antigen to cytotoxic T lymphocytes through major histocompatibility complex (MHC) class 1 may maintain CD8(+) responses in these patients...
  43. ncbi request reprint Brief communication: rituximab in HIV-associated multicentric Castleman disease
    Mark Bower
    Department of Oncology, Imperial College, The Chelsea and Westminster Hospital, Barts and The London NHS Trust, and Queen Mary s University, London, United Kingdom
    Ann Intern Med 147:836-9. 2007
    ..Many therapeutic approaches in small series of patients have proved largely unsuccessful to date...
  44. pmc The CD8 and CD4 T-cell response against Kaposi's sarcoma-associated herpesvirus is skewed towards early and late lytic antigens
    Rebecca C Robey
    Department of Immunology, Imperial College London, London, United Kingdom
    PLoS ONE 4:e5890. 2009
    ..This knowledge will be important to future immunological investigations into KSHV and may eventually lead to the development of better immunotherapies for KSHV-related diseases...
  45. ncbi request reprint Host pharmacogenetics in the treatment of HIV and cancer
    Alan Winston
    The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Curr Drug Saf 1:107-16. 2006
    ....
  46. ncbi request reprint HIV-related lung cancer in the era of highly active antiretroviral therapy
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    AIDS 17:371-5. 2003
    ..To address the impact of highly active antiretroviral therapy (HAART) on the incidence and outcome of patients with HIV-related lung cancer...
  47. doi request reprint Immunotherapy for HIV-associated non-Hodgkin's lymphoma
    Thomas Newsom-Davis
    Chelsea and Westminster Hospital, Oncology Department, 369 Fulham Road, London SW10 9NH, UK
    Expert Opin Biol Ther 9:1313-24. 2009
    ..As the prognosis for HIV-associated NHL nears that of the general population, these approaches are of increasing importance and value...
  48. doi request reprint Interim fluoro-2-deoxy-D-glucose-PET predicts response and progression-free survival in patients with Hodgkin lymphoma and HIV infection
    Jessica Okosun
    Department of Haematology, Royal Free Hampstead NHS Trust, London, UK
    AIDS 26:861-5. 2012
    ..Interim PET scans in HIV-negative patients with Hodgkin lymphoma has emerged as one of the most important prognostic tools. However, equivalent studies in HIV-positive patients are yet to be performed...
  49. doi request reprint A long-term durable remission with high-dose therapy and autologous stem cell transplant for stage IVB HIV-associated Hodgkins disease
    Ian Gabriel
    Department of Clinical Haematology, Hammersmith Hospital, London, UK
    AIDS 22:539-40. 2008
    ..The transplant was uncomplicated and the patient remains in complete remission at 59 months. Autologous stem cell transplantation is safe in HIV patients and can achieve long-term durable remissions in Hodgkin's disease...
  50. ncbi request reprint The evidence-based treatment of AIDS-related non-Hodgkin's lymphoma
    Justin Stebbing
    Medical Day Unit, Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Cancer Treat Rev 30:249-53. 2004
    ..In this review, we discuss the evidence for choosing particular therapies in patients with AIDS-related NHL...
  51. ncbi request reprint Should cervical cancer be an acquired immunodeficiency syndrome-defining cancer?
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, United Kingdom
    J Clin Oncol 24:2417-9. 2006
  52. doi request reprint Presence of monoclonal T-cell populations in B-cell post-transplant lymphoproliferative disorders
    Hazem A H Ibrahim
    Department of Histopathology, Hammersmith Hospital, Imperial College, London, UK
    Mod Pathol 24:232-40. 2011
    ....
  53. ncbi request reprint Cardiotoxicity after liposomal anthracyclines
    Anne Marie Young
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    Lancet Oncol 5:654. 2004
  54. ncbi request reprint AIDS-associated malignancies
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    Cancer Chemother Biol Response Modif 22:687-706. 2005
  55. ncbi request reprint Renal dysfunction with tenofovir disoproxil fumarate-containing highly active antiretroviral therapy regimens is not observed more frequently: a cohort and case-control study
    Rachael Jones
    Department of HIV and Genitourinary Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    J Acquir Immune Defic Syndr 37:1489-95. 2004
    ..We investigated the overall incidence and risk of renal dysfunction in individuals receiving tenofovir DF and compared this with other antiretrovirals...
  56. ncbi request reprint The immunological effects of concomitant highly active antiretroviral therapy and liposomal anthracycline treatment of HIV-1-associated Kaposi's sarcoma
    Ben Esdaile
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    AIDS 16:2344-7. 2002
    ..We showed in 50 patients that liposomal anthracyclines used with HAART did not lead to a significant loss of CD4 or CD8 cells or an increase in HIV-1 viral load during or up to 12 months after chemotherapy...
  57. pmc Killing of Kaposi's sarcoma-associated herpesvirus-infected fibroblasts during latent infection by activated natural killer cells
    Nick C Matthews
    Department of Immunology, Chelsea and Westminster Hospital, Imperial College London, London, UK
    Eur J Immunol 41:1958-68. 2011
    ..These data demonstrate that physiologically relevant levels of latent KSHV infection in primary cells cause limited activation of resting NK cells and confer little specific resistance to control by activated NK cells...
  58. ncbi request reprint Acquired immunodeficiency syndrome-related lymphoma in the era of highly active antiretroviral therapy
    Christina Thirlwell
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    Clin Lymphoma 4:86-92. 2003
    ..This has led to a more aggressive approach to the management of AIDS-related NHL and response rates and overall survival durations that are approaching those seen in stage-matched high-grade lymphomas in the immunocompetent population...
  59. doi request reprint Lymph nodes involved by multicentric Castleman disease among HIV-positive individuals are often involved by Kaposi sarcoma
    Kikkeri N Naresh
    Department of Histopathology, Hammersmith Hospital and Imperial College, London, UK
    Am J Surg Pathol 32:1006-12. 2008
    ....
  60. ncbi request reprint Paclitaxel for AIDS-associated Kaposi's sarcoma
    Tony Dhillon
    Department of Oncology, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Expert Rev Anticancer Ther 5:215-9. 2005
    ..For patients with refractory or recurrent AIDS-KS, treatment algorithms are less well defined. The use of paclitaxel in these circumstances is reviewed...
  61. ncbi request reprint HIV-associated Kaposi sarcoma and gender
    Jayson Wang
    Department of Oncology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    Gend Med 4:266-73. 2007
    ..As antiretrovirals are distributed with greater equity across the globe, individuals with HIV and AIDS are living longer and developing malignancies, as opposed to other opportunistic infections...
  62. pmc Hepatocellular carcinoma, human immunodeficiency virus and viral hepatitis in the HAART era
    Douglas C Macdonald
    Chelsea and Westminster Hospital, London, United Kingdom
    World J Gastroenterol 14:1657-63. 2008
    ..Once HCC develops, there is growing evidence that HIV co-infection should not preclude conventional therapeutic strategies, including liver transplantation...
  63. ncbi request reprint Comparative pharmacogenomics of antiretroviral and cytotoxic treatments
    Justin Stebbing
    Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Lancet Oncol 7:61-8. 2006
    ..Common and classic features of pharmacogenomics that are related to both antiretroviral treatment and to cytotoxic treatment are discussed in this review, providing a framework for individual treatment of these diseases...
  64. ncbi request reprint Kaposi's sarcoma as a model for cancer immunotherapy
    Justin Stebbing
    The Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London, UK SW10 9NH
    Trends Mol Med 10:187-93. 2004
    ..This also enables the sustained induction and expansion of specific anti-tumour T cells with cytolytic activity...
  65. ncbi request reprint Significance of variation within HIV, EBV, and KSHV subtypes
    Justin Stebbing
    Department of HIV Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London, United Kingdom
    J Int Assoc Physicians AIDS Care (Chic) 5:93-102. 2006
    ..An understanding of diversity will help delineate whether population-specific vaccine strategies are necessary...
  66. ncbi request reprint Leptomeningeal disease in AIDS-related non-Hodgkin's lymphoma
    Debashish Sarker
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    AIDS 17:861-5. 2003
    ..In addition to evaluate intrathecal chemoprophylaxis for patients with good immunological parameters and high risk of meningeal relapse (bone marrow, paraspinal or paranasal involvement or Burkitt's lymphoma histology)...
  67. ncbi request reprint Virological suppression at 6 months is related to choice of initial regimen in antiretroviral-naive patients: a cohort study
    Gail V Matthews
    Department of HIV Medicine, Chelsea Hospital, London, UK
    AIDS 16:53-61. 2002
    ....
  68. doi request reprint Epstein-Barr virus (EBV) genotypes among human immunodeficiency virus (HIV)-related B-cell lymphomas and B-cell post-transplant lymphoproliferative disorders (B-PTLD)--late-onset lymphomas, especially in the HIV setting, are associated with type-B-EBV
    Hazem A H Ibrahim
    Departments of Histopathology, Hammersmith Hospital and Imperial College, London, London, UK
    Eur J Haematol 85:227-30. 2010
    ..037) although there were no correlations with ethnicity, CD4 cell counts or plasma HIV viral load...
  69. doi request reprint Cancer vaccines: clinical development challenges and proposed regulatory approaches for patient access to promising treatments
    Justin Stebbing
    Imperial College School of Science, Medicine, and Technology, The Hammersmith Hospitals National Health Service Trust, London, UK
    Cancer 112:955-61. 2008
    ..All of these solutions aim to balance a complex equation of biologic rationale, weight of the evidence for efficacy and safety, regulatory expectations, and cost and timeline of clinical development...
  70. ncbi request reprint The rationale and development of new drugs to treat HIV infection
    Justin Stebbing
    St Bartholomew s Hospital, The Bodley Scott Unit, W Smithfield, London EC1A, London, UK
    Med Chem 1:635-42. 2005
    ..The replacement of older therapies with newer drugs that avoid cross resistance even within the same class of antiretroviral, represents a new hope in retroviral targeting...
  71. ncbi request reprint Chemotherapy for advanced cholangiocarcinoma: what is standard treatment?
    Danish Mazhar
    Chelsea and Westminster Hospital, Department of Oncology, 369 Fulham Road, London SW10 9NH, UK
    Future Oncol 2:509-14. 2006
    ..This review examines this data and assesses whether a new standard of care for advanced cholangiocarcinoma can be found...
  72. doi request reprint Primary esophageal carcinoma in the era of highly active antiretroviral therapy
    Justin Stebbing
    Department of Medical Oncology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, First Floor, East Wing, Fulham Palace Road, London W6 8RF, England
    Arch Intern Med 170:203-7. 2010
    ..Primary esophageal tumors in people living with HIV have seldom been reported. We sought to document patient, virologic, and tumor characteristics and clinical outcomes in this patient group...
  73. doi request reprint No evidence for a polyomavirus association or aetiology in AIDS-associated nonsmall cell lung cancer
    Justin Stebbing
    Department of Oncology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    AIDS 24:1221-3. 2010
    ..Although viruses target conserved pathways in cellular evolution, we are unable to suggest that the viruses studied here induce novel mechanisms of oncogenic dysregulation in AIDS-associated lung cancer...
  74. doi request reprint A meta-analysis of transient elastography for the detection of hepatic fibrosis
    Justin Stebbing
    Department of HIV Medicine, Chelsea and Westminster Hospital, St Stephen s Centre, Imperial College School of Medicine, London, UK
    J Clin Gastroenterol 44:214-9. 2010
    ..We performed a meta-analysis to further assess its use in comparison with liver biopsy...
  75. ncbi request reprint AIDS-related malignancies: changing epidemiology and the impact of highly active antiretroviral therapy
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    Curr Opin Infect Dis 19:14-9. 2006
    ..This review discusses the impact of highly active antiretroviral therapy on the epidemiology and outcome of AIDS-defining cancers...
  76. doi request reprint HIV-associated multicentric Castleman's disease
    Justin Stebbing
    Department of Medical Oncology, Imperial College School of Science, Technology and Medicine, The Hammersmith Hospitals NHS Trust, London, United Kingdom
    Am J Hematol 83:498-503. 2008
    ..MCD represents a model of disease at the interplay between tumor biology, infection, and immunology...
  77. ncbi request reprint Lessons for HIV from Tuskegee
    Justin Stebbing
    Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    J HIV Ther 9:50-2. 2004
    ..It continues to cast its shadow on the relationship between black Americans and the broader biomedical community. Parallels and the relationship with the HIV pandemic are discussed...
  78. ncbi request reprint What can oncologists learn from HIV?
    Justin Stebbing
    Chelsea and Westminster Hospital, London, UK
    Lancet Oncol 4:438-45. 2003
    ..In this review, we discuss what oncologists can learn from the HIV epidemic...
  79. ncbi request reprint Emtricitabine intolerance in treatment-experienced patients switched from lamivudine: a method of assessing toxicity
    Katrina Pollock
    J Antimicrob Chemother 58:227-8. 2006
  80. ncbi request reprint Potential antiretroviral drug interactions with cyclophosphamide, Doxorubicin, and Etoposide
    Mark Bower
    J Clin Oncol 23:1328-9; author reply 1329-30. 2005
  81. ncbi request reprint Fifty years of multicentric Castleman's disease
    Ashita Waterston
    Department of Oncology The Chelsea and Westminster Hospital London UK
    Acta Oncol 43:698-704. 2004
    ..The introduction of HAART has altered the natural history of HIV infection; however, its impact on MCD is difficult to ascertain. Optimization and consensus in treatment of these patients remains a target for the future...
  82. ncbi request reprint Lack of response of anal intra-epithelial neoplasia to highly active antiretroviral therapy
    Paul Fox
    AIDS 17:279-80. 2003
  83. ncbi request reprint The effect of statins on HIV rebound and blips
    Laura Waters
    J Acquir Immune Defic Syndr 39:637-8. 2005
  84. ncbi request reprint The management of meningeal lymphoma in patients with HIV in the era of HAART: intrathecal depot cytarabine is effective and safe
    Danish Mazhar
    Blood 107:3412-4. 2006
  85. ncbi request reprint A tale of three Hs: HPV, HIV & HAART
    Justin Stebbing
    Future Oncol 2:1-9. 2006
  86. ncbi request reprint The effects of HAART on AIDS-related Kaposi's sarcoma and non-Hodgkin's lymphoma
    Gail Clayton
    J HIV Ther 11:51-3. 2006
  87. ncbi request reprint Hepatitis B reactivation during combination chemotherapy for AIDS-related lymphoma is uncommon and does not adversely affect outcome
    Justin Stebbing
    Blood 103:2431-2. 2004
  88. ncbi request reprint Non-AIDS-defining cancers in people with HIV infection: a sleeping giant?
    Thomas Powles
    Department of Medical Oncology, St Bartholomew s Hospital, West Smithfield, London
    J HIV Ther 11:57-60. 2006
  89. ncbi request reprint Risk of cancers during interrupted antiretroviral therapy in the SMART study
    Michael J Silverberg
    Division of Research, Kaiser Permanente Northern California, Oakland, California 94110, USA
    AIDS 21:1957-63. 2007
    ..To compare rates of AIDS-defining and non-AIDS-defining malignancies between patients on a CD4 T-cell-guided antiretroviral therapy (ART) strategy and continuous ART...
  90. ncbi request reprint Rituximab as retreatment for rituximab pretreated HIV-associated multicentric Castleman disease
    Tom Powles
    Blood 110:4132-3. 2007
  91. doi request reprint Activity and safety of pegylated liposomal doxorubicin as first-line therapy in the treatment of non-visceral classic Kaposi's sarcoma: a multicenter study
    Giuseppe Di Lorenzo
    J Invest Dermatol 128:1578-80. 2008
  92. doi request reprint AIDS-associated Kaposi's sarcoma associated with a low viral load and a high CD4 cell count
    Justin Stebbing
    AIDS 22:551-2. 2008
  93. doi request reprint Triple-class antiretroviral agent resistance in a large cohort: prevalence and clinical outcomes
    Rachael Jones
    Arch Intern Med 168:1926-7. 2008
  94. ncbi request reprint HIV and the risk of lung cancer
    Thomas Powles
    J Clin Oncol 22:1348-9; author reply 1349-50. 2004
  95. ncbi request reprint Burkitt's lymphoma and previous AIDS-defining illnesses are not prognostic factors in AIDS-related non-Hodgkin's lymphoma
    Justin Stebbing
    J Clin Oncol 23:8538-40; author reply 8540-1. 2005