A Boasso

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes
    Barbara Tavano
    Division of Infectious Diseases, Immunology Section, Chelsea and Westminster Hospital, Department of Medicine, Faculty of Medicine, Imperial College, London SW10 9NH, United Kingdom
    J Immunol 190:2622-30. 2013
  2. pmc Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis
    Adriano Boasso
    Immunology Section, Chelsea and Westminster Hospital, Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Imperial College, London, United Kingdom
    Blood 118:5152-62. 2011
  3. pmc HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2961. 2008
  4. pmc PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Clin Immunol 129:132-44. 2008
  5. doi Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques
    Adriano Boasso
    Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:4313-20. 2009
  6. ncbi Wounding the immune system with its own blade: HIV-induced tryptophan catabolism and pathogenesis
    A Boasso
    Imperial College, Faculty of Medicine, Department of Medicine, Division of Infectious Diseases, Immunology Section, Chelsea and Westminster Hospital, London, UK
    Curr Med Chem 18:2247-56. 2011
  7. ncbi Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells
    Adriano Boasso
    Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 105:1574-81. 2005
  8. pmc CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques
    Anna Hryniewicz
    NCI, Bldg 41 Rm D 804, Bethesda, MD 20892 5065, USA
    Blood 108:3834-42. 2006
  9. pmc Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
    Valentina Cecchinato
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    J Immunol 180:5439-47. 2008
  10. ncbi Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques
    Anna Hryniewicz
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Building 41, Bethesda, MD 20892, USA
    J Immunol 178:3492-504. 2007

Collaborators

Detail Information

Publications31

  1. pmc Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes
    Barbara Tavano
    Division of Infectious Diseases, Immunology Section, Chelsea and Westminster Hospital, Department of Medicine, Faculty of Medicine, Imperial College, London SW10 9NH, United Kingdom
    J Immunol 190:2622-30. 2013
    ..Our data indicate that BST2-mediated ILT7 cross-linking may act as a homeostatic regulatory mechanism on immature circulating pDC, rather than a negative feedback for activated mature pDCs that have downregulated ILT7...
  2. pmc Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis
    Adriano Boasso
    Immunology Section, Chelsea and Westminster Hospital, Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Imperial College, London, United Kingdom
    Blood 118:5152-62. 2011
    ..These enhanced responses were dependent on the inability of cholesterol-depleted HIV to induce IFN-α/β...
  3. pmc HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2961. 2008
    ....
  4. pmc PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Clin Immunol 129:132-44. 2008
    ..Finally, T cell proliferation was improved by PDL-1 blockade in HIV-treated PBMC. In the setting of HIV infection, IFN-alpha may negatively affect T cell responses by inducing PDL-1...
  5. doi Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques
    Adriano Boasso
    Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:4313-20. 2009
    ..Further studies are required to elucidate the immunologic or virologic mechanism by which d-1mT inhibited SIV replication in vivo...
  6. ncbi Wounding the immune system with its own blade: HIV-induced tryptophan catabolism and pathogenesis
    A Boasso
    Imperial College, Faculty of Medicine, Department of Medicine, Division of Infectious Diseases, Immunology Section, Chelsea and Westminster Hospital, London, UK
    Curr Med Chem 18:2247-56. 2011
    ....
  7. ncbi Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells
    Adriano Boasso
    Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 105:1574-81. 2005
    ....
  8. pmc CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques
    Anna Hryniewicz
    NCI, Bldg 41 Rm D 804, Bethesda, MD 20892 5065, USA
    Blood 108:3834-42. 2006
    ..Therefore, blunting T(reg) function in macaques infected with SIV did not have detrimental virologic effects and may provide a valuable approach to complement ART and therapeutic vaccination in the treatment of HIV-1 infection...
  9. pmc Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
    Valentina Cecchinato
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    J Immunol 180:5439-47. 2008
    ..These data provide the first direct evidence that immune activation drives viral replication, and suggest caution in the use of therapeutic approaches for HIV infection in vivo that increase CD4(+) T cell proliferation...
  10. ncbi Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques
    Anna Hryniewicz
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Building 41, Bethesda, MD 20892, USA
    J Immunol 178:3492-504. 2007
    ..These results underscore the importance of testing immunomodulatory approaches in vivo to assess potential risks and benefits for HIV-1-infected individuals...
  11. pmc HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20815, USA
    Blood 109:3351-9. 2007
    ..Thus, induction of IDO in pDCs by HIV may contribute to the T-cell functional impairment observed in HIV/AIDS by a non-interferon-dependent mechanism...
  12. pmc Altered phenotype of regulatory T cells associated with lack of human immunodeficiency virus (HIV)-1-specific suppressive function
    C T Burton
    Department of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Clin Exp Immunol 166:191-200. 2011
    ..We propose that before immunotherapeutic manipulation of T(regs) is considered, the immunoregulatory profile and distribution kinetics of this population in chronic HIV-1 infection must be elucidated fully...
  13. ncbi TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, 9000 Rockville Pike, Bethesda, MD, USA
    Blood 105:2458-64. 2005
    ..The high production of TRAIL by antigen-presenting cells may contribute to the death of CD4+ T cells during progression to AIDS...
  14. pmc Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Virol 81:11593-603. 2007
    ..Increased T(reg) and IDO in LT of SIV-infected macaques may be the consequence of increased tissue inflammation and/or may favor virus replication during the chronic phase of SIV infection...
  15. pmc Immune dysregulation in human immunodeficiency virus infection: know it, fix it, prevent it?
    A Boasso
    Department of Immunology, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, London, UK
    J Intern Med 265:78-96. 2009
    ..In this review we consider the extent and the limits of our knowledge of HIV pathogenesis, and how this knowledge may be used to design preventive and therapeutic approaches...
  16. pmc Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13974-9. 2005
    ..Our findings suggest a potential unique role of pDCs in the immunopathogenesis of HIV-1 infection by inducing the death molecule TRAIL...
  17. doi HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques
    Jean Philippe Herbeuval
    Experimental Immunology Branch, CCR, NCI, NIH, Bethesda, Maryland, USA
    AIDS 23:35-40. 2009
    ..To determine how antiretroviral therapy (ART) or HAART affects the expression of apoptotic ligands and their death receptors in the blood and lymphoid tissues of HIV-infected patients and simian immunodeficiency virus-infected macaques...
  18. pmc CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA
    Blood 106:3524-31. 2005
    ..We propose a novel model in which a type 1 IFN-regulated TRAIL /DR5 mechanism induces apoptosis of HIV-1-exposed CD4(+) T cells...
  19. pmc Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20092, USA
    Proc Natl Acad Sci U S A 103:7000-5. 2006
    ..TRAIL mRNA levels in LT correlated with plasma viral load. We show that HIV-1 induces IFN-alpha and the TRAIL/DR5 apoptotic pathway in LT, suggesting a role for these cytokines in HIV-1 immunopathogenesis...
  20. pmc Chronic innate immune activation as a cause of HIV-1 immunopathogenesis
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Immunol 126:235-42. 2008
    ..Subsequent production of type I interferon and indoleamine 2,3-dioxygenase may exert suppressive and cytotoxic effects on T cells...
  21. doi CD4+ T-cell loss and delayed expression of modulators of immune responses at mucosal sites of vaccinated macaques following SIV(mac251) infection
    M Vaccari
    Animal Models and Retroviral Vaccine Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mucosal Immunol 1:497-507. 2008
    ....
  22. doi Differential effect of type I and type II interferons on neopterin production and amino acid metabolism in human astrocyte-derived cells
    Oscar D Cano
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Neurosci Lett 438:22-5. 2008
    ..Thus type I and type II IFN stimulate astrocyte-derived cells to produce neopterin and exert differential effects on amino acid metabolism...
  23. ncbi How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
    Curr Drug Metab 8:217-23. 2007
    ..Therapeutic approaches aimed at manipulating this powerful immune suppressive mechanism might be considered in the setting of HIV infection...
  24. doi The hunt for an HIV vaccine: time to rethink recent failures
    Adriano Boasso
    Department of Immunology, Chelsea and Westminster Hospital, Imperial College, London, UK
    Lancet 371:1897-8. 2008
  25. ncbi B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression
    Daria Trabattoni
    Chair of Immunolgy, Dipartimento Scienze Precliniche Laboratorio Integrato Tecnologie Avanzate DISP LITA Vialba, University of Milano, Milano, Italy
    Blood 101:2514-20. 2003
    ..B7-H1 is a surrogate marker potentially involved in AIDS disease progression...
  26. ncbi The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients
    Jan Andersson
    Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Immunol 174:3143-7. 2005
    ..Our data could provide a new basis for immune-based therapies that counteract in vivo Treg and thereby reinforce appropriate antiviral immunity...
  27. pmc HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS
    Jakob Nilsson
    Division of Molecular Immunology ML 7021, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 108:3808-17. 2006
    ..Considered together, our findings imply that therapeutic manipulation of Treg-cell number and/or function could improve immune control of HIV infection...
  28. ncbi Granule-dependent mechanisms of lysis are defective in CD8 T cells of HIV-infected, antiretroviral therapy-treated individuals
    Daria Trabattoni
    Department of Immunology, University of Milan, Via GB Grassi 74, 20157 Milan, Italy
    AIDS 18:859-69. 2004
    ..CTL are stimulated by type 1 cytokines and can kill targets via granule-dependent (perforin and granzymes) and -independent (tumour necrosis factor-alpha, CD95) mechanisms...
  29. ncbi IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai
    Mara Biasin
    Department of Immunology, Universita di Milano, 20157 Milan, Italy
    AIDS 17:1563-5. 2003
    ..Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism...
  30. ncbi Ribonucleases in HIV type 1 inhibition: effect of recombinant RNases on infection of primary T cells and immune activation-induced RNase gene and protein expression
    Victoria I Bedoya
    Immunovirology Group, Universidad de Antioquia, Medelin, Colombia
    AIDS Res Hum Retroviruses 22:897-907. 2006
    ..These findings raise the possibilities that multiple naturally occurring RNases may contribute to protection against HIV-1 infection and could be considered for utilization in HIV-1 therapy...
  31. ncbi AIDS in Africa
    Mario Clerici
    Lancet 360:1424. 2002