Steve Bloom

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Gut feeling--the secret of satiety?
    Steve Bloom
    Endocrine Unit, Imperial College, Faculty of Medicine, Hammersmith Hospital, London
    Clin Med 5:147-52. 2005
  2. pmc Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake
    James V Gardiner
    Department of Investigative Medicine, Imperial College London, London, UK
    Diabetes 59:397-406. 2010
  3. pmc PYY3-36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans
    Benjamin C T Field
    Department of Investigative Medicine, Imperial College London, UK
    Diabetes 59:1635-9. 2010
  4. pmc Mice with hyperghrelinemia are hyperphagic and glucose intolerant and have reduced leptin sensitivity
    Gavin A Bewick
    Department of Investigative Medicine, Hammersmith Campus, Imperial College London, London, UK
    Diabetes 58:840-6. 2009
  5. pmc The gut hormones in appetite regulation
    Keisuke Suzuki
    Section of Investigative Medicine, Imperial College London, London W12 0NN, UK
    J Obes 2011:528401. 2011
  6. pmc Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance
    N M Semjonous
    Department of Investigative Medicine, Imperial College London, London, UK
    Int J Obes (Lond) 33:775-85. 2009
  7. pmc Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity
    Akila De Silva
    Department of Diabetes, Endocrinology and Metabolism, Hammersmith Campus, Imperial College London, London, UK
    Gut Liver 6:10-20. 2012
  8. pmc Obesity and appetite control
    Keisuke Suzuki
    Section of Investigative Medicine, Imperial College London, Commonwealth Building, Du Cane Road, London W12 0NN, UK
    Exp Diabetes Res 2012:824305. 2012
  9. pmc Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia
    Tricia M Tan
    Section of Investigative Medicine, Imperial College London, London, U K
    Diabetes 62:1131-8. 2013
  10. pmc Minireview: Glucagon in stress and energy homeostasis
    B J Jones
    Department of Investigative Medicine, Commonwealth Building, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0HS, United Kingdom
    Endocrinology 153:1049-54. 2012

Research Grants

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Gut feeling--the secret of satiety?
    Steve Bloom
    Endocrine Unit, Imperial College, Faculty of Medicine, Hammersmith Hospital, London
    Clin Med 5:147-52. 2005
    ....
  2. pmc Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake
    James V Gardiner
    Department of Investigative Medicine, Imperial College London, London, UK
    Diabetes 59:397-406. 2010
    ..Prokineticin 2 (PK2) is a hypothalamic neuropeptide expressed in central nervous system areas known to be involved in food intake. We therefore hypothesized that PK2 plays a role in energy homeostasis...
  3. pmc PYY3-36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans
    Benjamin C T Field
    Department of Investigative Medicine, Imperial College London, UK
    Diabetes 59:1635-9. 2010
    ..The aim of the current study was to investigate whether the anorectic effects of PYY(3-36) and oxyntomodulin can be additive...
  4. pmc Mice with hyperghrelinemia are hyperphagic and glucose intolerant and have reduced leptin sensitivity
    Gavin A Bewick
    Department of Investigative Medicine, Hammersmith Campus, Imperial College London, London, UK
    Diabetes 58:840-6. 2009
    ..We hypothesized that overexpression of ghrelin in its physiological tissues would increase food intake and body weight...
  5. pmc The gut hormones in appetite regulation
    Keisuke Suzuki
    Section of Investigative Medicine, Imperial College London, London W12 0NN, UK
    J Obes 2011:528401. 2011
    ..Here, we discuss the role of gut hormones in the regulation of food intake and body weight...
  6. pmc Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance
    N M Semjonous
    Department of Investigative Medicine, Imperial College London, London, UK
    Int J Obes (Lond) 33:775-85. 2009
    ..Overnight-food-deprived rats received an ICV injection of the anorectic peptides alpha-melanocyte-stimulating hormone (MSH), corticotrophin-releasing factor (CRF) or neuromedin U (NMU)...
  7. pmc Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity
    Akila De Silva
    Department of Diabetes, Endocrinology and Metabolism, Hammersmith Campus, Imperial College London, London, UK
    Gut Liver 6:10-20. 2012
    ..They may provide new therapeutic targets. This review article provides an overview of the central control of food intake and the role of PYY and GLP-1 in appetite control. Key translational animal and human studies are reviewed...
  8. pmc Obesity and appetite control
    Keisuke Suzuki
    Section of Investigative Medicine, Imperial College London, Commonwealth Building, Du Cane Road, London W12 0NN, UK
    Exp Diabetes Res 2012:824305. 2012
    ..In this paper, we focus on the role of gut hormones and their related neuronal networks (the gut-brain axis) in appetite control, and their potentials as novel therapies for obesity...
  9. pmc Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia
    Tricia M Tan
    Section of Investigative Medicine, Imperial College London, London, U K
    Diabetes 62:1131-8. 2013
    ..Long-term studies are required to demonstrate that this combination will reduce weight and improve glycemia in patients...
  10. pmc Minireview: Glucagon in stress and energy homeostasis
    B J Jones
    Department of Investigative Medicine, Commonwealth Building, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0HS, United Kingdom
    Endocrinology 153:1049-54. 2012
    ..These findings seem more in keeping with glucagon having some role as a hormone enhancing the response to stress...
  11. pmc Postprandial ghrelin suppression is exaggerated following major surgery; implications for nutritional recovery
    Mohsen Nematy
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK
    Nutr Metab (Lond) 4:20. 2007
    ..These findings reinforce the need to investigate ghrelin in other patients groups undergoing major surgery...
  12. pmc Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study
    Mohsen Nematy
    Nutrition and Dietetic Research Group, Imperial College, Hammersmith Hospitals NHS Trust, Du Cane Road, London W12 0HS, UK
    Crit Care 10:R10. 2006
    ..The aim of this study was to assess the patterns of ghrelin and PYY levels during the stay of ICU patients in hospital...
  13. ncbi request reprint Gut hormones in the control of appetite
    K G Murphy
    Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Exp Physiol 89:507-16. 2004
    ..Gut hormone appetite-regulatory systems represent a potential target for the design of antiobesity drugs...
  14. ncbi request reprint Oxyntomodulin suppresses appetite and reduces food intake in humans
    Mark A Cohen
    Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom W12 0NN
    J Clin Endocrinol Metab 88:4696-701. 2003
    ..0001). Elevated levels of endogenous OXM associated with disorders of the gastrointestinal tract may contribute to anorexia...
  15. ncbi request reprint Investigation of structure-activity relationships of Oxyntomodulin (Oxm) using Oxm analogs
    Maralyn R Druce
    Department of Investigative Medicine, Imperial College London, London, United Kingdom
    Endocrinology 150:1712-22. 2009
    ..An Oxm analog was developed with enhanced pharmaceutical characteristics, with greater potency and longevity with respect to effects on food intake. These studies suggest that Oxm is a potential target for antiobesity drug design...
  16. pmc The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans
    Channa N Jayasena
    Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 96:E1963-72. 2011
    ..If kisspeptin is to be useful for treating reproductive disease, its effects in both men and women must be established...
  17. ncbi request reprint The gut and regulation of body weight
    Katie Wynne
    Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 89:2576-82. 2004
    ..Signals from the gut and adipose tissue are integrated in the central nervous system to provide energy homeostasis. Knowledge of the body's control of appetite is important because we strive to combat obesity in man...
  18. ncbi request reprint Peripheral oxyntomodulin reduces food intake and body weight gain in rats
    Catherine L Dakin
    Endocrine Unit, Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Endocrinology 145:2687-95. 2004
    ..Seven-day ip administration of OXM caused a reduction in the rate of body weight gain and adiposity. Circulating OXM may have a role in the regulation of food intake and body weight...
  19. ncbi request reprint Appetite control
    Katie Wynne
    Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    J Endocrinol 184:291-318. 2005
    ..It also considers future therapeutic targets for the treatment of obesity...
  20. ncbi request reprint Inhibition of food intake in obese subjects by peptide YY3-36
    Rachel L Batterham
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
    N Engl J Med 349:941-8. 2003
    ..However, in obesity there is a marked resistance to the action of leptin, which greatly limits its therapeutic effectiveness. We investigated whether obese subjects were also resistant to the anorectic effects of PYY...
  21. doi request reprint Measurement of gut hormones in plasma
    Steve Bloom
    Division of Diabetes, Endocrinology and Metabolism, Imperial College Healthcare NHS Trust, London, UK
    Methods Mol Biol 1065:147-70. 2013
    ..The object of this chapter is to provide an overview of measuring gastrointestinal hormones and neuropeptides by radioimmunoassay. ..
  22. ncbi request reprint Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease
    Damien R Ashby
    Imperial College Kidney and Transplant Institute, Hammersmith Hospital, Imperial College London, London, UK
    Kidney Int 75:976-81. 2009
    ..Our results show that hepcidin is elevated in renal disease and suggest that higher hepcidin levels do not predict increased erythropoietin requirements...
  23. ncbi request reprint Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively
    Nicola M Neary
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, UK
    Endocrinology 146:5120-7. 2005
    ..Thus, PYY(3-36) and GLP-1(7-36), cosecreted after a meal, may inhibit food intake additively...
  24. ncbi request reprint Low-dose pancreatic polypeptide inhibits food intake in man
    David R Jesudason
    Department of Metabolic Medicine, Faculty of Medicene, Imperial College London, London, UK
    Br J Nutr 97:426-9. 2007
    ..Preprandial hunger as assessed by a visual analogue score was decreased in the PP-treated group compared to saline. These effects were achieved with plasma levels of PP within the pathophysiological range of pancreatic tumours...
  25. doi request reprint Hypothalamic injection of oxyntomodulin suppresses circulating ghrelin-like immunoreactivity
    Michael Patterson
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, United Kingdom
    Endocrinology 150:3513-20. 2009
    ..Postprandial release of anorexic gut hormones may thus act centrally to contribute to the postprandial reduction in circulating ghrelin...
  26. pmc Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass
    Marco Bueter
    Imperial Weight Centre, Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, Du Cane Road, London W12 0NN, UK
    Obes Surg 20:616-22. 2010
    ..The aim of this study was to evaluate whether gastric bypass with or without vagal preservation resulted in a different outcome...
  27. ncbi request reprint Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial
    Katie Wynne
    Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Diabetes 54:2390-5. 2005
    ..The anorectic effect was maintained over the 4-week period. Oxyntomodulin represents a potential therapy for obesity...
  28. ncbi request reprint Impaired circulating glucagon-like peptide-1 response to oral glucose in women with previous gestational diabetes
    Shareen Forbes
    Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London, London, UK
    Clin Endocrinol (Oxf) 62:51-5. 2005
    ..The aim of the study was to see if decreased GLP-1 secretion might be an early abnormality in the progression to Type 2 diabetes and would therefore be diminished in women with pGDM...
  29. ncbi request reprint A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10
    Annette E Curtis
    Dept of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, UK
    Am J Physiol Endocrinol Metab 298:E296-303. 2010
    ..Should manipulation of the kisspeptin/KISS1R signaling system prove therapeutically useful, long-lasting analogs such as [dY](1)KP-10 may have greater therapeutic potential than endogenous forms of kisspeptin...
  30. pmc Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin
    Damien R Ashby
    Renal Medicine, Imperial College London, Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    Haematologica 95:505-8. 2010
    ....
  31. ncbi request reprint Sustained appetite improvement in malnourished dialysis patients by daily ghrelin treatment
    Damien R Ashby
    Department of Investigative Medicine, Imperial College London, London, UK
    Kidney Int 76:199-206. 2009
    ..Direct manipulation of appetite with ghrelin or its analogs represents an attractive and promising therapeutic strategy for this difficult clinical problem...
  32. pmc Gastrointestinal hormones regulating appetite
    Owais Chaudhri
    Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
    Philos Trans R Soc Lond B Biol Sci 361:1187-209. 2006
    ..As physiological mediators of satiety, gut hormones offer an attractive therapeutic target in the treatment of obesity...
  33. ncbi request reprint Gut hormones as peripheral anti obesity targets
    Caroline J Small
    Department of Metabolic Medicine, Division of Investigative Science, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 ONN, UK
    Curr Drug Targets CNS Neurol Disord 3:379-88. 2004
    ..Here we consider the therapeutic potential of some gut hormones, and the GPCR's through which they act, in the treatment of obesity...
  34. ncbi request reprint Constitutional thinness and lean anorexia nervosa display opposite concentrations of peptide YY, glucagon-like peptide 1, ghrelin, and leptin
    Natacha Germain
    Departments of Endocrinology and Psychiatry, CHU Saint Etienne, St Etienne, France, and Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Clin Nutr 85:967-71. 2007
    ..Women with CT have normal menstrual periods and do not have the psychological or hormonal features of AN. Little is currently known about regulation of food intake in subjects with CT...
  35. ncbi request reprint Gut hormones and the control of appetite
    Caroline J Small
    Department of Metabolic Medicine, Division of Investigative Science, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 ONN, UK
    Trends Endocrinol Metab 15:259-63. 2004
    ..Administration of gut hormones might provide a novel and physiological approach in anti-obesity therapy. Here, we summarize some of the recent advances in this field...
  36. ncbi request reprint Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial
    Nicola M Neary
    Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom W12 0NN
    J Clin Endocrinol Metab 89:2832-6. 2004
    ..The stimulatory effects of ghrelin on food intake and meal appreciation seen in this preliminary study suggest that ghrelin could be an effective treatment for cancer anorexia and possibly for appetite loss in other patient groups...
  37. ncbi request reprint Gastrointestinal satiety signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide
    Sarah Stanley
    Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Am J Physiol Gastrointest Liver Physiol 286:G693-7. 2004
    ..This review considers the anorectic peptides PYY, PP, GLP-1, and oxyntomodulin, which decrease appetite and promote satiety in both animal models and humans...
  38. ncbi request reprint Who's to say that the risk is worth taking? Faced with the fear that their science might be misused, what should a researcher do?
    Steve Bloom
    Division of Investigative Science, Imperial College, London, UK
    New Sci 175:25. 2002
  39. ncbi request reprint Endocrinology: the next 60 years
    Waljit S Dhillo
    Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK
    J Endocrinol 190:7-10. 2006
    ..Finally, we propose that in 2066 we may prescribe designer hormones to healthy subjects...
  40. pmc Obesity treatment: novel peripheral targets
    Benjamin C T Field
    Department of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
    Br J Clin Pharmacol 68:830-43. 2009
    ..This review focuses on the role of gut hormones in short- and long-term regulation of food intake, and on the current state of development of gut hormone-based obesity therapies...
  41. pmc Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
    Carel W le Roux
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, UK
    Ann Surg 243:108-14. 2006
    ..To study the effect of bariatric surgery on the entero-hypothalamic endocrine axis of humans and rodents...
  42. ncbi request reprint Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype
    Gavin A Bewick
    Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, London, UK
    FASEB J 19:1680-2. 2005
    ..Transgenic mice failed to respond to peripherally administered ghrelin but retained sensitivity to PYY 3-36. These data suggest that postembryonic partial loss of AgRP/NPY neurons leads to a lean, hypophagic phenotype...
  43. ncbi request reprint Gut peptides in the regulation of food intake and energy homeostasis
    Kevin G Murphy
    Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Campus, London W12 ONN, UK
    Endocr Rev 27:719-27. 2006
    ..We also speculate on the role of gut hormones in the future treatment of obesity...
  44. ncbi request reprint Neuroendocrine control of food intake
    Adrian J Park
    Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, United Kingdom
    Curr Opin Gastroenterol 21:228-33. 2005
    ..This regulation depends on energy intake (in the form of food) and energy expenditure. Recently, there has been a remarkable increase in our understanding of the homeostatic mechanisms that control food intake and energy homeostasis...
  45. ncbi request reprint The gut hormone peptide YY regulates appetite
    Rachell L Batterham
    Imperial College Faculty of Medicine, Hammersmith Campus, London, W12 0NN, United Kingdom
    Ann N Y Acad Sci 994:162-8. 2003
    ..These findings suggest that PYY(3-36) released in response to a meal acts via the Y2R in the arcuate nucleus to physiologically regulate food intake...
  46. ncbi request reprint Men at increased risk of coronary heart disease are not different from age- and weight-matched healthy controls in their postprandial triglyceride, nonesterified fatty acid, or incretin responses to sucrose
    Audrey E Brynes
    Nutrition and Dietetic Research Group, Hammersmith Hospital, London, UK
    Metabolism 51:195-200. 2002
    ..Although long-term data is needed, this begs the question whether a moderate intake of sucrose has been overemphasized as a detrimental dietary message in middle-aged men...
  47. ncbi request reprint Central regulators of food intake
    Maralyn Druce
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College, London, UK
    Curr Opin Clin Nutr Metab Care 6:361-7. 2003
    ..Recently there has been a remarkable increase in our understanding of the molecular mechanisms regulating food intake and energy homeostasis...
  48. ncbi request reprint Triiodothyronine stimulates food intake via the hypothalamic ventromedial nucleus independent of changes in energy expenditure
    Wing May Kong
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom
    Endocrinology 145:5252-8. 2004
    ..Thus, we propose a novel hypothalamic feeding circuit in which T(3), from the peripheral circulation or produced by local conversion, stimulates food intake via the VMN...
  49. ncbi request reprint A randomised four-intervention crossover study investigating the effect of carbohydrates on daytime profiles of insulin, glucose, non-esterified fatty acids and triacylglycerols in middle-aged men
    Audrey E Brynes
    Nutrition and Dietetic Research Group, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    Br J Nutr 89:207-18. 2003
    ..Conversely the HIGH-GI diet appeared to increase postprandial insulin resistance over the study period...
  50. ncbi request reprint Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome
    Anthony P Goldstone
    Endocrine Unit, the Department of Dietetics, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Clin Nutr 75:468-75. 2002
    ..Obesity in Prader-Willi syndrome (PWS) may be related to abnormalities in the adipocyte-leptin-hypothalamic pathway and may be exacerbated by reductions in the resting metabolic rate (RMR)...
  51. ncbi request reprint Ghrelin gets its GOAT
    James Gardiner
    Department of Investigative Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK
    Cell Metab 7:193-4. 2008
    ..A recent study (Yang et al., 2008) reports identification of the enzyme catalyzing the addition of this octanyl, GOAT...
  52. ncbi request reprint Measurement of gut hormones in plasma
    Shahrad Taheri
    Department of Metabolic Medicine, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Methods Mol Biol 324:213-33. 2006
    ..The object of this chapter is to describe the techniques used in the radioimmunoassay of common gastrointestinal hormones...
  53. doi request reprint The obesity epidemic: pharmacological challenges
    Stephen R Bloom
    Hammersmith Hospital, Imperial College, London, UK W120NN
    Mol Interv 8:82-98. 2008
    ..These high rates have led to dramatic increases in diseases such as type 2 diabetes, cardiovascular and respiratory diseases, depression, and some forms of cancer...
  54. ncbi request reprint Relaxin-3 and its role in neuroendocrine function
    Barbara M C McGowan
    Department of Investigative Medicine, Division of Investigative Science, Imperial College London, Hammersmith Hospital, London, UK
    Ann N Y Acad Sci 1160:250-5. 2009
    ..Further studies will be required to determine whether these are physiological roles for relaxin-3 and to determine the receptors involved...
  55. ncbi request reprint AMP-activated protein kinase plays a role in the control of food intake
    Ulrika Andersson
    Medical Research Council Clinical Sciences Centre, Cellular Stress Group and Endocrine Unit, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, United Kingdom
    J Biol Chem 279:12005-8. 2004
    ..These findings demonstrate that AMPK plays a role in the regulation of feeding and identify AMPK as a novel target for anti-obesity drugs...
  56. ncbi request reprint Gut hormones and the regulation of energy homeostasis
    Kevin G Murphy
    Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Nature 444:854-9. 2006
    ..New research suggests that gut hormones can be used to specifically regulate energy homeostasis in humans, and offer a target for anti-obesity drugs...
  57. ncbi request reprint Chronic administration of NMU into the paraventricular nucleus stimulates the HPA axis but does not influence food intake or body weight
    Emily L Thompson
    Division of Metabolic Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Campus, London W12 ONN, UK
    Biochem Biophys Res Commun 323:65-71. 2004
    ..These results suggest NMU may have a role in the regulation of the HPA axis and behavior...
  58. ncbi request reprint Characterization of ghrelin-like immunoreactivity in human plasma
    Michael Patterson
    Department of Metabolic Medicine, Imperial College, London Hammersmith Hospital, Du Cane Road, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 90:2205-11. 2005
    ..Assays measuring specific forms of ghrelin may be more useful in determining its physiological role than those that detect both acylated and des-acylated forms...
  59. ncbi request reprint Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese-enhanced magnetic resonance imaging
    Owais B Chaudhri
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Biochem Biophys Res Commun 350:298-306. 2006
    ..Our data show that these two apparently similar peptides generate distinct patterns of activation within the hypothalamus, suggesting that GLP-1 and OXM may act via different hypothalamic pathways...
  60. doi request reprint Gastric bypass increases energy expenditure in rats
    Marco Bueter
    Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    Gastroenterology 138:1845-53. 2010
    ..Mechanisms underlying weight loss maintenance after gastric bypass are poorly understood. Our aim was to examine the effects of gastric bypass on energy expenditure in rats...
  61. ncbi request reprint Gut hormone PYY(3-36) physiologically inhibits food intake
    Rachel L Batterham
    Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 418:650-4. 2002
    ..Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway...
  62. ncbi request reprint Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis
    Waljit S Dhillo
    Endocrine Unit, Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 ONN, United Kingdom
    Endocrinology 144:1420-5. 2003
    ..75 +/- 0.4; controls, 3.65 +/- 0.34; P < 0.05]. Our data suggest that CGRP administered to the PVN inhibits food intake and stimulates the HPA axis...
  63. ncbi request reprint The hyperphagic effect of ghrelin is inhibited in mice by a diet high in fat
    James V Gardiner
    Department of Investigative Medicine, Hammersmith Campus, Imperial College London, London, UK
    Gastroenterology 138:2468-76, 2476.e1. 2010
    ..These mice, as expected, are hyperphagic and glucose intolerant. We investigated whether exposure to a high-fat diet (HFD) would exacerbate this phenotype...
  64. doi request reprint PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones
    James R C Parkinson
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, Du Cane Road, London, W12 ONN UK
    Am J Physiol Endocrinol Metab 294:E698-708. 2008
    ..These data indicate that PYY(3-36) injection results in an acute anorexigenic effect followed by a delayed orexigenic effect...
  65. ncbi request reprint Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake
    Caroline R Abbott
    Endocrine Unit, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Brain Res 1043:139-44. 2005
    ..These studies suggest that the Y2R plays an important role in post-prandial satiety and provide further insight into the mechanisms of action of PYY((3-36))...
  66. ncbi request reprint Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release
    Gavin A Bewick
    Department of Metabolic Medicine, Division of Investigative Science, Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom
    Endocrinology 146:3526-34. 2005
    ..Our data suggest that nociceptin via the NOP1 receptor may increase food intake by decreasing the release of the anorectic peptide CART and increasing the release of the orexigenic peptide AgRP...
  67. ncbi request reprint Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone
    Caroline R Abbott
    Endocrine Unit, Imperial College London, Hammersmith Campus, London W12 ONN, United Kingdom
    Endocrinology 144:3943-9. 2003
    ..0 fmol/explant; P < 0.001). These studies suggest that the orexigenic effect of MCH may be mediated via activation or inhibition of these feeding circuits within the arcuate nucleus and paraventricular nucleus of the hypothalamus...
  68. ncbi request reprint Fasting and postprandial hyperghrelinemia in Prader-Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3-36 deficiency or seen in hypothalamic obesity due to craniopharyngioma
    Anthony P Goldstone
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom
    J Clin Endocrinol Metab 90:2681-90. 2005
    ....
  69. ncbi request reprint Can gut hormones control appetite and prevent obesity?
    Owais B Chaudhri
    Department of Metabolic Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    Diabetes Care 31:S284-9. 2008
    ..This review discusses the hormones oxyntomodulin, peptide YY, glucagon-like peptide 1, pancreatic polypeptide, and ghrelin and their emerging potential as anti-obesity treatments...
  70. ncbi request reprint Hormonal interactions between gut and brain
    Sagen Zac-Varghese
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, United Kingdom
    Discov Med 10:543-52. 2010
    ..Increased understanding and successful manipulation of this system should enable the design of a successful and much needed anti-obesity treatment...
  71. ncbi request reprint Interactions between the melanocortin system and the hypothalamo-pituitary-thyroid axis
    Niamh M Martin
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Peptides 27:333-9. 2006
    ..Here we will discuss the evidence demonstrating interactions between the melanocortin system and the HPT axis...
  72. ncbi request reprint The hypothalamic mechanisms of the hypophysiotropic action of ghrelin
    Alison M Wren
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Neuroendocrinology 76:316-24. 2002
    ..These data suggest that the mechanisms of GH and ACTH regulation by ghrelin may include hypothalamic release of GHRH, CRH, AVP and NPY...
  73. ncbi request reprint Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin
    Preeti H Jethwa
    Dept of Metabolic Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    Am J Physiol Endocrinol Metab 289:E301-5. 2005
    ..8 +/- 2.6 g (P < 0.01 vs. vehicle); leptin/NMU IgG, 28.7 +/- 1.1 g (P < 0.01 vs. leptin)]. These results suggest that NMU plays a physiological role in the regulation of appetite and partially mediates the leptin-induced satiety...
  74. ncbi request reprint Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women
    Waljit S Dhillo
    Department of Metabolic Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 92:3958-66. 2007
    ..GPR54-null mice exhibit reproductive dysfunction, and exogenous kisspeptin potently stimulates the HPG axis in rodents, primates, and human males. The effects of kisspeptin administration to human females are unknown...
  75. doi request reprint Overexpression of CART in the PVN increases food intake and weight gain in rats
    Kirsty L Smith
    Department of Investigative Medicine, Imperial College London, London, UK
    Obesity (Silver Spring) 16:2239-44. 2008
    ..To investigate the role of CART in the regulation of energy balance in the PVN, we used recombinant adeno-associated virus (rAAV) to overexpress CART in the PVN...
  76. ncbi request reprint Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat
    Preeti H Jethwa
    Department of Metabolic Medicine, Imperial College London, London W12 0NN, United Kingdom
    Endocrinology 147:2886-92. 2006
    ..05)]. These studies suggest that NMU may play a role in the regulation of the HPA axis and partially mediate leptin-induced HPA stimulation...
  77. ncbi request reprint Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats
    Catherine L Dakin
    Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    Am J Physiol Endocrinol Metab 283:E1173-7. 2002
    ..In summary, ICV OXM causes reduced body weight gain and body adiposity following chronic administration...
  78. ncbi request reprint Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic-pituitary-gonadal axis via gonadotropin-releasing hormone in rats
    Sejal R Patel
    Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, United Kingdom
    Endocrinology 149:4747-54. 2008
    ..These results suggest that icv QRFP43 activates the hypothalamic-pituitary-gonadal axis via GnRH...
  79. ncbi request reprint Neuropeptide S stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intake
    Kirsty L Smith
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, United Kingdom
    Endocrinology 147:3510-8. 2006
    ..PVN administration of NPS caused a significant increase in rearing activity. These data demonstrate a novel role for NPS in the stimulation of the HPA axis...
  80. ncbi request reprint The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
    Caroline R Abbott
    Imperial College London, 6th Floor Commonwealth Building, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Brain Res 1044:127-31. 2005
    ..These findings suggest that the vagal-brainstem-hypothalamic pathway may also play a role in the effects of circulating PYY(3-36) and GLP-1 on food intake...
  81. ncbi request reprint The temporal sequence of gut peptide CNS interactions tracked in vivo by magnetic resonance imaging
    Yu Ting Kuo
    Molecular Imaging Group, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Neurosci 27:12341-8. 2007
    ..We conclude that manganese-enhanced MRI constitutes a powerful tool for the future investigation of the effects of drugs, hormones, and environmental influences on neuronal activity...
  82. doi request reprint Supraphysiological doses of intravenous PYY3-36 cause nausea, but no additional reduction in food intake
    Carel W le Roux
    Department of Metabolic Medicine, 6th Floor Commonwealth Building, Hammersmith Hospital, Imperial College London, London, UK
    Ann Clin Biochem 45:93-5. 2008
    ..Peptide YY (PYY(3-36)) infused to levels within the physiological range reduces appetite and food intake in humans without nausea. However, PYY(3-36) has previously been shown to cause nausea at higher doses...
  83. ncbi request reprint Subcutaneous ghrelin enhances acute food intake in malnourished patients who receive maintenance peritoneal dialysis: a randomized, placebo-controlled trial
    Katie Wynne
    Renal Services, Ground Floor Pilot Wing, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
    J Am Soc Nephrol 16:2111-8. 2005
    ..0030 by ANOVA). There were no significant adverse events during the study. Subcutaneous ghrelin administration enhances short-term food intake in dialysis patients with mild to moderate malnutrition...
  84. ncbi request reprint Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents
    Sue Stock
    Endocrinology and Diabetes Unit, Room K4 212, British Columbia s Children s Hospital, 4480 Oak Street, Vancouver, British Columbia V6H 3V4, Canada
    J Clin Endocrinol Metab 90:2161-8. 2005
    ..Ghrelin is unlikely to play a causal role in anorexia nervosa or obesity. The lower GIP observed in AN subjects despite a similar caloric intake may appropriately prevent an excessive insulin response in these patients...
  85. ncbi request reprint The effect of different macronutrient infusions on appetite, ghrelin and peptide YY in parenterally fed patients
    Charles D Murray
    Physiology Unit, St Mark s Hospital, Watford Road, Harrow HAI 3UJ, UK
    Clin Nutr 25:626-33. 2006
    ..It is not known whether PN or its constituent macronutrients acutely affect appetite and to what degree this may be mediated by ghrelin and peptide YY (PYY)...
  86. ncbi request reprint Elevated fasting plasma ghrelin in prader-willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance
    Anthony P Goldstone
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom EC1A 7BE
    J Clin Endocrinol Metab 89:1718-26. 2004
    ..The hyperghrelinemia in PWS adults is therefore not solely explained by their reduced visceral adiposity and relative hypoinsulinemia. Its cause and consequences await further elucidation...
  87. ncbi request reprint Peptides and obesity: the PYY3-36 story
    Adrian Park
    Regul Pept 119:1-2. 2004
  88. ncbi request reprint Effects of exercise on gut peptides, energy intake and appetite
    Catia Martins
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    J Endocrinol 193:251-8. 2007
    ..This impact on appetite and subsequent energy homeostasis was not explained by changes in postprandial levels of ghrelin; however, 'exercise-induced anorexia' may potentially be linked to increased PYY, GLP-1 and PP levels...
  89. ncbi request reprint Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome
    Lisa J Moran
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia
    Am J Clin Nutr 86:1603-10. 2007
    ..Polycystic ovary syndrome (PCOS) is a common condition associated with obesity and with reproductive and metabolic dysfunction. Abnormalities in appetite regulation in PCOS patients may contribute to difficulties in weight management...
  90. ncbi request reprint Ghrelin for the gastroenterologist: history and potential
    Charles D R Murray
    Physiology Unit, St Mark s Hospital, Watford Road, Harrow HA1 3UJ, Middlesex, England, UK
    Gastroenterology 125:1492-502. 2003
    ..This review will discuss the recent literature concerning this exciting novel neuropeptide and discuss the possible therapeutic possibilities it may open up to us...
  91. ncbi request reprint The therapeutic potential of gut hormone peptide YY3-36 in the treatment of obesity
    Caroline J Small
    Department of Metabolic Medicine, Division of Investigative Science, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 ONN, UK
    Expert Opin Investig Drugs 14:647-53. 2005
    ..Worldwide its prevalence is accelerating. The administration of the naturally occurring gut hormone may offer a long-term therapeutic approach to weight control. Here, the therapeutic potential of PYY is considered...
  92. ncbi request reprint Novel therapeutic targets for appetite regulation
    Caroline J Small
    Department of Metabolic Medicine, Division of Investigative Science, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Curr Opin Investig Drugs 6:369-72. 2005
    ....
  93. ncbi request reprint Sustained orexigenic effect of Agouti related protein may be not mediated by the melanocortin 4 receptor
    Min Seon Kim
    Department of Internal Medicine and Institute of Endocrinology, Nutrition and Metabolism, Medical Research Center, Seoul National University College of Medicine, 110 744, Seoul, South Korea
    Peptides 23:1069-76. 2002
    ..An increase in body weight at 24 and 48 h was observed following AgRP (83-132) but not JKC-363 treatment. These data suggest that the sustained orexigenic action of AgRP (83-132) may not be through MC4-R antagonism...
  94. ncbi request reprint Fat digestion is required for suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid
    Christine Feinle-Bisset
    Dept of Medicine, Royal Adelaide Hospital, North Terrace, Adelaide SA 5000, Australia
    Am J Physiol Endocrinol Metab 289:E948-53. 2005
    ..In conclusion, in healthy humans, 1) the presence of fat in the small intestine suppresses ghrelin secretion, and 2) fat-induced suppression of ghrelin and stimulation of PYY and PP is dependent on fat digestion...
  95. ncbi request reprint Are all fats created equal?
    Kevin G Murphy
    Nat Med 12:32-3. 2006
  96. ncbi request reprint Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men
    Kate L Feltrin
    University of Adelaide, Department of Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia
    Peptides 27:1638-43. 2006
    ..Both C10 and C12 increased PP concentrations slightly (P < 0.05). We conclude that the effects of intraduodenal fatty acids on ghrelin, PYY and GLP-2 secretion are dependent on their chain length...
  97. ncbi request reprint Regulation of food intake by gastrointestinal hormones
    Kevin C R Baynes
    Department of Metabolic Medicine, Hammersmith Campus, Imperial College London, UK
    Curr Opin Gastroenterol 22:626-31. 2006
    ..Understanding the interactions between different gut peptides has produced a rewardingly active research field with many unanswered questions...
  98. ncbi request reprint Gut hormones as potential new targets for appetite regulation and the treatment of obesity
    Benjamin C T Field
    Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
    Drugs 68:147-63. 2008
    ..Several gut hormone-based treatments for obesity are under investigation in phase II and III clinical trials, and many more are in the pipeline...
  99. ncbi request reprint The relationship of ghrelin to biochemical and anthropometric markers of adult growth hormone deficiency
    Iqbal A Malik
    Diabetes and Endocrinology Research Group, University Hospital Aintree, Liverpool, UK
    Clin Endocrinol (Oxf) 60:137-41. 2004
    ..We therefore measured circulating ghrelin concentrations, leptin and body composition in subjects with GHD and healthy controls...
  100. ncbi request reprint The role of oxyntomodulin and peptide tyrosine-tyrosine (PYY) in appetite control
    Katie Wynne
    Department of Metabolic Medicine, Imperial College London, and Hammersmith Hospital, UK
    Nat Clin Pract Endocrinol Metab 2:612-20. 2006
    ..This research suggests that modulation of these gut hormones could prove to be effective long-term therapies in the quest to combat the obesity epidemic...
  101. ncbi request reprint Peptide YY: a gut hormone associated with anorexia during infectious diarrhea in children
    Amy L Beck
    From the Department of Pediatrics, University of California San Francisco, San Francisco, CA
    J Pediatr 153:677-82. 2008
    ....

Research Grants1

  1. Gut Hormones/Other Circulatory Regulators of Appetite
    Stephen Bloom; Fiscal Year: 2006
    ..Obesity produces over 6,000 excess deaths a week in the USA alone, yet there is no really effective treatment. This meeting is to advance the most promising approach to a safe practical therapy seen in the last 50 years. ..