B J Bain

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Diagnosis from the blood smear
    Barbara J Bain
    Department of Haematology, St Mary s Hospital, London, United Kingdom
    N Engl J Med 353:498-507. 2005
  2. ncbi request reprint Clinical applications of molecular haematology: an overview
    Barbara J Bain
    Department of Haematology, St Mary s Hospital Campus of Imperial College, St Mary s Hospital, Praed Street, London W2 1NY, United Kingdom
    J Assoc Physicians India 55:503-6. 2007
  3. ncbi request reprint An overview of translocation-related oncogenesis in the chronic myeloid leukaemias
    Barbara J Bain
    Department of Haematology, Imperial College Faculty of Medicine, St Mary s Hospital, London, UK
    Acta Haematol 107:57-63. 2002
  4. ncbi request reprint Spurious automated platelet count
    Barbara J Bain
    Am J Clin Pathol 122:316; author reply 316. 2004
  5. ncbi request reprint Morphology in the diagnosis of red cell disorders
    Barbara J Bain
    Department of Haematology, Imperial College Faculty of Medicine, St Mary s Hospital, Praed Street, London, W2 1NY, UK
    Hematology 10:178-81. 2005
  6. pmc Bone marrow trephine biopsy
    B J Bain
    Department of Haematology, St Mary s Hospital Campus of Imperial College School of Medicine, Praed Street, London, W2 1NY, UK
    J Clin Pathol 54:737-42. 2001
  7. doi request reprint The importance of a negative image
    Barbara J Bain
    Department of Haematology, Imperial College Faculty of Medicine, St, Mary s Hospital, London, United Kingdom
    Am J Hematol 83:410. 2008
  8. doi request reprint Thrombocytopenia
    Barbara J Bain
    Imperial College Healthcare NHS Trust, St Mary s Hospital, Praed Street, London, W2 1NY, United Kingdom
    Am J Hematol 83:303. 2008
  9. ncbi request reprint Chronic eosinophilic leukemias and the myeloproliferative variant of the hypereosinophilic syndrome
    Barbara J Bain
    Department of Haematology, St Mary s Hospital Campus of Imperial College Faculty of Medicine, St Mary s Hospital, Praed Street, London, W2 1NY, UK
    Immunol Allergy Clin North Am 27:377-88. 2007
  10. ncbi request reprint British society for haematology slide session, annual scientific meeting, Harrogate, 2001
    Barbara J Bain
    Department of Haematology, St Mary s Hospital, London, UK
    Clin Lab Haematol 25:1-8. 2003

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Diagnosis from the blood smear
    Barbara J Bain
    Department of Haematology, St Mary s Hospital, London, United Kingdom
    N Engl J Med 353:498-507. 2005
  2. ncbi request reprint Clinical applications of molecular haematology: an overview
    Barbara J Bain
    Department of Haematology, St Mary s Hospital Campus of Imperial College, St Mary s Hospital, Praed Street, London W2 1NY, United Kingdom
    J Assoc Physicians India 55:503-6. 2007
    ....
  3. ncbi request reprint An overview of translocation-related oncogenesis in the chronic myeloid leukaemias
    Barbara J Bain
    Department of Haematology, Imperial College Faculty of Medicine, St Mary s Hospital, London, UK
    Acta Haematol 107:57-63. 2002
    ..The molecular mechanisms underlying the great majority of cases of Philadelphia-negative chronic myeloid leukaemia remain to be discovered...
  4. ncbi request reprint Spurious automated platelet count
    Barbara J Bain
    Am J Clin Pathol 122:316; author reply 316. 2004
  5. ncbi request reprint Morphology in the diagnosis of red cell disorders
    Barbara J Bain
    Department of Haematology, Imperial College Faculty of Medicine, St Mary s Hospital, Praed Street, London, W2 1NY, UK
    Hematology 10:178-81. 2005
    ..Polycythaemic as well as anaemic patients require blood film examination...
  6. pmc Bone marrow trephine biopsy
    B J Bain
    Department of Haematology, St Mary s Hospital Campus of Imperial College School of Medicine, Praed Street, London, W2 1NY, UK
    J Clin Pathol 54:737-42. 2001
    ..A signed or computer authorised report should be issued in a timely manner. If the report is a preliminary, this must be clearly stated...
  7. doi request reprint The importance of a negative image
    Barbara J Bain
    Department of Haematology, Imperial College Faculty of Medicine, St, Mary s Hospital, London, United Kingdom
    Am J Hematol 83:410. 2008
  8. doi request reprint Thrombocytopenia
    Barbara J Bain
    Imperial College Healthcare NHS Trust, St Mary s Hospital, Praed Street, London, W2 1NY, United Kingdom
    Am J Hematol 83:303. 2008
  9. ncbi request reprint Chronic eosinophilic leukemias and the myeloproliferative variant of the hypereosinophilic syndrome
    Barbara J Bain
    Department of Haematology, St Mary s Hospital Campus of Imperial College Faculty of Medicine, St Mary s Hospital, Praed Street, London, W2 1NY, UK
    Immunol Allergy Clin North Am 27:377-88. 2007
    ..The molecular mechanism is often a fusion gene, incorporating part of PDGFRA or PDGFRB, encoding anaberrant tyrosine kinase. Prompt diagnosis of such cases is important since specific tyrosine kinase inhibitor therapy is indicated...
  10. ncbi request reprint British society for haematology slide session, annual scientific meeting, Harrogate, 2001
    Barbara J Bain
    Department of Haematology, St Mary s Hospital, London, UK
    Clin Lab Haematol 25:1-8. 2003
  11. ncbi request reprint Di Guglielmo and his syndromes
    Barbara J Bain
    Department of Haematology, St Mary s Hospital Campus, Imperial College Faculty of Medicine, London, UK
    Br J Haematol 120:939-43. 2003
  12. ncbi request reprint Bone marrow biopsy morbidity and mortality
    Barbara J Bain
    Department of Haematology, St Mary s Hospital Campus, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Praed Street, London W2 1NY, UK
    Br J Haematol 121:949-51. 2003
    ..Other potential risk factors were warfarin therapy, disseminated intravascular coagulation and obesity...
  13. doi request reprint Haemoglobinopathy diagnosis: algorithms, lessons and pitfalls
    Barbara J Bain
    Department of Haematology, St Mary s Hospital and St Mary s Hospital Campus of Imperial College Faculty of Medicine, London, UK
    Blood Rev 25:205-13. 2011
    ..Capillary electrophoresis is being increasingly used. All these methods permit only a presumptive diagnosis with definitive diagnosis requiring either DNA analysis or protein analysis, for example by tandem mass spectrometry...
  14. ncbi request reprint British Society for Haematology, slide session, Annual Scientific Meeting, Edinburgh, 2006
    Barbara J Bain
    Clin Lab Haematol 28:363-9. 2006
    ....
  15. doi request reprint Seeing what isn't there
    Barbara J Bain
    Department of Haematology, Imperial College Faculty of Medicine, St Mary s Hospital, London, United Kingdom
    Am J Hematol 83:504. 2008
  16. doi request reprint Pitfalls in obtaining and interpreting bone marrow aspirates: to err is human
    Barbara J Bain
    St Mary s Hospital, Paddington, London, UK
    J Clin Pathol 64:373-9. 2011
    ..A constant awareness of potential pitfalls and an assessment of the aspirate in the appropriate clinical context will help to reduce errors...
  17. ncbi request reprint Hypereosinophilia
    B J Bain
    Department of Haematology, St Mary s Hospital, Campus of Imperial College School of Medicine, London, United Kingdom
    Curr Opin Hematol 7:21-5. 2000
    ..The roles of various therapeutic modalities-including cytotoxic chemotherapy, interferon and bone marrow transplantation-in eosinophilic leukemia and in the idiopathic hypereosinophilic syndrome also have been further defined...
  18. ncbi request reprint Investigation of the effect of marathon running on leucocyte counts of subjects of different ethnic origins: relevance to the aetiology of ethnic neutropenia
    B J Bain
    Department of Haematology, St Mary s Hospital Campus of Imperial College School of Medicine, St Mary s Hospital, London W2 1NY, UK
    Br J Haematol 108:483-7. 2000
    ....
  19. pmc Bone marrow aspiration
    B J Bain
    Department of Haematology, St Mary s Hospital Campus of Imperial College School of Medicine, Praed Street, London, W2 1NY, UK
    J Clin Pathol 54:657-63. 2001
    ..An interpretation of the findings, in the light of the clinical and haematological features, should be given. The report should be signed or computer authorised, using a secure password, and issued in a timely manner...
  20. doi request reprint Irregularly contracted cells
    Barbara J Bain
    Department of Haematology, Imperial College Faculty of Medicine, St Mary s Hospital, Praed Street, London, W2 1NY, United Kingdom
    Am J Hematol 83:592. 2008
  21. doi request reprint Neonatal/newborn haemoglobinopathy screening in Europe and Africa
    B J Bain
    Department of Haematology, St Mary s Hospital, London, UK
    J Clin Pathol 62:53-6. 2009
    ..Despite the logistic problems and economic constraints, neonatal haemoglobinopathy screening is also being gradually introduced in a number of African countries...
  22. ncbi request reprint Slide session, British Society for Haematology, 45th Annual Scientific Meeting, Manchester, 2005
    B J Bain
    Department of Haematology, St Mary s Hospital, London, UK
    Clin Lab Haematol 27:363-9. 2005
    ..Further data and the final diagnosis are then provided. The slide session is presented here, as it occurred at the meeting...
  23. pmc Are routine iron stains on bone marrow trephine biopsy specimens necessary?
    S E Stuart-Smith
    Department of Haematology, St Mary s Hospital, Praed Street, London W2 1NY, UK
    J Clin Pathol 58:269-72. 2005
    ..To determine the role of Perls' staining in bone marrow trephine biopsy sections...
  24. ncbi request reprint Investigation of ethnic neutropenia by assessment of bone marrow colony-forming cells
    K Rezvani
    Department of Haematology, St. Mary's Hospital, Campus of Imperial College School of Medicine, Praed Street, London W2 1NY, UK
    Acta Haematol 105:32-7. 2001
    ..These observations suggest that ethnic neutropenia observed in those with African ancestry is likely to result from reduced numbers of bone marrow progenitor cells in comparison with numbers present in Caucasians...
  25. ncbi request reprint Report on slide session, British Society for Haematology, 44th Annual Scientific Meeting, Cardiff, 2004
    B J Bain
    Department of Haematology, St Mary s Hospital, London, UK
    Clin Lab Haematol 26:309-14. 2004
  26. ncbi request reprint Report on slide session, British Society for Haematology, 43rd Annual Scientific Meeting, Glasgow, 2003
    B J Bain
    Department of Haematology, St Mary s Hospital Campus of Imperial College, London
    Clin Lab Haematol 26:87-93. 2004
    ..Diagnostic problems dealt with included lymphoproliferative and myeloproliferative disorders and haemolytic anaemia...
  27. ncbi request reprint Relationship between idiopathic hypereosinophilic syndrome, eosinophilic leukemia, and systemic mastocytosis
    Barbara J Bain
    Department of Haematology, St Mary s Hospital Campus, Imperial College Faculty of Medicine, St Mary s Hospital, London, United Kingdom
    Am J Hematol 77:82-5. 2004
    ....
  28. ncbi request reprint Cytogenetic and molecular genetic aspects of eosinophilic leukaemias
    Barbara J Bain
    Department of Haematology, St Mary s Hospital Campus, Imperial College Faculty of Medicine, St Mary s Hospital, London, UK
    Br J Haematol 122:173-9. 2003
  29. ncbi request reprint Bone marrow biopsy morbidity and mortality: 2002 data
    B J Bain
    Department of Haematology, Faculty of Medicine, St Mary s Hospital Campus of Imperial College, London, UK
    Clin Lab Haematol 26:315-8. 2004
    ..One patient suffered considerable pain for 2 weeks. The adverse event may have contributed to death in two patients and in a third patient was life-threatening. Risk factors for adverse events were identified...
  30. ncbi request reprint Evaluation of a new screening test for sickle cell haemoglobin
    J Balasubramaniam
    Department of Haematology, St Mary's Hospital, Praed Street, London, W21NY, UK
    Clin Lab Haematol 23:379-83. 2001
    ..In conclusion, unless improved performance can be demonstrated, use of this kit cannot be recommended...
  31. pmc Bone marrow biopsy morbidity: review of 2003
    B J Bain
    Department of Haematology, St Mary s Hospital Campus of Imperial College Faculty of Medicine, Praed Street, London W2 1NY, UK
    J Clin Pathol 58:406-8. 2005
    ..Three consecutive years have now been surveyed, the results for 2003 being presented here and compared with earlier results...
  32. ncbi request reprint Prospective study of HTLV-I infection in an initially asymptomatic cohort
    G P Taylor
    Clinical Trials Centre, Imperial College School of Medicine, St Mary s Hospital, London, UK
    J Acquir Immune Defic Syndr 22:92-100. 1999
    ..Persistently high proviral load appears to predate the development of HTLV-I-associated inflammation in neuro-ophthalmic tissue...
  33. ncbi request reprint Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
    Jane F Apperley
    Department of Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    N Engl J Med 347:481-7. 2002
    ..The tyrosine kinase inhibitor imatinib mesylate specifically inhibits ABL, PDGFR, and KIT kinases and has impressive clinical efficacy in BCR-ABL-positive chronic myeloid leukemia...
  34. ncbi request reprint Blood film features of sickle cell-haemoglobin C disease
    B J Bain
    Department of Haematology, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London
    Br J Haematol 83:516-8. 1993
    ..In addition, SC differed from SS in having fewer classical sickle cells and nucleated red cells, more irregularly-contracted cells and less polychromasia and evidence of hyposplenism...
  35. pmc How should stainable iron in bone marrow films be assessed?
    D A Hughes
    Department of Academic Haematology, St Mary s Hospital, Praed Street, London W2 1NY, UK
    J Clin Pathol 57:1038-40. 2004
    ..To identify how many particles should be examined to enable a confident assessment of the presence or absence of iron stores and the quantity of iron in a bone marrow aspirate to be made...
  36. ncbi request reprint Overview. Cytogenetic analysis in haematology
    B J Bain
    Department of Haematology, St Mary's Hospital, Praed Street, London, W2 1NY, UK
    Best Pract Res Clin Haematol 14:463-77. 2001
    ....
  37. ncbi request reprint Teaching cases from the Royal Marsden and St Mary's Hospitals. Case 24: striking lymphocytosis in a 2-year-old girl
    Michael Gattens
    Department of Haematology, St Mary s Hospital, Praed Street, London W2 1NY, UK
    Leuk Lymphoma 45:851-2. 2004
  38. doi request reprint Case 41. A misdiagnosis of erythroleukemia
    Allison C Y Tso
    Department of Haematology, North Middlesex Hospital, London, UK
    Leuk Lymphoma 50:1030-2. 2009
    ..An increased percentage of CD34-positive and CD117-positive cells suggested a diagnosis of pure erythroleukemia. Further investigations were performed...
  39. ncbi request reprint Eosinophilic leukaemias and the idiopathic hypereosinophilic syndrome
    B J Bain
    Department of Haematology, Imperial College School of Medicine, St Mary s Hospital, London
    Br J Haematol 95:2-9. 1996
    ..However, eosinophilia in association with acute lymphoblastic leukaemia is usually reactive. Rare cases have a biphenotypic leukaemia/lymphoma with both eosinophils and lymphoid cells arising from a mutant pluripotent stem cell...
  40. ncbi request reprint Inaccuracy of high-performance liquid chromatography estimation of haemoglobin F in the presence of increased haemoglobin A1c
    V Grey
    Department of Haematology, St Mary s Hospital, London, UK
    Int J Lab Hematol 29:42-4. 2007
    ..15 min, the normal retention time being 1.08-1.15 min. Haemoglobinopathy laboratories need to be alert to the possibility of this erroneous result...
  41. pmc Unusual splenic sinusoidal iron overload in sickle cell/haemoglobin D-Punjab disease
    P M C Jiskoot
    Department of Histopathology, St Mary s Hospital, Praed Street, London W2 1NY, UK
    J Clin Pathol 57:539-40. 2004
    ..Transfusion programmes ameliorate the symptoms of sickle cell disease but the dangers of iron overload should always be remembered...
  42. pmc Reassessment of a simple chemical method using DCIP for screening for haemoglobin E
    L Chapple
    Department of Haematology, St Mary s Hospital, Praed Street, London W2 1NY, UK
    J Clin Pathol 59:74-6. 2006
    ..A simple visual test using 2,6-dichlorophenolindophenol (DCIP) has been developed in Thailand, but its use has not become widespread. This test has now become available in kit form...
  43. doi request reprint Haemoglobin A2' and its significance in beta thalassaemia diagnosis
    D Abdel-Gadir
    Haematology, Imperial College, London, UK
    Int J Lab Hematol 31:315-9. 2009
    ..On the high-performance liquid chromatography instrument studied, haemoglobin A(2)' fell in the haemoglobin S window but its retention time differed from that of haemoglobin S...
  44. ncbi request reprint Case 34: acute leukemia in a patient with a previous history of breast cancer
    Ian H Gabriel
    Department of Haematology, St Mary s Hospital, London, UK
    Leuk Lymphoma 48:403-5. 2007
    ..A 56-year-old woman presented with acute myeloid leukemia 3 years after presenting with carcinoma of the breast. Detailed investigations led to a precise diagnosis...
  45. ncbi request reprint Cytogenetic and molecular genetic abnormalities in systemic mastocytosis
    Rajeev Gupta
    Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Acta Haematol 107:123-8. 2002
    ..c-KIT mutations may play a significant role in the biology of mast cell malignancies, although other mutations may be needed for a malignant phenotype...
  46. ncbi request reprint Teaching cases from the Royal Marsden and St Mary's Hospitals case 28: a patient with acute leukemia with rare leukemic cells of unusual morphology
    D Wrench
    Department of Haematology, St Mary s Hospital, Praed Street, London, W2 1NY, UK
    Leuk Lymphoma 45:2361-2. 2004
  47. doi request reprint Dysplastic neutrophils in an HIV-positive woman
    Barbara J Bain
    Department of Haematology, St Mary s Hospital Campus of Imperial College Faculty of Medicine, Praed Street, London, W2 1NY, United Kingdom
    Am J Hematol 83:738. 2008
  48. ncbi request reprint Teaching cases from the Royal Marsden and St Mary's Hospitals. Case 23: an unexpected finding during investigation of thrombocytopenia
    Ketan C Patel
    Department of Haematology, St Mary s Hospital, Paddington, London, UK
    Leuk Lymphoma 43:1155-7. 2002
  49. ncbi request reprint Teaching cases from the Royal Marsden and St Mary's Hospitals case 21: abnormal circulating lymphoid cells in a patient with an intestinal T-cell lymphoma associated with coeliac disease
    Chi C Wong
    Department of Haematology, St Mary s Hospital, Paddington, London, UK
    Leuk Lymphoma 43:675-7. 2002
  50. ncbi request reprint Diabetes mellitus diagnosed following request for haemoglobin electrophoresis
    Carolyn M Millar
    Department of Haematology, St Mary s Hospital, London W2 1NY, UK
    Br J Haematol 117:778. 2002
  51. doi request reprint Case 39: an elderly man with red cell aplasia
    James Uprichard
    Department of Haematology, Faculty of Medicine, St Mary s Hospital Campus of Imperial College, St Mary s Hospital, London, UK
    Leuk Lymphoma 49:1810-2. 2008
    ..An elderly man presented with a macrocytic anemia with severe reticulocytopenia. The observation of trilineage dysplasia in addition to red cell aplasia led to a diagnosis...
  52. ncbi request reprint Case 36: a difficult diagnosis in a patient with fever and progressive multi-organ failure
    Ian H Gabriel
    Department of Haematology, St Mary s Hospital, London, UK
    Leuk Lymphoma 48:1407-9. 2007
    ..A man in late middle age presented with fever, systemic symptoms, raised inflammatory markers and anaemia of chronic disease. Despite two months of investigation, the diagnosis of a haematological malignancy was made only at autopsy...
  53. ncbi request reprint Evaluation of single-tube osmotic fragility as a screening test for thalassemia
    Jason Chow
    Department of Haematology, Imperial College Faculty of Medicine at St Mary s Hospital, and Department of Haematology, St Mary s Hospital, London, England
    Am J Hematol 79:198-201. 2005
    ..The sensitivity was 95% and specificity 86%. The single-tube osmotic fragility test is potentially useful in under-resourced laboratories although it cannot replace automated red cell indices using electronic counters...
  54. ncbi request reprint Case 35: an unusual haematological neoplasm characterized by cells with cytoplasmic tails
    Shireen Kassam
    Department of Haematology, St Mary s Hospital, London, UK
    Leuk Lymphoma 48:1208-10. 2007
    ..There was bone marrow infiltration by small apparently lymphoid cells, many with cytoplasmic tails; these cells were CD56(+) and weakly CD4(+). A provisional diagnosis was confirmed by further immunophenotyping...
  55. ncbi request reprint Case 30: hypereosinophilia
    Alexandra J Marks
    Department of Haematology, St Mary s Hospital Medical School, London, UK
    Leuk Lymphoma 47:1665-6. 2006
    ..A young man presented with systemic symptoms and marked eosinophilia. Subsequently cyclical weight gain and edema contributed to a diagnosis...
  56. ncbi request reprint Case 31: Eosinophilia and pruritus
    V Jayakar
    Department of Haematology, St Mary s Hospital, London, UK
    Leuk Lymphoma 47:2404-5. 2006
    ..A 39-year-old man presented with a pruritic rash, abdominal pain, weight loss and eosinophilia. A subsequent emergency laparotomy disclosed the nature of his underlying illness and the cause of the eosinophilia...
  57. ncbi request reprint Case 32. Eosinophilia: reactive or neoplastic?
    Sarah Fletcher
    Department of Haematology, St Mary s Hospital, London, UK
    Leuk Lymphoma 48:174-6. 2007
    ..A diagnosis of eosinophilic leukemia was suspected in a patient who presented with eosinophilia and a mild macrocytic anemia and was found to have trisomy 8. Further tests and the subsequent clinical course permitted an accurate diagnosis...
  58. ncbi request reprint Increased haemoglobin A2 percentage in HIV infection: disease or treatment?
    Michelle J Wilkinson
    Department of Haematology, Imperial College Faculty of Medicine, St Mary s Hospital, London, UK
    AIDS 21:1207-8. 2007
    ..The haemoglobin A2 may be high enough to lead to a misdiagnosis of beta thalassemia trait if there is a lack of awareness of this unexpected effect of HIV infection and its treatment...
  59. ncbi request reprint Eosinophilic leukemia and idiopathic hypereosinophilic syndrome are mutually exclusive diagnoses
    Barbara J Bain
    Blood 104:3836; author reply 3836-7. 2004
  60. ncbi request reprint Adult T-biphenotypic acute leukaemia: clinical and biological features and outcomes
    Barbara J Bain
    Br J Haematol 125:94. 2004
  61. ncbi request reprint Detection and quantitation of normal and variant haemoglobins: an analytical review
    Barbara J Wild
    Department of Haematological Medicine, King s College Hospital, London SE5 9RS, UK
    Ann Clin Biochem 41:355-69. 2004
    ....
  62. ncbi request reprint Morbidity associated with bone marrow aspiration and trephine biopsy - a review of UK data for 2004
    Barbara J Bain
    Haematologica 91:1293-4. 2006
    ..The latest annual survey documented 15 adverse events, mainly hemorrhagic, among 20323 procedures...