D Azzopardi

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data
    A David Edwards
    Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London SW7 2AZ
    BMJ 340:c363. 2010
  2. doi request reprint Anticonvulsant effect of xenon on neonatal asphyxial seizures
    Denis Azzopardi
    Centre for the Developing Brain, King s College London, UK
    Arch Dis Child Fetal Neonatal Ed 98:F437-9. 2013
  3. pmc Implementation and conduct of therapeutic hypothermia for perinatal asphyxial encephalopathy in the UK--analysis of national data
    Denis Azzopardi
    Centre for the Developing Brain, Imperial College London, London, United Kingdom
    PLoS ONE 7:e38504. 2012
  4. pmc Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial
    Mary Rutherford
    Perinatal Imaging, MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Lancet Neurol 9:39-45. 2010
  5. pmc Neonatal ECMO Study of Temperature (NEST)--a randomised controlled trial
    David J Field
    Department of Heath Science, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester, UK
    BMC Pediatr 10:24. 2010
  6. doi request reprint Clinical management of the baby with hypoxic ischaemic encephalopathy
    Denis Azzopardi
    The Institute of Clinical Sciences, Hammersmith Campus, Imperial College London, United Kingdom
    Early Hum Dev 86:345-50. 2010
  7. ncbi request reprint Magnetic resonance biomarkers of neuroprotective effects in infants with hypoxic ischemic encephalopathy
    Denis Azzopardi
    Institute of Clinical Sciences, Imperial College London and MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Semin Fetal Neonatal Med 15:261-9. 2010
  8. ncbi request reprint Moderate hypothermia to treat perinatal asphyxial encephalopathy
    Denis V Azzopardi
    Division of Clinical Sciences and Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, London, United Kingdom
    N Engl J Med 361:1349-58. 2009
  9. ncbi request reprint Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial
    D Azzopardi
    Division of Clinical Sciences, Hammersmith Campus, Imperial College, London W12 0NN, UK
    Arch Dis Child Fetal Neonatal Ed 94:F260-4. 2009
  10. pmc The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial
    Dennis Azzopardi
    Division of Clinical Sciences, Faculty of Medicine, Imperial College London, UK
    BMC Pediatr 8:17. 2008

Detail Information

Publications18

  1. pmc Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data
    A David Edwards
    Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London SW7 2AZ
    BMJ 340:c363. 2010
    ..To determine whether moderate hypothermia after hypoxic-ischaemic encephalopathy in neonates improves survival and neurological outcome at 18 months of age...
  2. doi request reprint Anticonvulsant effect of xenon on neonatal asphyxial seizures
    Denis Azzopardi
    Centre for the Developing Brain, King s College London, UK
    Arch Dis Child Fetal Neonatal Ed 98:F437-9. 2013
    ..Our data show that subanaesthetic levels of xenon may have an anticonvulsant effect. Inhaled xenon may be a valuable new therapy in this hard-to-treat population...
  3. pmc Implementation and conduct of therapeutic hypothermia for perinatal asphyxial encephalopathy in the UK--analysis of national data
    Denis Azzopardi
    Centre for the Developing Brain, Imperial College London, London, United Kingdom
    PLoS ONE 7:e38504. 2012
    ..Data from the UK TOBY Cooling Register provides the opportunity to examine how one new effective therapy for newborn infants suspected of suffering asphyxial encephalopathy--therapeutic hypothermia- was implemented in the UK...
  4. pmc Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial
    Mary Rutherford
    Perinatal Imaging, MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Lancet Neurol 9:39-45. 2010
    ..To ascertain more precisely the effect of therapeutic hypothermia on neonatal cerebral injury, we assessed cerebral lesions on MRI scans of infants who participated in the Total Body Hypothermia for Neonatal Encephalopathy (TOBY) trial...
  5. pmc Neonatal ECMO Study of Temperature (NEST)--a randomised controlled trial
    David J Field
    Department of Heath Science, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester, UK
    BMC Pediatr 10:24. 2010
    ..Infants allocated to the control group will receive ECMO at 37 degrees C throughout their course, which is currently standard practice around the world. Health status of both groups will be assessed formally at 2 years corrected age...
  6. doi request reprint Clinical management of the baby with hypoxic ischaemic encephalopathy
    Denis Azzopardi
    The Institute of Clinical Sciences, Hammersmith Campus, Imperial College London, United Kingdom
    Early Hum Dev 86:345-50. 2010
    ..This article is a summary of the in hospital clinical management of infants with hypoxic ischaemic encephalopathy...
  7. ncbi request reprint Magnetic resonance biomarkers of neuroprotective effects in infants with hypoxic ischemic encephalopathy
    Denis Azzopardi
    Institute of Clinical Sciences, Imperial College London and MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Semin Fetal Neonatal Med 15:261-9. 2010
    ..Standardisation of scanning protocols and data analysis between different scanners is essential...
  8. ncbi request reprint Moderate hypothermia to treat perinatal asphyxial encephalopathy
    Denis V Azzopardi
    Division of Clinical Sciences and Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, London, United Kingdom
    N Engl J Med 361:1349-58. 2009
    ..Whether hypothermic therapy improves neurodevelopmental outcomes in newborn infants with asphyxial encephalopathy is uncertain...
  9. ncbi request reprint Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial
    D Azzopardi
    Division of Clinical Sciences, Hammersmith Campus, Imperial College, London W12 0NN, UK
    Arch Dis Child Fetal Neonatal Ed 94:F260-4. 2009
    ..The registry was established on completion of enrolLment to the TOBY randomised trial of treatment with whole body hypothermia following perinatal asphyxia at the end of November 2006...
  10. pmc The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial
    Dennis Azzopardi
    Division of Clinical Sciences, Faculty of Medicine, Imperial College London, UK
    BMC Pediatr 8:17. 2008
    ..5 degrees C have been reported. No complications were noted but the group sizes were too small to evaluate benefit...
  11. ncbi request reprint Hypothermia
    D Azzopardi
    Division of Clinical Sciences, Department of Medicine, Hammersmith Campus, Imperial College, DuCane Road, London, UK
    Semin Fetal Neonatal Med 12:303-10. 2007
    ....
  12. ncbi request reprint Combined use of electroencephalogram and magnetic resonance imaging in full-term neonates with acute encephalopathy
    E Biagioni
    Department of Paediatrics and Neonatal Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Pediatrics 107:461-8. 2001
    ..When the MRI showed moderate abnormalities, the EEG in all cases but one identified patients with normal and abnormal outcome.EEG, MRI, HIE, neurodevelopment...
  13. ncbi request reprint Pilot study of treatment with whole body hypothermia for neonatal encephalopathy
    D Azzopardi
    Department of Paediatrics, Imperial College School of Medicine, London, United Kingdom
    Pediatrics 106:684-94. 2000
    ..However, clinical studies have been delayed by the difficulty in predicting long-term outcome very soon after birth and by concern about adverse effects of hypothermia...
  14. ncbi request reprint Prediction of neurological outcome after birth asphyxia from early continuous two-channel electroencephalography
    D Azzopardi
    Department of Paediatrics and Neonatal Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Early Hum Dev 55:113-23. 1999
    ..To determine whether two-channel continuous electroencephalography (EEG) applied within 12 h of birth can predict the severity of neurological complications and neurodevelopmental outcome following birth asphyxia...
  15. ncbi request reprint Noninvasive characterization of neonatal adipose tissue by 13C magnetic resonance spectroscopy
    E L Thomas
    Robert Steiner MRI Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Lipids 32:645-51. 1997
    ..Our results demonstrate that 13C MRS can be utilized to assess noninvasively neonatal adipose tissue lipid composition and to monitor the effects of developmental changes due to gestational age and oral feeding...
  16. ncbi request reprint Maturation of cerebral electrical activity and development of cortical folding in young very preterm infants
    E Biagioni
    Department of Paediatrics, Imperial College Hammersmith Hospital, London, UK
    Clin Neurophysiol 118:53-9. 2007
    ..The aim of this study was to examine the relationship between cortical development and cerebral electrical activity at early gestational ages...
  17. ncbi request reprint Comparison of findings on cranial ultrasound and magnetic resonance imaging in preterm infants
    E F Maalouf
    Department of Paediatrics, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Pediatrics 107:719-27. 2001
    ..In addition, normal WM echogenicity on US is not a good predictor of normal WM signal intensity on MRI...