Stefan D Anker

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 86:123-30. 2002
  2. ncbi request reprint Statin use and survival in patients with chronic heart failure--results from two observational studies with 5200 patients
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 112:234-42. 2006
  3. ncbi request reprint Cardiac cachexia
    Stefan D Anker
    Department of Clinical Cardiology National Heart and Lung Institute, Imperial College London, UK
    Ann Med 36:518-29. 2004
  4. pmc Inflammatory mediators in chronic heart failure: an overview
    Stefan D Anker
    Department of Clinical Cardiology, Imperial College School of Medicine, National Heart and Lung Institute, London, UK
    Heart 90:464-70. 2004
  5. ncbi request reprint Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Lancet 361:1077-83. 2003
  6. ncbi request reprint Effect of anemia on exercise tolerance in chronic heart failure in men
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, London, United Kingdom
    Am J Cardiol 91:888-91. 2003
  7. ncbi request reprint Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity
    Constantinos H Davos
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    J Card Fail 9:29-35. 2003
  8. ncbi request reprint Cellular endotoxin desensitization in patients with severe chronic heart failure
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Heart Fail 7:865-8. 2005
  9. doi request reprint Mid-regional pro-adrenomedullin as a novel predictor of mortality in patients with chronic heart failure
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charité Medical School Campus Virchow Klinikum, 13353 Berlin, Germany
    Eur J Heart Fail 12:484-91. 2010
  10. ncbi request reprint The relationship between age and production of tumour necrosis factor-alpha in healthy volunteers and patients with chronic heart failure
    Stephan von Haehling
    Department of Clinical Cardiology, National Heart and Lung Institute, London SW3 6LY, UK
    Int J Cardiol 90:197-204. 2003

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. ncbi request reprint How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 86:123-30. 2002
    ..During follow-up, compared to placebo the hazard to reach this endpoint was similar in the medium dose group (RR 0.80, 95%CI 0.22-2.99), but increased in the high dose group (RR 2.84, 95%CI 1.01-7.97, p<0.05)...
  2. ncbi request reprint Statin use and survival in patients with chronic heart failure--results from two observational studies with 5200 patients
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 112:234-42. 2006
    ..Treatment with statins may lead to a lower mortality in CHF, independent of cholesterol levels, CHF etiology and clinical status...
  3. ncbi request reprint Cardiac cachexia
    Stefan D Anker
    Department of Clinical Cardiology National Heart and Lung Institute, Imperial College London, UK
    Ann Med 36:518-29. 2004
    ..The available evidence suggests that cardiac cachexia is a multifactorial neuroendocrine and metabolic disorder with a poor prognosis. A complex imbalance of different body systems may cause the development of body wasting...
  4. pmc Inflammatory mediators in chronic heart failure: an overview
    Stefan D Anker
    Department of Clinical Cardiology, Imperial College School of Medicine, National Heart and Lung Institute, London, UK
    Heart 90:464-70. 2004
  5. ncbi request reprint Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Lancet 361:1077-83. 2003
    ..We aimed to assess the frequency of weight loss in patients with this disease, whether the degree of weight loss predicts mortality, and whether weight loss can be prevented by angiotensin-converting-enzyme (ACE) inhibitors...
  6. ncbi request reprint Effect of anemia on exercise tolerance in chronic heart failure in men
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, London, United Kingdom
    Am J Cardiol 91:888-91. 2003
  7. ncbi request reprint Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity
    Constantinos H Davos
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    J Card Fail 9:29-35. 2003
    ..Cachexia in chronic heart failure carries a poor prognosis, but little is known about the influence of body mass on the prognosis of noncachectic heart failure patients...
  8. ncbi request reprint Cellular endotoxin desensitization in patients with severe chronic heart failure
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Heart Fail 7:865-8. 2005
    ..It is not known if LPS desensitization occurs in CHF...
  9. doi request reprint Mid-regional pro-adrenomedullin as a novel predictor of mortality in patients with chronic heart failure
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charité Medical School Campus Virchow Klinikum, 13353 Berlin, Germany
    Eur J Heart Fail 12:484-91. 2010
    ..Adrenomedullin (ADM) is a vasodilatory peptide. Its plasma levels or its precursors have not been evaluated in large populations of patients with chronic heart failure (CHF). We sought to explore mid-regional proADM (MR-proADM)...
  10. ncbi request reprint The relationship between age and production of tumour necrosis factor-alpha in healthy volunteers and patients with chronic heart failure
    Stephan von Haehling
    Department of Clinical Cardiology, National Heart and Lung Institute, London SW3 6LY, UK
    Int J Cardiol 90:197-204. 2003
    ..Elevated plasma levels of tumour necrosis factor-alpha (TNF-alpha) are present in patients with advanced chronic heart failure (CHF). However, the relationship between age and the immune response in CHF is unknown...
  11. ncbi request reprint Heat shock protein 70 in patients with chronic heart failure: relation to disease severity and survival
    Sabine Genth-Zotz
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Int J Cardiol 96:397-401. 2004
    ..We hypothesised that circulating Hsp70 levels are elevated in patients with CHF, more so in cachechtic patients, and that Hsp70 levels would relate to mortality...
  12. ncbi request reprint Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging
    Stefan D Anker
    Applied Cachexia Research Unit, Charite, Campus Virchow Klinikum, Berlin, Germany
    Circulation 107:1991-7. 2003
    ..Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF)...
  13. ncbi request reprint Elevated circulating levels of inflammatory cytokines and bacterial endotoxin in adults with congenital heart disease
    Rakesh Sharma
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Am J Cardiol 92:188-93. 2003
    ..Congenital heart disease in adults may be amenable to novel anti-inflammatory therapies in selected patients...
  14. doi request reprint Impact of remote telemedical management on mortality and hospitalizations in ambulatory patients with chronic heart failure: the telemedical interventional monitoring in heart failure study
    Friedrich Koehler
    Department of Cardiology and Angiology and Center for Cardiovascular Telemedicine, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Circulation 123:1873-80. 2011
    ..This study was designed to determine whether physician-led remote telemedical management (RTM) compared with usual care would result in reduced mortality in ambulatory patients with chronic heart failure (HF)...
  15. ncbi request reprint Whole blood endotoxin responsiveness in patients with chronic heart failure: the importance of serum lipoproteins
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, Dovehouse Street, SW3 6LY, London, UK
    Eur J Heart Fail 7:479-84. 2005
    ..We sought to investigate the relationship between whole blood endotoxin responsiveness and serum lipoprotein concentrations. It is not known if low-dose LPS is sufficient to stimulate immune activation...
  16. doi request reprint Assessment of serum cotinine in patients with chronic heart failure: self-reported versus objective smoking behaviour
    Nicole Ebner
    Department of Cardiology, Applied Cachexia Research, Charite Medical School, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Clin Res Cardiol 102:95-101. 2013
    ..The value of self-reported smoking behaviour has not been validated in patients with HF. We sought to assess serum cotinine levels, a marker of recent tobacco exposure, in a cohort of clinically stable patients with chronic HF...
  17. ncbi request reprint Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors
    Stephan von Haehling
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Cardiol 95:885-9. 2005
    ..This study demonstrated that noradrenaline and isoproterenol inhibit TNF-alpha production in patients with CHF in ex vivo whole blood in a dose-dependent fashion. The beta-blocker bisoprolol abolishes this effect...
  18. doi request reprint Mechanism and novel therapeutic approaches to wasting in chronic disease
    Nicole Ebner
    Applied Cachexia Research, Department of Cardiology, Charite University, Medical School, Campus Virchow Klinikum, Berlin, Germany
    Maturitas 75:199-206. 2013
    ..We discuss therapeutic targets and such potential modulators as appetite stimulants, selective androgen receptor modulators, amino acids and naturally occurring peptide hormones...
  19. doi request reprint Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia
    Jochen Springer
    Department of Cardiology, Applied Cachexia Research, Charite Medical School, Berlin, Germany
    Int J Cancer 131:2187-96. 2012
    ..Food intake and spontaneous locomotor activity were higher, indicating a higher quality of life. Inhibition of XO can reduce tissue wasting and improve survival in cancer cachexia and clearly clinical studies are needed...
  20. ncbi request reprint The relationship between cholesterol and survival in patients with chronic heart failure
    Mathias Rauchhaus
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    J Am Coll Cardiol 42:1933-40. 2003
    ..We sought to describe the relationship between cholesterol and survival in patients with chronic heart failure (CHF)...
  21. doi request reprint The effects of bilateral lung transplantation on ventilatory efficiency, oxygen uptake and the right heart: a two-yr follow-up
    Dirk Habedank
    Department of Cardiology, Charite University Medicine Berlin, Campus Virchow, Germany
    Clin Transplant 25:E38-45. 2011
    ....
  22. ncbi request reprint Cardiac cachexia: a systematic overview
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Pharmacol Ther 121:227-52. 2009
    ..Other drug classes of interest comprise angiotensin-converting enzyme inhibitors, beta-blockers, anabolic steroids, beta-adrenergic agonists, anti-inflammatory substances, statins, thalidomide, proteasome inhibitors, and pentoxifylline...
  23. doi request reprint Reduced glucose transporter GLUT4 in skeletal muscle predicts insulin resistance in non-diabetic chronic heart failure patients independently of body composition
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 138:19-24. 2010
    ..GLUT4, the predominant glucose transporter in the skeletal muscle promotes the rate-limiting step of glucose utilization in skeletal muscle. The significance of skeletal muscle GLUT4 in patients with CHF has not been studied in detail...
  24. doi request reprint Anaemia is an independent predictor of death in patients hospitalized for acute heart failure
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Clin Res Cardiol 99:107-13. 2010
    ..Acute heart failure is associated with a poor prognosis. It is important to identify patients at increased risk of adverse events. The presence of anaemia could help in this regard...
  25. ncbi request reprint Heart transplantation in heart failure: the prognostic importance of body mass index at time of surgery and subsequent weight changes
    Andrew L Clark
    Department of Cardiology, Univerity of Hull, and Department of Cardiac Surgery, Royal Brompton Hospital, London, UK
    Eur J Heart Fail 9:839-44. 2007
    ..We studied the effect of body mass index (BMI), and the effect of subsequent weight change, on survival following transplantation in 1902 consecutive patients...
  26. pmc Rationale and design of Ferinject assessment in patients with IRon deficiency and chronic Heart Failure (FAIR-HF) study: a randomized, placebo-controlled study of intravenous iron supplementation in patients with and without anaemia
    Stefan D Anker
    Department of Cardiology, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin D 13353, Germany
    Eur J Heart Fail 11:1084-91. 2009
    ..gov NCT00520780) was designed to determine the effect of i.v. iron repletion therapy using ferric carboxymaltose on self-reported patient global assessment (PGA) and New York Heart Association (NYHA) in patients with CHF and ID...
  27. ncbi request reprint Haemoglobin predicts survival in patients with chronic heart failure: a substudy of the ELITE II trial
    Rakesh Sharma
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London SW3 6LY, UK
    Eur Heart J 25:1021-8. 2004
    ..We aimed to investigate the relationship between the concentration of haemoglobin and survival in CHF...
  28. ncbi request reprint Increased catabolic activity in adipose tissue of patients with chronic heart failure
    Tibor Szabo
    Charite University Medicine, Campus Virchow Klinikum, Department of Cardiology, Applied Cachexia Research, Berlin, Germany
    Eur J Heart Fail 15:1131-7. 2013
    ..We tested the hypothesis that increased plasma ANP levels are associated with an increased catabolic (lipolytic) state of white AT in patients with CHF...
  29. pmc Leukocyte redistribution: effects of beta blockers in patients with chronic heart failure
    Stephan von Haehling
    Applied Cachexia Research, Dept of Cardiology, Charite Medical School, Campus Virchow Clinic, Berlin, Germany
    PLoS ONE 4:e6411. 2009
    ..Here we investigate whether a leukocyte redistribution occurs in CHF and whether this effect is influenced by beta-blocker therapy...
  30. doi request reprint Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure
    Anja Sandek
    Dept of Cardiology, Charite Universitatsmedizin, Berlin, Germany
    Int J Cardiol 157:80-5. 2012
    ..Small intestinal function may be altered in decompensated chronic heart failure (CHF) and translocating LPS may contribute to systemic inflammation observed in CHF...
  31. doi request reprint The relationship between tumor necrosis factor-α, brain natriuretic peptide and atrial natriuretic peptide in patients with chronic heart failure
    Amalia Vaz Pérez
    Competence Network Heart Failure, Department of Cardiology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Cardiol 141:39-43. 2010
    ..Brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) are thought to reflect cardiac functional and structural damage...
  32. ncbi request reprint Uric acid in chronic heart failure
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Humboldt University, D 13353 Berlin, Germany
    Semin Nephrol 25:61-6. 2005
    ..In this article, the significance of the xanthine oxidase metabolic pathway in CHF is discussed. Data on xanthine oxidase inhibition are reviewed, which suggest a beneficial effect of therapeutically targeting this enzymatic pathway...
  33. ncbi request reprint Biomarkers for chronic heart failure
    Mitja Lainscak
    Division of Applied Cachexia Research, Department of Cardiology, Campus Virchow Clinic, Charite Universitatsmedizin Berlin, Berlin, Germany
    Heart Fail Monit 5:77-82. 2007
    ..Lastly, we anticipate the potential of biomarkers in a variety of chronic diseases with similar pathophysiology...
  34. doi request reprint Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial
    Darlington O Okonko
    Clinical Cardiology, NHLI, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 51:103-12. 2008
    ..We tested the hypothesis that intravenous iron improves exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure (CHF) and iron deficiency...
  35. doi request reprint Anaemia among patients with heart failure and preserved or reduced ejection fraction: results from the SENIORS study
    Stephan von Haehling
    Department of Cardiology, Applied Cachexia Research, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Eur J Heart Fail 13:656-63. 2011
    ..In addition, we sought to study the effects of nebivolol on the development of anaemia...
  36. ncbi request reprint Cardiac cachexia is associated with right ventricular failure and liver dysfunction
    Miroslava Valentová
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany 1st Department of Internal Medicine, Faculty Hospital, Bratislava, Slovak Republic Electronic address
    Int J Cardiol 169:219-24. 2013
    ..The mechanisms involved in cardiac cachexia remain poorly understood. We examined the association of right ventricular (RV) and hepatic dysfunction with cardiac cachexia...
  37. ncbi request reprint Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia
    Sandra Palus
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany Center for Cardiovascular Research, Charite Medical School, Berlin, Germany
    Int J Cardiol 168:3412-8. 2013
    ..Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC...
  38. ncbi request reprint The anti-CD14 antibody IC14 suppresses ex vivo endotoxin stimulated tumor necrosis factor-alpha in patients with chronic heart failure
    Sabine Genth-Zotz
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Eur J Heart Fail 8:366-72. 2006
    ..Plasma LPS activity is elevated in patients with severe chronic heart failure (CHF). An anti-CD14 antibody, IC14, blocks TNF production in healthy volunteers. It is not known whether IC14 prevents TNF production in CHF patients...
  39. ncbi request reprint Hormonal consequences and prognosis of chronic heart failure
    Philipp Attanasio
    Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Curr Opin Endocrinol Diabetes Obes 18:224-30. 2011
    ..This review aims to highlight players of the catabolic-anabolic imbalance, regulators or appetite, and other mediators that are involved in the progression of CHF to cachexia...
  40. ncbi request reprint Neurohormonal activation and inflammation in chronic cardiopulmonary disease: a brief systematic review
    Wolfram Doehner
    Center for Stroke Research Berlin, Charite, Berlin, Germany
    Wien Klin Wochenschr 121:293-6. 2009
    ..Retrospective and epidemiological data for their beneficial effect in chronic obstructive pulmonary disease begin to accumulate and new fields (e.g. cancer and stroke) could be pending in the future...
  41. ncbi request reprint Exercise hyperventilation in chronic heart failure is not caused by systemic lactic acidosis
    Roland Wensel
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    Eur J Heart Fail 7:1105-11. 2005
    ..Patients with heart failure have an abnormally high ventilatory response to exercise associated with gas exchange defects and reduced arterial pCO(2)...
  42. ncbi request reprint Comparison of midregional pro-atrial natriuretic peptide with N-terminal pro-B-type natriuretic peptide in predicting survival in patients with chronic heart failure
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany
    J Am Coll Cardiol 50:1973-80. 2007
    ..Our aim was assess the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) using a new immunoassay in patients with chronic heart failure (HF)...
  43. ncbi request reprint Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Am Coll Cardiol 46:1019-26. 2005
    ..The aim of this study was to determine the significance of insulin resistance as an independent risk factor for impaired prognosis in patients with chronic heart failure (CHF)...
  44. ncbi request reprint Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure
    Gabor Foldes
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Int J Cardiol 124:80-5. 2008
    ..Innate immune activation mediated by myocardial Toll-like receptors (TLRs) is involved in cardiovascular disease. The function and role of TLRs on peripheral leukocytes in human chronic heart failure (CHF) are not known...
  45. ncbi request reprint Association of deranged adrenal steroid metabolism with anemia in chronic heart failure
    Darlington O Okonko
    Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, UK
    Am J Cardiol 96:101-3. 2005
    ..The cortisol/DHEA ratio was independently and inversely associated with hemoglobin concentrations, suggesting that alterations of the steroid milieu may play a role in the pathogenesis of anemia in CHF...
  46. doi request reprint Usefulness of minimal modelling to assess impaired insulin sensitivity in patients with chronic heart failure
    Tibor Szabo
    Applied Cachexia Research, Department of Cardiology, Campus Virchow Klinikum, Charite University Medical School, Berlin, Germany
    Int J Cardiol 147:47-51. 2011
    ..Their value and discriminatory power in comparison to dynamic range assessment of Si by minimal modelling are not well established...
  47. ncbi request reprint Pathophysiologic quantities of endotoxin-induced tumor necrosis factor-alpha release in whole blood from patients with chronic heart failure
    Sabine Genth-Zotz
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Cardiol 90:1226-30. 2002
    ..These results suggest that elevated plasma endotoxin activity observed in patients with HF is of pathophysiologic relevance...
  48. doi request reprint Ferric carboxymaltose in patients with heart failure and iron deficiency
    Stefan D Anker
    Department of Cardiology, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin
    N Engl J Med 361:2436-48. 2009
    ....
  49. ncbi request reprint The cardiac component of cardiac cachexia
    Viorel G Florea
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Heart J 144:45-50. 2002
    ..This study sought to assess the cardiac dimensions, mass, and function and changes in these parameters over time in patients with chronic heart failure with and without cachexia...
  50. doi request reprint Anemia in heart failure: an overview of current concepts
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Future Cardiol 7:119-29. 2011
    ..Finally, this article describes the potential costs incurred by treating anemic patients with heart failure...
  51. ncbi request reprint Furosemide induces mortality in a rat model of chronic heart failure
    Hirofumi Rokutan
    Center for Cardiovascular Research, Charite Medical School, Campus Mitte, Berlin, Germany
    Int J Cardiol 160:20-5. 2012
    ..In an experimental heart failure model, we tested the hypothesis that furosemide causes excess mortality...
  52. ncbi request reprint Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF)
    Susann Fülster
    Department of Cardiology, Applied Cachexia Research, Charite Medical School, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Eur Heart J 34:512-9. 2013
    ..To assess the prevalence and clinical impact of reductions in the skeletal muscle mass of patients with chronic heart failure (HF). Chronic HF is accompanied by co-morbidities that influence the quality of life and outcomes...
  53. doi request reprint Anemia in chronic heart failure: can we treat? What to treat?
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, 13353 Berlin, Germany
    Heart Fail Rev 17:203-10. 2012
    ..The RED-HF study will show whether use of darbepoetin alfa in anemic patients with chronic HF will reduce the combined endpoint of death for any reason or hospitalization for heart failure...
  54. pmc Ghrelin and its analogues, BIM-28131 and BIM-28125, improve body weight and regulate the expression of MuRF-1 and MAFbx in a rat heart failure model
    Sandra Palus
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany
    PLoS ONE 6:e26865. 2011
    ..The GHS-1a-receptor is not only found in the brain, but also in other tissues, including the myocardium. Human clinical trials with native ghrelin in cardiac cachexia demonstrated increases in appetite, weight and cardiac output...
  55. doi request reprint Role of iron deficiency and anemia in cardio-renal syndromes
    Philipp Attanasio
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Semin Nephrol 32:57-62. 2012
    ..This article summarizes studies investigating the influence of iron deficiency with or without anemia in chronic kidney disease and CHF and gives an overview of preparations of intravenous iron currently available...
  56. doi request reprint Ursodeoxycholic acid in patients with chronic heart failure: a double-blind, randomized, placebo-controlled, crossover trial
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    J Am Coll Cardiol 59:585-92. 2012
    ..This study sought to assess the effects of ursodeoxycholic acid (UDCA) on endothelial function and inflammatory markers in patients with chronic heart failure (CHF)...
  57. doi request reprint Reversibility of cachexia after bilateral lung transplantation
    Dirk Habedank
    Department of Cardiology, Division of Applied Cachexia Research, Charite Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 133:46-50. 2009
    ....
  58. ncbi request reprint Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Eur Heart J 28:821-8. 2007
    ....
  59. ncbi request reprint Anorexia in chronic obstructive pulmonary disease--association to cachexia and hormonal derangement
    Friedrich Koehler
    Department of Cardiology, Charite University Hospital, Campus Mitte, Berlin, Germany
    Int J Cardiol 119:83-9. 2007
    ..Anorexia may importantly contribute to weight loss in COPD, however, the association between immune and hormonal derangement and altered appetite has not been studied in detail...
  60. doi request reprint The emerging role of the gut in chronic heart failure
    Anja Sandek
    Applied Cachexia Research, Department of Cardiology, Campus Virchow Klinikum, Charite, Berlin, Germany
    Curr Opin Clin Nutr Metab Care 11:632-9. 2008
    ..Circulating cytokines act as cardiosuppressors. Their plasma levels predict increased mortality in chronic heart failure...
  61. doi request reprint No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure
    Yoshihiro J Akashi
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany
    Int J Cardiol 137:267-75. 2009
    ..Ghrelin, was observed to have treatment-potential for severe chronic heart failure (CHF) and cardiac cachexia based on anti-cachectic and cardio-protective effects...
  62. doi request reprint Exercise capacity and body composition in living-donor renal transplant recipients over time
    Dirk Habedank
    Department Cardiology, Applied Cachexia Research, Charite Campus Virchow Klinikum, Berlin, Germany
    Nephrol Dial Transplant 24:3854-60. 2009
    ..Renal transplantation (RTx) restitutes the function of the failing organ and induces convalescence of the entire organism. Our study investigates whether this is accompanied by improvements in cardiovascular function and structural changes...
  63. ncbi request reprint Studies on intragastric PCO2 at rest and during exercise as a marker of intestinal perfusion in patients with chronic heart failure
    Andreas Krack
    Department of Cardiology, Friedrich Schiller University, Erlanger Allee 101, D 07740, Jena, Germany
    Eur J Heart Fail 6:403-7. 2004
    ..In CHF inflammatory immune activation is hypothesized to result from a chronic endotoxin challenge due to bacterial translocation of hypoperfused intestinal mucosa...
  64. ncbi request reprint Clinical characteristics and survival of patients with chronic heart failure and prolonged QRS duration
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Int J Cardiol 86:225-31. 2002
    ..Whilst resynchronisation of ventricular conduction may benefit patients with QRS>150 ms, this has yet to be determined for patients with moderate QRS prolongation...
  65. pmc Value of serum pregnancy-associated plasma protein A for predicting cardiovascular events among patients presenting with cardiac chest pain
    Stephan von Haehling
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    CMAJ 185:E295-303. 2013
    ..We assessed the value of PAPP-A for predicting short-term cardiovascular events in a large cohort of patients presenting with cardiac chest pain...
  66. doi request reprint Absolute and functional iron deficiency in professional athletes during training and recovery
    Simon Reinke
    Division of Applied Cachexia Research, Department of Cardiology, Charite Universitatsmedizin Berlin, Germany
    Int J Cardiol 156:186-91. 2012
    ..We hypothesised that physical extremes result in ID in elite athletes and that the short recovery period may be insufficient to allow a lasting replenishment of iron reserves...
  67. ncbi request reprint Inflammatory biomarkers in heart failure revisited: much more than innocent bystanders
    Stephan von Haehling
    Department of Cardiology, Applied Cachexia Research, Charite Medical School, Berlin, Germany
    Heart Fail Clin 5:549-60. 2009
    ..In addition to these acute phase reactants, several adhesion molecules, and lipopolysaccharide-signaling pathways are discussed...
  68. doi request reprint Nutrition in heart failure: an update
    Anja Sandek
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany
    Curr Opin Clin Nutr Metab Care 12:384-91. 2009
    ..Chronic heart failure (CHF) is increasingly recognized as a multisystem disease with important comorbidities such as anemia, insulin resistance, autonomic dysbalance, or cardiac cachexia...
  69. ncbi request reprint Natriuretic peptides and other biomarkers in chronic heart failure: from BNP, NT-proBNP, and MR-proANP to routine biochemical markers
    Mitja Lainscak
    Department of Cardiology, Division of Applied Cachexia Research, Campus Virchow Clinic, Charite Universitatsmedizin Berlin, Germany
    Int J Cardiol 132:303-11. 2009
    ..Finally, we speculate about the potential of sharing the biomarkers over a variety of chronic diseases with similar pathophysiology...
  70. ncbi request reprint The gut and intestinal bacteria in chronic heart failure
    Anja Sandek
    Applied Cachexia Research, Department of Cardiology, Campus Virchow Klinikum, Charite Medical School, Augustenburger Platz 1, 13353 Berlin, Germany
    Curr Drug Metab 10:22-8. 2009
    ..Therefore, the gut poses an interesting target for therapeutic interventions in patients with CHF...
  71. ncbi request reprint Prognosis and therapy approaches of cardiac cachexia
    Jochen Springer
    Division of Applied Cachexia Research, Center for Cardiovascular Research, Charite Campus Mitte, Berlin, Germany
    Curr Opin Cardiol 21:229-33. 2006
    ..This review focuses on the prognostic implications and therapeutic approaches in cardiac cachexia - a syndrome that has been recognized for a long time, although it has only received increased attention lately...
  72. ncbi request reprint Atrial natriuretic peptide and related peptides
    Yoshihiro J Akashi
    Division of Applied Cachexia Research, Center for Cardiovascular Research, Charite Campus Mitte, Berlin, Germany
    Clin Chem Lab Med 45:1259-67. 2007
    ..This article summarizes existing data on ANP and related peptides in cardiovascular and other disorders, and outlines the potential clinical usefulness of these markers...
  73. ncbi request reprint Changes in exercise capacity, ventilation, and body weight following heart transplantation
    Dirk Habedank
    Division of Applied Cachexia Research, Department of Cardiology, Charite Campus Virchow Klinikum, Berlin, Germany
    Eur J Heart Fail 9:310-6. 2007
    ..Our study prospectively examined changes in these parameters over 24 months following heart transplantation (HTx) and evaluated the potentially confounding effects of weight gain...
  74. ncbi request reprint Effect of interleukin-10 on the production of tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with chronic heart failure
    Aidan P Bolger
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Cardiol 90:384-9. 2002
    ..IL-10 is, therefore, a potential therapy for use in chronic HF associated with inflammatory immune activation...
  75. ncbi request reprint Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS)
    Marcus D Flather
    Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust, London, UK
    Eur Heart J 26:215-25. 2005
    ..The SENIORS study was performed to assess effects of the beta-blocker, nebivolol, in patients >/=70 years, regardless of ejection fraction...
  76. ncbi request reprint Nutrition, metabolism, and the complex pathophysiology of cachexia in chronic heart failure
    Stephan von Haehling
    Department of Clinical Cardiology, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Cardiovasc Res 73:298-309. 2007
    ..Finally, therapeutic approaches are discussed. These include dietary advice, ongoing studies, and future possibilities...
  77. ncbi request reprint Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY, UK
    Int J Cardiol 83:73-81. 2002
    ..The purpose of this study was to examine in patients with CHF and in comparison to healthy controls subjects whether norepinephrine, TNFalpha or leptin relate to insulin sensitivity...
  78. ncbi request reprint Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies
    Wolfram Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 105:2619-24. 2002
    ..We therefore studied the effects of XO inhibition with allopurinol on endothelial function and peripheral blood flow in CHF patients after intra-arterial infusion and after oral administration in 2 independent placebo-controlled studies...
  79. ncbi request reprint Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease
    Aidan P Bolger
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    Circulation 106:92-9. 2002
    ....
  80. ncbi request reprint Metabolic and immunologic derangements in cardiac cachexia: where to from here?
    Sabine Strassburg
    Dept of Cardiology, Applied Cachexia Research, Charite, Campus Virchow Klinikum, Berlin, Germany
    Heart Fail Rev 11:57-64. 2006
    ..Many further investigations are needed to find out more about the pathophysiological pathways, to confirm the previous results, and to evaluate new therapeutics...
  81. ncbi request reprint Statins and the role of nitric oxide in chronic heart failure
    Stephan von Haehling
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College, School of Medicine, London, UK
    Heart Fail Rev 8:99-106. 2003
    ..The doses needed to achieve the desired effects might be much lower than those needed to treat hypercholesterolemia...
  82. ncbi request reprint Reduced peripheral skeletal muscle mass and abnormal reflex physiology in chronic heart failure
    Massimo F Piepoli
    Heart Failure Unit, Cardiology, Guglielmo da Saliceto Polichirurgico Hospital, Cantone del Cristo, Piacenza, 29100, Italy
    Circulation 114:126-34. 2006
    ....
  83. ncbi request reprint Cytokines, apoptosis and cachexia: the potential for TNF antagonism
    Rakesh Sharma
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Int J Cardiol 85:161-71. 2002
    ..Although this review will concentrate predominantly on the syndrome of CHF, other chronic illnesses such as liver disease, cancer, and sepsis will also be discussed...
  84. doi request reprint How does cachexia influence survival in cancer, heart failure and other chronic diseases?
    Mitja Lainscak
    Division of Applied Cachexia Research, Department of Cardiology, Campus Virchow Clinic, Charite Universitatsmedizin Berlin, Berlin, Germany
    Curr Opin Support Palliat Care 1:299-305. 2007
    ..Ultimately, cachexia may develop in 10-15% of patients, who usually perish soon after. We currently have neither a globally accepted definition of cachexia nor any treatment to prevent or treat cachexia...
  85. ncbi request reprint Muscle wasting in cardiac cachexia
    Sabine Strassburg
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Int J Biochem Cell Biol 37:1938-47. 2005
    ..As there is no validated therapy for cardiac cachexia yet, further research is necessary to find more therapeutic options for the wasting process...
  86. ncbi request reprint Statins: a treatment option for chronic heart failure?
    Stephan von Haehling
    National Heart and Lung Institute, Department of Clinical Cardiology, Imperial College School of Medicine, London, UK
    Heart Fail Monit 4:90-7. 2004
    ..It is therefore tempting to speculate that low doses of statins still confer pleiotropic effects without lowering plasma cholesterol levels...
  87. ncbi request reprint Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension
    Christian F Opitz
    Department of Cardiology, DRK Kliniken Berlin Westend, Spandauer Damm 130, 14050 Berlin, Germany
    Eur Heart J 26:1895-902. 2005
    ..To describe the long-term clinical efficacy of inhaled iloprost as first-line vasodilator mono-therapy in patients with idiopathic pulmonary arterial hypertension (IPAH)...
  88. ncbi request reprint Tumour necrosis factor-alpha and the failing heart--pathophysiology and therapeutic implications
    Stephan von Haehling
    Imperial College School of Medicine, National Heart and Lung Institute, Department of Clinical Cardiology, London, UK
    Basic Res Cardiol 99:18-28. 2004
    ..Nevertheless, TNFalpha antagonism remains a major target of CHF therapy, although counterbalancing this cytokine alone may not be sufficient...
  89. ncbi request reprint Immune and neurohormonal pathways in chronic heart failure
    Rakesh Sharma
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Congest Heart Fail 8:23-8, 48. 2002
    ..In the future, it may not be enough to monitor cardiac function alone. Rather, the immune and neurohormonal status of patients may also need to be included in the performance of a complete assessment...
  90. ncbi request reprint Cachexia in chronic heart failure: prognostic implications and novel therapeutic approaches
    Yoshihiro J Akashi
    Division of Applied Cachexia Research, Department of Cardiology, Charite Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Curr Heart Fail Rep 2:198-203. 2005
    ..However, further research will be necessary to identify the exact pathways involved and to find the best therapeutic strategies of using ghrelin to fight the wasting process...
  91. ncbi request reprint Beta-blocker therapy for dynamic left-ventricular outflow tract obstruction
    Faisal Al-Nasser
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Int J Cardiol 86:199-205. 2002
    ..The aim of our study was to investigate the effect of beta-blockade on ventricular physiology and symptoms in patients with DLVOTO...
  92. doi request reprint Weight loss and mortality risk in patients with chronic heart failure in the candesartan in heart failure: assessment of reduction in mortality and morbidity (CHARM) programme
    Stuart J Pocock
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, UK
    Eur Heart J 29:2641-50. 2008
    ....
  93. doi request reprint Overview of emerging pharmacotherapy in chronic heart failure
    Tibor Szabo
    Charite Medical School, Campus Virchow Klinikum, Applied Cachexia Research, Department of Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
    Expert Opin Pharmacother 10:2055-74. 2009
    ..This review will focus on recent developments and potential future candidates of pharmacological CHF therapy...
  94. ncbi request reprint The syndrome of cardiac cachexia
    Stefan D Anker
    Franz Volhard Klinik Charité, Campus Berlin Buch at Max Delbrück Centrum for Molecular Medicine, Berlin, Germany
    Int J Cardiol 85:51-66. 2002
    ..It is hoped that a better understanding of the pathophysiological mechanisms involved in cardiac cachexia will lead to novel therapeutic strategies in the (near) future...
  95. ncbi request reprint Future prospects of anticytokine therapy in chronic heart failure
    Stephan von Haehling
    Imperial College School of Medicine, Department of Clinical Cardiology, NationalHeart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Expert Opin Investig Drugs 14:163-76. 2005
    ....
  96. ncbi request reprint Cardiac cachexia in early literature: a review of research prior to Medline
    Wolfram Doehner
    Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Int J Cardiol 85:7-14. 2002
    ..This review presents an overview of early thoughts and milestone studies on metabolic abnormalities and cachexia in chronic heart failure...
  97. ncbi request reprint Anemia in chronic heart failure--clinical and prognostic significance
    T Karhausen
    Div of Applied Cachexia Research, Dept of Cardiology, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Curr Med Chem Cardiovasc Hematol Agents 3:297-303. 2005
    ..The option of therapeutically targeting anemia in CHF is an intriguing novel approach to improve morbidity and potentially mortality in these patients...
  98. ncbi request reprint Pathophysiology of peripheral muscle wasting in cardiac cachexia
    Gerasimos S Filippatos
    2nd University Department of Cardiology, Atticon University Hospital, Athens, Greece
    Curr Opin Clin Nutr Metab Care 8:249-54. 2005
    ..This manuscript looks at current developments concerning the pathophysiology of skeletal muscle wasting in cardiac cachexia...
  99. ncbi request reprint The Seattle Heart Failure Model: prediction of survival in heart failure
    Wayne C Levy
    University of Washington, Seattle, WA 98177, USA
    Circulation 113:1424-33. 2006
    ....
  100. ncbi request reprint Effect of darbepoetin alfa on exercise tolerance in anemic patients with symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled trial
    Piotr Ponikowski
    Cardiac Department, Military Hospital, Wroclaw, Poland
    J Am Coll Cardiol 49:753-62. 2007
    ..This study sought to investigate whether darbepoetin alfa, an erythropoiesis-stimulating protein (ESP), improves exercise capacity in patients with symptomatic chronic heart failure (CHF) and anemia...
  101. ncbi request reprint Uric acid in CHF: marker or player in a metabolic disease?
    Wolfram Doehner
    Int J Cardiol 115:156-8. 2007