S D Anker

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Wasting as independent risk factor for mortality in chronic heart failure
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London
    Lancet 349:1050-3. 1997
  2. ncbi request reprint How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 86:123-30. 2002
  3. ncbi request reprint Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging
    Stefan D Anker
    Applied Cachexia Research Unit, Charite, Campus Virchow Klinikum, Berlin, Germany
    Circulation 107:1991-7. 2003
  4. ncbi request reprint Acquired growth hormone resistance in patients with chronic heart failure: implications for therapy with growth hormone
    S D Anker
    Franz Volhard Klinik, Max Delbrück Centrum for Molecular Medicine, Charite, Berlin, Germany
    J Am Coll Cardiol 38:443-52. 2001
  5. ncbi request reprint The syndrome of cardiac cachexia
    Stefan D Anker
    Franz Volhard Klinik Charité, Campus Berlin Buch at Max Delbrück Centrum for Molecular Medicine, Berlin, Germany
    Int J Cardiol 85:51-66. 2002
  6. ncbi request reprint Heart failure as a metabolic problem
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Eur J Heart Fail 1:127-31. 1999
  7. ncbi request reprint Cardiac cachexia: a syndrome with impaired survival and immune and neuroendocrine activation
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Chest 115:836-47. 1999
  8. ncbi request reprint Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia
    S D Anker
    Cardiac Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 96:526-34. 1997
  9. ncbi request reprint Insights into the pathogenesis of chronic heart failure: immune activation and cachexia
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Curr Opin Cardiol 14:211-6. 1999
  10. ncbi request reprint Tumour necrosis factor alpha as a predictor of impaired peak leg blood flow in patients with chronic heart failure
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College, London, UK
    QJM 91:199-203. 1998

Collaborators

Detail Information

Publications98

  1. ncbi request reprint Wasting as independent risk factor for mortality in chronic heart failure
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London
    Lancet 349:1050-3. 1997
    ..Wasting in chronic heart failure (CHF) has long been known but is little investigated. We sought to find out whether the cachectic state in CHF provides additional prognostic information about all-cause mortality...
  2. ncbi request reprint How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 86:123-30. 2002
    ..During follow-up, compared to placebo the hazard to reach this endpoint was similar in the medium dose group (RR 0.80, 95%CI 0.22-2.99), but increased in the high dose group (RR 2.84, 95%CI 1.01-7.97, p<0.05)...
  3. ncbi request reprint Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging
    Stefan D Anker
    Applied Cachexia Research Unit, Charite, Campus Virchow Klinikum, Berlin, Germany
    Circulation 107:1991-7. 2003
    ..Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF)...
  4. ncbi request reprint Acquired growth hormone resistance in patients with chronic heart failure: implications for therapy with growth hormone
    S D Anker
    Franz Volhard Klinik, Max Delbrück Centrum for Molecular Medicine, Charite, Berlin, Germany
    J Am Coll Cardiol 38:443-52. 2001
    ..We aimed to determine whether growth hormone (GH) resistance is present in patients with chronic heart failure (CHF) and whether it may be linked to the biochemical response to GH treatment...
  5. ncbi request reprint The syndrome of cardiac cachexia
    Stefan D Anker
    Franz Volhard Klinik Charité, Campus Berlin Buch at Max Delbrück Centrum for Molecular Medicine, Berlin, Germany
    Int J Cardiol 85:51-66. 2002
    ..It is hoped that a better understanding of the pathophysiological mechanisms involved in cardiac cachexia will lead to novel therapeutic strategies in the (near) future...
  6. ncbi request reprint Heart failure as a metabolic problem
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Eur J Heart Fail 1:127-31. 1999
    ..Joint efforts of cardiologists, endocrinologists, and immunologists are required to develop therapeutic strategies able to improve the metabolic status of CHF patients...
  7. ncbi request reprint Cardiac cachexia: a syndrome with impaired survival and immune and neuroendocrine activation
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Chest 115:836-47. 1999
    ..The available evidence suggests that cardiac cachexia is a multifactorial neuroendocrine and metabolic disorder with a poor prognosis. A complex imbalance of different body systems may cause the development of body wasting...
  8. ncbi request reprint Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia
    S D Anker
    Cardiac Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 96:526-34. 1997
    ..The role of hormonal and cytokine abnormalities in the development of cardiac cachexia remains obscure...
  9. ncbi request reprint Insights into the pathogenesis of chronic heart failure: immune activation and cachexia
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Curr Opin Cardiol 14:211-6. 1999
    ..A complex catabolic-anabolic imbalance in different body systems may cause body wasting in patients with CHF...
  10. ncbi request reprint Tumour necrosis factor alpha as a predictor of impaired peak leg blood flow in patients with chronic heart failure
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College, London, UK
    QJM 91:199-203. 1998
    ..This study shows a close and inverse relationship between peak leg blood flow and the plasma concentration of TNF alpha, suggesting a pathophysiological role for TNF alpha in reducing peak peripheral blood flow in CHF...
  11. ncbi request reprint Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia
    W Doehner
    Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Endocrinol 145:727-35. 2001
    ..This study aimed to examine the influence of leptin on GHBP in CHF patients with and without cardiac cachexia compared with healthy control subjects...
  12. ncbi request reprint Plasma cytokine parameters and mortality in patients with chronic heart failure
    M Rauchhaus
    Clinical Cardiology, National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Circulation 102:3060-7. 2000
    ..Little is known about the prognostic importance of tumor necrosis factor-alpha (TNF-alpha), soluble TNF-receptor 1 and 2 (sTNF-R1/sTNF-R2), interleukin-6 (IL-6), and soluble CD14 receptors (sCD14) in CHF patients...
  13. ncbi request reprint Peripheral chemoreceptor hypersensitivity: an ominous sign in patients with chronic heart failure
    P Ponikowski
    Clinical Cardiology, NHLI, London, UK
    Circulation 104:544-9. 2001
    ..We studied whether augmented peripheral chemosensitivity carries independent prognostic significance...
  14. ncbi request reprint Uric acid in cachectic and noncachectic patients with chronic heart failure: relationship to leg vascular resistance
    W Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Am Heart J 141:792-9. 2001
    ..We aimed to study the relationship between serum uric acid levels and leg vascular resistance in patients with CHF with and without cachexia and in healthy control subjects...
  15. ncbi request reprint Enhanced ventilatory response to exercise in patients with chronic heart failure and preserved exercise tolerance: marker of abnormal cardiorespiratory reflex control and predictor of poor prognosis
    P Ponikowski
    Cardiac Medicine Department, Imperial College, National Heart and Lung Institute, London, UK
    Circulation 103:967-72. 2001
    ..CONCLUSIONS: In CHF patients with preserved exercise capacity, enhanced ventilatory response to exercise is a simple marker of a widespread derangement of cardiovascular reflex control; it predicts poor prognosis, which VO(2) does not...
  16. ncbi request reprint Chronic heart failure in the very elderly: clinical status, survival, and prognostic factors in 188 patients more than 70 years old
    M Cicoira
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Heart J 142:174-80. 2001
    ..There are no data on the prognostic value of cardiopulmonary exercise testing in this population. We aimed to assess exercise capacity, survival, and prognostic parameters in elderly patients with CHF...
  17. ncbi request reprint Intraventricular conduction delay: a prognostic marker in chronic heart failure
    W Shamim
    Royal Brompton Hospital and National Heart and Lung Institute, Cardiac Medicine Department, London, UK
    Int J Cardiol 70:171-8. 1999
    ..We have found that IVCD is an important ECG predictor of prognosis in patients with CHF...
  18. doi request reprint Elevated levels of asymmetric dimethylarginine in chronic heart failure: a pathophysiologic link between oxygen radical load and impaired vasodilator capacity and the therapeutic effect of allopurinol
    S von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Clin Pharmacol Ther 88:506-12. 2010
    ..02); postischemic vasodilation as well as endothelium-dependent vasodilation (both P < 0.05) improved. ADMA may be a pathophysiologic factor that is modulated by ROS accumulation and contributes to impaired vascular regulation in CHF...
  19. pmc Loss of the normal coupling between the anaerobic threshold and insulin sensitivity in chronic heart failure
    F Leyva
    Department of Cardiac Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London SW3, UK
    Heart 82:348-51. 1999
    ....
  20. ncbi request reprint Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy
    K J Osterziel
    Franz Volhard Klinik am Max Delbrück Centrum für Molekulare Medizin, Charite, Humboldt Universitat zu Berlin, Germany
    Lancet 351:1233-7. 1998
    ..We did a double-blind, randomised, placebo-controlled study of rhGH in patients with chronic heart failure due to dilated cardiomyopathy...
  21. ncbi request reprint High tumour necrosis factor-alpha levels are associated with exercise intolerance and neurohormonal activation in chronic heart failure patients
    M Cicoira
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Cytokine 15:80-6. 2001
    ..In CHF patients only the highest levels of TNF are associated with poor functional status and neurohormonal activation. This group of patients may represent the appropriate target population for TNF antagonism...
  22. ncbi request reprint Inflammatory cytokines and the possible immunological role for lipoproteins in chronic heart failure
    M Rauchhaus
    Department of Clinical Cardiology, Imperial College School of Medicine at the National Heart and Lung Institute, London, UK
    Int J Cardiol 76:125-33. 2000
    ....
  23. ncbi request reprint Non-invasive assessment of vascular function; paradoxical vascular response to intravenous glucose in coronary heart disease
    F Leyva
    Department of Cardiac Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, U K
    Eur Heart J 21:39-44. 2000
    ....
  24. ncbi request reprint Relation of changes over time in ventricular size and function to those in exercise capacity in patients with chronic heart failure
    V G Florea
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Heart J 139:913-7. 2000
    ..We studied the direction and magnitude of changes in left ventricular (LV) cavity size and mass over time and whether these changes were related to those in exercise performance in patients with chronic heart failure (CHF)...
  25. ncbi request reprint Three year mortality in heart failure patients with very low left ventricular ejection fractions
    J Niebauer
    Department of Cardiac Medicine, National Heart and Lung Institute, London, UK
    Int J Cardiol 70:245-7. 1999
    ..Left ventricular ejection fraction is a predictor of the outcome in patients with chronic heart failure. Some treatments cause a small increase in ejection fraction and may, thereby, improve prognosis...
  26. pmc Wasting as an independent predictor of mortality in patients with cystic fibrosis
    R Sharma
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London SW3 6LY, UK
    Thorax 56:746-50. 2001
    ..CONCLUSIONS: Body wasting is a significant predictor of survival in patients with CF independent of lung function, arterial blood oxygen and carbon dioxide tensions...
  27. ncbi request reprint Superiority of endothelin-1 over norepinephrine in exercise-induced alterations of the conduit artery tone of the non-exercised arm in patients with chronic heart failure
    M Yousufuddin
    Divisions of Cardiac Medicine and Biochemistry, National Heart and Lung Institute and Royal Brompton Hospital, London, UK
    Int J Cardiol 73:15-25. 2000
    ..These findings suggest that endothelin-1 is potentially more important than norepinephrine in contributing exercise-induced brachial artery constriction in patients with chronic heart failure...
  28. doi request reprint ESPEN Guidelines on Parenteral Nutrition: on cardiology and pneumology
    S D Anker
    Department of Cardiology, Charite Universitatsmedizin, Berlin, Germany
    Clin Nutr 28:455-60. 2009
    ....
  29. ncbi request reprint Pyrexia, procalcitonin, immune activation and survival in cardiogenic shock: the potential importance of bacterial translocation
    F M Brunkhorst
    Krankenhaus Zehlendorf, Department of Internal Medicine, Berlin, Germany
    Int J Cardiol 72:3-10. 1999
    ..It is known that blood procalcitonin rises in response to bacterial endotoxin exposure...
  30. doi request reprint Impaired insulin sensitivity as an underlying mechanism linking hepatitis C and posttransplant diabetes mellitus in kidney recipients
    S Baid-Agrawal
    Division of Nephrology and Medical Intensive Care, Department of Medicine, Berlin, Germany
    Am J Transplant 9:2777-84. 2009
    ....
  31. ncbi request reprint Anemia in chronic heart failure--frequency and prognostic impact
    W Steinborn
    Imperial College, NHLI, Department of Clinical Cardiology, London, UK
    Clin Nephrol 60:S103-7. 2003
    ..However, the anemia seen in CHF is generally an "anemia of chronic illness". Furthermore, it has been shown that hemoglobin levels independently predict increased mortality in CHF...
  32. ncbi request reprint The importance of tumor necrosis factor and lipoproteins in the pathogenesis of chronic heart failure
    R Sharma
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Heart Fail Monit 2:42-7. 2001
    ..The factors that influence endotoxin responsiveness in patients with CHF, in particular the potential importance of serum lipoproteins, will be discussed in this review...
  33. ncbi request reprint The endotoxin-lipoprotein hypothesis
    M Rauchhaus
    Department of Clinical Cardiology, National Heart and Lung Institute, London, UK
    Lancet 356:930-3. 2000
    ..We also propose that, in patients with CHF, a non-lipid-lowering statin (with ancillary properties such as immune modulatory and anti-inflammatory actions) could be as effective or even more beneficial than a lipid-lowering statin...
  34. ncbi request reprint Optimizing insulin sensitivity assessment using the minimal model in chronic heart failure
    W Doehner
    Applied Cachexia Research, Dept of Cardiology, Charite Medical School, Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Horm Metab Res 37:106-10. 2005
    ..Continuing experience in minimal model methodology has raised questions about how best to assign basal glucose concentrations during such analyses...
  35. ncbi request reprint [Tumor necrosis factor alpha in chronic heart failure. Clinical manifestation and therapeutic possibilities]
    S Genth-Zotz
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Herz 26:437-46. 2001
    ..Therapies directed against this cytokine might therefore represent a novel approach to heart failure management...
  36. doi request reprint Ferric carboxymaltose in patients with heart failure and iron deficiency
    Stefan D Anker
    Department of Cardiology, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin
    N Engl J Med 361:2436-48. 2009
    ....
  37. doi request reprint ADQI 7: the clinical management of the Cardio-Renal syndromes: work group statements from the 7th ADQI consensus conference
    A Davenport
    UCL Center for Nephrology, University College London Medical School, London, UK
    Nephrol Dial Transplant 25:2077-89. 2010
    ..We have therefore reviewed the currently available published literature to outline a consensus of current best clinical practice for these patients...
  38. ncbi request reprint ESPEN Guidelines on Enteral Nutrition: Cardiology and pulmonology
    S D Anker
    Division of Applied Cachexia Research, Department of Cardiology, Charite Universitatsmedizin Berlin, CVK, Berlin, Germany
    Clin Nutr 25:311-8. 2006
    ..Frequent small amounts of ONS are preferred in order to avoid postprandial dyspnoea and satiety as well as to improve compliance...
  39. ncbi request reprint Cachexia: a therapeutic approach beyond cytokine antagonism
    S von Haehling
    Department of Clinical Cardiology, National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Int J Cardiol 85:173-83. 2002
    ..The role of other approaches such as proteasome-inhibitors remains to be elucidated. Alternatively, interleukin-10 and other immunosuppressive cytokines may also be able to counterbalance certain features of cachexia...
  40. ncbi request reprint The impact of new onset anaemia on morbidity and mortality in chronic heart failure: results from COMET
    Michel Komajda
    Institut de Cardiologie, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, 47 83 bld de l Hôpital, Paris, France
    Eur Heart J 27:1440-6. 2006
    ..Anaemia is a common comorbidity in chronic heart failure (CHF). The predictors of new onset anaemia (NOA) and its long-term prognostic value, particularly in patients treated with beta-blockers, are not known...
  41. ncbi request reprint The significance of 123I-BMIPP delayed scintigraphic imaging in cardiac patients
    Yoshihiro J Akashi
    Department of Cardiology, St Marianna University Yokohama City Seibu Hospital, 1197 1 Yasashi cho Asahi district, Yokohama City, Kanagawa Prefecture, 241 0811, Japan
    Int J Cardiol 117:145-51. 2007
    ..Earlier studies have not fully investigated the significance of radionuclide planar imaging in cardiac patients using the fatty acid analogue 123I-beta-methyl-iodophenylpentadecanoic acid (123I-BMIPP)...
  42. ncbi request reprint Whole blood endotoxin responsiveness in patients with chronic heart failure: the importance of serum lipoproteins
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, Dovehouse Street, SW3 6LY, London, UK
    Eur J Heart Fail 7:479-84. 2005
    ..We sought to investigate the relationship between whole blood endotoxin responsiveness and serum lipoprotein concentrations. It is not known if low-dose LPS is sufficient to stimulate immune activation...
  43. ncbi request reprint Association of deranged adrenal steroid metabolism with anemia in chronic heart failure
    Darlington O Okonko
    Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, UK
    Am J Cardiol 96:101-3. 2005
    ..The cortisol/DHEA ratio was independently and inversely associated with hemoglobin concentrations, suggesting that alterations of the steroid milieu may play a role in the pathogenesis of anemia in CHF...
  44. ncbi request reprint The Seattle Heart Failure Model: prediction of survival in heart failure
    Wayne C Levy
    University of Washington, Seattle, WA 98177, USA
    Circulation 113:1424-33. 2006
    ....
  45. ncbi request reprint Changes in exercise capacity, ventilation, and body weight following heart transplantation
    Dirk Habedank
    Division of Applied Cachexia Research, Department of Cardiology, Charite Campus Virchow Klinikum, Berlin, Germany
    Eur J Heart Fail 9:310-6. 2007
    ..Our study prospectively examined changes in these parameters over 24 months following heart transplantation (HTx) and evaluated the potentially confounding effects of weight gain...
  46. ncbi request reprint Anemia in chronic heart failure--clinical and prognostic significance
    T Karhausen
    Div of Applied Cachexia Research, Dept of Cardiology, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Curr Med Chem Cardiovasc Hematol Agents 3:297-303. 2005
    ..The option of therapeutically targeting anemia in CHF is an intriguing novel approach to improve morbidity and potentially mortality in these patients...
  47. ncbi request reprint Prevalence of anemia in chronic obstructive pulmonary disease: comparison to other chronic diseases
    Matthias John
    Department of Pneumology Campus Mitte, Universitätsmedizin Charité, Schumannstr 20 21, 10098 Berlin, Germany
    Int J Cardiol 111:365-70. 2006
    ..The high prevalence of anemia in hospitalised COPD patients that were treated mostly for exacerbations gives evidence that anemia is also a comorbidity in COPD and may contribute to exercise limitation and dyspnoea...
  48. ncbi request reprint Cellular endotoxin desensitization in patients with severe chronic heart failure
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Heart Fail 7:865-8. 2005
    ..It is not known if LPS desensitization occurs in CHF...
  49. ncbi request reprint The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure
    Klaus K A Witte
    Department of Academic Cardiology, Castle Hill Hospital, Castle Road, Cottingham, Hull HU16 5JQ, UK
    Eur Heart J 26:2238-44. 2005
    ..Therefore, we examined the influence of long-term multiple micronutrient supplementation on left ventricular (LV) function, levels of pro-inflammatory cytokines, and quality-of-life (QoL) in elderly patients with CHF...
  50. ncbi request reprint The importance of the gastrointestinal system in the pathogenesis of heart failure
    Andreas Krack
    Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur Heart J 26:2368-74. 2005
    ..It is hoped that by improving our understanding of the role of the gut in cardiac disease will lead to the development of novel therapeutic strategies in the future...
  51. ncbi request reprint Prognosis and therapy approaches of cardiac cachexia
    Jochen Springer
    Division of Applied Cachexia Research, Center for Cardiovascular Research, Charite Campus Mitte, Berlin, Germany
    Curr Opin Cardiol 21:229-33. 2006
    ..This review focuses on the prognostic implications and therapeutic approaches in cardiac cachexia - a syndrome that has been recognized for a long time, although it has only received increased attention lately...
  52. ncbi request reprint Statin use and survival in patients with chronic heart failure--results from two observational studies with 5200 patients
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 112:234-42. 2006
    ..Treatment with statins may lead to a lower mortality in CHF, independent of cholesterol levels, CHF etiology and clinical status...
  53. doi request reprint Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial
    Darlington O Okonko
    Clinical Cardiology, NHLI, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 51:103-12. 2008
    ..We tested the hypothesis that intravenous iron improves exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure (CHF) and iron deficiency...
  54. ncbi request reprint Comparison of midregional pro-atrial natriuretic peptide with N-terminal pro-B-type natriuretic peptide in predicting survival in patients with chronic heart failure
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany
    J Am Coll Cardiol 50:1973-80. 2007
    ..Our aim was assess the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) using a new immunoassay in patients with chronic heart failure (HF)...
  55. ncbi request reprint Prognostic utility of growth differentiation factor-15 in patients with chronic heart failure
    Tibor Kempf
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    J Am Coll Cardiol 50:1054-60. 2007
    ..We explored the prognostic utility of growth differentiation factor (GDF)-15 in patients with chronic heart failure (CHF)...
  56. ncbi request reprint Excessive ventilation during early phase of exercise: a new predictor of poor long-term outcome in patients with chronic heart failure
    Ewa A Jankowska
    Cardiology Department, Military Hospital, Weigla 5, 50 981 Wroclaw, Poland
    Eur J Heart Fail 9:1024-31. 2007
    ..Whether ventilatory response to early phase of exercise is useful for risk stratification in CHF is unknown...
  57. ncbi request reprint Atrial natriuretic peptide and related peptides
    Yoshihiro J Akashi
    Division of Applied Cachexia Research, Center for Cardiovascular Research, Charite Campus Mitte, Berlin, Germany
    Clin Chem Lab Med 45:1259-67. 2007
    ..This article summarizes existing data on ANP and related peptides in cardiovascular and other disorders, and outlines the potential clinical usefulness of these markers...
  58. ncbi request reprint Prediction of mode of death in heart failure: the Seattle Heart Failure Model
    Dariush Mozaffarian
    Harvard Medical School and Harvard School of Public Health, Boston, Mass, USA
    Circulation 116:392-8. 2007
    ..Prediction of mode of death may facilitate decisions about specific medications or devices...
  59. ncbi request reprint Heart transplantation in heart failure: the prognostic importance of body mass index at time of surgery and subsequent weight changes
    Andrew L Clark
    Department of Cardiology, Univerity of Hull, and Department of Cardiac Surgery, Royal Brompton Hospital, London, UK
    Eur J Heart Fail 9:839-44. 2007
    ..We studied the effect of body mass index (BMI), and the effect of subsequent weight change, on survival following transplantation in 1902 consecutive patients...
  60. ncbi request reprint Biomarkers for chronic heart failure
    Mitja Lainscak
    Division of Applied Cachexia Research, Department of Cardiology, Campus Virchow Clinic, Charite Universitatsmedizin Berlin, Berlin, Germany
    Heart Fail Monit 5:77-82. 2007
    ..Lastly, we anticipate the potential of biomarkers in a variety of chronic diseases with similar pathophysiology...
  61. ncbi request reprint Uric acid as a prognostic marker in acute heart failure--new expectations from an old molecule
    Wolfram Doehner
    Eur J Heart Fail 9:437-9. 2007
  62. ncbi request reprint Effect of darbepoetin alfa on exercise tolerance in anemic patients with symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled trial
    Piotr Ponikowski
    Cardiac Department, Military Hospital, Wroclaw, Poland
    J Am Coll Cardiol 49:753-62. 2007
    ..This study sought to investigate whether darbepoetin alfa, an erythropoiesis-stimulating protein (ESP), improves exercise capacity in patients with symptomatic chronic heart failure (CHF) and anemia...
  63. ncbi request reprint Anorexia in chronic obstructive pulmonary disease--association to cachexia and hormonal derangement
    Friedrich Koehler
    Department of Cardiology, Charite University Hospital, Campus Mitte, Berlin, Germany
    Int J Cardiol 119:83-9. 2007
    ..Anorexia may importantly contribute to weight loss in COPD, however, the association between immune and hormonal derangement and altered appetite has not been studied in detail...
  64. ncbi request reprint Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival
    Ewa A Jankowska
    Cardiology Department, Military Hospital, ul Weigla 5, 50 981 Wroclaw, Poland
    Circulation 114:1829-37. 2006
    ....
  65. ncbi request reprint Neurohumoral activation as a link to systemic manifestations of chronic lung disease
    Stefan Andreas
    Department of Cardiology and Pneumology, Georg August University, Gottingen, Germany
    Chest 128:3618-24. 2005
    ..Currently, little is known about the effect of treatments directed at neurohumoral activation and COPD. As this aspect of COPD becomes better understood, new insights may direct novel therapeutic approaches...
  66. ncbi request reprint Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension
    Christian F Opitz
    Department of Cardiology, DRK Kliniken Berlin Westend, Spandauer Damm 130, 14050 Berlin, Germany
    Eur Heart J 26:1895-902. 2005
    ..To describe the long-term clinical efficacy of inhaled iloprost as first-line vasodilator mono-therapy in patients with idiopathic pulmonary arterial hypertension (IPAH)...
  67. ncbi request reprint Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors
    Stephan von Haehling
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Cardiol 95:885-9. 2005
    ..This study demonstrated that noradrenaline and isoproterenol inhibit TNF-alpha production in patients with CHF in ex vivo whole blood in a dose-dependent fashion. The beta-blocker bisoprolol abolishes this effect...
  68. ncbi request reprint Effect of anemia on exercise tolerance in chronic heart failure in men
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, London, United Kingdom
    Am J Cardiol 91:888-91. 2003
  69. ncbi request reprint Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity
    Constantinos H Davos
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    J Card Fail 9:29-35. 2003
    ..Cachexia in chronic heart failure carries a poor prognosis, but little is known about the influence of body mass on the prognosis of noncachectic heart failure patients...
  70. ncbi request reprint Myocardial production of C-type natriuretic peptide in chronic heart failure
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, London, UK
    Circulation 107:571-3. 2003
    ..We assessed the hypothesis that CNP is produced by the heart in patients with CHF...
  71. ncbi request reprint Pathophysiologic quantities of endotoxin-induced tumor necrosis factor-alpha release in whole blood from patients with chronic heart failure
    Sabine Genth-Zotz
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Cardiol 90:1226-30. 2002
    ..These results suggest that elevated plasma endotoxin activity observed in patients with HF is of pathophysiologic relevance...
  72. ncbi request reprint Clinical characteristics and survival of patients with chronic heart failure and prolonged QRS duration
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Int J Cardiol 86:225-31. 2002
    ..Whilst resynchronisation of ventricular conduction may benefit patients with QRS>150 ms, this has yet to be determined for patients with moderate QRS prolongation...
  73. ncbi request reprint Cytokines, apoptosis and cachexia: the potential for TNF antagonism
    Rakesh Sharma
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Int J Cardiol 85:161-71. 2002
    ..Although this review will concentrate predominantly on the syndrome of CHF, other chronic illnesses such as liver disease, cancer, and sepsis will also be discussed...
  74. ncbi request reprint Cardiac cachexia in early literature: a review of research prior to Medline
    Wolfram Doehner
    Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Int J Cardiol 85:7-14. 2002
    ..This review presents an overview of early thoughts and milestone studies on metabolic abnormalities and cachexia in chronic heart failure...
  75. ncbi request reprint Effect of interleukin-10 on the production of tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with chronic heart failure
    Aidan P Bolger
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Cardiol 90:384-9. 2002
    ..IL-10 is, therefore, a potential therapy for use in chronic HF associated with inflammatory immune activation...
  76. ncbi request reprint Assessment of survival in patients with primary pulmonary hypertension: importance of cardiopulmonary exercise testing
    Roland Wensel
    Department of Cardiothoracic Surgery, Deutsches Herzzentrum Berlin, Germany
    Circulation 106:319-24. 2002
    ..Prognostic assessment is an important factor in determining medical treatment and lung transplantation. Whether cardiopulmonary exercise testing data predict survival has not been reported previously...
  77. ncbi request reprint The cardiac component of cardiac cachexia
    Viorel G Florea
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Heart J 144:45-50. 2002
    ..This study sought to assess the cardiac dimensions, mass, and function and changes in these parameters over time in patients with chronic heart failure with and without cachexia...
  78. ncbi request reprint Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease
    Aidan P Bolger
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    Circulation 106:92-9. 2002
    ....
  79. ncbi request reprint The regulation and measurement of plasma volume in heart failure
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, London, United Kingdom
    J Am Coll Cardiol 39:1901-8. 2002
    ..Further studies evaluating plasma volume in HF may help to improve our understanding of the pathophysiologic mechanisms occurring in the development and progression of this complex condition...
  80. ncbi request reprint Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies
    Wolfram Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 105:2619-24. 2002
    ..We therefore studied the effects of XO inhibition with allopurinol on endothelial function and peripheral blood flow in CHF patients after intra-arterial infusion and after oral administration in 2 independent placebo-controlled studies...
  81. ncbi request reprint Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY, UK
    Int J Cardiol 83:73-81. 2002
    ..The purpose of this study was to examine in patients with CHF and in comparison to healthy controls subjects whether norepinephrine, TNFalpha or leptin relate to insulin sensitivity...
  82. ncbi request reprint Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Lancet 361:1077-83. 2003
    ..We aimed to assess the frequency of weight loss in patients with this disease, whether the degree of weight loss predicts mortality, and whether weight loss can be prevented by angiotensin-converting-enzyme (ACE) inhibitors...
  83. ncbi request reprint Effect of carvedilol on exercise tolerance in patients with chronic heart failure and a restrictive left ventricular filling pattern
    Faisal Al-Nasser
    Clinical Cardiology Department, Royal Brompton Hospital, London, United Kingdom
    Am J Cardiol 91:1281-3. 2003
  84. ncbi request reprint Uric acid in chronic heart failure
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Humboldt University, D 13353 Berlin, Germany
    Semin Nephrol 25:61-6. 2005
    ..In this article, the significance of the xanthine oxidase metabolic pathway in CHF is discussed. Data on xanthine oxidase inhibition are reviewed, which suggest a beneficial effect of therapeutically targeting this enzymatic pathway...
  85. ncbi request reprint Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS)
    Marcus D Flather
    Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust, London, UK
    Eur Heart J 26:215-25. 2005
    ..The SENIORS study was performed to assess effects of the beta-blocker, nebivolol, in patients >/=70 years, regardless of ejection fraction...
  86. ncbi request reprint Prediction of mortality in chronic heart failure from peak oxygen consumption adjusted for either body weight or lean tissue
    Mariantonietta Cicoira
    Divisione Clinicizzata di Cardiologia, Universita degli Studi di Verona, Italy
    J Card Fail 10:421-6. 2004
    ..We hypothesized that correcting pVO2 for lean tissue rather than total body weight would improve the prediction of prognosis in patients with chronic heart failure (CHF)...
  87. ncbi request reprint Prognostic impact of plasma N-terminal pro-brain natriuretic peptide in severe chronic congestive heart failure: a substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial
    Franz Hartmann
    Medizinische Klinik II, Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Circulation 110:1780-6. 2004
    ....
  88. ncbi request reprint Heat shock protein 70 in patients with chronic heart failure: relation to disease severity and survival
    Sabine Genth-Zotz
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Int J Cardiol 96:397-401. 2004
    ..We hypothesised that circulating Hsp70 levels are elevated in patients with CHF, more so in cachechtic patients, and that Hsp70 levels would relate to mortality...
  89. ncbi request reprint Haemoglobin predicts survival in patients with chronic heart failure: a substudy of the ELITE II trial
    Rakesh Sharma
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London SW3 6LY, UK
    Eur Heart J 25:1021-8. 2004
    ..We aimed to investigate the relationship between the concentration of haemoglobin and survival in CHF...
  90. ncbi request reprint Selective intestinal decontamination in advanced chronic heart failure: a pilot trial
    Viviane M Conraads
    Department of Cardiology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium
    Eur J Heart Fail 6:483-91. 2004
    ....
  91. ncbi request reprint Studies on intragastric PCO2 at rest and during exercise as a marker of intestinal perfusion in patients with chronic heart failure
    Andreas Krack
    Department of Cardiology, Friedrich Schiller University, Erlanger Allee 101, D 07740, Jena, Germany
    Eur J Heart Fail 6:403-7. 2004
    ..In CHF inflammatory immune activation is hypothesized to result from a chronic endotoxin challenge due to bacterial translocation of hypoperfused intestinal mucosa...
  92. pmc Inflammatory mediators in chronic heart failure: an overview
    Stefan D Anker
    Department of Clinical Cardiology, Imperial College School of Medicine, National Heart and Lung Institute, London, UK
    Heart 90:464-70. 2004
  93. ncbi request reprint The relationship between cholesterol and survival in patients with chronic heart failure
    Mathias Rauchhaus
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    J Am Coll Cardiol 42:1933-40. 2003
    ..We sought to describe the relationship between cholesterol and survival in patients with chronic heart failure (CHF)...
  94. ncbi request reprint Invasive assessment of bacterial endotoxin and inflammatory cytokines in patients with acute heart failure
    Thomas Peschel
    Herzzentrum der Universitat Leipzig, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Heart Fail 5:609-14. 2003
    ..To test the hypothesis that during acute heart failure endotoxin might be increased in hepatic veins as a sign of bacterial or endotoxin translocation from the bowel into the blood stream...
  95. ncbi request reprint The relationship between age and production of tumour necrosis factor-alpha in healthy volunteers and patients with chronic heart failure
    Stephan von Haehling
    Department of Clinical Cardiology, National Heart and Lung Institute, London SW3 6LY, UK
    Int J Cardiol 90:197-204. 2003
    ..Elevated plasma levels of tumour necrosis factor-alpha (TNF-alpha) are present in patients with advanced chronic heart failure (CHF). However, the relationship between age and the immune response in CHF is unknown...
  96. ncbi request reprint Elevated circulating levels of inflammatory cytokines and bacterial endotoxin in adults with congenital heart disease
    Rakesh Sharma
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Am J Cardiol 92:188-93. 2003
    ..Congenital heart disease in adults may be amenable to novel anti-inflammatory therapies in selected patients...
  97. ncbi request reprint Studies on apoptosis and fibrosis in skeletal musculature: a comparison of heart failure patients with and without cardiac cachexia
    Gerasimos S Filippatos
    Second Department of Cardiology, Evangelismos General Hospital, 28 Doukissis Plakentias street, 115 23, Athens, Greece
    Int J Cardiol 90:107-13. 2003
    ....
  98. ncbi request reprint Immune and neurohormonal pathways in chronic heart failure
    Rakesh Sharma
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Congest Heart Fail 8:23-8, 48. 2002
    ..In the future, it may not be enough to monitor cardiac function alone. Rather, the immune and neurohormonal status of patients may also need to be included in the performance of a complete assessment...