Praveen Anand

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
    Iain P Chessell
    Pain Research, N and GI CEDD, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK
    Pain 114:386-96. 2005
  2. pmc COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
    Yiangos Yiangou
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    BMC Neurol 6:12. 2006
  3. pmc Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves
    Christoph Scheiermann
    National Heart and Lung Institute, Imperial College London, London, UK
    Science 318:1472-5. 2007
  4. doi request reprint Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury
    Praveen Anand
    Peripheral Neuropathy Unit, Hammersmith Hospital, Imperial College, London, UK
    Eur J Pain 15:1040-8. 2011
  5. pmc Influence of pregnancy and labor on the occurrence of nerve fibers expressing the capsaicin receptor TRPV1 in human corpus and cervix uteri
    Berith K Tingaker
    Karolinska Institutet, Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Reprod Biol Endocrinol 6:8. 2008
  6. pmc Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons
    Uma Anand
    Histopathology Unit, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC1A 3PX, UK
    Mol Pain 6:82. 2010
  7. ncbi request reprint Neurotrophic factors and their receptors in human sensory neuropathies
    Praveen Anand
    Department of Neurology, Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Prog Brain Res 146:477-92. 2004
  8. doi request reprint Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons
    Uma Anand
    Peripheral Neuropathy Unit, Department of Clinical Neuroscience, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W120NN, UK
    Pain 138:667-80. 2008
  9. pmc Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked pain
    Katherine Roberts
    Imperial College Healthcare NHS Trust, London, UK
    BMC Anesthesiol 8:8. 2008
  10. doi request reprint Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
    Praveen Anand
    Imperial College London, UK
    Brain Res Rev 60:255-66. 2009

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
    Iain P Chessell
    Pain Research, N and GI CEDD, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK
    Pain 114:386-96. 2005
    ..Drugs which block this target may have the potential to deliver broad-spectrum analgesia...
  2. pmc COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
    Yiangos Yiangou
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    BMC Neurol 6:12. 2006
    ..Therefore, three key molecules known to be expressed in activated microglial cells/macrophages, COX-2, CB2 and P2X7, which plays a role in inflammatory cascades, were studied in MS and ALS post-mortem human spinal cord...
  3. pmc Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves
    Christoph Scheiermann
    National Heart and Lung Institute, Imperial College London, London, UK
    Science 318:1472-5. 2007
    ..These results demonstrate that JAM-C is a component of the autotypic junctional attachments of Schwann cells and plays an important role in maintaining the integrity and function of myelinated peripheral nerves...
  4. doi request reprint Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury
    Praveen Anand
    Peripheral Neuropathy Unit, Hammersmith Hospital, Imperial College, London, UK
    Eur J Pain 15:1040-8. 2011
    ..Dilmapimod was well tolerated, with no clinically relevant safety findings. p38 MAPK inhibitors merit further evaluation for neuropathic pain in larger clinical trials, particularly for clinically meaningful analgesic effect size...
  5. pmc Influence of pregnancy and labor on the occurrence of nerve fibers expressing the capsaicin receptor TRPV1 in human corpus and cervix uteri
    Berith K Tingaker
    Karolinska Institutet, Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Reprod Biol Endocrinol 6:8. 2008
    ..Therefore, the aim of this study was to investigate human corpus and cervix uteri during pregnancy and labor and non-pregnant controls for the presence of TRPV1...
  6. pmc Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons
    Uma Anand
    Histopathology Unit, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC1A 3PX, UK
    Mol Pain 6:82. 2010
    ..This study examined the morphological and functional effects of oxaliplatin treatment in cultured adult rat DRG neurons...
  7. ncbi request reprint Neurotrophic factors and their receptors in human sensory neuropathies
    Praveen Anand
    Department of Neurology, Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Prog Brain Res 146:477-92. 2004
    ..g., at painful amputation stumps)...
  8. doi request reprint Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons
    Uma Anand
    Peripheral Neuropathy Unit, Department of Clinical Neuroscience, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W120NN, UK
    Pain 138:667-80. 2008
    ..We conclude that CB2 agonists deserve imminent clinical trials for nociceptive, inflammatory and neuropathic chronic pain, in which capsaicin or heat-activated responses via TRPV1 may provide a clinical marker...
  9. pmc Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked pain
    Katherine Roberts
    Imperial College Healthcare NHS Trust, London, UK
    BMC Anesthesiol 8:8. 2008
    ....
  10. doi request reprint Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
    Praveen Anand
    Imperial College London, UK
    Brain Res Rev 60:255-66. 2009
    ..Hopefully, these approaches will yield novel analgesics that do not produce the psychotropic effects that limit the medicinal use of cannabis...
  11. pmc Capsaicin and menthol in the treatment of itch and pain: recently cloned receptors provide the key
    P Anand
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, UK
    Gut 52:1233-5. 2003
    ....
  12. pmc Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch
    P Anand
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, Area A, Ground Floor, Du Cane Road, London W12 ONN, UK
    Br J Anaesth 107:490-502. 2011
    ..Evidence suggests that the utility of topical capsaicin may extend beyond painful peripheral neuropathies...
  13. pmc Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study
    Pascal F Durrenberger
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    BMC Neurol 6:1. 2006
    ..We have now investigated the time course of EP1 and Cox-2 changes in injured human nerves and dorsal root ganglia (DRG), and the chronic constriction nerve injury (CCI) model in the rat...
  14. doi request reprint Increased nerve fiber expression of sensory sodium channels Nav1.7, Nav1.8, And Nav1.9 in rhinitis
    Siew M Keh
    Peripheral Neuropathy Unit, Hammersmith Hospital, Faculty of Medicine, Imperial College London, London, UK
    Laryngoscope 118:573-9. 2008
    ..Voltage-gated sodium channels Nav1.7, Nav1.8, and Nav1.9 are involved in nerve action potentials and have been proposed to underlie neuronal hypersensitivity. We have therefore studied their levels in allergic and nonallergic rhinitis...
  15. pmc Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy
    Paul Facer
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    BMC Neurol 7:11. 2007
    ..However, the role of TRPs in common clinical sensory neuropathies needs to be established...
  16. doi request reprint Cytosine arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons
    Uma Anand
    Peripheral Neuropathy Unit, Department of Clinical Neurosciences, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London, UK
    J Neurooncol 89:1-7. 2008
    ..We studied the effects of Ara C on human dorsal root ganglion (DRG) neurons, especially the expression and sensitivity of the ion channel TRPV1, which responds to noxious heat and capsaicin and is a key mediator of neuropathic pain...
  17. pmc Sodium channel Na v 1.7 immunoreactivity in painful human dental pulp and burning mouth syndrome
    Kiran Beneng
    Dental Institute, King s College London, Guy s Hospital, Oral Surgery Department, Great Maze Pond, London, UK
    BMC Neurosci 11:71. 2010
    ..Voltage gated sodium channels Na v 1.7 are involved in nociceptor nerve action potentials and are known to affect pain sensitivity in clinical genetic disorders...
  18. doi request reprint Increased cannabinoid receptor 1-immunoreactive nerve fibers in overactive and painful bladder disorders and their correlation with symptoms
    Gaurav Mukerji
    Peripheral Neuropathy Unit, Hammersmith Hospital and Imperial College, London, United Kingdom
    Urology 75:1514.e15-20. 2010
    ....
  19. ncbi request reprint Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain)
    Yiangos Yiangou
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, London, UK
    Neurosci Lett 427:77-82. 2007
    ..7 immunoreactivity or expression. Drugs that target Na(v)1.7-expressing nerve terminals may be useful for treating rectal hypersensitivity, and combining these with TRPV1 antagonists may enhance efficacy...
  20. ncbi request reprint Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy
    Daniel Sanchez
    Imperial College Faculty of Medicine, London Centre for Nanotechnology, Division of Medicine, 5th Floor MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    J Neurosci Methods 159:26-34. 2007
    ..Our methods will enable the identification and characterisation of compounds being developed for the treatment of clinical mechanical hypersensitivity states...
  21. ncbi request reprint Expression of the sodium channel beta3 subunit in injured human sensory neurons
    Maria A Casula
    Peripheral Neuropathy Unit, Imperial College London, Area A, Ground Floor, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    Neuroreport 15:1629-32. 2004
    ..beta3-subunit expression may thus be regulated differently from beta1, beta2 and Nav1.8. Targeting beta3 interactions with key alpha-subunits, particularly Nav1.3 and Nav1.8, may provide novel selective analgesics...
  22. ncbi request reprint Localization of M2 and M3 muscarinic receptors in human bladder disorders and their clinical correlations
    Gaurav Mukerji
    Peripheral Neuropathy Unit, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    J Urol 176:367-73. 2006
    ..We studied the cellular localization of muscarinic receptor subtypes 2 and 3 in the human bladder and related any changes in overactive and painful bladder syndromes to measures of clinical dysfunction...
  23. pmc Increased levels of SV2A botulinum neurotoxin receptor in clinical sensory disorders and functional effects of botulinum toxins A and E in cultured human sensory neurons
    Yiangos Yiangou
    Department of Clinical Neuroscience, Imperial College London, Hammersmith Hospital, London
    J Pain Res 4:347-55. 2011
    ..There is increasing evidence that botulinum neurotoxin A may affect sensory nociceptor fibers, but the expression of its receptors in clinical pain states, and its effects in human sensory neurons, are largely unknown...
  24. pmc Use of the novel Contact Heat Evoked Potential Stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre counts
    Duncan D Atherton
    Peripheral Neuropathy Unit, Hammersmith Hospital and Imperial College London, UK
    BMC Neurol 7:21. 2007
    ..e. the histamine-induced skin flare response and intra-epidermal fibres (IEF), and also quantitative sensory testing (QST), a subjective measure...
  25. pmc Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders
    Gaurav Mukerji
    Peripheral Neuropathy Unit, Hammersmith Hospital and Imperial College London, UK
    BMC Urol 6:31. 2006
    ..We have therefore studied the bladder cooling reflex and associated sensory symptoms in patients with PBS and overactivity disorders...
  26. ncbi request reprint Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 56:4015-23. 2007
    ..We then validated the model using anti-tumor necrosis factor (anti-TNF) therapy, which has analgesic effects in models of inflammation as well as in human RA...
  27. ncbi request reprint Transient receptor potential vanilloid receptor subtype 1 in painful bladder syndrome and its correlation with pain
    Gaurav Mukerji
    Peripheral Neuropathy Unit, Hammersmith Hospital and Imperial College London, UK
    J Urol 176:797-801. 2006
    ..We studied the heat and capsaicin receptor transient receptor potential vanilloid receptor subtype 1 in the bladder in patients with painful bladder syndrome and their relationship to pain symptoms...
  28. doi request reprint Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain
    Ayesha Akbar
    Department of Gastroenterology, Imperial College London, UK
    Gut 59:767-74. 2010
    ..We investigated TRPV1-immunoreactive fibres in rectosigmoid biopsies taken from such patients with correlation to abdominal pain severity...
  29. ncbi request reprint Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury
    Pascal F Durrenberger
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    J Peripher Nerv Syst 9:15-25. 2004
    ..Selection of patients 4-6 weeks after nerve injury would be more likely to show any efficacy of Cox-2 inhibitors...
  30. pmc Noncontact measurement of the local mechanical properties of living cells using pressure applied via a pipette
    Daniel Sanchez
    Division of Medicine, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, United Kingdom
    Biophys J 95:3017-27. 2008
    ..This method is well suited to probe the nanomechanical properties and mechanosensitivity of living cells...
  31. ncbi request reprint Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel
    Steven J Arnold
    Imperial College of Sciences, Technology and Medicine, Hammersmith Hospital, London, UK
    Neuroreport 14:191-5. 2003
    ..Our findings may explain the diarrhoea and colicky abdominal pain produced by inflammatory bowel disease, and by IK1-blocking pyridine drugs prescribed for neuromuscular disorders...
  32. doi request reprint IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration
    Kay E McNamee
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Pain 152:1838-45. 2011
    ..The subsequent production of keratinocyte chemoattractant then triggers neutrophil chemotaxis to the plantar tissue, releasing algesic mediators locally to sensitise the nerve...
  33. ncbi request reprint Neuronal markers in allergic rhinitis: expression and correlation with sensory testing
    Paul Facer
    Peripheral Neuropathy Unit, Hammersmith Hospital, Faculty of Medicine, Imperial College London, London, UK
    Laryngoscope 117:1519-27. 2007
    ..5 (PGP 9.5), sensory and autonomic neuropeptides, the capsaicin/heat receptor TRPV1, and nerve growth factor (NGF) in patients with allergic rhinitis and controls and their correlation with nasal sensitivity...
  34. pmc Functional MRI brain imaging studies using the Contact Heat Evoked Potential Stimulator (CHEPS) in a human volunteer topical capsaicin pain model
    Ravikiran Shenoy
    Peripheral Neuropathy Unit, Hammersmith Hospital, Imperial College London
    J Pain Res 4:365-71. 2011
    ....
  35. ncbi request reprint Molecular forms of NGF in human and rat neuropathic tissues: decreased NGF precursor-like immunoreactivity in human diabetic skin
    Yiangos Yiangou
    Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    J Peripher Nerv Syst 7:190-7. 2002
    ..The different molecular forms derived from prepro-NGF are likely to be of importance in sensory mechanisms, and deserve further investigation...
  36. ncbi request reprint Localisation of SCN10A gene product Na(v)1.8 and novel pain-related ion channels in human heart
    Paul Facer
    Department of Clinical Neuroscience, Hammersmith Hospital, Faculty of Medicine, Imperial College London, London, UK
    Int Heart J 52:146-52. 2011
    ..We conclude that sodium channel Na(v)1.8 is present in sensory nerves and cardiomyocytes of human heart. Na(v)1.8 and other pain channels provide new targets for the understanding and treatment of cardiac pain and dysrhythmia...
  37. doi request reprint Sensory purinergic receptor P2X3 is elevated in burning mouth syndrome
    Kiran Beneng
    Kings College London, Dental Institute, Oral Surgery Department, Guy s Hospital, London, UK
    Int J Oral Maxillofac Surg 39:815-9. 2010
    ..Increased P2X(3) immunoreactivity in the trigeminal sensory system may play a role in the symptoms observed in BMS. P2X(3) may therefore be a therapeutic target for treating BMS and trigeminal neuropathic pain...
  38. pmc Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations
    Gaurav Mukerji
    Peripheral Neuropathy Unit, Hammersmith Hospital, Imperial College London, UK
    BMC Urol 6:6. 2006
    ..In this study, we report the distribution of the cool and menthol receptor TRPM8 in the urinary bladder in patients with overactive and painful bladder syndromes, and its relationship with clinical symptoms...
  39. pmc Functional neurons and melanocytes induced from immortal lines of postnatal neural crest-like stem cells
    Elena V Sviderskaya
    Centre for Molecular and Metabolic Signalling, Division of Basic Medical Sciences, St George s, University of London, London, UK
    FASEB J 23:3179-92. 2009
    ....
  40. doi request reprint Age-dependent development of chronic neuropathic pain, allodynia and sensory recovery after upper limb nerve injury in children
    Duncan D Atherton
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, London, UK
    J Hand Surg Eur Vol 33:186-91. 2008
    ..60, P<0.0001). These findings indicate that young children show better sensory recovery and are less likely to develop long-term chronic neuropathic pain syndromes than adults following nerve injury...
  41. ncbi request reprint Nerve fibers in lumbar spine structures and injured spinal roots express the sensory neuron-specific sodium channels SNS/PN3 and NaN/SNS2
    Andrew T Bucknill
    Department of Musculoskeletal Surgery, Imperial College School of Medicine, Charing Cross Campus, London, UK
    Spine (Phila Pa 1976) 27:135-40. 2002
    ..This prospective study examined the innervation of lumbar spine in tissues from patients with lower back pain and spine nerve roots from patients with traumatic brachial plexus injuries...
  42. ncbi request reprint P2X3-immunoreactive nerve fibres in neurogenic detrusor overactivity and the effect of intravesical resiniferatoxin
    Ciaran M Brady
    Department of Uro Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Eur Urol 46:247-53. 2004
    ....
  43. ncbi request reprint Restoration of sensory function and lack of long-term chronic pain syndromes after brachial plexus injury in human neonates
    P Anand
    Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London, UK
    Brain 125:113-22. 2002
    ..We propose that differences in neonates are related to later maturation of injured fibres, and that CNS plasticity may account for their lack of long-term chronic pain after spinal root avulsion injury...
  44. ncbi request reprint Novel capsaicin (VR1) and purinergic (P2X3) receptors in Hirschsprung's intestine
    P Facer
    Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London, England
    J Pediatr Surg 36:1679-84. 2001
    ..The functional significance of P2X(3) and VR1 receptors in enteric nerves deserves further investigation...
  45. ncbi request reprint Vanilloid receptor 1 immunoreactivity in inflamed human bowel
    Y Yiangou
    Peripheral Neuropathy Unit, Imperial College School ofMedicine, Hammersmith Hospital, London, UK
    Lancet 357:1338-9. 2001
    ..Thus, the discovery of new drugs that can bind the VR1 receptor, or antagonise endogenous inflammatory substances that activate this receptor, could lead to new therapies for pain and dysmotility...
  46. ncbi request reprint Studies of vasoactive intestinal polypeptide expression in injured peripheral neurons using capsaicin, sympathectomy and mf mutant rats
    P Anand
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, U K
    Neurosci Lett 118:61-6. 1990
    ....
  47. ncbi request reprint Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder
    Y Yiangou
    Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London
    BJU Int 87:774-9. 2001
    ..Intravesical vanilloids act via VR1 and are effective in the treatment of detrusor hyper-reflexia. P2X3 may represent a selective therapeutic target for other causes of overactive bladder...
  48. ncbi request reprint Cizolirtine citrate (E-4018) in the treatment of chronic neuropathic pain
    P Shembalkar
    Department of Neurology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Curr Med Res Opin 17:262-6. 2001
    ..03) but not with placebo (p = 0.9) in this subgroup. Cizolirtine may be effective in primary allodynia after peripheral nerve injury, and a further trial in a larger number of such subjects is warranted...
  49. ncbi request reprint Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency
    C L H Chan
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, London, UK
    Lancet 361:385-91. 2003
    ..We aimed to determine whether expression of the heat and capsaicin receptor vanilloid receptor 1 (TRPV1 or VR1) was changed in rectal sensory fibres, and to correlate nerve fibre density with sensory abnormalities...
  50. ncbi request reprint Parallel changes in bladder suburothelial vanilloid receptor TRPV1 and pan-neuronal marker PGP9.5 immunoreactivity in patients with neurogenic detrusor overactivity after intravesical resiniferatoxin treatment
    C M Brady
    Department of Uro Neurology, Institute of Neurology, Queen Square, London, UK
    BJU Int 93:770-6. 2004
    ..5-staining nerve fibres decrease in patients with spinal NDO who respond to intravesical capsaicin, and TRPV1 is present on these suburothelial nerve fibres in normal and overactive human urinary bladder...
  51. ncbi request reprint The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons
    U Anand
    Peripheral Neuropathy Unit, Imperial College, Area A, Ground Floor, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Neurosci Lett 399:51-6. 2006
    ..NTFs thus increase size, elevate TRPV1 levels and enhance capsaicin responses in cultured human DRG neurons; these changes may relate to pathophysiology in disease states, and provide an in vitro model to study novel analgesics...
  52. doi request reprint TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons
    U Anand
    Peripheral Neuropathy Unit, Imperial College London, Area A, Ground Floor, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Neurosci Lett 438:221-7. 2008
    ..While TRPA1 localisation is more widespread than TRPV1, it represents a promising novel drug target for the treatment of chronic pain and hypersensitivity...
  53. ncbi request reprint Plasticity of gene expression in injured human dorsal root ganglia revealed by GeneChip oligonucleotide microarrays
    Douglas Rabert
    Neurobiology Unit, Roche Bioscience, Palo Alto, CA, USA
    J Clin Neurosci 11:289-99. 2004
    ..This study represents an important step in identifying new genes and molecular mechanisms in human DRG, with potential therapeutic relevance for nerve repair and relief of chronic neuropathic pain...
  54. ncbi request reprint Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin
    Apostolos Apostolidis
    Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
    Urology 65:400-5. 2005
    ..In patients with NDO, TRPV1 suburothelial nerve density is increased, which is reversed by successful treatment with intravesical RTX. However, the role of urothelial TRPV1 in human bladder disorders is unknown...
  55. ncbi request reprint Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human oesophagus
    Philip J Matthews
    Hope Hospital, Department of Gastrointestinal Sciences, Manchester, UK
    Eur J Gastroenterol Hepatol 16:897-902. 2004
    ..The capsaicin receptor vanilloid receptor 1 (TRPV1) (VR1) is a cation channel expressed by sensory neurones and activated by heat, acid pH and ethanol, which may trigger burning pain...
  56. ncbi request reprint Restoration of hand function and so called "breathing arm" after intraspinal repair of C5-T1 brachial plexus avulsion injury. Case report
    Thomas Carlstedt
    The Periphery Nerve Injury Unit, The Royal National Orthopaedic Hospital, Stanmore, United Kingdom
    Neurosurg Focus 16:E7. 2004
    ..To the best of the authors' knowledge, the present case demonstrates, for the first time, that spinal cord surgery can restore hand function after a complete brachial plexus avulsion injury...
  57. ncbi request reprint Co-treatment with riluzole and GDNF is necessary for functional recovery after ventral root avulsion injury
    Astrid Bergerot
    Department of Anatomy and Developmental Biology, University College London, WC1 6BT London, UK
    Exp Neurol 187:359-66. 2004
    ..Thus, combination treatment may offer a new therapeutic strategy for treating patients with avulsion injury...
  58. ncbi request reprint Increased vanilloid receptor VR1 innervation in vulvodynia
    Penelope Tympanidis
    Department of Dermatology, University College London Hospitals Trust, UK
    Eur J Pain 8:129-33. 2004
    ..We hypothesize that increased expression of VR1 by nociceptors could mediate some of the symptoms in vulvodynia, for which systemic or topical specific VR1 antagonists may provide novel treatment...
  59. doi request reprint Relocation of painful neuromas in Zone III of the hand and forearm
    Duncan D Atherton
    Hand Surgery Department, St Andrew s Centre for Plastic Surgery, Broomfield Hospital, Chelmsford, Essex, UK
    J Hand Surg Eur Vol 33:155-62. 2008
    ..The technical difficulties encountered in this region, in particular on the radial aspect of the wrist, are discussed...