E W Alton

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Gene therapy for cystic fibrosis
    E Alton
    National Heart and Lung Institute, Imperial College, Ion Transport Unit, Manresa Road, London SW3 6LR, UK
    Expert Opin Investig Drugs 9:1523-35. 2000
  2. ncbi request reprint Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial
    E W Alton
    Department of Gene Therapy, Imperial College at National Heart and Lung Institute, London, UK
    Lancet 353:947-54. 1999
  3. ncbi request reprint Inflammation in cystic fibrosis airways: relationship to increased bacterial adherence
    P Scheid
    Dept. of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    Eur Respir J 17:27-35. 2001
  4. ncbi request reprint Bioelectric characteristics of exon 10 insertional cystic fibrosis mouse: comparison with humans
    S N Smith
    Ion Transport Unit, National Heart and Lung Institute, London, United Kingdom
    Am J Physiol 268:C297-307. 1995
  5. ncbi request reprint Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice
    S N Smith
    Ion Transport Unit, National Heart and Lung Institute, London, United Kingdom
    Am J Physiol 274:C492-9. 1998
  6. pmc Second-messenger regulation of sodium transport in mammalian airway epithelia
    A Graham
    Ion Transport Laboratory, National Heart and Lung Institute, London
    J Physiol 453:475-91. 1992
  7. ncbi request reprint In vivo transfer of bacterial marker genes results in differing levels of gene expression and tumor progression in immunocompetent and immunodeficient mice
    K V Lukacs
    National Heart and Lung Institute at Imperial College, London, UK
    Hum Gene Ther 10:2373-9. 1999
  8. ncbi request reprint Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium
    S Ferrari
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    Gene Ther 8:1380-6. 2001
  9. ncbi request reprint Gene therapy for cystic fibrosis
    J C Davies
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    J Gene Med 3:409-17. 2001
  10. ncbi request reprint Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice
    E W Alton
    Ion Transport Laboratory, National Heart and Lung Institute, London, UK
    Nat Genet 5:135-42. 1993

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Gene therapy for cystic fibrosis
    E Alton
    National Heart and Lung Institute, Imperial College, Ion Transport Unit, Manresa Road, London SW3 6LR, UK
    Expert Opin Investig Drugs 9:1523-35. 2000
    ..Current research is now focusing more on the barriers faced by delivery agents, with the aim that more efficient gene delivery will lead to a gene therapeutic for cystic fibrosis...
  2. ncbi request reprint Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial
    E W Alton
    Department of Gene Therapy, Imperial College at National Heart and Lung Institute, London, UK
    Lancet 353:947-54. 1999
    ..We studied the safety and efficacy of this gene transfer to the lungs and nose of patients with cystic fibrosis in a double-blind placebo-controlled trial...
  3. ncbi request reprint Inflammation in cystic fibrosis airways: relationship to increased bacterial adherence
    P Scheid
    Dept. of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    Eur Respir J 17:27-35. 2001
    ..The authors conclude that the stimulus produced by Pseudomonas aeruginosa is the predominant inflammatory trigger in their models...
  4. ncbi request reprint Bioelectric characteristics of exon 10 insertional cystic fibrosis mouse: comparison with humans
    S N Smith
    Ion Transport Unit, National Heart and Lung Institute, London, United Kingdom
    Am J Physiol 268:C297-307. 1995
    ..We conclude that the majority of the salient electrophysiological features of CF required for studies of pathogenesis or testing of new treatments are present in these cf/cf mice...
  5. ncbi request reprint Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice
    S N Smith
    Ion Transport Unit, National Heart and Lung Institute, London, United Kingdom
    Am J Physiol 274:C492-9. 1998
    ..We conclude that IBMX is able to induce detectable levels of CFTR-related Cl- secretion in the intestinal tract but not the respiratory tract through the G551D mutant protein...
  6. pmc Second-messenger regulation of sodium transport in mammalian airway epithelia
    A Graham
    Ion Transport Laboratory, National Heart and Lung Institute, London
    J Physiol 453:475-91. 1992
    ..Neither effect could be abolished by amiloride pretreatment. In human bronchi, a small decrease in ISC which could not be distinguished from that occurring in controls was observed.(ABSTRACT TRUNCATED AT 400 WORDS)..
  7. ncbi request reprint In vivo transfer of bacterial marker genes results in differing levels of gene expression and tumor progression in immunocompetent and immunodeficient mice
    K V Lukacs
    National Heart and Lung Institute at Imperial College, London, UK
    Hum Gene Ther 10:2373-9. 1999
    ....
  8. ncbi request reprint Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium
    S Ferrari
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    Gene Ther 8:1380-6. 2001
    ..These results, whilst unlikely to be sufficient in themselves to achieve clinically relevant gene therapy, may be a further useful step in the attainment of this goal...
  9. ncbi request reprint Gene therapy for cystic fibrosis
    J C Davies
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    J Gene Med 3:409-17. 2001
    ..We highlight the problems encountered, and likely future directions of the field...
  10. ncbi request reprint Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice
    E W Alton
    Ion Transport Laboratory, National Heart and Lung Institute, London, UK
    Nat Genet 5:135-42. 1993
    ..The non-viral nature and potentially lower immunogenicity of DNA-liposomes suggest that this may offer a therapeutic alternative to adenoviral therapies...
  11. ncbi request reprint Recent progress in gene therapy for cystic fibrosis
    U Griesenbach
    Department of Gene Therapy, Imperial College School of Medicine, National Heart and Lung Institute, London, UK
    Curr Opin Mol Ther 3:385-9. 2001
    ..Here, we review the progress in CF gene therapy over the last 12 months, including recent advances in viral and non-viral gene transfer agents and novel strategies, such as RNA repair and stem cell gene therapy...
  12. pmc Taking stock of gene therapy for cystic fibrosis
    M Stern
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, UK
    Respir Res 1:78-81. 2000
    ..Gene therapy for CF remains the most promising possibility for curative rather than symptomatic therapy...
  13. ncbi request reprint Prospects for gene therapy in lung disease
    J C Davies
    Imperial College at the National Heart and Lung Institute, London, UK
    Curr Opin Pharmacol 1:272-7. 2001
    ..Recently, progress has been made in both laboratory and clinical studies of gene therapy for cystic fibrosis, alpha1-antitrypsin deficiency and lung cancer...
  14. ncbi request reprint Localization and up-regulation of mucin (MUC2) gene expression in human nasal biopsies of patients with cystic fibrosis
    D Li
    Lung Pathology Unit, National Heart and Lung Institute, London, U K
    J Pathol 181:305-10. 1997
    ..It is concluded that the MUC2 gene is expressed at three- to four-fold higher levels in CF nasal mucosa than in non-CF nasal tissue and that it is expressed in a variety of cells additional to submucosal mucus-secreting glands...
  15. ncbi request reprint Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects
    G M Nichol
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Rev Respir Dis 142:576-80. 1990
    ..Nasal PD was measured before and after placebo or furosemide, and again after MBS inhalation.(ABSTRACT TRUNCATED AT 250 WORDS)..