Simak Ali

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera
    Dongsheng Chen
    Department of Cancer Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Oncogene 21:4921-31. 2002
  2. ncbi request reprint Endocrine-responsive breast cancer and strategies for combating resistance
    Simak Ali
    Department of Cancer Medicine and Cancer Research Campaign Laboratories, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Nat Rev Cancer 2:101-12. 2002
  3. pmc Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activity
    Ross S Thomas
    Cancer Research UK Laboratories, Department of Oncology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    J Mol Endocrinol 40:173-84. 2008
  4. doi request reprint Transient over-expression of estrogen receptor-α in breast cancer cells promotes cell survival and estrogen-independent growth
    Robert S Tolhurst
    Division of Cancer, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Breast Cancer Res Treat 128:357-68. 2011
  5. pmc T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif
    Marie J Lucey
    Department of Oncology, Imperial College London, Du Cane Road, London, W12 0NN, UK
    Nucleic Acids Res 33:6393-404. 2005
  6. ncbi request reprint Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines
    John Patrick Alao
    Department of Cancer Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom
    Clin Cancer Res 10:8094-104. 2004
  7. pmc ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases
    Jorge Lopez-Garcia
    Department of Oncology, Imperial College London, Du Cane Road, London W12 0NN, UK
    Nucleic Acids Res 34:6126-36. 2006
  8. ncbi request reprint T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha
    Dongsheng Chen
    Department of Cancer Medicine, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom
    J Biol Chem 278:38586-92. 2003
  9. ncbi request reprint Reporter gene assay demonstrates functional differences in estrogen receptor activity in purified breast cancer cells: a pilot study
    Anjana Singh
    Cancer Research UK Laboratories, Department of Cancer Medicine, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Int J Cancer 107:700-6. 2003
  10. ncbi request reprint The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity
    Sandra N Lauber
    Molecular Toxicology, Biomedical Sciences, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    Carcinogenesis 25:2509-17. 2004

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera
    Dongsheng Chen
    Department of Cancer Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Oncogene 21:4921-31. 2002
    ..Finally, we show that ERalpha is phosphorylated at S118 in vivo using immunoblotting of extracts prepared from a series of ERalpha-positive breast tumours...
  2. ncbi request reprint Endocrine-responsive breast cancer and strategies for combating resistance
    Simak Ali
    Department of Cancer Medicine and Cancer Research Campaign Laboratories, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Nat Rev Cancer 2:101-12. 2002
    ..However, many breast tumours either fail to respond or become resistant to endocrine therapies. By understanding the mechanisms that underlie this resistance, we might be able to develop strategies for overcoming or bypassing it...
  3. pmc Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activity
    Ross S Thomas
    Cancer Research UK Laboratories, Department of Oncology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    J Mol Endocrinol 40:173-84. 2008
    ....
  4. doi request reprint Transient over-expression of estrogen receptor-α in breast cancer cells promotes cell survival and estrogen-independent growth
    Robert S Tolhurst
    Division of Cancer, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Breast Cancer Res Treat 128:357-68. 2011
    ....
  5. pmc T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif
    Marie J Lucey
    Department of Oncology, Imperial College London, Du Cane Road, London, W12 0NN, UK
    Nucleic Acids Res 33:6393-404. 2005
    ..These findings highlight a new protein-protein interaction motif based on Y-X-X-X-Y and provide new insight into the interaction of diverse proteins in coactivator complexes...
  6. ncbi request reprint Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines
    John Patrick Alao
    Department of Cancer Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom
    Clin Cancer Res 10:8094-104. 2004
    ..The purpose of the study was to investigate the mechanisms underlying this differential response...
  7. pmc ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases
    Jorge Lopez-Garcia
    Department of Oncology, Imperial College London, Du Cane Road, London W12 0NN, UK
    Nucleic Acids Res 34:6126-36. 2006
    ..Together, our results indicate that ZNF366 may play an important role in regulating the expression of genes in response to estrogen...
  8. ncbi request reprint T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha
    Dongsheng Chen
    Department of Cancer Medicine, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom
    J Biol Chem 278:38586-92. 2003
    ..Together with recent reports linking TFIIH in regulating NR function, our findings provide new data to further support an important link between DNA repair proteins and nuclear receptor function...
  9. ncbi request reprint Reporter gene assay demonstrates functional differences in estrogen receptor activity in purified breast cancer cells: a pilot study
    Anjana Singh
    Cancer Research UK Laboratories, Department of Cancer Medicine, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Int J Cancer 107:700-6. 2003
    ..Our findings indicate that this reporter assay could be useful in decisions regarding use of adjuvant endocrine therapies in breast cancer...
  10. ncbi request reprint The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity
    Sandra N Lauber
    Molecular Toxicology, Biomedical Sciences, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    Carcinogenesis 25:2509-17. 2004
    ..We suggest that the combination of genetic toxicology and oestrogen-like promotion of genomic and cellular events provide a mechanism for the tissue-specific tumorigenicity of this compound...
  11. doi request reprint Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells
    Chun Fui Lai
    Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK, Department of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands and Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK
    Nucleic Acids Res 41:10228-40. 2013
    ....
  12. doi request reprint Antiestrogens and their therapeutic applications in breast cancer and other diseases
    Simak Ali
    Division of Cancer, Department of Surgery and Oncology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Annu Rev Med 62:217-32. 2011
    ..Thus, antiestrogens define an important and well-understood class of cancer drug, which continue to be a mainstay in breast cancer treatment...
  13. doi request reprint The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells
    Paul T R Thiruchelvam
    Department of Oncology, Imperial College London, Hammersmith Hospital, London, UK
    Breast Cancer Res Treat 127:385-96. 2011
    ..Hence, inhibition of LRH-1 could provide a powerful new approach for the treatment of endocrine-resistant breast cancer...
  14. pmc Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells
    Silvia Ottaviani
    Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK School of Biological Sciences, University of Essex, Colchester, UK
    J Mol Endocrinol 51:301-12. 2013
    ..Together, these studies identify GNMT as a direct transcriptional target of the AR. As this is an evolutionarily conserved regulatory element, this highlights androgen regulation as an important feature of GNMT regulation. ..
  15. ncbi request reprint Silencing of androgen-regulated genes using a fusion of AR with the PLZF transcriptional repressor
    Joanna Pike
    Department of Cancer Medicine, Imperial College London, Du Cane Road, W12 0NN, UK
    Oncogene 23:7561-70. 2004
    ..Together, our results show that this strategy is able to bring about potent repression of AR-regulated responses and, therefore, could be of value in the development of new therapies for prostate cancer...
  16. ncbi request reprint Elevated ERK1/ERK2/estrogen receptor cross-talk enhances estrogen-mediated signaling during long-term estrogen deprivation
    Lesley Ann Martin
    Molecular Endocrinology, Breakthrough Breast Cancer Centre, Institute of Cancer Research, Chester Beatty Laboratories, Fulham Rd, London SW3 6JB, UK
    Endocr Relat Cancer 12:S75-84. 2005
    ....
  17. ncbi request reprint Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation
    Christina M W Chan
    Department of Academic Biochemistry, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK
    J Steroid Biochem Mol Biol 81:333-41. 2002
    ..Thus, the resistance of these human breast cancer cells to oestrogen-deprivation appears to be due to acquired hypersensitivity which may be explained in part by increased levels of and phosphorylated ERalpha...
  18. ncbi request reprint Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation
    Lesley Ann Martin
    Academic Department of Biochemistry, Institute of Cancer Research, London, United Kingdom
    J Biol Chem 278:30458-68. 2003
    ..These data suggest that although elevated levels of MAPK occur during LTED and influence the phenotype, this is unlikely to be the sole pathway operating to achieve adaptation...
  19. ncbi request reprint Estrogen receptors and anti-estrogen therapies
    Lakjaya Buluwela
    Department of Cancer Medicine, Imperial College London, United Kingdom
    Cancer Treat Res 119:271-92. 2004
  20. ncbi request reprint Phosphorylation of estrogen receptor-alpha at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients
    Jie Jiang
    Cancer Research UK Laboratories, Department of Oncology, Imperial College London, London, United Kingdom
    Clin Cancer Res 13:5769-76. 2007
    ..The purpose of this study was to determine the importance of Ser(167) phosphorylation in breast cancer progression...
  21. ncbi request reprint ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line
    Rana Varshochi
    Cancer Research UK Laboratories and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, United Kingdom
    J Biol Chem 280:3185-96. 2005
    ....
  22. ncbi request reprint Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: a double-blind placebo-controlled phase II randomised trial
    Andreas Polychronis
    Cancer Research UK Laboratories, Department of Cancer Medicine, Imperial College, London, UK
    Lancet Oncol 6:383-91. 2005
    ..Some oestrogen-receptor (ER) positive breast cancers express epidermal growth factor receptor (EGFR), but whether inhibition of EGFR can suppress proliferation of breast cancer cells and ER function is not known...