Genomes and Genes
Affiliation: Imperial College
- Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antiseraDongsheng Chen
Department of Cancer Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
Oncogene 21:4921-31. 2002..Finally, we show that ERalpha is phosphorylated at S118 in vivo using immunoblotting of extracts prepared from a series of ERalpha-positive breast tumours...
- Endocrine-responsive breast cancer and strategies for combating resistanceSimak Ali
Department of Cancer Medicine and Cancer Research Campaign Laboratories, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Nat Rev Cancer 2:101-12. 2002..However, many breast tumours either fail to respond or become resistant to endocrine therapies. By understanding the mechanisms that underlie this resistance, we might be able to develop strategies for overcoming or bypassing it...
- Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activityRoss S Thomas
Cancer Research UK Laboratories, Department of Oncology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
J Mol Endocrinol 40:173-84. 2008....
- Transient over-expression of estrogen receptor-α in breast cancer cells promotes cell survival and estrogen-independent growthRobert S Tolhurst
Division of Cancer, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
Breast Cancer Res Treat 128:357-68. 2011....
- Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell linesJohn Patrick Alao
Department of Cancer Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom
Clin Cancer Res 10:8094-104. 2004..Taken together, our data show that TSA effectively induces cyclin D1 down-regulation through both ERalpha-dependent and ERalpha-independent mechanisms, providing an important new strategy for combating resistance to antiestrogens...
- T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motifMarie J Lucey
Department of Oncology, Imperial College London, Du Cane Road, London, W12 0NN, UK
Nucleic Acids Res 33:6393-404. 2005..These findings highlight a new protein-protein interaction motif based on Y-X-X-X-Y and provide new insight into the interaction of diverse proteins in coactivator complexes...
- ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylasesJorge Lopez-Garcia
Department of Oncology, Imperial College London, Du Cane Road, London W12 0NN, UK
Nucleic Acids Res 34:6126-36. 2006..Together, our results indicate that ZNF366 may play an important role in regulating the expression of genes in response to estrogen...
- T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alphaDongsheng Chen
Department of Cancer Medicine, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom
J Biol Chem 278:38586-92. 2003..Together with recent reports linking TFIIH in regulating NR function, our findings provide new data to further support an important link between DNA repair proteins and nuclear receptor function...
- The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicitySandra N Lauber
Molecular Toxicology, Biomedical Sciences, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
Carcinogenesis 25:2509-17. 2004..We suggest that the combination of genetic toxicology and oestrogen-like promotion of genomic and cellular events provide a mechanism for the tissue-specific tumorigenicity of this compound...
- Reporter gene assay demonstrates functional differences in estrogen receptor activity in purified breast cancer cells: a pilot studyAnjana Singh
Cancer Research (UK) Laboratories, Department of Cancer Medicine, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
Int J Cancer 107:700-6. 2003..Our findings indicate that this reporter assay could be useful in decisions regarding use of adjuvant endocrine therapies in breast cancer...
- The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cellsPaul T R Thiruchelvam
Department of Oncology, Imperial College London, Hammersmith Hospital, London, UK
Breast Cancer Res Treat 127:385-96. 2011..Hence, inhibition of LRH-1 could provide a powerful new approach for the treatment of endocrine-resistant breast cancer...
- Antiestrogens and their therapeutic applications in breast cancer and other diseasesSimak Ali
Division of Cancer, Department of Surgery and Oncology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
Annu Rev Med 62:217-32. 2011..Thus, antiestrogens define an important and well-understood class of cancer drug, which continue to be a mainstay in breast cancer treatment...
- Silencing of androgen-regulated genes using a fusion of AR with the PLZF transcriptional repressorJoanna Pike
Department of Cancer Medicine, Imperial College London, Du Cane Road, W12 0NN, UK
Oncogene 23:7561-70. 2004..Together, our results show that this strategy is able to bring about potent repression of AR-regulated responses and, therefore, could be of value in the development of new therapies for prostate cancer...
- Elevated ERK1/ERK2/estrogen receptor cross-talk enhances estrogen-mediated signaling during long-term estrogen deprivationLesley Ann Martin
Molecular Endocrinology, Breakthrough Breast Cancer Centre, Institute of Cancer Research, Chester Beatty Laboratories, Fulham Rd, London SW3 6JB, UK
Endocr Relat Cancer 12:S75-84. 2005....
- Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivationLesley Ann Martin
Academic Department of Biochemistry, Institute of Cancer Research, London, United Kingdom
J Biol Chem 278:30458-68. 2003..These data suggest that although elevated levels of MAPK occur during LTED and influence the phenotype, this is unlikely to be the sole pathway operating to achieve adaptation...
- Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivationChristina M W Chan
Department of Academic Biochemistry, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK
J Steroid Biochem Mol Biol 81:333-41. 2002..Thus, the resistance of these human breast cancer cells to oestrogen-deprivation appears to be due to acquired hypersensitivity which may be explained in part by increased levels of and phosphorylated ERalpha...
- Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: a double-blind placebo-controlled phase II randomised trialAndreas Polychronis
Cancer Research UK Laboratories, Department of Cancer Medicine, Imperial College, London, UK
Lancet Oncol 6:383-91. 2005..INTERPRETATION: Single-agent gefitinib and gefitinib combined with anastrozole are well-tolerated and effective treatments for reducing the size of breast tumours and levels of ER phosphorylation when given as neoadjuvant therapy...
- ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell lineRana Varshochi
Cancer Research UK Laboratories and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, United Kingdom
J Biol Chem 280:3185-96. 2005....
- Phosphorylation of estrogen receptor-alpha at Ser167 is indicative of longer disease-free and overall survival in breast cancer patientsJie Jiang
Cancer Research UK Laboratories, Department of Oncology, Imperial College London, London, United Kingdom
Clin Cancer Res 13:5769-76. 2007..The purpose of this study was to determine the importance of Ser(167) phosphorylation in breast cancer progression...
- Estrogen receptors and anti-estrogen therapiesLakjaya Buluwela
Department of Cancer Medicine, Imperial College London, United Kingdom
Cancer Treat Res 119:271-92. 2004