P J Hutchinson

Summary

Country: UK

Publications

  1. ncbi request reprint Clinical cerebral microdialysis: a methodological study
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, United Kingdom
    J Neurosurg 93:37-43. 2000
  2. ncbi request reprint A new cranial access device for cerebral monitoring
    P J Hutchinson
    Academic Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Neurosurg 14:46-8. 2000
  3. ncbi request reprint Outcome from poor grade aneurysmal subarachnoid haemorrhage--which poor grade subarachnoid haemorrhage patients benefit from aneurysm clipping?
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Addenbroke s Hospital, UK
    Br J Neurosurg 14:105-9. 2000
  4. ncbi request reprint Imaging of cerebral blood flow and metabolism in brain injury in the ICU
    J D Pickard
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:459-64. 2005
  5. ncbi request reprint Ventriculostomy for control of raised ICP in acute traumatic brain injury
    I Timofeev
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, P O Box 167, Hills Road, Cambridge CB2 0QQ, UK
    Acta Neurochir Suppl 102:99-104. 2008
  6. ncbi request reprint Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com)
    P J Hutchinson
    Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:17-20. 2006
  7. ncbi request reprint Monitoring and interpretation of intracranial pressure after head injury
    M Czosnyka
    Department of Clinical Neurosciences, Neurosurgical Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:114-8. 2006
  8. ncbi request reprint Use of ICM+ software for on-line analysis of intracranial and arterial pressures in head-injured patients
    K Guendling
    Academic Department of Clinical Neuroscience, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:108-13. 2006
  9. ncbi request reprint Cerebrovascular reactivity during hypothermia and rewarming
    A Lavinio
    Department of Clinical Neurosciences, Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Br J Anaesth 99:237-44. 2007
  10. ncbi request reprint Multiparameter brain tissue monitoring--correlation between parameters and identification of CPP thresholds
    P G Al-Rawi
    University Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Zentralbl Neurochir 61:74-9. 2000

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Clinical cerebral microdialysis: a methodological study
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, United Kingdom
    J Neurosurg 93:37-43. 2000
    ....
  2. ncbi request reprint A new cranial access device for cerebral monitoring
    P J Hutchinson
    Academic Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Neurosurg 14:46-8. 2000
    ..The bolt has been successfully applied to 100 patients with severe head injury and subarachnoid haemorrhage...
  3. ncbi request reprint Outcome from poor grade aneurysmal subarachnoid haemorrhage--which poor grade subarachnoid haemorrhage patients benefit from aneurysm clipping?
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Addenbroke s Hospital, UK
    Br J Neurosurg 14:105-9. 2000
    ..However, following resuscitation and correction of any acute hydrocephalus, a patient subgroup identified on simple clinical criteria can be identified who can expect a better outcome...
  4. ncbi request reprint Imaging of cerebral blood flow and metabolism in brain injury in the ICU
    J D Pickard
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:459-64. 2005
    ..New modelling and analytical approaches have been developed...
  5. ncbi request reprint Ventriculostomy for control of raised ICP in acute traumatic brain injury
    I Timofeev
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, P O Box 167, Hills Road, Cambridge CB2 0QQ, UK
    Acta Neurochir Suppl 102:99-104. 2008
    ....
  6. ncbi request reprint Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com)
    P J Hutchinson
    Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:17-20. 2006
    ..We describe the concept of decompressive craniectomy in traumatic brain injury and the rationale and protocol of the RESCUEicp study...
  7. ncbi request reprint Monitoring and interpretation of intracranial pressure after head injury
    M Czosnyka
    Department of Clinical Neurosciences, Neurosurgical Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:114-8. 2006
    ..To investigate the relationships between long-term computer-assisted monitoring of intracranial pressure (ICP) and indices derived from its waveform versus outcome, age, and sex...
  8. ncbi request reprint Use of ICM+ software for on-line analysis of intracranial and arterial pressures in head-injured patients
    K Guendling
    Academic Department of Clinical Neuroscience, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:108-13. 2006
    ..To summarize our experience from the first 2 years of use of the ICM+ software in our Neurocritical Care Unit (NCCU)...
  9. ncbi request reprint Cerebrovascular reactivity during hypothermia and rewarming
    A Lavinio
    Department of Clinical Neurosciences, Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Br J Anaesth 99:237-44. 2007
    ..The effects of hypothermia and subsequent rewarming on cerebral vasoreactivity in human TBI are unknown...
  10. ncbi request reprint Multiparameter brain tissue monitoring--correlation between parameters and identification of CPP thresholds
    P G Al-Rawi
    University Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Zentralbl Neurochir 61:74-9. 2000
    ..The results must be interpreted whilst considering catheter position, autoregulation and systemic arterial changes for each individual...
  11. ncbi request reprint Microdialysis in the management of hepatic encephalopathy
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 5:202-5. 2006
    ..Fulminant hepatic encephalopathy has a high mortality...
  12. pmc Increases in GABA concentrations during cerebral ischaemia: a microdialysis study of extracellular amino acids
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 72:99-105. 2002
    ....
  13. ncbi request reprint Cerebral microdialysis methodology--evaluation of 20 kDa and 100 kDa catheters
    P J Hutchinson
    Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Physiol Meas 26:423-8. 2005
    ..CMA71 microdialysis catheters can, therefore, be used for routine clinical monitoring of extracellular substances, as well as for their intended research role of larger molecular weight protein sampling...
  14. ncbi request reprint Decompressive craniectomy in traumatic brain injury: outcome following protocol-driven therapy
    I Timofeev
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:11-6. 2006
    ..Formal prospective randomized studies of decompressive craniectomy are now indicated...
  15. ncbi request reprint Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury
    A K Gupta
    Department of Anesthesia, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Anesth Analg 88:549-53. 1999
    ..Thus, monitoring of PbO2 is a useful addition to multimodal monitoring of patients with traumatic head injury...
  16. ncbi request reprint Effects of variation in cerebral haemodynamics during aneurysm surgery on brain tissue oxygen and metabolism
    R Kett-White
    Academic Department of Neurosurgery, Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 81:327-9. 2002
    ....
  17. ncbi request reprint Glucose metabolism in traumatic brain injury: a combined microdialysis and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) study
    M T O'Connell
    Department of Anaesthesia, University of Cambridge, Cambridge CB2 2QQ, UK
    Acta Neurochir Suppl 95:165-8. 2005
    ..Further observations are required with regions of interest (microdialysis catheters positioned) adjacent to mass lesions notably contusions...
  18. pmc Investigation of the effect of chlormethiazole on cerebral chemistry in neurosurgical patients: a combined study of microdialysis and a neuroprotective agent
    P J Hutchinson
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Clin Pharmacol 53:275-83. 2002
    ....
  19. pmc Standards for head injury management in acute hospitals: evidence from the six million population of the Eastern region
    H M Seeley
    Neurosciences Department, Addenbrooke s Hospital, Cambridge, UK
    Emerg Med J 23:128-32. 2006
    ..To develop standards of care for head injury and thereby identify and prioritize areas of the service needing development; to report the findings from a survey of compliance with such standards in the Eastern region of UK...
  20. ncbi request reprint Potential role of NovoSeven in the prevention of rebleeding following aneurysmal subarachnoid haemorrhage
    J D Pickard
    Academic Neurosurgery Unit and Wolfson Brain Imaging Centre, University of Cambridge, UK
    Blood Coagul Fibrinolysis 11:S117-20. 2000
    ..The last patient developed middle cerebral artery branch thrombosis contralateral to the aneurysm. The study is currently suspended pending further investigation...
  21. ncbi request reprint Outcome after surgical decompression of severe traumatic brain injury
    I Timofeev
    University of Cambridge Academic Neurosurgery Unit, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    Injury 37:1125-32. 2006
    ..This article reviews the existing evidence on the role of decompressive craniectomy in management of patients with traumatic brain injury and stresses the need for randomised controlled trials...
  22. doi request reprint Critical thresholds for cerebrovascular reactivity after traumatic brain injury
    E Sorrentino
    Neurosurgery, University of Cambridge, Cambridge, UK
    Neurocrit Care 16:258-66. 2012
    ..We also investigated how these thresholds depend on clinical factors such as age, gender and initial GCS...
  23. ncbi request reprint Multi-modal monitoring of acute brain injury
    R Kett-White
    Academic Neurosurgical Unit and the Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Adv Tech Stand Neurosurg 27:87-134. 2002
    ..Thirdly, the respective roles of jugular venous oxygen and brain tissue oxygen monitoring are analysed. Fourthly, the use of cerebral microdialysis is described, together with an overview of its utility...
  24. ncbi request reprint How can we measure substrate, metabolite and neurotransmitter concentrations in the human brain?
    P J Hutchinson
    Department of Neurosurgery and Wolfson Brain Imaging Centre, Addenbrooke s Hospital, University of Cambridge, UK
    Physiol Meas 23:R75-109. 2002
    ..voltammetry and spectrophotometry) and functional imaging (e.g. positron emission tomography and magnetic resonance spectroscopy). This review describes these techniques in terms of their principles and clinical applications...
  25. pmc Late epilepsy following open surgery for aneurysmal subarachnoid haemorrhage
    S J Buczacki
    University of Cambridge, Academic Department of Neurosurgery, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 75:1620-2. 2004
    ..To determine the risk for late epilepsy (>2 weeks postoperatively) following aneurysmal subarachnoid haemorrhage (SAH) treated by early aneurysm clipping...
  26. ncbi request reprint Microdialysis in traumatic brain injury--methodology and pathophysiology
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, UK
    Acta Neurochir Suppl 95:441-5. 2005
    ..This manuscript describes the place of microdialysis in traumatic brain injury in terms of the fundamental principles, methodology, pathophysiology and clinical application...
  27. doi request reprint Correlation of MR relative cerebral blood volume measurements with cellular density and proliferation in high-grade gliomas: an image-guided biopsy study
    S J Price
    Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, UK
    AJNR Am J Neuroradiol 32:501-6. 2011
    ..The aim of this study was to see how rCBV, a known marker of tumor vascularity, relates to cellular packing attenuation and cellular proliferation...
  28. ncbi request reprint Is the recommended target of 4 hours from head injury to emergency craniotomy achievable?
    I G Sergides
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 20:301-5. 2006
    ..In order to investigate whether it is possible to reduce delays in transportation time, theoretical models were created to determine whether direct transfer to the RNU would be faster by land or air ambulance...
  29. ncbi request reprint Inappropriate acute neurosurgical bed occupancy and short falls in rehabilitation: implications for the National Service Framework
    L J Bradley
    Department of Rehabilitation Medicine, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 20:36-9. 2006
    ..Addressing this unmet need would increase the availability of acute neurosurgery beds, without needing to build and staff more neurosurgery wards...
  30. ncbi request reprint Decompressive craniectomy in head injury
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, UK
    Curr Opin Crit Care 10:101-4. 2004
    ..To examine the evidence for the role of decompressive craniectomy in the management of traumatic brain injury...
  31. pmc Acute head injury for the neurologist
    P J Hutchinson
    Academic Department of Neurosurgery, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 73:i3-7. 2002
  32. ncbi request reprint Effect of hypothermia on brain tissue oxygenation in patients with severe head injury
    A K Gupta
    Department of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, UK
    Br J Anaesth 88:188-92. 2002
    ..In this study we have investigated the effects of hypothermia on brain tissue oxygenation in patients with severe head injury...
  33. ncbi request reprint Concept of "true ICP" in monitoring and prognostication in head trauma
    M Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:341-4. 2005
    ..To propose a new coefficient, which contains information about both the absolute ICP and the position of the 'working point' on the pressure-volume curve...
  34. ncbi request reprint Assessment of the Ventrix parenchymal intracranial pressure monitoring probe (NL950-P) and Monitor (NL950-100) in a 3 Tesla magnetic resonance scanner
    J P Coles
    Department of Anaesthesia and Wolfson Brain Imaging Centre, Box 93, Addenbrookes Hospital, University of Cambridge, CB2 2QQ, UK
    Anaesthesia 58:143-8. 2003
    ..Although the system is MR compatible and produces generally acceptable imaging even at 3 Tesla, there is significant degradation of image quality during gradient echo sequences...
  35. doi request reprint Low-dose and high-dose synacthen tests and the hemodynamic response to hydrocortisone in acute traumatic brain injury
    R S Wijesurendra
    University Division of Anaesthesia, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Box 93, Hills Road, Cambridge CB2 2QQ, UK
    Neurocrit Care 11:158-64. 2009
    ....
  36. doi request reprint Effects of fluid therapy following aneurysmal subarachnoid haemorrhage: a prospective clinical study
    M Y Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Br J Neurosurg 22:257-68. 2008
    ..Intravenous fluid therapy using synthetic colloids or blood transfusions may be associated with increased unfavourable outcome following aSAH...
  37. doi request reprint The management of primary chronic subdural haematoma: a questionnaire survey of practice in the United Kingdom and the Republic of Ireland
    T Santarius
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Br J Neurosurg 22:529-34. 2008
    ..The current literature provides Class II and III evidence and there is a need for randomized studies to address the role of external drainage, steroids and postoperative bed rest...
  38. ncbi request reprint Head injury rehabilitation: the role of a neurotrauma clinic
    Helen M Seeley
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 23:530-7. 2009
    ..Early indications show that a specialist clinic can assist in providing continuity of patient care, in improving coordination of services, and act as a resource for further research on epidemiology, outcome and impact of rehabilitation...
  39. ncbi request reprint Future perspectives in the acute management of head injury
    P J Hutchinson
    Academic Neurosurgery Unit, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Br J Surg 90:769-71. 2003
  40. ncbi request reprint Improved delineation of glioma margins and regions of infiltration with the use of diffusion tensor imaging: an image-guided biopsy study
    S J Price
    Academic Neurosurgical Unit and Wolfson Brain Imaging Centre, Department pf Radiology, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Cambridge, United Kingdom
    AJNR Am J Neuroradiol 27:1969-74. 2006
    ..In this study, results of histologic examination from samples obtained from image-guided brain biopsies were correlated with diffusion tensor images...
  41. pmc Mapping rehabilitation resources for head injury
    J D Pickard
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J R Soc Med 97:384-9. 2004
    ..The definitions and mapping system that emerged from this study should facilitate the design of care pathways for patients and identify gaps in the services...
  42. ncbi request reprint The pharmacology of chlormethiazole: a potential neuroprotective agent?
    M J Wilby
    Academic Department of Neurosurgery, Box 167, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    CNS Drug Rev 10:281-94. 2004
    ..In addition, novel approaches involving human neurochemical analyses in vivo are described which may help bridge the gap between animal models and future phase III trials...
  43. ncbi request reprint Neurosurgical history: Comparing the management of penetrating head injury in 1969 with 2005
    N C H Keong
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 20:227-32. 2006
    ..Two unusual cases demonstrate the progress made in emergency medicine, radiology neurointensive care, and neurosurgical head injury management over 36 years...
  44. ncbi request reprint Post traumatic brain contusions and lacerations. An international focus meeting, September 19-20, 2003, Rimini, Italy
    P J Hutchinson
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir (Wien) 146:535-6. 2004
  45. ncbi request reprint Prospective study of clinical and radiological outcome after anterior cervical discectomy
    R J Laing
    Academic Department of Neurosurgery, University of Cambridge, Cambridge, UK
    Br J Neurosurg 15:319-23. 2001
    ..Disturbance of cervical and segmental alignment is common in patients following cervical discectomy, but does not appear to compromise clinical outcome at 12 months...