R A C Hughes

Summary

Country: UK

Publications

  1. doi request reprint Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain-Barré syndrome
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 2:CD008630. 2013
  2. doi request reprint Corticosteroids for Guillain-Barré syndrome
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 8:CD001446. 2012
  3. doi request reprint Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 8:CD002062. 2012
  4. doi request reprint Intravenous immunoglobulin for Guillain-Barré syndrome
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 7:CD002063. 2012
  5. pmc Give or take? Intravenous immunoglobulin or plasma exchange for Guillain-Barré syndrome
    Richard A C Hughes
    Cochrane Neuromuscular Disease Group, MRC Centre for Neuromuscular Disease, PO Box 114, National Hospital for Neurology and Neurosurgery, 8 11 Queen Square, London WC1N 3BG, UK
    Crit Care 15:174. 2011
  6. pmc Clinical applications of intravenous immunoglobulins in neurology
    R A C Hughes
    National Hospital for Neurology and Neurosurgery, Queens Square, London, UK
    Clin Exp Immunol 158:34-42. 2009
  7. ncbi request reprint European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of paraproteinaemic demyelinating neuropathies: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Socie
    R D M Hadden
    Department of Neurology, King s College Hospital, London, UK
    Eur J Neurol 13:809-18. 2006
  8. ncbi request reprint Practice parameter: immunotherapy for Guillain-Barré syndrome: report of the Quality Standards Subcommittee of the American Academy of Neurology
    R A C Hughes
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, London, UK
    Neurology 61:736-40. 2003
  9. doi request reprint Intravenous immune globulin (10% caprylate-chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial
    Richard A C Hughes
    Department of Clinical Neuroscience, King s College London, Guy s Hospital, London, UK
    Lancet Neurol 7:136-44. 2008
  10. doi request reprint Humoral and cellular immune responses to myelin protein peptides in chronic inflammatory demyelinating polyradiculoneuropathy
    L Sanvito
    Department of Clinical Neuroscience, King s College London, Guy s Hospital, London, UK
    J Neurol Neurosurg Psychiatry 80:333-8. 2009

Detail Information

Publications19

  1. doi request reprint Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain-Barré syndrome
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 2:CD008630. 2013
    ..The efficacy of other pharmacological agents is unknown. This review was first published in 2011 and this update in 2013. ..
  2. doi request reprint Corticosteroids for Guillain-Barré syndrome
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 8:CD001446. 2012
    ..Guillain-Barré syndrome (GBS) is an acute paralysing disease caused by inflammation of the peripheral nerves, which corticosteroids would be expected to benefit...
  3. doi request reprint Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 8:CD002062. 2012
    ..Prednisone is converted into prednisolone in the liver so that the effect of the two drugs is usually the same. Another corticosteroid, called dexamethasone, is more potent and is used in smaller doses...
  4. doi request reprint Intravenous immunoglobulin for Guillain-Barré syndrome
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 7:CD002063. 2012
    ..Other Cochrane systematic reviews have shown that plasma exchange (PE) significantly hastens recovery in GBS compared with supportive treatment alone, and that corticosteroids alone are ineffective...
  5. pmc Give or take? Intravenous immunoglobulin or plasma exchange for Guillain-Barré syndrome
    Richard A C Hughes
    Cochrane Neuromuscular Disease Group, MRC Centre for Neuromuscular Disease, PO Box 114, National Hospital for Neurology and Neurosurgery, 8 11 Queen Square, London WC1N 3BG, UK
    Crit Care 15:174. 2011
    ..Two larger trials in adults showed the opposite result...
  6. pmc Clinical applications of intravenous immunoglobulins in neurology
    R A C Hughes
    National Hospital for Neurology and Neurosurgery, Queens Square, London, UK
    Clin Exp Immunol 158:34-42. 2009
    ..These changes at the molecular level were accompanied by improved cognitive function, and large-scale randomized trials are under way...
  7. ncbi request reprint European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of paraproteinaemic demyelinating neuropathies: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Socie
    R D M Hadden
    Department of Neurology, King s College Hospital, London, UK
    Eur J Neurol 13:809-18. 2006
    ..Objectives. To prepare evidence-based and consensus guidelines on the clinical management of patients with both a demyelinating neuropathy and a paraprotein (paraproteinaemic demyelinating neuropathy, PDN)...
  8. ncbi request reprint Practice parameter: immunotherapy for Guillain-Barré syndrome: report of the Quality Standards Subcommittee of the American Academy of Neurology
    R A C Hughes
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, London, UK
    Neurology 61:736-40. 2003
    ..To provide an evidence-based statement to guide physicians in the management of Guillain-Barré syndrome (GBS)...
  9. doi request reprint Intravenous immune globulin (10% caprylate-chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial
    Richard A C Hughes
    Department of Clinical Neuroscience, King s College London, Guy s Hospital, London, UK
    Lancet Neurol 7:136-44. 2008
    ..We aimed to establish whether 10% caprylate-chromatography purified immune globulin intravenous (IGIV-C) has short-term and long-term benefit in patients with CIDP...
  10. doi request reprint Humoral and cellular immune responses to myelin protein peptides in chronic inflammatory demyelinating polyradiculoneuropathy
    L Sanvito
    Department of Clinical Neuroscience, King s College London, Guy s Hospital, London, UK
    J Neurol Neurosurg Psychiatry 80:333-8. 2009
    ..Evidence that chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease was sought, by studying cellular and humoral immune responses to peripheral nerve myelin proteins...
  11. ncbi request reprint Intravenous immunoglobulin modulates lymphocyte CD54 and monocyte FcgammaRII expression in patients with chronic inflammatory neuropathies
    A Creange
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, SE1 1UL, London, UK
    J Neuroimmunol 135:91-5. 2003
    ..Thus, the mechanism of action of IVIg in both CIDP and MMN may involve inhibition of T cell transmigration and modulation of antigen presentation capacities through FcgammaR expression...
  12. ncbi request reprint A randomized controlled trial of recombinant interferon-beta 1a in Guillain-Barré syndrome
    J Pritchard
    Department of Clinical Neurosciences, Guy s, King s and St Thomas School of Medicine, London, UK
    Neurology 61:1282-4. 2003
    ..IFN[beta] did not have any unexpected interaction with IVIg and there was no significant difference in rate of improvement...
  13. ncbi request reprint European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripher
    R A C Hughes
    King s College London School of Medicine, London, UK
    Eur J Neurol 13:326-32. 2006
    ....
  14. ncbi request reprint Epidemiology of chronic inflammatory neuropathies in southeast England
    M Mahdi-Rogers
    Department of Clinical Neuroscience, King s College London, London, UK
    Eur J Neurol 21:28-33. 2014
    ..There is little information about the prevalence and disease burden of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and paraproteinaemic demyelinating neuropathy (PDN)...
  15. ncbi request reprint Economic costs and quality of life in chronic inflammatory neuropathies in southeast England
    M Mahdi-Rogers
    Department of Clinical Neuroscience, King s College London, London, UK
    Eur J Neurol 21:34-9. 2014
    ....
  16. pmc Systematic reviews of treatment for inflammatory demyelinating neuropathy
    R A C Hughes
    Cochrane Neuromuscular Disease Review Group, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, London, UK
    J Anat 200:331-9. 2002
    ..They already demonstrate major deficiencies in the existing evidence base...
  17. doi request reprint Variable phenotypes are associated with PMP22 missense mutations
    M Russo
    MRC Centre for Neuromuscular Diseases, Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK
    Neuromuscul Disord 21:106-14. 2011
    ....
  18. ncbi request reprint A prospective study of physiotherapist prescribed community based exercise in inflammatory peripheral neuropathy
    R C Graham
    Applied Biomedical Research Division, Shepherd s House, Guy s Campus, King s College London, London, UK
    J Neurol 254:228-35. 2007
    ..Future randomised controlled trials are needed to examine the efficacy of this complex community based intervention...
  19. ncbi request reprint Characterization of matrix metalloproteinases in denervated muscle
    M Demestre
    Department of Clinical Neurosciences, Guy s, King s and St Thomas School of Medicine, London, SEI 1UL, UK
    Neuropathol Appl Neurobiol 31:545-55. 2005
    ..Further experiments are required to test the hypothesis that MMP inhibition may be beneficial in protecting muscle from excessive remodelling following denervation and therefore improve reinnervation...