R A C Hughes

Summary

Country: UK

Publications

  1. ncbi request reprint Chronic Inflammatory Demyelinating Polyradiculoneuropathy
    Richard Hughes
    MRC Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, PO Box 114, Queen Square, London, WC1N 3BG, UK
    J Clin Immunol 30:S70-3. 2010
  2. doi request reprint Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain-Barré syndrome
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 2:CD008630. 2013
  3. doi request reprint Corticosteroids for Guillain-Barré syndrome
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 8:CD001446. 2012
  4. doi request reprint Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 8:CD002062. 2012
  5. doi request reprint Intravenous immunoglobulin for Guillain-Barré syndrome
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 7:CD002063. 2012
  6. pmc Give or take? Intravenous immunoglobulin or plasma exchange for Guillain-Barré syndrome
    Richard A C Hughes
    Cochrane Neuromuscular Disease Group, MRC Centre for Neuromuscular Disease, PO Box 114, National Hospital for Neurology and Neurosurgery, 8 11 Queen Square, London WC1N 3BG, UK
    Crit Care 15:174. 2011
  7. pmc Clinical applications of intravenous immunoglobulins in neurology
    R A C Hughes
    National Hospital for Neurology and Neurosurgery, Queens Square, London, UK
    Clin Exp Immunol 158:34-42. 2009
  8. ncbi request reprint European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of paraproteinaemic demyelinating neuropathies: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Socie
    R D M Hadden
    Department of Neurology, King s College Hospital, London, UK
    Eur J Neurol 13:809-18. 2006
  9. ncbi request reprint Practice parameter: immunotherapy for Guillain-Barré syndrome: report of the Quality Standards Subcommittee of the American Academy of Neurology
    R A C Hughes
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, London, UK
    Neurology 61:736-40. 2003
  10. doi request reprint Intravenous immune globulin (10% caprylate-chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial
    Richard A C Hughes
    Department of Clinical Neuroscience, King s College London, Guy s Hospital, London, UK
    Lancet Neurol 7:136-44. 2008

Detail Information

Publications24

  1. ncbi request reprint Chronic Inflammatory Demyelinating Polyradiculoneuropathy
    Richard Hughes
    MRC Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, PO Box 114, Queen Square, London, WC1N 3BG, UK
    J Clin Immunol 30:S70-3. 2010
    ..Chronic inflammatory demyelinating polyradiculoneuropathy is a chronic progressive or relapsing and remitting disease with a prevalence of up to 8.9 per 100,000...
  2. doi request reprint Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain-Barré syndrome
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 2:CD008630. 2013
    ..The efficacy of other pharmacological agents is unknown. This review was first published in 2011 and this update in 2013. ..
  3. doi request reprint Corticosteroids for Guillain-Barré syndrome
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 8:CD001446. 2012
    ..Guillain-Barré syndrome (GBS) is an acute paralysing disease caused by inflammation of the peripheral nerves, which corticosteroids would be expected to benefit...
  4. doi request reprint Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 8:CD002062. 2012
    ..Prednisone is converted into prednisolone in the liver so that the effect of the two drugs is usually the same. Another corticosteroid, called dexamethasone, is more potent and is used in smaller doses...
  5. doi request reprint Intravenous immunoglobulin for Guillain-Barré syndrome
    Richard A C Hughes
    MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK
    Cochrane Database Syst Rev 7:CD002063. 2012
    ..Other Cochrane systematic reviews have shown that plasma exchange (PE) significantly hastens recovery in GBS compared with supportive treatment alone, and that corticosteroids alone are ineffective...
  6. pmc Give or take? Intravenous immunoglobulin or plasma exchange for Guillain-Barré syndrome
    Richard A C Hughes
    Cochrane Neuromuscular Disease Group, MRC Centre for Neuromuscular Disease, PO Box 114, National Hospital for Neurology and Neurosurgery, 8 11 Queen Square, London WC1N 3BG, UK
    Crit Care 15:174. 2011
    ..Two larger trials in adults showed the opposite result...
  7. pmc Clinical applications of intravenous immunoglobulins in neurology
    R A C Hughes
    National Hospital for Neurology and Neurosurgery, Queens Square, London, UK
    Clin Exp Immunol 158:34-42. 2009
    ..These changes at the molecular level were accompanied by improved cognitive function, and large-scale randomized trials are under way...
  8. ncbi request reprint European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of paraproteinaemic demyelinating neuropathies: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Socie
    R D M Hadden
    Department of Neurology, King s College Hospital, London, UK
    Eur J Neurol 13:809-18. 2006
    ..Objectives. To prepare evidence-based and consensus guidelines on the clinical management of patients with both a demyelinating neuropathy and a paraprotein (paraproteinaemic demyelinating neuropathy, PDN)...
  9. ncbi request reprint Practice parameter: immunotherapy for Guillain-Barré syndrome: report of the Quality Standards Subcommittee of the American Academy of Neurology
    R A C Hughes
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, London, UK
    Neurology 61:736-40. 2003
    ..To provide an evidence-based statement to guide physicians in the management of Guillain-Barré syndrome (GBS)...
  10. doi request reprint Intravenous immune globulin (10% caprylate-chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial
    Richard A C Hughes
    Department of Clinical Neuroscience, King s College London, Guy s Hospital, London, UK
    Lancet Neurol 7:136-44. 2008
    ..We aimed to establish whether 10% caprylate-chromatography purified immune globulin intravenous (IGIV-C) has short-term and long-term benefit in patients with CIDP...
  11. ncbi request reprint A prospective study of physiotherapist prescribed community based exercise in inflammatory peripheral neuropathy
    R C Graham
    Applied Biomedical Research Division, Shepherd s House, Guy s Campus, King s College London, London, UK
    J Neurol 254:228-35. 2007
    ..Future randomised controlled trials are needed to examine the efficacy of this complex community based intervention...
  12. pmc Clinimetric properties of a walking scale in peripheral neuropathy
    R C Graham
    Division of Applied Biomedical Research, King s College London, London, UK
    J Neurol Neurosurg Psychiatry 77:977-9. 2006
    ..Owing to its excellent internal consistency and reliability, and strong correlation with measures of physical and social function (r>0.8), the Walk-12 is recommended for measuring walking ability in peripheral neuropathies...
  13. pmc Systematic reviews of treatment for inflammatory demyelinating neuropathy
    R A C Hughes
    Cochrane Neuromuscular Disease Review Group, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, London, UK
    J Anat 200:331-9. 2002
    ..They already demonstrate major deficiencies in the existing evidence base...
  14. doi request reprint Humoral and cellular immune responses to myelin protein peptides in chronic inflammatory demyelinating polyradiculoneuropathy
    L Sanvito
    Department of Clinical Neuroscience, King s College London, Guy s Hospital, London, UK
    J Neurol Neurosurg Psychiatry 80:333-8. 2009
    ..Evidence that chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease was sought, by studying cellular and humoral immune responses to peripheral nerve myelin proteins...
  15. doi request reprint Economic costs and quality of life in chronic inflammatory neuropathies in southeast England
    M Mahdi-Rogers
    Department of Clinical Neuroscience, King s College London, London, UK
    Eur J Neurol 21:34-9. 2014
    ....
  16. ncbi request reprint Intravenous immunoglobulin modulates lymphocyte CD54 and monocyte FcgammaRII expression in patients with chronic inflammatory neuropathies
    A Creange
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, SE1 1UL, London, UK
    J Neuroimmunol 135:91-5. 2003
    ..Thus, the mechanism of action of IVIg in both CIDP and MMN may involve inhibition of T cell transmigration and modulation of antigen presentation capacities through FcgammaR expression...
  17. ncbi request reprint European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripher
    R A C Hughes
    King s College London School of Medicine, London, UK
    Eur J Neurol 13:326-32. 2006
    ....
  18. ncbi request reprint A randomized controlled trial of recombinant interferon-beta 1a in Guillain-Barré syndrome
    J Pritchard
    Department of Clinical Neurosciences, Guy s, King s and St Thomas School of Medicine, London, UK
    Neurology 61:1282-4. 2003
    ..IFN[beta] did not have any unexpected interaction with IVIg and there was no significant difference in rate of improvement...
  19. pmc Intravenous immunoglobulin in neurological disease: a specialist review
    C M Wiles
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    J Neurol Neurosurg Psychiatry 72:440-8. 2002
    ..Evidence of efficacy has been classified into levels for healthcare interventions (tables 1 and 2)...
  20. pmc A modified peripheral neuropathy scale: the Overall Neuropathy Limitations Scale
    R C Graham
    Division of Applied Biomedical Research, King s College London, London, UK
    J Neurol Neurosurg Psychiatry 77:973-6. 2006
    ..The simplicity of the ODSS is shared by the ONLS, but the ONLS has better content validity and less ceiling effect, which may make it more useful for clinical practice and research...
  21. doi request reprint Grey matter magnetization transfer ratio independently correlates with neurological deficit in secondary progressive multiple sclerosis
    T Hayton
    Dept of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 256:427-35. 2009
    ..The apparent paucity of correlation between MRI measures and EDSS is likely to represent the relative insensitivity of the latter measure in this study group...
  22. doi request reprint Epidemiology of chronic inflammatory neuropathies in southeast England
    M Mahdi-Rogers
    Department of Clinical Neuroscience, King s College London, London, UK
    Eur J Neurol 21:28-33. 2014
    ..There is little information about the prevalence and disease burden of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and paraproteinaemic demyelinating neuropathy (PDN)...
  23. doi request reprint Variable phenotypes are associated with PMP22 missense mutations
    M Russo
    MRC Centre for Neuromuscular Diseases, Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK
    Neuromuscul Disord 21:106-14. 2011
    ....
  24. ncbi request reprint Characterization of matrix metalloproteinases in denervated muscle
    M Demestre
    Department of Clinical Neurosciences, Guy s, King s and St Thomas School of Medicine, London, SEI 1UL, UK
    Neuropathol Appl Neurobiol 31:545-55. 2005
    ..Further experiments are required to test the hypothesis that MMP inhibition may be beneficial in protecting muscle from excessive remodelling following denervation and therefore improve reinnervation...