Research Topics
Species | Alan R HipkissSummaryCountry: UK Publications
| Collaborators
|
Detail Information
Publications
On the mechanisms of ageing suppression by dietary restriction-is persistent glycolysis the problem?Alan R Hipkiss
Centre for Experimental Therapeutics, William Harvey Research Institute, John Vane Science Centre, Bart s and the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
Mech Ageing Dev 127:8-15. 2006..The possible impact of diet and intracellular glycating agents on age-related mitochondrial dysfunction is also discussed...
Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?Alan R Hipkiss
Aston Research Centre for Healthy Ageing, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
Chem Cent J 7:38. 2013..These include cancer, Alzheimer's disease, Parkinson's disease and the complications of type-2 diabetes (nephropathy, cataracts, stroke and pain), which might all benefit from knowledge of carnosine's mode of action on human cells...
Can the beneficial effects of methionine restriction in rats be explained in part by decreased methylglyoxal generation resulting from suppressed carbohydrate metabolism?Alan R Hipkiss
Aston Research Centre for Healthy Ageing ARCHA, School of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK
Biogerontology 13:633-6. 2012..Additionally, decreased protein synthesis will lower the error-protein load which the protein quality system (proteasomal and autophagic) must deal with to maintain proteostasis...- Energy metabolism, proteotoxic stress and age-related dysfunction - protection by carnosineAlan R Hipkiss
Aston Research Centre for Healthy Ageing, School of Health and Life Sciences, Aston University, Birmingham B4 7ET, United Kingdom
Mol Aspects Med 32:267-78. 2011..Whether carnosine could be regarded as a rapamycin mimic is briefly discussed... - Could carnosine or related structures suppress Alzheimer's disease?Alan R Hipkiss
Centre for Experimental Therapeutics, William Harvey Research Institute, Bart s and the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1 6BQ, UK
J Alzheimers Dis 11:229-40. 2007..These observations suggest that carnosine and related structures should be explored for therapeutic potential towards AD and other neurodegenerative disorders... - Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms?Alan R Hipkiss
Centre for Experimental Therapeutics, William Harvey Research Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Biogerontology 9:49-55. 2008..Variation in mitochondrial DNA composition and consequent mutation rate, arising from dietary-controlled differences in DNA precursor ratios, could also contribute to tissue differences in age-related mitochondrial dysfunction... - On methionine restriction, suppression of mitochondrial dysfunction and agingAlan R Hipkiss
Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Bart s and the London Queen Mary s School of Medicine and Dentistry, London, UK
Rejuvenation Res 11:685-8. 2008..Changes in SAM levels may also affect gene silencing. All the above may help explain, at least in part, the beneficial effects of MetR... - Error-protein metabolism and ageingAlan R Hipkiss
Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Bart s and the London Queen Mary s School of Medicine and Dentistry, London, UK
Biogerontology 10:523-9. 2009..These proposals may help explain, in part, the latency of those age-related pathologies where altered proteins accumulate only late in life, and the beneficial effects of aerobic exercise and dietary restriction... - On the enigma of carnosine's anti-ageing actionsAlan R Hipkiss
School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The University of Birmingham, Edgbaston, Birmingham, UK
Exp Gerontol 44:237-42. 2009..These new observations only add to the enigma of carnosine's real in vivo functions. More experimentation is clearly required... - NAD+ availability and proteotoxicityAlan R Hipkiss
School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
Neuromolecular Med 11:97-100. 2009..Recognition and elimination of altered proteins is enhanced by NAD(+) through effects on stress protein expression and autophagy... - NAD(+) and metabolic regulation of age-related proteoxicity: A possible role for methylglyoxal?Alan R Hipkiss
The University of Birmingham, Edgbaston, UK
Exp Gerontol 45:395-9. 2010.... - Mitochondrial dysfunction, proteotoxicity, and aging: causes or effects, and the possible impact of NAD+-controlled protein glycationAlan R Hipkiss
School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom
Adv Clin Chem 50:123-50. 2010..Increased synthesis of glutathione, humanin, and mitochondrial chaperone proteins are other additional consequences of increased mitogenesis and which would help ensure proteostasis... - Proteotoxicity and the contrasting effects of oxaloacetate and glycerol on Caenorhabditis elegans life span: a role for methylglyoxal?Alan R Hipkiss
School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom
Rejuvenation Res 13:547-51. 2010.... - Energy metabolism and ageing regulation: metabolically driven deamidation of triosephosphate isomerase may contribute to proteostatic dysfunctionAlan R Hipkiss
Aston Research Centre for Healthy Ageing, School of Health and Life Sciences, Aston University, Birmingham, United Kingdom
Ageing Res Rev 10:498-502. 2011..It is proposed that these effects on TPI activity, though seemingly neglected in biogerontological contexts, reveal a mechanistic link between energy metabolism and age-related proteostatic dysfunction... - On why decreasing protein synthesis can increase lifespanAlan R Hipkiss
Centre for Experimental Therapeutics, William Harvey Research Institute, John Vane Science Centre, Bart s and the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
Mech Ageing Dev 128:412-4. 2007..This increased availability of proteolytic and chaperone functions may thereby contribute to the observed increase in organism stress resistance and lifespan... - Dietary restriction, glycolysis, hormesis and ageingAlan R Hipkiss
Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and The London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, EC1 6BQ, UK
Biogerontology 8:221-4. 2007..It is proposed that periods of fasting might be a more acceptable approach than permanent undernutrition in our attempts to slow human ageing, although timing of meals may prove important... - Do developmentally-related changes in constitutive proteolysis affect aberrant protein accumulation and generation of the aged phenotype?Alan R Hipkiss
Department of Experimental Therapeutics, William Harvey Research Institute, Charterhouse Square, London EC1M 6BQ, UK
Mech Ageing Dev 124:575-9. 2003..It is proposed that developmentally-regulated diminution of constitutive proteolytic activities contribute to the onset of age-relate pathologies... - Errors, mitochondrial dysfunction and ageingAlan R Hipkiss
Department of Experimental Therapeutics, William Harvey Research Institute, Charterhouse Square, London EC1M 6BQ, UK
Biogerontology 4:397-400. 2003..It is suggested that a search for age-related changes in the accuracy of mitochondrial ribosomes be carried out to test the validity or otherwise of these ideas... - Is carnosine a naturally occurring suppressor of oxidative damage in olfactory neurones?Alan R Hipkiss
Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom
Rejuvenation Res 7:253-5. 2004..Should the peptide prove beneficial, olfactory carnosine administration could provide a direct route to compromised tissue, avoiding serum carnosinases... - Glycation, ageing and carnosine: are carnivorous diets beneficial?Alan R Hipkiss
Centre for Experimental Therapeutics, William Harvey Research Institute, John Vane Science Centre, Bart s and the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
Mech Ageing Dev 126:1034-9. 2005..The possible beneficial effects of carnosine and related structures on protein carbonyl stress, AGE formation, secondary diabetic complications and age-related neuropathology are discussed... - Could carnosine suppress zinc-mediated proteasome inhibition and neurodegeneration? Therapeutic potential of a non-toxic but non-patentable dipeptideAlan R Hipkiss
Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, UK
Biogerontology 6:147-9. 2005..It is suggested that nasal administration of carnosine should be explored as a possible way of suppressing zinc/copper-mediated proteasome inhibition and consequent neurodegeneration... - Accumulation of altered proteins and ageing: causes and effectsAlan R Hipkiss
Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Experimental Therapeutics, Charterhouse Square, London EC1M 6BQ, UK
Exp Gerontol 41:464-73. 2006..Other possible explanations for the age-related changes in the defence systems, enzymatic and non-enzymatic, which normally counter generation of altered proteins are also discussed... - Does chronic glycolysis accelerate aging? Could this explain how dietary restriction works?Alan R Hipkiss
Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, UK
Ann N Y Acad Sci 1067:361-8. 2006..Occasional glycolysis during DR would decrease MG and reactive oxygen species (ROS) production and could be hormetic, inducing synthesis of glyoxalase-1 and anti-glycating agents (carnosine and polyamines)... - Would carnosine or a carnivorous diet help suppress aging and associated pathologies?Alan R Hipkiss
Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, UK
Ann N Y Acad Sci 1067:369-74. 2006..Olfactory administration of carnosine could provide a direct route to compromised tissue, avoiding serum carnosinases... - L-carnosine affects the growth of Saccharomyces cerevisiae in a metabolism-dependent mannerStephanie P Cartwright
Aston Research Centre for Healthy Ageing, School of Health and Life Sciences, Aston University, Birmingham, United Kingdom
PLoS ONE 7:e45006. 2012..These findings suggest that L-carnosine affects cells in a metabolism-dependent manner and provide a rationale for its effects on different cell types... - Carnosine and its possible roles in nutrition and healthAlan R Hipkiss
School of Clinicial and Experimental Medicine, College of Medical and Dental Sciences, The Univeristy of Birmingham, Edgbaston, Birmingham, UK
Adv Food Nutr Res 57:87-154. 2009..Evidence for carnosine's possible protective action against secondary diabetic complications, neurodegeneration, cancer, and other age-related pathologies is briefly discussed... - Reaction of carnosine with aged proteins: another protective process?Alan R Hipkiss
GKT School of Biomedical Sciences, King s College London, Guy s Campus, London Bridge, London SE1 1UL, United Kingdom
Ann N Y Acad Sci 959:285-94. 2002.... - The necessity of chance: would elimination of aging suppress evolution?Alan R Hipkiss
Exp Gerontol 38:1029. 2003 - Could carnosine be a naturally-occurring scavenger for acrolein and other reactive aldehydes in the brain?Alan R Hipkiss
Neurobiol Aging 23:645-6. 2002 - Age-related apoptotic dysfunction: any role for polypeptide aspartate instability?Alan R Hipkiss
Exp Gerontol 38:489-90. 2003