Alan R Hipkiss

Summary

Country: UK

Publications

  1. ncbi request reprint On the mechanisms of ageing suppression by dietary restriction-is persistent glycolysis the problem?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, John Vane Science Centre, Bart s and the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Mech Ageing Dev 127:8-15. 2006
  2. doi request reprint Carnosine and its possible roles in nutrition and health
    Alan R Hipkiss
    School of Clinicial and Experimental Medicine, College of Medical and Dental Sciences, The Univeristy of Birmingham, Edgbaston, Birmingham, UK
    Adv Food Nutr Res 57:87-154. 2009
  3. doi request reprint Aging risk factors and Parkinson's disease: contrasting roles of common dietary constituents
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing ARCHA, School of Health and Life Sciences, Aston University, Birmingham, UK Electronic address
    Neurobiol Aging 35:1469-72. 2014
  4. doi request reprint Inhibition of tumour cell growth by carnosine: some possible mechanisms
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing ARCHA, School of Health and Life Sciences, Aston University, Birmingham, B4 7ET, UK
    Amino Acids 46:327-37. 2014
  5. pmc Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Chem Cent J 7:38. 2013
  6. doi request reprint Can the beneficial effects of methionine restriction in rats be explained in part by decreased methylglyoxal generation resulting from suppressed carbohydrate metabolism?
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing ARCHA, School of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK
    Biogerontology 13:633-6. 2012
  7. doi request reprint Energy metabolism, proteotoxic stress and age-related dysfunction - protection by carnosine
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing, School of Health and Life Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    Mol Aspects Med 32:267-78. 2011
  8. pmc Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Biogerontology 9:49-55. 2008
  9. doi request reprint On methionine restriction, suppression of mitochondrial dysfunction and aging
    Alan R Hipkiss
    Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Bart s and the London Queen Mary s School of Medicine and Dentistry, London, UK
    Rejuvenation Res 11:685-8. 2008
  10. doi request reprint Error-protein metabolism and ageing
    Alan R Hipkiss
    Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Bart s and the London Queen Mary s School of Medicine and Dentistry, London, UK
    Biogerontology 10:523-9. 2009

Collaborators

Detail Information

Publications32

  1. ncbi request reprint On the mechanisms of ageing suppression by dietary restriction-is persistent glycolysis the problem?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, John Vane Science Centre, Bart s and the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Mech Ageing Dev 127:8-15. 2006
    ..The possible impact of diet and intracellular glycating agents on age-related mitochondrial dysfunction is also discussed...
  2. doi request reprint Carnosine and its possible roles in nutrition and health
    Alan R Hipkiss
    School of Clinicial and Experimental Medicine, College of Medical and Dental Sciences, The Univeristy of Birmingham, Edgbaston, Birmingham, UK
    Adv Food Nutr Res 57:87-154. 2009
    ..Evidence for carnosine's possible protective action against secondary diabetic complications, neurodegeneration, cancer, and other age-related pathologies is briefly discussed...
  3. doi request reprint Aging risk factors and Parkinson's disease: contrasting roles of common dietary constituents
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing ARCHA, School of Health and Life Sciences, Aston University, Birmingham, UK Electronic address
    Neurobiol Aging 35:1469-72. 2014
    ..As double blind, placebo-controlled carnosine supplementation studies have revealed beneficial outcomes in humans, it is suggested that MG scavengers such as carnosine be further explored for their therapeutic potential toward PD. ..
  4. doi request reprint Inhibition of tumour cell growth by carnosine: some possible mechanisms
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing ARCHA, School of Health and Life Sciences, Aston University, Birmingham, B4 7ET, UK
    Amino Acids 46:327-37. 2014
    ..It is possible, by acting at various sites that this pluripotent dipeptide may be an example of an endogenous "smart drug". ..
  5. pmc Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Chem Cent J 7:38. 2013
    ..These include cancer, Alzheimer's disease, Parkinson's disease and the complications of type-2 diabetes (nephropathy, cataracts, stroke and pain), which might all benefit from knowledge of carnosine's mode of action on human cells...
  6. doi request reprint Can the beneficial effects of methionine restriction in rats be explained in part by decreased methylglyoxal generation resulting from suppressed carbohydrate metabolism?
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing ARCHA, School of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK
    Biogerontology 13:633-6. 2012
    ..Additionally, decreased protein synthesis will lower the error-protein load which the protein quality system (proteasomal and autophagic) must deal with to maintain proteostasis...
  7. doi request reprint Energy metabolism, proteotoxic stress and age-related dysfunction - protection by carnosine
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing, School of Health and Life Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    Mol Aspects Med 32:267-78. 2011
    ..Whether carnosine could be regarded as a rapamycin mimic is briefly discussed...
  8. pmc Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Biogerontology 9:49-55. 2008
    ..Variation in mitochondrial DNA composition and consequent mutation rate, arising from dietary-controlled differences in DNA precursor ratios, could also contribute to tissue differences in age-related mitochondrial dysfunction...
  9. doi request reprint On methionine restriction, suppression of mitochondrial dysfunction and aging
    Alan R Hipkiss
    Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Bart s and the London Queen Mary s School of Medicine and Dentistry, London, UK
    Rejuvenation Res 11:685-8. 2008
    ..Changes in SAM levels may also affect gene silencing. All the above may help explain, at least in part, the beneficial effects of MetR...
  10. doi request reprint Error-protein metabolism and ageing
    Alan R Hipkiss
    Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Bart s and the London Queen Mary s School of Medicine and Dentistry, London, UK
    Biogerontology 10:523-9. 2009
    ..These proposals may help explain, in part, the latency of those age-related pathologies where altered proteins accumulate only late in life, and the beneficial effects of aerobic exercise and dietary restriction...
  11. doi request reprint On the enigma of carnosine's anti-ageing actions
    Alan R Hipkiss
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The University of Birmingham, Edgbaston, Birmingham, UK
    Exp Gerontol 44:237-42. 2009
    ..These new observations only add to the enigma of carnosine's real in vivo functions. More experimentation is clearly required...
  12. doi request reprint NAD+ availability and proteotoxicity
    Alan R Hipkiss
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Neuromolecular Med 11:97-100. 2009
    ..Recognition and elimination of altered proteins is enhanced by NAD(+) through effects on stress protein expression and autophagy...
  13. doi request reprint NAD(+) and metabolic regulation of age-related proteoxicity: A possible role for methylglyoxal?
    Alan R Hipkiss
    The University of Birmingham, Edgbaston, UK
    Exp Gerontol 45:395-9. 2010
    ....
  14. ncbi request reprint Mitochondrial dysfunction, proteotoxicity, and aging: causes or effects, and the possible impact of NAD+-controlled protein glycation
    Alan R Hipkiss
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Adv Clin Chem 50:123-50. 2010
    ..Increased synthesis of glutathione, humanin, and mitochondrial chaperone proteins are other additional consequences of increased mitogenesis and which would help ensure proteostasis...
  15. doi request reprint Proteotoxicity and the contrasting effects of oxaloacetate and glycerol on Caenorhabditis elegans life span: a role for methylglyoxal?
    Alan R Hipkiss
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Rejuvenation Res 13:547-51. 2010
    ....
  16. doi request reprint Energy metabolism and ageing regulation: metabolically driven deamidation of triosephosphate isomerase may contribute to proteostatic dysfunction
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing, School of Health and Life Sciences, Aston University, Birmingham, United Kingdom
    Ageing Res Rev 10:498-502. 2011
    ..It is proposed that these effects on TPI activity, though seemingly neglected in biogerontological contexts, reveal a mechanistic link between energy metabolism and age-related proteostatic dysfunction...
  17. ncbi request reprint Could carnosine or related structures suppress Alzheimer's disease?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Bart s and the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1 6BQ, UK
    J Alzheimers Dis 11:229-40. 2007
    ..These observations suggest that carnosine and related structures should be explored for therapeutic potential towards AD and other neurodegenerative disorders...
  18. ncbi request reprint On why decreasing protein synthesis can increase lifespan
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, John Vane Science Centre, Bart s and the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Mech Ageing Dev 128:412-4. 2007
    ..This increased availability of proteolytic and chaperone functions may thereby contribute to the observed increase in organism stress resistance and lifespan...
  19. ncbi request reprint Do developmentally-related changes in constitutive proteolysis affect aberrant protein accumulation and generation of the aged phenotype?
    Alan R Hipkiss
    Department of Experimental Therapeutics, William Harvey Research Institute, Charterhouse Square, London EC1M 6BQ, UK
    Mech Ageing Dev 124:575-9. 2003
    ..It is proposed that developmentally-regulated diminution of constitutive proteolytic activities contribute to the onset of age-relate pathologies...
  20. ncbi request reprint Errors, mitochondrial dysfunction and ageing
    Alan R Hipkiss
    Department of Experimental Therapeutics, William Harvey Research Institute, Charterhouse Square, London EC1M 6BQ, UK
    Biogerontology 4:397-400. 2003
    ..It is suggested that a search for age-related changes in the accuracy of mitochondrial ribosomes be carried out to test the validity or otherwise of these ideas...
  21. ncbi request reprint Is carnosine a naturally occurring suppressor of oxidative damage in olfactory neurones?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Rejuvenation Res 7:253-5. 2004
    ..Should the peptide prove beneficial, olfactory carnosine administration could provide a direct route to compromised tissue, avoiding serum carnosinases...
  22. ncbi request reprint Glycation, ageing and carnosine: are carnivorous diets beneficial?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, John Vane Science Centre, Bart s and the London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Mech Ageing Dev 126:1034-9. 2005
    ..The possible beneficial effects of carnosine and related structures on protein carbonyl stress, AGE formation, secondary diabetic complications and age-related neuropathology are discussed...
  23. ncbi request reprint Could carnosine suppress zinc-mediated proteasome inhibition and neurodegeneration? Therapeutic potential of a non-toxic but non-patentable dipeptide
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, UK
    Biogerontology 6:147-9. 2005
    ..It is suggested that nasal administration of carnosine should be explored as a possible way of suppressing zinc/copper-mediated proteasome inhibition and consequent neurodegeneration...
  24. ncbi request reprint Accumulation of altered proteins and ageing: causes and effects
    Alan R Hipkiss
    Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Experimental Therapeutics, Charterhouse Square, London EC1M 6BQ, UK
    Exp Gerontol 41:464-73. 2006
    ..Other possible explanations for the age-related changes in the defence systems, enzymatic and non-enzymatic, which normally counter generation of altered proteins are also discussed...
  25. ncbi request reprint Does chronic glycolysis accelerate aging? Could this explain how dietary restriction works?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, UK
    Ann N Y Acad Sci 1067:361-8. 2006
    ..Occasional glycolysis during DR would decrease MG and reactive oxygen species (ROS) production and could be hormetic, inducing synthesis of glyoxalase-1 and anti-glycating agents (carnosine and polyamines)...
  26. ncbi request reprint Would carnosine or a carnivorous diet help suppress aging and associated pathologies?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, UK
    Ann N Y Acad Sci 1067:369-74. 2006
    ..Olfactory administration of carnosine could provide a direct route to compromised tissue, avoiding serum carnosinases...
  27. ncbi request reprint Dietary restriction, glycolysis, hormesis and ageing
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and The London Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, EC1 6BQ, UK
    Biogerontology 8:221-4. 2007
    ..It is proposed that periods of fasting might be a more acceptable approach than permanent undernutrition in our attempts to slow human ageing, although timing of meals may prove important...
  28. pmc L-carnosine affects the growth of Saccharomyces cerevisiae in a metabolism-dependent manner
    Stephanie P Cartwright
    Aston Research Centre for Healthy Ageing, School of Health and Life Sciences, Aston University, Birmingham, United Kingdom
    PLoS ONE 7:e45006. 2012
    ..These findings suggest that L-carnosine affects cells in a metabolism-dependent manner and provide a rationale for its effects on different cell types...
  29. ncbi request reprint Reaction of carnosine with aged proteins: another protective process?
    Alan R Hipkiss
    GKT School of Biomedical Sciences, King s College London, Guy s Campus, London Bridge, London SE1 1UL, United Kingdom
    Ann N Y Acad Sci 959:285-94. 2002
    ....
  30. ncbi request reprint Age-related apoptotic dysfunction: any role for polypeptide aspartate instability?
    Alan R Hipkiss
    Exp Gerontol 38:489-90. 2003
  31. ncbi request reprint Could carnosine be a naturally-occurring scavenger for acrolein and other reactive aldehydes in the brain?
    Alan R Hipkiss
    Neurobiol Aging 23:645-6. 2002
  32. ncbi request reprint The necessity of chance: would elimination of aging suppress evolution?
    Alan R Hipkiss
    Exp Gerontol 38:1029. 2003