Alexander Heazell

Summary

Country: UK

Publications

  1. doi request reprint Sharing experiences to improve bereavement support and clinical care after stillbirth: report of the 7th annual meeting of the International Stillbirth Alliance
    Alexander E P Heazell
    Maternal and Fetal Health Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Acta Obstet Gynecol Scand 92:352-61. 2013
  2. ncbi request reprint Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast
    A E P Heazell
    University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    Placenta 29:175-86. 2008
  3. doi request reprint Midwives' and obstetricians' knowledge and management of women presenting with decreased fetal movements
    Alexander E P Heazell
    Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK
    Acta Obstet Gynecol Scand 87:331-9. 2008
  4. doi request reprint Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers
    A E P Heazell
    Maternal and Fetal Health Research Group, University of Manchester, Research Floor, St Mary s Hospital, Manchester, M13 0JH, UK
    Placenta 29:691-8. 2008
  5. doi request reprint Live and let die - regulation of villous trophoblast apoptosis in normal and abnormal pregnancies
    A E P Heazell
    Maternal and Fetal Health Research Group, St Mary s Hospital, Manchester M13 0JH, UK
    Placenta 29:772-83. 2008
  6. doi request reprint Altered expression of regulators of caspase activity within trophoblast of normal pregnancies and pregnancies complicated by preeclampsia
    Alexander E P Heazell
    Division of Human Development, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester, United Kingdom
    Reprod Sci 15:1034-43. 2008
  7. ncbi request reprint Does altered oxygenation or reactive oxygen species alter cell turnover of BeWo choriocarcinoma cells?
    Alexander E P Heazell
    Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Manchester, UK
    Reprod Biomed Online 18:111-9. 2009
  8. doi request reprint Can post-mortem examination of the placenta help determine the cause of stillbirth?
    A E P Heazell
    Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Manchester, UK
    J Obstet Gynaecol 29:225-8. 2009
  9. doi request reprint A case of intrauterine growth restriction in association with placental mesenchymal dysplasia with abnormal placental lymphatic development
    A E P Heazell
    Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Manchester M13 0JH, UK
    Placenta 30:654-7. 2009
  10. doi request reprint Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast
    Alexander E P Heazell
    Maternal and Fetal Health Research Group, St Mary s Hospital, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Apoptosis 16:135-44. 2011

Collaborators

Detail Information

Publications26

  1. doi request reprint Sharing experiences to improve bereavement support and clinical care after stillbirth: report of the 7th annual meeting of the International Stillbirth Alliance
    Alexander E P Heazell
    Maternal and Fetal Health Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Acta Obstet Gynecol Scand 92:352-61. 2013
    ....
  2. ncbi request reprint Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast
    A E P Heazell
    University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    Placenta 29:175-86. 2008
    ..The potential role of the p53-pathway in the control of cell turnover in villous trophoblast and the regulation of p53 by altered O(2) tension merits further investigation...
  3. doi request reprint Midwives' and obstetricians' knowledge and management of women presenting with decreased fetal movements
    Alexander E P Heazell
    Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK
    Acta Obstet Gynecol Scand 87:331-9. 2008
    ..It has been proposed that maternal perception of DFM may be used as a screening tool for IUFD or IUGR. However, this proposal is complicated by variations in definitions and management of DFM...
  4. doi request reprint Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers
    A E P Heazell
    Maternal and Fetal Health Research Group, University of Manchester, Research Floor, St Mary s Hospital, Manchester, M13 0JH, UK
    Placenta 29:691-8. 2008
    ..Metabolomics could be used to identify changes in conditions associated with placental pathology...
  5. doi request reprint Live and let die - regulation of villous trophoblast apoptosis in normal and abnormal pregnancies
    A E P Heazell
    Maternal and Fetal Health Research Group, St Mary s Hospital, Manchester M13 0JH, UK
    Placenta 29:772-83. 2008
    ..This review describes current knowledge regarding the expression and function of these regulators in villous trophoblast, both in normal and complicated pregnancies...
  6. doi request reprint Altered expression of regulators of caspase activity within trophoblast of normal pregnancies and pregnancies complicated by preeclampsia
    Alexander E P Heazell
    Division of Human Development, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester, United Kingdom
    Reprod Sci 15:1034-43. 2008
    ..In non-placental cells increased smac expression in the presence of normal IAP expression induces apoptosis. In conclusion, the increased expression of smac in villous trophoblast may have a role in increased apoptosis in PE...
  7. ncbi request reprint Does altered oxygenation or reactive oxygen species alter cell turnover of BeWo choriocarcinoma cells?
    Alexander E P Heazell
    Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Manchester, UK
    Reprod Biomed Online 18:111-9. 2009
    ..In addition, these data support a role for p53 in mediating altered trophoblast cell turnover in response to oxidative stress...
  8. doi request reprint Can post-mortem examination of the placenta help determine the cause of stillbirth?
    A E P Heazell
    Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Manchester, UK
    J Obstet Gynaecol 29:225-8. 2009
    ..05). We conclude that assessment of the placenta can aid classification of stillbirth and recommend that histological analysis of placental tissue be offered in all cases of stillbirth, even when full infant post-mortem is declined...
  9. doi request reprint A case of intrauterine growth restriction in association with placental mesenchymal dysplasia with abnormal placental lymphatic development
    A E P Heazell
    Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Manchester M13 0JH, UK
    Placenta 30:654-7. 2009
    ..Furthermore, such observations suggest that placental villous mesenchyme may differentiate into various cell types, even those not normally found in the human placenta...
  10. doi request reprint Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast
    Alexander E P Heazell
    Maternal and Fetal Health Research Group, St Mary s Hospital, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Apoptosis 16:135-44. 2011
    ..These observations provide further insight into the potential pathogenesis of IUGR. Further research is required to elicit the role and interactions of p53 and its place in the pathogenesis of IUGR...
  11. ncbi request reprint Formation of syncytial knots is increased by hyperoxia, hypoxia and reactive oxygen species
    A E P Heazell
    Maternal and Fetal Health Research Centre, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    Placenta 28:S33-40. 2007
    ....
  12. ncbi request reprint A case of fetal pericardial effusion in association with maternal hypertension and HIV infection
    A E P Heazell
    City Hospital, Dudley Road, Birmingham, UK
    J Obstet Gynaecol 24:89. 2004
  13. ncbi request reprint An unusual cause of urinary retention in early pregnancy
    Alexander E P Heazell
    Department of Obstetrics and Gynaecology, City Hospital, Dudley Road, Birmingham, United Kingdom
    Am J Obstet Gynecol 191:364-5. 2004
    ..Cervical pregnancy should be considered as a rare cause of acute retention of urine in early pregnancy, especially in the presence of vaginal bleeding...
  14. ncbi request reprint A retrospective study to determine if umbilical cord pH correlates with duration of delay between delivery of the head and body in shoulder dystocia
    A E P Heazell
    Department of Obstetrics and Gynaecology, Sandwell and West Birmingham NHS Trust, Dudley Road, Birmingham B18 7QH, UK
    J Obstet Gynaecol 24:776-7. 2004
  15. ncbi request reprint Vasculitic lesion involving the uterine cervix in a patient with anti-nuclear antibodies
    A E P Heazell
    Department of Obstetrics and Gynaecology, City Hospital, Sandwell and West Birmingham NHS Trust, Birmingham, UK
    J Obstet Gynaecol 24:711-2. 2004
  16. ncbi request reprint The treatment of severe hypertension in pregnancy: a review of current practice and knowledge in West-Midlands maternity units
    A E P Heazell
    City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
    J Obstet Gynaecol 24:897-8. 2004
  17. ncbi request reprint The use of levomepromazine in Hyperemesis Gravidarum resistant to drug therapy--a case series
    Alexander E P Heazell
    Maternal and Fetal Health Research Centre, Division of Human Development, University of Manchester, St Mary s Hospital, Whitworth Park, Manchester M13 0JH, UK
    Reprod Toxicol 20:569-72. 2005
    ..One pregnancy resulted in an intra-uterine death with no external or ultrasound evidence of congenital anomaly. The role of phenothiazines in the pharmacological management of HG is discussed...
  18. ncbi request reprint What investigation is appropriate following maternal perception of reduced fetal movements?
    A E P Heazell
    Maternal and Fetal Health Research Centre, St Mary s Hospital, Manchester, UK
    J Obstet Gynaecol 25:648-50. 2005
    ..To reduce unnecessary intervention, SFH measurement may be used as a screening tool for those who merit ultrasound assessment of growth and umbilical artery Doppler...
  19. ncbi request reprint A case of gestational diabetes arising following treatment with glucocorticosteroids for pemphigoid gestationis
    A E P Heazell
    Department of Obstetrics and Gynaecology, City Hospital, Birmingham, UK
    J Matern Fetal Neonatal Med 18:353-5. 2005
    ..The pregnancy continued to 37 weeks and a live male infant was delivered. There was no evidence of macroscopic changes in the placenta. The skin lesions resolved in the postpartum period...
  20. ncbi request reprint Acupressure for the in-patient treatment of nausea and vomiting in early pregnancy: a randomized control trial
    Alexander Heazell
    Maternal and Fetal Health Research Centre, St Mary s Hospital, Manchester, UK
    Am J Obstet Gynecol 194:815-20. 2006
    ..The purpose of this study was to evaluate the efficacy of acupressure at the P6 point for the in-patient treatment of severe nausea and vomiting in early pregnancy...
  21. ncbi request reprint A case of isolated peripartum elevation of alkaline phosphatase in pregnancy complicated by gestational diabetes
    Alexander E P Heazell
    Maternal and Fetal Health Research Centre, St Mary s Hospital, Manchester, UK
    J Matern Fetal Neonatal Med 19:311-3. 2006
    ..Elevations in total serum alkaline phosphatase during pregnancy or labor cannot be assumed to arise from the placenta, and should be further investigated to determine the specific isoenzyme...
  22. doi request reprint Predicting poor perinatal outcome in women who present with decreased fetal movements
    O O'Sullivan
    Department of Obstetrics and Gynaecology, Royal Blackburn Hospital, Blackburn, UK
    J Obstet Gynaecol 29:705-10. 2009
    ..Such patients may be prioritised for detailed assessment of fetal growth and wellbeing...
  23. doi request reprint Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia
    W B Dunn
    Manchester Centre for Integrative Systems Biology, University of Manchester, M1 7DN, UK
    Placenta 30:974-80. 2009
    ..Three areas of metabolism were highlighted for systems biology investigation; glutamate and glutamine, tryptophan metabolism and leukotriene or prostaglandin metabolism...
  24. doi request reprint Methods of fetal movement counting and the detection of fetal compromise
    A E P Heazell
    Division of Human Development, Maternal and Fetal Health Research Centre, St Mary s Hospital, University of Manchester, UK
    J Obstet Gynaecol 28:147-54. 2008
    ..Further investigation is required to determine an effective method of identifying patients with reduced fetal movements and to determine the best subsequent management...
  25. ncbi request reprint Is regional anaesthesia better than general anaesthesia for caesarean section?
    J Bowring
    Department of Obstetrics and Gynaecology, St Mary s Hospital, Manchester, UK
    J Obstet Gynaecol 26:433-4. 2006
    ..Despite a longer time taken to induce anaesthesia there was no increase in adverse fetal outcome, supporting the use of regional anaesthesia wherever possible to keep maternal complications to a minimum...
  26. ncbi request reprint Epidermal growth factor rescues trophoblast apoptosis induced by reactive oxygen species
    Sarah J Moll
    Division of Human Development, St Mary s Hospital, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Apoptosis 12:1611-22. 2007
    ..This study shows that apoptosis may be induced in villous trophoblast following exposure to ROS, and demonstrates the anti-apoptotic effect of EGF in trophoblast, the maintenance of which is essential for normal pregnancy...