N Woodford

Summary

Affiliation: Health Protection Agency
Country: UK

Publications

  1. ncbi request reprint Real-time TaqMan PCR for rapid detection and typing of genes encoding CTX-M extended-spectrum beta-lactamases
    Christopher I Birkett
    Health Protection Agency, Clinical Microbiology and Public Health Laboratory, Addenbrooke s Hospital, Cambridge, UK
    J Med Microbiol 56:52-5. 2007
  2. ncbi request reprint Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, 61 Colindale Ave, London NW9 5HT, UK
    Int J Antimicrob Agents 27:351-3. 2006
  3. doi request reprint Detection of Pseudomonas aeruginosa isolates producing VEB-type extended-spectrum beta-lactamases in the United Kingdom
    Neil Woodford
    Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 62:1265-8. 2008
  4. ncbi request reprint Two widely disseminated strains of Enterococcus faecalis highly resistant to gentamicin and ciprofloxacin from bacteraemias in the UK and Ireland
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency Colindale, London NW9 5HT UK
    J Antimicrob Chemother 52:711-4. 2003
  5. ncbi request reprint Successful, multiresistant bacterial clones
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 61:233-4. 2008
  6. doi request reprint In vitro activity of retapamulin against Staphylococcus aureus isolates resistant to fusidic acid and mupirocin
    N Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, HPA Centre for Infections, London NW9 5EQ, UK
    J Antimicrob Chemother 62:766-8. 2008
  7. ncbi request reprint Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum beta-lactamases in the UK
    N Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division Colindale, Health Protection Agency, London
    J Antimicrob Chemother 54:735-43. 2004
  8. pmc Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division Colindale, Health Protection Agency, London, United Kingdom
    Antimicrob Agents Chemother 48:4793-9. 2004
  9. ncbi request reprint The emergence of antibiotic resistance by mutation
    N Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London, UK
    Clin Microbiol Infect 13:5-18. 2007
  10. doi request reprint Arrival of Klebsiella pneumoniae producing KPC carbapenemase in the United Kingdom
    Neil Woodford
    Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 62:1261-4. 2008

Collaborators

Detail Information

Publications85

  1. ncbi request reprint Real-time TaqMan PCR for rapid detection and typing of genes encoding CTX-M extended-spectrum beta-lactamases
    Christopher I Birkett
    Health Protection Agency, Clinical Microbiology and Public Health Laboratory, Addenbrooke s Hospital, Cambridge, UK
    J Med Microbiol 56:52-5. 2007
    ..The new TaqMan assay detected and typed bla(CTX-M) genes in 21 of 28 ESBL-producing isolates...
  2. ncbi request reprint Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, 61 Colindale Ave, London NW9 5HT, UK
    Int J Antimicrob Agents 27:351-3. 2006
    ..Genes encoding OXA-58 were detected (with bla(OXA-51-like)) in a cluster of related isolates from a single hospital. This simple assay will assist in monitoring the mechanisms responsible for carbapenem resistance in Acinetobacter spp...
  3. doi request reprint Detection of Pseudomonas aeruginosa isolates producing VEB-type extended-spectrum beta-lactamases in the United Kingdom
    Neil Woodford
    Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 62:1265-8. 2008
    ..The aim of this study was to investigate the presence of VEB enzymes among Pseudomonas spp. referred to the UK's national reference laboratory and with phenotypic evidence of extended-spectrum beta-lactamase (ESBL) production...
  4. ncbi request reprint Two widely disseminated strains of Enterococcus faecalis highly resistant to gentamicin and ciprofloxacin from bacteraemias in the UK and Ireland
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency Colindale, London NW9 5HT UK
    J Antimicrob Chemother 52:711-4. 2003
    ..Further work is needed to characterize these two 'epidemic' E. faecalis strains and to investigate the presence of virulence genes...
  5. ncbi request reprint Successful, multiresistant bacterial clones
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 61:233-4. 2008
    ..For many of these species, we now recognize the existence of internationally prevalent clones, which are often resistant to multiple antibiotics...
  6. doi request reprint In vitro activity of retapamulin against Staphylococcus aureus isolates resistant to fusidic acid and mupirocin
    N Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, HPA Centre for Infections, London NW9 5EQ, UK
    J Antimicrob Chemother 62:766-8. 2008
    ..We determined the in vitro activity of retapamulin, a novel pleuromutilin antibiotic, against 664 Staphylococcus aureus isolates from the UK, including many resistant to fusidic acid and/or highly resistant to mupirocin...
  7. ncbi request reprint Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum beta-lactamases in the UK
    N Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division Colindale, Health Protection Agency, London
    J Antimicrob Chemother 54:735-43. 2004
    ..e. MICs of cefotaxime > or = 8-fold higher than MICs of ceftazidime. Many were referred as being from community patients. We examined 291 CTX-M-producing isolates from the UK and investigated the genetic basis of their phenotype...
  8. pmc Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division Colindale, Health Protection Agency, London, United Kingdom
    Antimicrob Agents Chemother 48:4793-9. 2004
    ..Although producers of these enzymes remain rare, the progress of this enzyme group merits monitoring...
  9. ncbi request reprint The emergence of antibiotic resistance by mutation
    N Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London, UK
    Clin Microbiol Infect 13:5-18. 2007
    ....
  10. doi request reprint Arrival of Klebsiella pneumoniae producing KPC carbapenemase in the United Kingdom
    Neil Woodford
    Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 62:1261-4. 2008
    ..KPC-type carbapenemases are increasingly prevalent in parts of the USA and Israel and are an emerging concern in South America, Europe and China. We investigated the UK's first two KPC-producing Klebsiella pneumoniae isolates...
  11. ncbi request reprint Biological counterstrike: antibiotic resistance mechanisms of Gram-positive cocci
    N Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London NW9 5HT, UK
    Clin Microbiol Infect 11:2-21. 2005
    ..This review describes the various antibiotic resistance mechanisms identified in isolates of staphylococci, enterococci and streptococci, including mechanisms of resistance to recently introduced anti-Gram-positive agents...
  12. ncbi request reprint Molecular detection of antibiotic resistance: when and where?
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5HT, UK
    J Antimicrob Chemother 56:259-61. 2005
    ....
  13. doi request reprint Infections caused by Gram-positive bacteria: a review of the global challenge
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London, UK
    J Infect 59:S4-16. 2009
    ..The emergence of antibiotic resistance is inevitable, but we must seek to decrease its impact and prolong the effectiveness of the agents available to us...
  14. pmc Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone
    Neil Woodford
    ARMRL, Centre for Infections, Health Protection Agency, London, United Kingdom
    Antimicrob Agents Chemother 53:4472-82. 2009
    ..coli...
  15. doi request reprint Tackling antibiotic resistance: a dose of common antisense?
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London NW9 5EQ, UK
    J Antimicrob Chemother 63:225-9. 2009
    ....
  16. pmc Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London, United Kingdom
    J Clin Microbiol 48:2999-3002. 2010
    ..OXA-48 producers were poorly detected, but all systems reliably detected isolates with KPC and most with metallo-carbapenemases...
  17. ncbi request reprint Wide geographic spread of diverse acquired AmpC beta-lactamases among Escherichia coli and Klebsiella spp. in the UK and Ireland
    Neil Woodford
    Centre for Infections, Health Protection Agency, London, NW9 5EQ, UK
    J Antimicrob Chemother 59:102-5. 2007
    ..To determine the distribution of acquired AmpC beta-lactamases in 173 isolates of Escherichia coli and Klebsiella spp. submitted to the UK's national reference laboratory for antibiotic resistance...
  18. ncbi request reprint Ertapenem resistance among Klebsiella and Enterobacter submitted in the UK to a reference laboratory
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London NW9 5EQ, UK
    Int J Antimicrob Agents 29:456-9. 2007
    ..or an AmpC enzyme in Enterobacter spp. - plus impermeability and/or increased efflux. Imipenem and meropenem often remain moderately active against isolates with low-level ertapenem resistance...
  19. ncbi request reprint Molecular epidemiology of multiresistant Escherichia coli isolates from community-onset urinary tract infections in Cornwall, England
    Neil Woodford
    Centre for Infections, Health Protection Agency, London, UK
    J Antimicrob Chemother 59:106-9. 2007
    ..To study the clonality of gentamicin-resistant, extended-spectrum beta-lactamase (ESBL)-negative and ESBL-producing Escherichia coli isolated from community-onset urinary tract infections (UTIs) in Cornwall...
  20. pmc Strains of glycopeptide-resistant Enterococcus faecium can alter their van genotypes during an outbreak
    N Woodford
    Laboratory of Hospital Infection, Central Public Health Laboratory, London, United Kingdom
    J Clin Microbiol 35:2966-8. 1997
    ..The genotype of this strain changed from vanB to vanA through an intermediate isolate that contained both the vanA and vanB gene clusters on distinct plasmids...
  21. ncbi request reprint Molecular characterization of plasmids encoding CTX-M-15 beta-lactamases from Escherichia coli strains in the United Kingdom
    E Karisik
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London, UK
    J Antimicrob Chemother 58:665-8. 2006
    ..Five major clonally related strains have been identified among CTX-M-15 producers. We characterize here the plasmids from clonal strains A and D...
  22. doi request reprint Phylogenetic diversity of Escherichia coli strains producing NDM-type carbapenemases
    S Mushtaq
    Antibiotic Resistance Monitoring and Reference Laboratory, HPA Microbiology Services Colindale, London, UK
    J Antimicrob Chemother 66:2002-5. 2011
    ..More recently, E. coli have emerged that produce NDM carbapenemase. We sought to determine the clonal diversity of E. coli with this enzyme from English hospitals, and to compare them with isolates from Pakistan and India...
  23. ncbi request reprint Emerging linezolid-resistant Enterococcus faecalis and Enterococcus faecium isolated from two Austrian patients in the same intensive care unit
    A P Johnson
    Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, Colindale, London NW9 5HT, UK
    Eur J Clin Microbiol Infect Dis 21:751-4. 2002
    ..The linezolid-resistant isolates showed cross-resistance to the experimental oxazolidinone AZD2563, suggesting that oxazolidinone resistance might be a class effect...
  24. pmc Diversity of VanA glycopeptide resistance elements in enterococci from humans and nonhuman sources
    N Woodford
    Antibiotic Reference Unit and Laboratory of Hospital Infection, Central Public Health Laboratory, London, United Kingdom
    Antimicrob Agents Chemother 42:502-8. 1998
    ....
  25. pmc DNA banding pattern polymorphism in vancomycin-resistant Enterococcus faecium and criteria for defining strains
    D Morrison
    Laboratory of Hospital Infection, Central Public Health Laboratory, London, United Kingdom
    J Clin Microbiol 37:1084-91. 1999
    ..This study demonstrates the high degree of DNA banding pattern polymorphism found for some strains of VREM and illustrates the complexity involved in defining such strains...
  26. doi request reprint AdeABC-mediated efflux and tigecycline MICs for epidemic clones of Acinetobacter baumannii
    Michael Hornsey
    Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 65:1589-93. 2010
    ..baumannii clones. The role of AdeABC in the emergence of tigecycline resistance during therapy was also investigated for two representatives of the prevalent UK lineage, OXA-23 clone 1...
  27. ncbi request reprint Development of high-level ceftazidime resistance via single-base substitutions of blaCTX-M-3 in hyper-mutable Escherichia coli
    E Karisik
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London, UK
    Clin Microbiol Infect 12:803-6. 2006
    ..These data emphasise the potential for further diversification of CTX-M enzymes...
  28. pmc Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients
    Maria Tomas
    Centre for Infections, Health Protection Agency, London, United Kingdom
    Antimicrob Agents Chemother 54:2219-24. 2010
    ..Overexpressed mexA or ampC and reduced oprD were associated with beta-lactam resistance. A specific combination of mexR, nalC, and nalD mutations occurred in 11 Liverpool strain isolates, including 7 with upregulated mexA...
  29. doi request reprint Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates
    D M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, HPA Microbiology Services, London, UK
    J Antimicrob Chemother 66:48-53. 2011
    ..They included 53 Klebsiella spp., 19 Enterobacter spp., 6 Escherichia coli and 4 others; most were multiresistant. Genes were identified by PCR and sequencing; MICs were measured by CLSI agar dilution...
  30. ncbi request reprint Virulence factors in Escherichia coli with CTX-M-15 and other extended-spectrum beta-lactamases in the UK
    E Karisik
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 61:54-8. 2008
    ..Multiresistant Escherichia coli with CTX-M-15 extended-spectrum beta-lactamase (ESBL) are widespread in the UK. We examined their phylogenetic groups and virulence factors...
  31. ncbi request reprint Epidemiology of the genetic elements responsible for acquired glycopeptide resistance in enterococci
    N Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London, United Kingdom
    Microb Drug Resist 7:229-36. 2001
    ..Characterization of glycopeptide resistance elements yields information on their evolution and broadens our insights into the epidemiology of resistant enterococci...
  32. ncbi request reprint Antibiotic resistance among clinical isolates of Acinetobacter in the UK, and in vitro evaluation of tigecycline (GAR-936)
    Caroline J Henwood
    Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, UK
    J Antimicrob Chemother 49:479-87. 2002
    ..In conclusion, carbapenems, colistin and minocycline retained greatest activity against the Acinetobacter isolates collected. Tigecycline was less active than minocycline, but both agents overcame most tetracycline resistance...
  33. pmc Detection of oxazolidinone-resistant Enterococcus faecalis and Enterococcus faecium strains by real-time PCR and PCR-restriction fragment length polymorphism analysis
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory Laboratory of Enteric Pathogens, Central Public Health Laboratory, London NW9 5HT, United Kingdom
    J Clin Microbiol 40:4298-300. 2002
    ..Both assays detected isolates heterozygous at this position. Recognition of isolates with what is presently the most frequent oxazolidinone resistance mutation may aid surveillance and individual case management...
  34. ncbi request reprint National glycopeptide-resistant enterococcal bacteraemia surveillance Working Group report to the Department of Health - August 2004
    D F J Brown
    Clinical Microbiology and Public Health Laboratory, Health Protection Agency, Addenbrooke s Hospital, Cambridge CB2 2QW, UK
    J Hosp Infect 62:S1-27. 2006
  35. ncbi request reprint Development of extended-spectrum activity in TEM beta-lactamases in hyper-mutable, mutS Escherichia coli
    M J Ellington
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London, UK
    Clin Microbiol Infect 12:800-3. 2006
    ..This correlated with a G-A point mutation at position 484 in the bla(TEM-1) and bla(TEM-pUC19) genes, conferring the Arg164His amino-acid substitution found in the TEM-29 ESBL. Non-ESBL mutants lacked changes in bla(TEM)...
  36. ncbi request reprint Multiresistant acinetobacter in the UK: how big a threat?
    J Coelho
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency Colindale, 61 Colindale Avenue, London NW9 5HT, UK
    J Hosp Infect 58:167-9. 2004
  37. doi request reprint Rapid characterization of beta-lactamases by multiplex PCR
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London, UK
    Methods Mol Biol 642:181-92. 2010
    ..These assays are suitable for deployment in national reference laboratories, but should also be considered for use in regional centres and in tertiary referral hospitals...
  38. pmc Occurrence of carbapenem-resistant Acinetobacter baumannii clones at multiple hospitals in London and Southeast England
    Juliana M Coelho
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, 61 Colindale Ave, London NW9 5HT, United Kingdom
    J Clin Microbiol 44:3623-7. 2006
    ..Their spread is forcing the use of unorthodox therapies, principally colistin and tigecycline, although the optimal regimens remain uncertain...
  39. pmc Rapid detection and estimation by pyrosequencing of 23S rRNA genes with a single nucleotide polymorphism conferring linezolid resistance in Enterococci
    Alistair Sinclair
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency Colindale, London NW9 5HT, United Kingdom
    Antimicrob Agents Chemother 47:3620-2. 2003
    ..A good correlation was found between linezolid MICs and the number of 23S rRNA gene copies carrying the mutation...
  40. pmc Carbapenemases of Chryseobacterium (Flavobacterium) meningosepticum: distribution of blaB and characterization of a novel metallo-beta-lactamase gene, blaB3, in the type strain, NCTC 10016
    N Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom
    Antimicrob Agents Chemother 44:1448-52. 2000
    ..are environmental organisms and occasional opportunist pathogens. They apparently represent a reservoir of diverse metallo-beta-lactamases, which potentially spread to gram-negative bacteria of greater clinical significance...
  41. ncbi request reprint Carbapenemases: a problem in waiting?
    D M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, 61 Colindale Avenue, NW9 5HT, London, UK
    Curr Opin Microbiol 3:489-95. 2000
    ..Is the emergence of carbapenemase a problem waiting to happen?..
  42. doi request reprint Linezolid-resistant ST36 methicillin-resistant Staphylococcus aureus associated with prolonged linezolid treatment in two paediatric cystic fibrosis patients
    Robert L R Hill
    Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 65:442-5. 2010
    ..To describe the emergence of linezolid-resistant methicillin-resistant Staphylococcus aureus (MRSA) of sequence type (ST)36 lineage in two paediatric patients with cystic fibrosis, after long-term low-dose linezolid treatment...
  43. pmc In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci
    David M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
    Antimicrob Agents Chemother 51:1112-4. 2007
    ..RWJ-416457 MICs for mutants with 23S rRNA mutations were 2 to 32 microg/ml, versus linezolid MICs of 8 to 64 microg/ml; actual values reflected the proportion of gene copies mutated...
  44. pmc Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-Producing Enterobacteriaceae
    David M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, HPA Centre for Infections, London, United Kingdom
    Antimicrob Agents Chemother 55:390-4. 2011
    ..with the KPC enzyme, but metallo-β-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 μg/ml, including those with metallo-β-lactamases...
  45. doi request reprint Cephalosporin resistance mechanisms in Escherichia coli isolated from raw chicken imported into the UK
    Hiran Dhanji
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London, UK
    J Antimicrob Chemother 65:2534-7. 2010
    ..coli belonging to the international uropathogenic ST131 clone...
  46. doi request reprint Tigecycline resistance in Serratia marcescens associated with up-regulation of the SdeXY-HasF efflux system also active against ciprofloxacin and cefpirome
    Michael Hornsey
    Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 65:479-82. 2010
    ....
  47. doi request reprint Real-time PCR for detection of the O25b-ST131 clone of Escherichia coli and its CTX-M-15-like extended-spectrum beta-lactamases
    Hiran Dhanji
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London NW9 5EQ, UK
    Int J Antimicrob Agents 36:355-8. 2010
    ..coli O25b:H4 ST131 clone that commonly produces this enzyme. We describe rapid real-time polymerase chain reaction (PCR) assays able to detect E. coli belonging to the ST131 clone and to identify bla(CTX-M-15)-like...
  48. doi request reprint Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK
    Michel Doumith
    Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency, Centre for Infections, 61 Colindale Avenue, London NW95EQ, UK
    J Antimicrob Chemother 63:659-67. 2009
    ..n = 28) and Enterobacter spp. (n = 27) referred from multiple hospitals to the UK national reference laboratory...
  49. doi request reprint NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum beta-lactamases and carbapenemases
    David M Livermore
    Health Protection Agency Centre for Infections, London, UK
    J Antimicrob Chemother 62:1053-6. 2008
    ..We examined whether combinations of oxyimino-cephalosporins with NXL104, a novel non-beta-lactam beta-lactamase inhibitor, overcame these resistances...
  50. doi request reprint Emergence of AcrAB-mediated tigecycline resistance in a clinical isolate of Enterobacter cloacae during ciprofloxacin treatment
    Michael Hornsey
    Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, London NW9 5EQ, UK
    Int J Antimicrob Agents 35:478-81. 2010
    ..Treatment with ciprofloxacin, a substrate of AcrAB in E. cloacae, possibly selected for cross-resistance to tigecycline as a result of RamA-mediated AcrAB upregulation...
  51. doi request reprint Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci
    David M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW95EQ, UK
    J Antimicrob Chemother 63:713-5. 2009
    ..TR-700 is the active moiety of TR-701 (DA-7157), a new oral/intravenous oxazolidinone prodrug. We examined its activity against linezolid-susceptible and -resistant staphylococci and enterococci...
  52. ncbi request reprint Detecting mutations that confer oxazolidinone resistance in gram-positive bacteria
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London, UK
    Methods Mol Biol 373:103-14. 2007
    ..This chapter summarizes the Pyrosequencing assays that have been developed in our laboratory for analyzing oxazolidinone-resistant enterococci and staphylococci...
  53. ncbi request reprint Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563
    Mark W Stockdale
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency Colindale, 61 Colindale Ave, London NW9 5HT, UK
    Int J Antimicrob Agents 23:88-91. 2004
    ..Mutants of one E. faecalis isolate had a G2576-->U 23S rRNA mutation; mutants derived from the second E. faecalis isolate lacked this mutation...
  54. ncbi request reprint CTX-M: changing the face of ESBLs in Europe
    David M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 59:165-74. 2007
    ..Irrespective of the particular enzyme, most producers are multiresistant. These changing patterns present major therapeutic and infection control challenges, with the public health intervention points unclear...
  55. ncbi request reprint Fluoroquinolone resistance and plasmid addiction systems: self-imposed selection pressure?
    Matthew J Ellington
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 57:1026-9. 2006
    ..Establishing the extent and mechanisms of cross-resistance to toxins and fluoroquinolones will aid the management of resistance and may contribute to the development of novel antimicrobials...
  56. ncbi request reprint The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii
    Jane F Turton
    Laboratory of HealthCare Associated Infection, Centre for Infections, Health Protection Agency, London, UK
    FEMS Microbiol Lett 258:72-7. 2006
    ..These results suggest that ISAba1 is providing the promoter for blaOXA-51-like and, probably, for blaOXA-23-like...
  57. ncbi request reprint The beta-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter
    David M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London, NW9 5EQ, UK
    Trends Microbiol 14:413-20. 2006
    ..This review discusses the epidemiology and microbiology of these resistance problems, along with possible solutions...
  58. ncbi request reprint Mutators among CTX-M beta-lactamase-producing Escherichia coli and risk for the emergence of fosfomycin resistance
    Matthew J Ellington
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 58:848-52. 2006
    ..Hypermutability among natural E. coli populations might facilitate the emergence of resistance to fosfomycin. We therefore examined the prevalence of mutators amongst urinary isolates of E. coli producing CTX-M beta-lactamases...
  59. pmc Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species
    Jane F Turton
    Laboratory of HealthCare Associated Infection, Centre for Infections, Health Protection Agency, 61 Colindale Ave, London NW9 5EQ, United Kingdom
    J Clin Microbiol 44:2974-6. 2006
    ..All isolates that gave a band for bla(OXA-51-like) identified as A. baumannii. This gene was detected in each of 141 isolates of A. baumannii but not in those of 22 other Acinetobacter species...
  60. pmc Improved multiplex PCR strategy for rapid assignment of the four major Escherichia coli phylogenetic groups
    M Doumith
    Microbiology Services Colindale, Health Protection Agency, London, United Kingdom
    J Clin Microbiol 50:3108-10. 2012
    ..It was validated using 185 isolates of known sequence types and showed improved congruence with multilocus sequence typing data...
  61. pmc Occurrence of OXA-58-like carbapenemases in Acinetobacter spp. collected over 10 years in three continents
    Juliana Coelho
    Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5HT, United Kingdom
    Antimicrob Agents Chemother 50:756-8. 2006
    ..Most isolates (28 of 30) also had bla(OXA-51). We conclude that bla(OXA-58) is geographically widespread and has occurred in Acinetobacter spp. for over 10 years...
  62. ncbi request reprint Glycopeptide-resistant Staphylococcus aureus
    Alan P Johnson
    Antibiotic Resistance Monitoring and Reference Laboratory, Colindale, London NW9 5HT
    J Antimicrob Chemother 50:621-3. 2002
  63. ncbi request reprint Novel agents for the treatment of resistant Gram-positive infections
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, 61 Colindale Avenue, London NW9 5HT, UK
    Expert Opin Investig Drugs 12:117-37. 2003
    ..In the next two decades, we should be optimistic that a regular flow of new anti-Gram-positive agents will enable us to offset the constant spectre of bacterial resistance...
  64. ncbi request reprint Multiplex PCR for rapid detection of genes encoding acquired metallo-beta-lactamases
    Matthew J Ellington
    J Antimicrob Chemother 59:321-2. 2007
  65. ncbi request reprint Activity of temocillin against prevalent ESBL- and AmpC-producing Enterobacteriaceae from south-east England
    David M Livermore
    J Antimicrob Chemother 57:1012-4. 2006
  66. pmc Mutations in the DNA mismatch repair proteins MutS and MutL of oxazolidinone-resistant or -susceptible Enterococcus faecium
    Rob J Willems
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Antimicrob Agents Chemother 47:3061-6. 2003
    ..Further studies are needed to investigate the prevalence of these MutSL mutations and their possible roles in the emergence of E. faecium strains resistant to oxazolidinones and other antibiotic classes...
  67. ncbi request reprint Isolation of streptogramin-resistant Enterococcus faecium from human and non-human sources in a rural community
    Sue Solway
    Truro Public Health Laboratory, Penventinnie Lane, Treliske, Truro, Cornwall TR1 3LQ, UK
    J Antimicrob Chemother 52:707-10. 2003
    ..To detect quinupristin-dalfopristin and virginiamycin M1 resistance in Enterococcus faecium from human, food and environmental sources...
  68. ncbi request reprint Detection of CTX-M-15 extended-spectrum beta-lactamase in the United Kingdom
    Shazad Mushtaq
    J Antimicrob Chemother 52:528-9. 2003
  69. pmc Outbreak of carbapenem-resistant Acinetobacter baumannii producing the OXA-23 enzyme in Curitiba, Brazil
    Libera M Dalla-Costa
    Hospital de Clínicas da Universidade Federal do Paraná HC, Curitiba, Brazil
    J Clin Microbiol 41:3403-6. 2003
    ..Treatment options were limited, although the isolates were susceptible to polymyxin B in vitro. The strain contributed to the deaths of five patients...
  70. ncbi request reprint Population structure and antibiotic resistance of Acinetobacter DNA group 2 and 13TU isolates from hospitals in the UK
    Richard P Spence
    Molecular Diagnostics and Typing Unit, Public Health Laboratory, Queens Medical Centre, Nottingham NG7 2UH
    J Med Microbiol 51:1107-12. 2002
    ....
  71. ncbi request reprint IMP-1 carbapenemase detected in an Acinetobacter clinical isolate from the UK
    Luke Tysall
    J Antimicrob Chemother 49:217-8. 2002
  72. pmc Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7)
    Alan Patrick Gibb
    Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Antimicrob Agents Chemother 46:255-8. 2002
    ..They produced a novel integron-associated metallo-beta-lactamase, designated IMP-7, with 91% identity to IMP-1. bla(IMP-7) was not detected with standard bla(IMP)-specific primers, owing to mismatches in the forward primer...
  73. ncbi request reprint Occurrence of insertion sequences within the genomes and Tn1546-like elements of glycopeptide-resistant enterococci isolated in Brazil, and identification of a novel element, ISEfa5
    Ilana L B C Camargo
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Monte Alegre, Ribeirao Preto, SP, Brazil
    Int J Med Microbiol 294:513-9. 2005
    ..However, the presence of IS-modified Tn1546-like elements, which appear to be rare in Brazil, could be a useful molecular marker in local epidemiological studies to monitor the evolution and horizontal transmission of VanA elements...
  74. ncbi request reprint Distribution of tetracycline resistance genes in genotypically related and unrelated multiresistant Acinetobacter baumannii strains from different European hospitals
    Geert Huys
    Laboratory of Microbiology, Ghent University, K L Ledeganckstraat 35, Ghent, Belgium
    Res Microbiol 156:348-55. 2005
    ..Collectively, our phenotypic and genotypic resistance data support the therapeutic evaluation of second-generation tetracyclines like MIN as promising agents for treating MDRAB infections...
  75. doi request reprint Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss
    Dolunay Gulmez
    Hacettepe University Faculty of Medicine, Department of Microbiology and Clinical Microbiology, 06100 Sihhiye, Ankara, Turkey
    Int J Antimicrob Agents 31:523-6. 2008
    ..Both isolates also had group 1 CTX-M-type ESBLs and had lost major outer membrane proteins. OXA-48-like carbapenemases appear to be scattered in Turkey and surveillance to determine their prevalence is warranted...
  76. pmc Dissemination of Acinetobacter baumannii clones with OXA-23 Carbapenemase in Colombian hospitals
    Maria Virginia Villegas
    John Stroger Hospital, 1900 W Polk, Rm 1236, Chicago, IL 60612, USA
    Antimicrob Agents Chemother 51:2001-4. 2007
    ..Blood, secretions, and abdominal fluids were the most frequent sites of isolation. This is the first description of widespread dissemination of OXA-23 in South America...
  77. pmc Sequence analysis of Enterococcus faecium strain 10/96A (VanD4), the original vancomycin-resistant E. faecium strain in Brazil
    Ilana L B C Camargo
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, and Hospital de Clinicas, Curitiba, Brazil 14040 903
    J Clin Microbiol 44:2635-7. 2006
    ..Multilocus sequence typing showed that strain 10/96A was isolated sporadically, has a unique sequence type (ST 281), and was not the progenitor of the VRE strains isolated from hospital outbreaks in Brazil...
  78. ncbi request reprint In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase
    Eugenne Elliott
    Department of Clinical Microbiology, Ampath Laboratories, Milpark Hospital, Johannesburg, South Africa
    Clin Infect Dis 42:e95-8. 2006
    ..All 4 isolates belonged to the same strain and produced a group 1 CTX-M enzyme; additionally, the resistant isolates had lost a porin...
  79. ncbi request reprint Comment on: Quinolone resistance determinant qnrA3 in clinical isolates of Salmonella in 2000-2005 in Hong Kong
    Matthew J Ellington
    J Antimicrob Chemother 59:157. 2007
  80. doi request reprint The British Society for Antimicrobial Chemotherapy Resistance Surveillance Project: a successful collaborative model
    Anthony R White
    Tony White Ltd, Newport, Essex, UK
    J Antimicrob Chemother 62:ii3-14. 2008
    ..The Project satisfies the requirement for sustainable defined-protocol high-quality resistance surveillance across the UK and Ireland...
  81. ncbi request reprint In vitro activity of tigecycline against carbapenem-susceptible and -resistant isolates of Klebsiella spp. and Enterobacter spp
    Neil Woodford
    J Antimicrob Chemother 59:582-3. 2007
  82. ncbi request reprint Reduced imipenem susceptibility in Klebsiella pneumoniae clinical isolates with plasmid-mediated CMY-2 and DHA-1 beta-lactamases co-mediated by porin loss
    Kyungwon Lee
    Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul 120 752, South Korea
    Int J Antimicrob Agents 29:201-6. 2007
    ..pneumoniae at this Korean hospital was largely co-mediated by production of plasmid-mediated AmpC beta-lactamases along with lack or greatly diminished expression of OmpK35 and OmpK36 porins...
  83. pmc Emergence of Enterobacteriaceae isolates producing CTX-M extended-spectrum beta-lactamase in Austria
    Alexandra Eisner
    Institute of Hygiene, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Antimicrob Agents Chemother 50:785-7. 2006
    ..coli isolate was identical to a United Kingdom epidemic CTX-M-15-producing strain, although no epidemiological link with the United Kingdom was apparent...
  84. ncbi request reprint Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum (beta)-lactamases
    Neil Woodford
    J Antimicrob Chemother 57:154-5. 2006
  85. doi request reprint Linkage of acquired quinolone resistance (qnrS1) and metallo-beta-lactamase (blaVIM-1) genes in multiple species of Enterobacteriaceae from Bolzano, Italy
    Richard Aschbacher
    Laboratorio Interaziendale di Microbiologia e Virologia, Via Amba Alagi 5, I 39100 Bolzano, Italy
    J Antimicrob Chemother 61:515-23. 2008
    ..Their resistance mechanisms were investigated...