James S Robertson

Summary

Affiliation: Health Protection Agency
Country: UK

Publications

  1. doi The development of vaccine viruses against pandemic A(H1N1) influenza
    James S Robertson
    Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar EN6 3QG, UK
    Vaccine 29:1836-43. 2011
  2. doi Prospects for controlling future pandemics of influenza
    James S Robertson
    National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, EN6 3QG, UK
    Virus Res 162:39-46. 2011
  3. pmc Permissible variation in the 3' non-coding region of the haemagglutinin genome segment of the H5N1 candidate influenza vaccine virus NIBRG-14 [corrected]
    Rachel E Johnson
    Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, Potters Bar, Hertfordshire, United Kingdom
    PLoS ONE 7:e36241. 2012
  4. doi An additional oligosaccharide moiety in the HA of a pandemic influenza H1N1 candidate vaccine virus confers increased antigen yield in eggs
    Carolyn Nicolson
    Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK
    Vaccine 30:745-51. 2012
  5. pmc Improved antigen yield in pandemic H1N1 (2009) candidate vaccine viruses with chimeric hemagglutinin molecules
    Ruth Harvey
    Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    J Virol 85:6086-90. 2011
  6. doi Current challenges in implementing cell-derived influenza vaccines: implications for production and regulation, July 2007, NIBSC, Potters Bar, UK
    Philip D Minor
    National Institute for Biological Standards and Control, South Mimms, Potters Bar, Herts, UK
    Vaccine 27:2907-13. 2009
  7. doi Improved haemagglutinin antigen content in H5N1 candidate vaccine viruses with chimeric haemagglutinin molecules
    Ruth Harvey
    Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    Vaccine 28:8008-14. 2010
  8. doi Application of deglycosylation to SDS PAGE analysis improves calibration of influenza antigen standards
    Ruth Harvey
    Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    Biologicals 40:96-9. 2012
  9. doi Quantitation of haemagglutinin in H5N1 influenza viruses reveals low haemagglutinin content of vaccine virus NIBRG-14 (H5N1)
    Ruth Harvey
    Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    Vaccine 26:6550-4. 2008
  10. ncbi Generation of influenza vaccine viruses on Vero cells by reverse genetics: an H5N1 candidate vaccine strain produced under a quality system
    Carolyn Nicolson
    Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Herts EN6 3QG, UK
    Vaccine 23:2943-52. 2005

Collaborators

Detail Information

Publications13

  1. doi The development of vaccine viruses against pandemic A(H1N1) influenza
    James S Robertson
    Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar EN6 3QG, UK
    Vaccine 29:1836-43. 2011
    ..Two approaches were followed, the classical reassortment approach and the more recent reverse genetics approach. This report describes the development and the characteristics of current pandemic H1N1 candidate vaccine viruses...
  2. doi Prospects for controlling future pandemics of influenza
    James S Robertson
    National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, EN6 3QG, UK
    Virus Res 162:39-46. 2011
    ..There needs to be a continued focus on improvement to the vaccine response system that will require close collaboration between influenza and vaccine experts, manufacturers, regulators and public health authorities around the world...
  3. pmc Permissible variation in the 3' non-coding region of the haemagglutinin genome segment of the H5N1 candidate influenza vaccine virus NIBRG-14 [corrected]
    Rachel E Johnson
    Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, Potters Bar, Hertfordshire, United Kingdom
    PLoS ONE 7:e36241. 2012
    ..These findings may serve to assure the influenza vaccine community that generation of CVVs using best-guess NCR sequences, based on sequence alignments, are likely to produce robust viruses...
  4. doi An additional oligosaccharide moiety in the HA of a pandemic influenza H1N1 candidate vaccine virus confers increased antigen yield in eggs
    Carolyn Nicolson
    Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK
    Vaccine 30:745-51. 2012
    ..However, position 119 may be a useful locus to monitor in future for viruses and CVVs with potentially high yield...
  5. pmc Improved antigen yield in pandemic H1N1 (2009) candidate vaccine viruses with chimeric hemagglutinin molecules
    Ruth Harvey
    Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    J Virol 85:6086-90. 2011
    ..Here we show that these new viruses have considerably improved growth in eggs and are therefore better candidate vaccine viruses for use in production of pandemic H1N1 (2009) vaccine...
  6. doi Current challenges in implementing cell-derived influenza vaccines: implications for production and regulation, July 2007, NIBSC, Potters Bar, UK
    Philip D Minor
    National Institute for Biological Standards and Control, South Mimms, Potters Bar, Herts, UK
    Vaccine 27:2907-13. 2009
    ..Future studies to progress the field were reviewed...
  7. doi Improved haemagglutinin antigen content in H5N1 candidate vaccine viruses with chimeric haemagglutinin molecules
    Ruth Harvey
    Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    Vaccine 28:8008-14. 2010
    ..Here we show that a number of these viruses have improved HA antigen content and yield and are therefore better candidate vaccine viruses for use in production of H5N1 vaccine...
  8. doi Application of deglycosylation to SDS PAGE analysis improves calibration of influenza antigen standards
    Ruth Harvey
    Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    Biologicals 40:96-9. 2012
    ..We found that while the final agreed HA value of the samples tested was not significantly different with or without deglycosylation, the deglycosylation step greatly improved between-laboratory agreement...
  9. doi Quantitation of haemagglutinin in H5N1 influenza viruses reveals low haemagglutinin content of vaccine virus NIBRG-14 (H5N1)
    Ruth Harvey
    Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    Vaccine 26:6550-4. 2008
    ..This was also found to be the case for the parent wild type A/Viet Nam/1194/2004 virus...
  10. ncbi Generation of influenza vaccine viruses on Vero cells by reverse genetics: an H5N1 candidate vaccine strain produced under a quality system
    Carolyn Nicolson
    Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Herts EN6 3QG, UK
    Vaccine 23:2943-52. 2005
    ....
  11. ncbi Assuring the quality, safety, and efficacy of DNA vaccines
    James S Robertson
    National Institute for Biological Standards and Control, Herts, UK
    Methods Mol Med 127:363-74. 2006
    ....
  12. ncbi Reference viruses for seasonal and pandemic influenza vaccine preparation
    John S Wood
    Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, UK
    Influenza Other Respir Viruses 1:5-9. 2007
    ..However, it is not possible to use such approaches in deriving vaccine reference viruses from highly pathogenic H5N1 viruses and alternative techniques such as reverse genetics must be employed...
  13. pmc Developing vaccines to combat pandemic influenza
    James S Robertson
    Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, EN6 3QG, UK E Mail O G E
    Viruses 2:532-46. 2010
    ..Reverse genetics has also been used successfully alongside classical reassorting techniques in the development of (swine flu) pandemic A(H1N1)v vaccine viruses...