Shamez N Ladhani

Summary

Affiliation: Health Protection Agency
Country: UK

Publications

  1. doi request reprint Immunoglobulin deficiency in children with Hib vaccine failure
    Shamez Ladhani
    Health Protection Agency Colindale, 61 Colindale Avenue, London NW9 5EQ, UK
    Vaccine 29:9137-40. 2011
  2. doi request reprint Impact of the 7-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in infants younger than 90 days in England and wales
    Shamez N Ladhani
    Health Protection Services Colindale, Health Protection Agency, Manchester Royal Infirmary, Manchester, United Kingdom
    Clin Infect Dis 56:633-40. 2013
  3. pmc Invasive pneumococcal disease after routine pneumococcal conjugate vaccination in children, England and Wales
    Shamez N Ladhani
    Immunisation Department, Health Protection Agency Colindale, London, UK
    Emerg Infect Dis 19:61-8. 2013
  4. doi request reprint Invasive meningococcal disease in England and Wales: implications for the introduction of new vaccines
    Shamez N Ladhani
    Health Protection Agency Colindale, Immunisation Department, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
    Vaccine 30:3710-6. 2012
  5. pmc Invasive Haemophilus influenzae serotype e and f disease, England and Wales
    Shamez N Ladhani
    Health Protection Agency, London, UK
    Emerg Infect Dis 18:725-32. 2012
  6. pmc Invasive meningococcal capsular group Y disease, England and Wales, 2007-2009
    Shamez N Ladhani
    Department, Health Protection Agency Colindale, 61 Colindale Ave, London NW9 5EQ, UK
    Emerg Infect Dis 18:63-70. 2012
  7. pmc Invasive Haemophilus influenzae Disease, Europe, 1996-2006
    Shamez Ladhani
    Health Protection Agency, London, UK
    Emerg Infect Dis 16:455-63. 2010
  8. doi request reprint Continuing impact of infectious diseases on childhood deaths in England and Wales, 2003-2005
    Shamez Ladhani
    Immunisation Department, Centre for Infections, Health Protection Agency, London, United Kingdom
    Pediatr Infect Dis J 29:310-3. 2010
  9. doi request reprint Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized children
    Shamez N Ladhani
    Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Clin Infect Dis 51:761-7. 2010
  10. doi request reprint The impact of Haemophilus influenzae serotype B resurgence on the epidemiology of childhood invasive Haemophilus influenzae disease in England and Wales
    Shamez N Ladhani
    Immunisation Department, Centre for Infections, Health Protection Agency, London, England
    Pediatr Infect Dis J 30:893-5. 2011

Detail Information

Publications33

  1. doi request reprint Immunoglobulin deficiency in children with Hib vaccine failure
    Shamez Ladhani
    Health Protection Agency Colindale, 61 Colindale Avenue, London NW9 5EQ, UK
    Vaccine 29:9137-40. 2011
    ..A proportion of children with Hib vaccine failure, especially where it occurs at a young age, appear to have a maturational delay in development of normal immunoglobulin concentrations...
  2. doi request reprint Impact of the 7-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in infants younger than 90 days in England and wales
    Shamez N Ladhani
    Health Protection Services Colindale, Health Protection Agency, Manchester Royal Infirmary, Manchester, United Kingdom
    Clin Infect Dis 56:633-40. 2013
    ....
  3. pmc Invasive pneumococcal disease after routine pneumococcal conjugate vaccination in children, England and Wales
    Shamez N Ladhani
    Immunisation Department, Health Protection Agency Colindale, London, UK
    Emerg Infect Dis 19:61-8. 2013
    ..4% (58/1,332) but higher for meningitis (11.0%) and children with comorbidities (9.1%). Thus, comorbidities were more prevalent in children with IPD caused by non-PCV13 serotypes and were associated with increased case fatality...
  4. doi request reprint Invasive meningococcal disease in England and Wales: implications for the introduction of new vaccines
    Shamez N Ladhani
    Health Protection Agency Colindale, Immunisation Department, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
    Vaccine 30:3710-6. 2012
    ....
  5. pmc Invasive Haemophilus influenzae serotype e and f disease, England and Wales
    Shamez N Ladhani
    Health Protection Agency, London, UK
    Emerg Infect Dis 18:725-32. 2012
    ..Multilocus sequence typing revealed a single major circulating clone for both Hif (sequence type 124; 89/99 isolates, 90%) and Hie (sequence type 18; 21/33, 64%), but no association between type and clinical disease or outcome was found...
  6. pmc Invasive meningococcal capsular group Y disease, England and Wales, 2007-2009
    Shamez N Ladhani
    Department, Health Protection Agency Colindale, 61 Colindale Ave, London NW9 5EQ, UK
    Emerg Infect Dis 18:63-70. 2012
    ..The increase in MenY disease requires careful epidemiologic and molecular monitoring...
  7. pmc Invasive Haemophilus influenzae Disease, Europe, 1996-2006
    Shamez Ladhani
    Health Protection Agency, London, UK
    Emerg Infect Dis 16:455-63. 2010
    ..Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality...
  8. doi request reprint Continuing impact of infectious diseases on childhood deaths in England and Wales, 2003-2005
    Shamez Ladhani
    Immunisation Department, Centre for Infections, Health Protection Agency, London, United Kingdom
    Pediatr Infect Dis J 29:310-3. 2010
    ..Data on the contribution of specific infections to childhood deaths in developed countries are limited...
  9. doi request reprint Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized children
    Shamez N Ladhani
    Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Clin Infect Dis 51:761-7. 2010
    ..The objective of this study was to investigate single-nucleotide polymorphisms (SNPs) known to affect function in biologically plausible genes in relation to the risk of Hib vaccine failure and its clinical manifestations...
  10. doi request reprint The impact of Haemophilus influenzae serotype B resurgence on the epidemiology of childhood invasive Haemophilus influenzae disease in England and Wales
    Shamez N Ladhani
    Immunisation Department, Centre for Infections, Health Protection Agency, London, England
    Pediatr Infect Dis J 30:893-5. 2011
    ..26/100,000), rising to 1.8/100,000 in 2002 before falling to 0.27/100,000 in 2008. During this period, nontype b H. influenzae disease remained stable, but there was a small year-on-year increase (3.4%/y; 95% CI: 1.4-5.5%) in incidence...
  11. doi request reprint Haemophilus influenzae serotype b conjugate vaccine failure in twelve countries with established national childhood immunization programmes
    S Ladhani
    Immunisation Department, Centre for Infections, Health Protection Agency, London, UK
    Clin Microbiol Infect 16:948-54. 2010
    ..Children with Hib vaccine failure should have immunoglobulin and convalescent Hib antibody concentrations measured after infection and receive additional vaccination, if required...
  12. doi request reprint Long-term immunological follow-up of children with haemophilus influenzae serotype b vaccine failure in the United Kingdom
    Shamez Ladhani
    Academic Unit of Paediatrics, Barts and the London School of Medicine and Dentistry, Centre for Infections, Health Protection Agency, St George s, University of London, London, United Kingdom
    Clin Infect Dis 49:372-80. 2009
    ..The objective of this study was to determine Hib antibody concentrations in children several years after infection and to identify risk factors for low antibody concentrations...
  13. doi request reprint Recommendations for the prevention of secondary Haemophilus influenzae type b (Hib) disease
    Shamez Ladhani
    Immunisation Department, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Infect 58:3-14. 2009
    ..Families of children attending the same pre-school or primary school as an index case should be advised to seek medical advice if their child becomes unwell...
  14. doi request reprint Changes in antibiotic resistance rates of invasive Haemophilus influenzae isolates in England and Wales over the last 20 years
    Shamez Ladhani
    Immunisation Department, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 62:776-9. 2008
    ..The aim of this study was to determine trends in antibiotic resistance profiles of invasive clinical Haemophilus influenzae isolates over the last 20 years...
  15. pmc Changes in ascertainment of Hib and its influence on the estimation of disease incidence in the United Kingdom
    S Ladhani
    Centre for Infections, Health Protection Agency, London, UK
    Epidemiol Infect 135:861-7. 2007
    ..Continued high-quality surveillance is needed in order to accurately monitor and detect changes in disease incidence...
  16. doi request reprint Risk of invasive Haemophilus influenzae infection during pregnancy and association with adverse fetal outcomes
    Sarah Collins
    Immunisation, Hepatitis, and Blood Safety Department, Public Health England, London, England
    JAMA 311:1125-32. 2014
    ..A number of studies have reported an increased incidence in neonates and suggested that pregnant women may have an increased susceptibility to invasive unencapsulated H. influenzae disease...
  17. ncbi request reprint Very low rates of culture-confirmed invasive bacterial infections in a prospective 3-year population-based surveillance in Southwest London
    Kirsty Le Doaré
    Paediatric Infectious Diseases Research Group, St George s Hospital, London, UK Wellcome Trust Imperial Centre for Global Health Research, Imperial College, London, UK
    Arch Dis Child 99:526-31. 2014
    ..To estimate the incidence, clinical characteristics and risk factors for culture-confirmed invasive bacterial infections in England...
  18. pmc Changes in molecular epidemiology of streptococcus pneumoniae causing meningitis following introduction of pneumococcal conjugate vaccination in England and Wales
    Bruno Pichon
    Respiratory and Systemic Infection Laboratory, Health Protection Agency, London, United Kingdom
    J Clin Microbiol 51:820-7. 2013
    ....
  19. ncbi request reprint Trends in bacterial, mycobacterial, and fungal meningitis in England and Wales 2004-11: an observational study
    Ifeanichukwu O Okike
    Paediatric Infectious Diseases Research Group and Vaccine Institute, St George s, University of London, London, UK Immunisation Department, Public Health England, London, UK
    Lancet Infect Dis 14:301-7. 2014
    ..Our aim was to do such a study using routinely reported data available in England and Wales...
  20. ncbi request reprint Pneumococcal carriage in children and adults two years after introduction of the thirteen valent pneumococcal conjugate vaccine in England
    Albert Jan van Hoek
    Immunisation, Hepatitis and Blood Safety Department, Public Health England, London NW9 5EQ, England, United Kingdom Electronic address
    Vaccine 32:4349-55. 2014
    ..In April 2010 the 7-valent pneumococcal conjugate vaccine (PCV7) was replaced by the 13-valent PCV. We investigated pneumococcal carriage in children eligible for PCV7 or PCV13 and their household contacts...
  21. doi request reprint The burden of nonencapsulated Haemophilus influenzae in children and potential for prevention
    Despoina Gkentzi
    St George s University of London, Cranmer Terrace, London, UK
    Curr Opin Infect Dis 25:266-72. 2012
    ..influenzae infections across all age groups and is associated with higher case fatality. A pneumococcal conjugate vaccine has recently been licensed, which may potentially also protect against invasive H. influenzae infections...
  22. doi request reprint Two decades of experience with the Haemophilus influenzae serotype b conjugate vaccine in the United Kingdom
    Shamez N Ladhani
    St George s University of London, London, United Kingdom
    Clin Ther 34:385-99. 2012
    ....
  23. ncbi request reprint Fall in Haemophilus influenzae serotype b (Hib) disease following implementation of a booster campaign
    S Ladhani
    Immunisation Department, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London, UK
    Arch Dis Child 93:665-9. 2008
    ....
  24. doi request reprint Trends in paediatric nosocomial bacteraemia in a London tertiary hospital
    Andrés Pérerz Lopéz
    Paediatric Infectious Disease Research Group, St George s Hospital NHS Trust, London, UK
    Acta Paediatr 102:1005-9. 2013
    ..To describe the incidence and microbiological characteristics of nosocomial bloodstream infections in childhood over a 9-year period at a South London tertiary hospital...
  25. pmc Validity of a reported history of chickenpox in targeting varicella vaccination at susceptible adolescents in England
    Nigel Field
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Services, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom 1 Research Department of Infection and Population Health, University College London, Mortimer Market Centre, off Capper Street, London WC1E 6JB, United Kingdom Electronic address
    Vaccine 32:1213-7. 2014
    ..To inform this approach, we estimated the proportion of adolescents with varicella antibodies by reported chickenpox history...
  26. ncbi request reprint Invasive bacterial and fungal infections in paediatric patients with cancer: Incidence, risk factors, aetiology and outcomes in a UK regional cohort 2009-2011
    Elizabeth A Calton
    Paediatric Infectious Diseases Group, St George s University of London, London, UK
    Pediatr Blood Cancer 61:1239-45. 2014
    ..This study aimed to estimate the risk, aetiology and outcome of bloodstream bacterial and fungal infections in children with cancer within a geographically defined region in South-West London over a 3-year period...
  27. ncbi request reprint Septicaemia due to glucose non-fermenting, gram-negative bacilli other than Pseudomonas aeruginosa in children
    S Ladhani
    Departments of Paediatrics and Microbiology, Guy s Hospital, London, UK
    Acta Paediatr 91:303-6. 2002
    ..Six patients were successfully treated with antibiotics alone. Four others received antibiotics, but also required line removal, and two patients responded to line removal without the need for antibiotics...
  28. ncbi request reprint Female genital mutilation: analysis of the first twelve months of a Southeast London specialist clinic
    C Momoh
    Guy's and St.Thomas's Hospital, UMDS, London, UK
    BJOG 108:186-91. 2001
    ..Doctors and midwives in particular, should enquire specifically about genital mutilation when caring for women from high risk countries, and offer the services of specialist clinics for female genital mutilation...
  29. doi request reprint No evidence for Haemophilus influenzae serotype replacement in Europe after introduction of the Hib conjugate vaccine
    Shamez Ladhani
    Lancet Infect Dis 8:275-6. 2008
  30. ncbi request reprint Changes in laboratory features of 192 children with imported falciparum malaria treated with quinine
    Shamez Ladhani
    Department of Pediatrics, Newham General Hospital, Queen Mary s School of Medicine and Dentistry, East London, United Kingdom
    Pediatr Infect Dis J 24:1017-20. 2005
    ..Thus most children presented with abnormal laboratory values, which initially worsened in a significant proportion, but none required active intervention once therapy was initiated...
  31. ncbi request reprint Staphylococcal skin infections in children: rational drug therapy recommendations
    Shamez Ladhani
    Department of Paediatrics, Newham General Hospital, London, UK
    Paediatr Drugs 7:77-102. 2005
    ..While the choice of antibacterial is important, supportive management, including removal of any infected foreign bodies, surgical drainage of walled-off lesions, and regular wound cleaning, play a vital role in ensuring cure...
  32. ncbi request reprint Childhood malaria in East London
    Shamez Ladhani
    Department of Pediatrics, Newham General Hospital, Queen Mary s School of Medicine and Dentistry, London, UK
    Pediatr Infect Dis J 22:814-9. 2003
    ..To describe the epidemiologic, clinical and laboratory features of children younger than 16 years with malaria in East London...