C A Harwood

Summary

Country: UK

Publications

  1. doi A surveillance model for skin cancer in organ transplant recipients: a 22-year prospective study in an ethnically diverse population
    C A Harwood
    Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
    Am J Transplant 13:119-29. 2013
  2. ncbi Clinicopathologic features of skin cancer in organ transplant recipients: a retrospective case-control series
    Catherine A Harwood
    Centre for Cutaneous Research, Institute for Cell and Molecular Science, Bart s and the London Queen Mary s School of Medicine and Dentistry, University of London, London, United Kingdom
    J Am Acad Dermatol 54:290-300. 2006
  3. pmc PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients
    C A Harwood
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Bart s and The London, Queen Mary School of Medicine and Dentistry, 4 Newark Street, London, UK
    Br J Cancer 99:1276-84. 2008
  4. ncbi Low-dose retinoids in the prevention of cutaneous squamous cell carcinomas in organ transplant recipients: a 16-year retrospective study
    Catherine A Harwood
    Centre for Cutaneous Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London, England
    Arch Dermatol 141:456-64. 2005
  5. ncbi Imiquimod cream 5% for recalcitrant cutaneous warts in immunosuppressed individuals
    C A Harwood
    Centre for Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary College, University of London, 2 Newark Street, London, E1 2AT, UK
    Br J Dermatol 152:122-9. 2005
  6. ncbi Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin
    C A Harwood
    Centre for Cutaneous Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, 2 Newark Street, London, E1 2AT, UK
    Br J Dermatol 150:949-57. 2004
  7. ncbi High frequency and diversity of cutaneous appendageal tumors in organ transplant recipients
    Catherine A Harwood
    Department of Academic Dermatology and Cancer Research, London, UK
    J Am Acad Dermatol 48:401-8. 2003
  8. ncbi Human papillomaviruses and non-melanoma skin cancer
    Catherine A Harwood
    Imperial Cancer Research Fund Skin Tumour Laboratory, Barts and The London NHS Trust, London, UK
    Curr Opin Infect Dis 15:101-14. 2002
  9. ncbi An association between sebaceous carcinoma and microsatellite instability in immunosuppressed organ transplant recipients
    C A Harwood
    Center for Cutaneous Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, 2 Newark Street, London E1 2AT, UK
    J Invest Dermatol 116:246-53. 2001
  10. ncbi Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals
    C A Harwood
    Department of Academic Dermatology, Royal Hospitals NHS Trust, London, United Kingdom
    J Med Virol 61:289-97. 2000

Detail Information

Publications38

  1. doi A surveillance model for skin cancer in organ transplant recipients: a 22-year prospective study in an ethnically diverse population
    C A Harwood
    Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
    Am J Transplant 13:119-29. 2013
    ..This study provides a comprehensive, prospective analysis of skin cancer morbidity and risk in an ethnically diverse transplant population from which we derive an evidence-based skin cancer surveillance program...
  2. ncbi Clinicopathologic features of skin cancer in organ transplant recipients: a retrospective case-control series
    Catherine A Harwood
    Centre for Cutaneous Research, Institute for Cell and Molecular Science, Bart s and the London Queen Mary s School of Medicine and Dentistry, University of London, London, United Kingdom
    J Am Acad Dermatol 54:290-300. 2006
    ..Non-melanoma skin cancers (NMSCs) are increased in organ transplant recipients, but transplant and immunocompetent squamous and basal cell carcinomas (SCCs, BCCs) have not been compared previously in a single-center study...
  3. pmc PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients
    C A Harwood
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Bart s and The London, Queen Mary School of Medicine and Dentistry, 4 Newark Street, London, UK
    Br J Cancer 99:1276-84. 2008
    ..This study of post-transplant BCC provides the first indication that azathioprine exposure may be associated with PTCH mutations, particularly in tumours from non-sun-exposed skin...
  4. ncbi Low-dose retinoids in the prevention of cutaneous squamous cell carcinomas in organ transplant recipients: a 16-year retrospective study
    Catherine A Harwood
    Centre for Cutaneous Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London, England
    Arch Dermatol 141:456-64. 2005
    ..To evaluate the long-term efficacy of systemic retinoids in reducing the incidence of cutaneous squamous cell carcinomas (SCCs) in organ transplant recipients (OTRs), who are at greatly increased risk of SCCs...
  5. ncbi Imiquimod cream 5% for recalcitrant cutaneous warts in immunosuppressed individuals
    C A Harwood
    Centre for Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary College, University of London, 2 Newark Street, London, E1 2AT, UK
    Br J Dermatol 152:122-9. 2005
    ..Imiquimod is a potent inducer of antiviral cytokine activity which has shown significant efficacy in the treatment of genital warts. Similar efficacy in cutaneous warts is not yet established...
  6. ncbi Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin
    C A Harwood
    Centre for Cutaneous Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, 2 Newark Street, London, E1 2AT, UK
    Br J Dermatol 150:949-57. 2004
    ..Human papillomaviruses (HPVs) are found in normal skin and in benign and malignant skin conditions. Epidermodysplasia verruciformis (EV) HPV types are those most plausibly linked to the development of squamous cell carcinomas of the skin...
  7. ncbi High frequency and diversity of cutaneous appendageal tumors in organ transplant recipients
    Catherine A Harwood
    Department of Academic Dermatology and Cancer Research, London, UK
    J Am Acad Dermatol 48:401-8. 2003
    ..Recipients of organ transplant who are immunosuppressed are at greatly increased risk of nonmelanoma skin cancers compared with the general population, but their risk of appendageal tumors is unknown...
  8. ncbi Human papillomaviruses and non-melanoma skin cancer
    Catherine A Harwood
    Imperial Cancer Research Fund Skin Tumour Laboratory, Barts and The London NHS Trust, London, UK
    Curr Opin Infect Dis 15:101-14. 2002
    ....
  9. ncbi An association between sebaceous carcinoma and microsatellite instability in immunosuppressed organ transplant recipients
    C A Harwood
    Center for Cutaneous Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, 2 Newark Street, London E1 2AT, UK
    J Invest Dermatol 116:246-53. 2001
    ..The role of mismatch repair defects in other post-transplant skin malignancies remains to be established...
  10. ncbi Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals
    C A Harwood
    Department of Academic Dermatology, Royal Hospitals NHS Trust, London, United Kingdom
    J Med Virol 61:289-97. 2000
    ..These data have important implications for future investigation of the role of HPV in cutaneous carcinogenesis at a functional level...
  11. pmc Degenerate and nested PCR: a highly sensitive and specific method for detection of human papillomavirus infection in cutaneous warts
    C A Harwood
    Department of Academic Dermatology, Royal Hospitals NHS Trust, London, United Kingdom
    J Clin Microbiol 37:3545-55. 1999
    ..Studies designed to assess the significance of these findings to cutaneous carcinogenesis are under way...
  12. ncbi Expression of DNA mismatch repair proteins and MSH2 polymorphisms in nonmelanoma skin cancers of organ transplant recipients
    C M Perrett
    Centre for Cutaneous Research and Department of Dermatology, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, 4 Newark Street, London E1 2AT, U K
    Br J Dermatol 162:732-42. 2010
    ..The MSH2 protein is an important component of DNA MMR. The -6 exon 13 T>C MSH2 polymorphism is associated with impaired MMR, drug resistance and certain cancers...
  13. doi Azathioprine treatment photosensitizes human skin to ultraviolet A radiation
    C M Perrett
    Centre for Cutaneous Research and Department of Dermatology, Institute of Cell and Molecular Science, Barts and The London, Queen Mary School of Medicine and Dentistry, 4 Newark Street, London, E1 2AT, UK
    Br J Dermatol 159:198-204. 2008
    ..Azathioprine is used to treat a variety of conditions and to prevent graft rejection in organ transplant recipients (OTRs)...
  14. pmc Beta-papillomaviruses and psoriasis: an intra-patient comparison of human papillomavirus carriage in skin and hair
    J G Cronin
    Centre for Cutaneous Research, Institute for Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, University of London, 4 Newark Street, London E1 2AT, UK
    Br J Dermatol 159:113-9. 2008
    ..Human papillomaviruses (HPVs) of the beta genus (beta-PV), especially HPV5 and HPV36, are proposed to play a pathogenic role in psoriasis, but many previous studies have failed to control for potential confounders, including treatment...
  15. pmc Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling
    S R Lambert
    1 Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK 2 Cancer Research UK Skin Tumour Laboratory, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Br J Cancer 110:520-9. 2014
    ..The purpose of this study was to elucidate key molecular events associated with progression from premalignant actinic keratoses (AKs) to invasive cSCC by transcriptome profiling...
  16. pmc Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy
    C M Perrett
    Centre for Cutaneous Research and Department of Dermatology, Institute of Cell and Molecular Science, Bart s and The London, Queen Mary School of Medicine and Dentistry, London, UK
    Br J Dermatol 156:320-8. 2007
    ..Epidermal dysplasia is often widespread and there are few comparative studies of available treatments...
  17. doi Melanoma in organ transplant recipients: clinicopathological features and outcome in 100 cases
    R N Matin
    Centre for Cutaneous Research and Department of Dermatology, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London, E1 2AT, UK
    Am J Transplant 8:1891-900. 2008
    ..These data have implications for both cutaneous surveillance in organ transplant recipients and management of transplant-associated melanoma...
  18. pmc High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia
    K J Purdie
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, UK
    Br J Cancer 102:1044-51. 2010
    ..The incidence of human papillomavirus-associated vulval neoplasia is increasing worldwide; yet the associated genetic changes remain poorly understood...
  19. doi A case-control study of betapapillomavirus infection and cutaneous squamous cell carcinoma in organ transplant recipients
    C M Proby
    Members of the EPI HPV UV CA group are Centre for Cutaneous Research, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
    Am J Transplant 11:1498-508. 2011
    ..Confirmation of a betaPV profile predictive of risk for SCC may pave the way for clinically relevant pretransplant HPV screening and the development of preventive and therapeutic HPV vaccination...
  20. pmc Vulval intraepithelial neoplasia and periungual Bowen's disease concordant for mucosal (HPV-34) and epidermodysplasia verruciformis (HPV-21) human papillomavirus types
    A L Ekeowa-Anderson
    Department of Dermatology, Whipps Cross University Hospital, London, UK
    Clin Exp Dermatol 32:304-7. 2007
    ..This case, in the context of accumulating epidemiological and experimental data in cutaneous SCC, raises the question of whether EV HPV may contribute to vulval malignancy, and further study is merited...
  21. doi The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling
    K Sully
    Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Oncogene 32:3254-62. 2013
    ....
  22. pmc Specialist dermatology clinics for organ transplant recipients significantly improve compliance with photoprotection and levels of skin cancer awareness
    F Ismail
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London E1 2AT, UK
    Br J Dermatol 155:916-25. 2006
    ..Cumulative exposure to ultraviolet radiation is the main risk factor and there is evidence that lack of dermatological surveillance may be responsible for poor levels of knowledge and photoprotection among OTRs...
  23. pmc Human papillomavirus gene expression in cutaneous squamous cell carcinomas from immunosuppressed and immunocompetent individuals
    Karin J Purdie
    Cancer Research UK, Skin Tumour Laboratory, London, UK
    J Invest Dermatol 125:98-107. 2005
    ..These observations, together with emerging epidemiological and functional data, provide further reason to focus on the contribution of EV-HPV types to the pathogenesis of cutaneous SCC...
  24. doi Synchronous melanoma and renal carcinoma: a clinicopathological study of five cases
    R N Matin
    Dermatology Department, Stoke Mandeville Hospital, Aylesbury, Buckinghamshire, UK
    Clin Exp Dermatol 38:47-9. 2013
    ..Further analysis of the synchronous occurrence of MM and renal cancer may provide therapeutic insights into these two important tumours...
  25. ncbi Primary cutaneous B-cell lymphoma associated with actinic prurigo
    C M Perrett
    Centre for Cutaneous Research and Department of Dermatology, Barts and the London School of Medicine and Dentistry, 2 Newark Street, London E1 2AT, UK
    Br J Dermatol 153:186-9. 2005
    ..We propose that chronic antigenic stimulation by ultraviolet radiation, in the context of actinic prurigo, may have been causal in the development of these unusual lymphomas...
  26. ncbi Safety and efficacy of 5% imiquimod cream for the treatment of skin dysplasia in high-risk renal transplant recipients: randomized, double-blind, placebo-controlled trial
    Victoria L Brown
    Centre for Cutaneous Research and Department of Dermatology, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, England
    Arch Dermatol 141:985-93. 2005
    ..To evaluate the safety and efficacy of 5% imiquimod cream for cutaneous dysplasia in high-risk renal transplant recipients...
  27. doi Reversal of UVA skin photosensitivity and DNA damage in kidney transplant recipients by replacing azathioprine
    G F L Hofbauer
    Department of Dermatology, University Hospital Zurich, Switzerland
    Am J Transplant 12:218-25. 2012
    ..Replacing azathioprine selectively reduced the skin photosensitivity to UVA, attenuated UVA-induced skin DNA damage, and is likely based on incorporated 6-TG in DNA...
  28. ncbi p53 codon 72 polymorphism and risk of cervical cancer in UK
    A N Rosenthal
    Gynaecology Cancer Research Unit, St Bartholomew s and Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK
    Lancet 352:871-2. 1998
    ..We examined a similar number of cervical cancers and a larger control group for their p53 codon 72 polymorphism status to see if we could confirm this result...
  29. doi Magnetic resonance imaging with gadolinium enhancement in renal failure: a need for caution
    Abha Gulati
    Department of Dermatology, Barts and The London NHS Trust, Whitechapel, London, UK
    Int J Dermatol 47:947-9. 2008
    ..He now has contractures of all the limbs (Figs 3 and 4) and great difficulty with the activities of daily living. He is receiving physiotherapy and being considered for extracorporeal photophoresis therapy...
  30. ncbi Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event
    Muy Teck Teh
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, England, United Kingdom
    Cancer Res 65:8597-603. 2005
    ..Furthermore, we provide the first evidence that uniparental disomy due to somatic recombination constitutes one of the mechanisms of LOH in basal cell carcinoma tumorigenesis...
  31. pmc Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis
    Karin J Purdie
    Cancer Research UK Skin Tumour Laboratory, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, England, UK
    Genes Chromosomes Cancer 46:661-9. 2007
    ..Two of the 3 primary SCC with PTPRD deletion had demonstrated metastatic potential. Our data identify PTPRD as a candidate tumor suppressor gene in cutaneous SCC with a possible association with metastasis...
  32. pmc Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors
    Ryan F L O'Shaughnessy
    Institute of Cell and Molecular Science, Barts and The London, Queen Mary School of Medicine and Dentistry, University of London, London, UK
    Cancer Res 67:8207-15. 2007
    ..These findings also suggest AKT2 as a possible therapeutic tumor target in SCC...
  33. ncbi p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma
    Victoria L Brown
    Centre for Cutaneous Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, University of London, London, UK
    J Invest Dermatol 122:1284-92. 2004
    ..These data confirm the importance of inactivation of p16(INK4a) and p14(ARF) TSGs in the pathogenesis of cutaneous SCCs...
  34. pmc Single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous SCCs
    Karin J Purdie
    Cancer Research UK Skin Tumour Laboratory, ICMS, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    J Invest Dermatol 129:1562-8. 2009
    ..No correlation was established between the frequency of chromosomal aberrations and immune or human papillomavirus status. Our data suggest that well-differentiated tumors are a genetically distinct subpopulation of cSCC...
  35. ncbi Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer
    Jane M McGregor
    Department of Photobiology, St Johns Institute of Dermatology, Guy s, Kings and St Thomas School of Medicine, St Thomas Hospital, London, U K
    J Invest Dermatol 119:84-90. 2002
    ..016), irrespective of the mutant status of the concomitant allele. Together these data infer functional differences between polymorphic forms of p53 that are likely to be relevant to skin carcinogenesis...
  36. pmc Keratotic skin lesions and other risk factors are associated with skin cancer in organ-transplant recipients: a case-control study in The Netherlands, United Kingdom, Germany, France, and Italy
    Jan N Bouwes Bavinck
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 127:1647-56. 2007
    ....
  37. pmc Azathioprine and UVA light generate mutagenic oxidative DNA damage
    Peter O'Donovan
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Science 309:1871-4. 2005
    ..These findings may partly explain the prevalence of skin cancer in long-term survivors of organ transplantation...
  38. ncbi Topical photodynamic therapy with methyl aminolevulinate to treat sebaceous hyperplasia in an organ transplant recipient
    Conal M Perrett
    Arch Dermatol 142:781-2. 2006