Christopher J Hammond

Summary

Country: UK

Publications

  1. pmc A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins
    Christopher J Hammond
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, and West Kent Eye Center, Princess Royal University Hospital, Orpington, United Kingdom
    Am J Hum Genet 75:294-304. 2004
  2. pmc Identification of a candidate gene for astigmatism
    Margarida C Lopes
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:1260-7. 2013
  3. pmc Copy number variation at chromosome 5q21.2 is associated with intraocular pressure
    Abhishek Nag
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:3607-12. 2013
  4. pmc Repeated measures of intraocular pressure result in higher heritability and greater power in genetic linkage studies
    Francis Carbonaro
    Department of Twin Research and Genetic Epidemiology, King s College London School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5115-9. 2009
  5. pmc The heritability of the ring-like distribution of macular pigment assessed in a twin study
    Ambreen Tariq
    Department of Ophthalmology, King s College London, St Thomas Hospital Campus, London, United Kingdom
    Invest Ophthalmol Vis Sci 55:2214-9. 2014
  6. pmc Cohort Profile: TwinsUK and healthy ageing twin study
    Alireza Moayyeri
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Int J Epidemiol 42:76-85. 2013
  7. pmc Increasing Prevalence of Myopia in Europe and the Impact of Education
    Katie M Williams
    Department of Ophthalmology, King s College London, St Thomas Hospital, London, United Kingdom Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Ophthalmology 122:1489-97. 2015
  8. doi request reprint Common polymorphisms in the SERPINI2 gene are associated with refractive error in the 1958 British Birth Cohort
    Pirro G Hysi
    MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 53:440-7. 2012
  9. pmc A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25
    Pirro G Hysi
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Nat Genet 42:902-5. 2010
  10. doi request reprint Estimating heritability and shared environmental effects for refractive error in twin and family studies
    Margarida C Lopes
    Department of Twin Research and Genetic Epidemiology, King s College London School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:126-31. 2009

Collaborators

Detail Information

Publications24

  1. pmc A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins
    Christopher J Hammond
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, and West Kent Eye Center, Princess Royal University Hospital, Orpington, United Kingdom
    Am J Hum Genet 75:294-304. 2004
    ....
  2. pmc Identification of a candidate gene for astigmatism
    Margarida C Lopes
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:1260-7. 2013
    ..Twin studies of astigmatism have found approximately 60% of phenotypic variance is explained by genetic factors. This study aimed to identify susceptibility loci for astigmatism...
  3. pmc Copy number variation at chromosome 5q21.2 is associated with intraocular pressure
    Abhishek Nag
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:3607-12. 2013
    ..We hypothesized that copy number variants (CNVs) might influence part of the susceptibility to glaucoma or its related quantitative endophenotypes...
  4. pmc Repeated measures of intraocular pressure result in higher heritability and greater power in genetic linkage studies
    Francis Carbonaro
    Department of Twin Research and Genetic Epidemiology, King s College London School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5115-9. 2009
    ..This was a cohort study in which 344 pairs of twins, 163 monozygotic (MZ) and 181 dizygotic (DZ), were enrolled...
  5. pmc The heritability of the ring-like distribution of macular pigment assessed in a twin study
    Ambreen Tariq
    Department of Ophthalmology, King s College London, St Thomas Hospital Campus, London, United Kingdom
    Invest Ophthalmol Vis Sci 55:2214-9. 2014
    ..We explored relative contributions of genetic and environmental factors in macular pigment optical density (MPOD) distributions using a classic twin study...
  6. pmc Cohort Profile: TwinsUK and healthy ageing twin study
    Alireza Moayyeri
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Int J Epidemiol 42:76-85. 2013
    ..Several collaborative projects in the field of epidemiology of complex disorders are ongoing in our cohort and interested researchers are encouraged to get in contact for future collaborations...
  7. pmc Increasing Prevalence of Myopia in Europe and the Impact of Education
    Katie M Williams
    Department of Ophthalmology, King s College London, St Thomas Hospital, London, United Kingdom Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Ophthalmology 122:1489-97. 2015
    ..To investigate whether myopia is becoming more common across Europe and explore whether increasing education levels, an important environmental risk factor for myopia, might explain any temporal trend...
  8. doi request reprint Common polymorphisms in the SERPINI2 gene are associated with refractive error in the 1958 British Birth Cohort
    Pirro G Hysi
    MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 53:440-7. 2012
    ..To identify heritable genetic factors altering susceptibility to refractive error in the general population...
  9. pmc A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25
    Pirro G Hysi
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Nat Genet 42:902-5. 2010
    ..001). The identification of a susceptibility locus for refractive error on 15q25 will be important in characterizing the molecular mechanism responsible for the most common cause of visual impairment...
  10. doi request reprint Estimating heritability and shared environmental effects for refractive error in twin and family studies
    Margarida C Lopes
    Department of Twin Research and Genetic Epidemiology, King s College London School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:126-31. 2009
    ..This large twin study aimed to explore the role of shared environment in refractive error...
  11. pmc Prevalence of refractive error in Europe: the European Eye Epidemiology (E(3)) Consortium
    Katie M Williams
    Department of Ophthalmology, King s College London, St Thomas Hospital, London, UK
    Eur J Epidemiol 30:305-15. 2015
    ..The greatest burden of refractive error is due to myopia, with high prevalence rates in young adults. Using the 2010 European population estimates, we estimate there are 227.2 million people with myopia across Europe...
  12. pmc The relationship between retinal arteriolar and venular calibers is genetically mediated, and each is associated with risk of cardiovascular disease
    Samantha J Fahy
    Department of Twin Research and Genetic Epidemiology, King s College London, School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:975-81. 2011
    ..59) between these two traits and to assess the shared and specific influence of established and novel cardiovascular disease risk factors on them...
  13. pmc Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping
    Toby Andrew
    Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    PLoS Genet 4:e1000220. 2008
    ..That two mitochondrial regulatory processes in the retina are implicated in the aetiology of myopia is surprising and is likely to provide novel insight into the molecular genetic basis of common myopia...
  14. pmc The heritability of dry eye disease in a female twin cohort
    Jelle Vehof
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 55:7278-83. 2014
    ..We estimated the relative importance of genes and environment in dry eye disease (DED) using a classic twin study...
  15. doi request reprint Prevalence and risk factors of dry eye disease in a British female cohort
    Jelle Vehof
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK Department of Ophthalmology and Epidemiology, University Medical Center Groningen, Groningen, The Netherlands
    Br J Ophthalmol 98:1712-7. 2014
    ..To estimate the prevalence and risk factors of dry eye disease (DED) in a female cohort in the UK...
  16. doi request reprint Twin studies in inherited eye disease
    Abhishek Nag
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Clin Experiment Ophthalmol 42:84-93. 2014
    ..Finally, we suggest other novel approaches that can be utilized to tap the potential of twin studies to provide a more complete understanding of genetic factors underlying ocular diseases...
  17. doi request reprint Relationship between dry eye symptoms and pain sensitivity
    Jelle Vehof
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Waterloo, London, England2Department of Ophthalmology and Epidemiology, University Medical Center Groningen, Groningen, The Netherlands
    JAMA Ophthalmol 131:1304-8. 2013
    ..Dry eye disease (DED) is common, but little is known about factors contributing to symptoms of dry eye, given the poor correlation between these symptoms and objective signs at the ocular surface...
  18. doi request reprint High heritability of posterior corneal tomography, as measured by Scheimpflug imaging, in a twin study
    Omar A Mahroo
    Ophthalmology, King s College London, St Thomas Hospital Campus, London, United Kingdom
    Invest Ophthalmol Vis Sci 55:8359-64. 2014
    ..Anterior corneal curvature shows significant heritability. Scheimpflug imaging also permits assessment of posterior tomography. We estimated heritability of posterior and anterior tomographic parameters...
  19. pmc The heritability of macular response to supplemental lutein and zeaxanthin: a classic twin study
    Christopher J Hammond
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital Campus, London, United Kingdom
    Invest Ophthalmol Vis Sci 53:4963-8. 2012
    ..This classic twin study was designed to determine the heritability of macular pigment (MP) augmentation in response to supplemental lutein (L) and zeaxanthin (Z)...
  20. pmc Association of CHRDL1 mutations and variants with X-linked megalocornea, Neuhäuser syndrome and central corneal thickness
    Alice E Davidson
    UCL Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 9:e104163. 2014
    ..This study highlights the importance of including X-chromosome SNP data in GWAS to identify potential loci associated with quantitative traits or disease risk...
  21. doi request reprint Shared genetic factors underlie chronic pain syndromes
    Jelle Vehof
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK Department of Ophthalmology and Epidemiology, University Medical Center Groningen, Groningen, The Netherlands
    Pain 155:1562-8. 2014
    ..These results are evidence of shared genetic factors in conditions manifesting chronic pain and justify the search for underlying genetic variants. ..
  22. pmc The UK Adult Twin Registry (TwinsUK Resource)
    Alireza Moayyeri
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, London, UK
    Twin Res Hum Genet 16:144-9. 2013
    ..The scientific community now can freely access parts of the phenotype data from the 'TwinsUK', and interested researchers are encouraged to contact us via our Web site (www.twinsuk.ac.uk) for future collaborations...
  23. ncbi request reprint Genetic dissection of myopia: evidence for linkage of ocular axial length to chromosome 5q
    Gu Zhu
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Ophthalmology 115:1053-1057.e2. 2008
    ..To estimate heritability and locate quantitative trait loci influencing axial length...
  24. ncbi request reprint Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopia
    Marja Majava
    Collagen Research Unit, Biocenter and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland
    Hum Mutat 28:336-44. 2007
    ..This study provides new insight into the genetics of high myopia, suggesting that sequence variations in the SLRP genes expressed in the eye may be among the genetic risk factors underlying the pathogenesis of high myopia...