John J Haddad

Summary

Country: UK

Publications

  1. ncbi request reprint Nuclear factor-kappa B-independent regulation of lipopolysaccharide-mediated interleukin-6 biosynthesis
    John J Haddad
    Oxygen Signaling Group, Center for Research into Human Development, Tayside Institute of Child Health, Faculty of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK corrected
    Biochem Biophys Res Commun 291:1045-51. 2002
  2. ncbi request reprint Hypoxia and the regulation of mitogen-activated protein kinases: gene transcription and the assessment of potential pharmacologic therapeutic interventions
    John J Haddad
    Severinghaus Radiometer Research Laboratories, University of California, San Francisco, CA, USA
    Int Immunopharmacol 4:1249-85. 2004
  3. ncbi request reprint Oxygen sensing and oxidant/redox-related pathways
    John J Haddad
    Severinghaus Radiometer Research Laboratories, University of California, San Francisco, CA, USA
    Biochem Biophys Res Commun 316:969-77. 2004
  4. ncbi request reprint Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment
    John J Haddad
    Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
    Int Immunopharmacol 4:475-93. 2004
  5. ncbi request reprint Redox regulation of pro-inflammatory cytokines and IkappaB-alpha/NF-kappaB nuclear translocation and activation
    John J Haddad
    Oxygen Signaling Group, Center for Research into Human Development, Tayside Institute of Child Health, Faculty of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK corrected
    Biochem Biophys Res Commun 296:847-56. 2002
  6. ncbi request reprint Mitogen-activated protein kinases and the evolution of Alzheimer's: a revolutionary neurogenetic axis for therapeutic intervention?
    John J Haddad
    Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
    Prog Neurobiol 73:359-77. 2004
  7. ncbi request reprint On the antioxidant mechanisms of Bcl-2: a retrospective of NF-kappaB signaling and oxidative stress
    John J Haddad
    Severinghaus Radiometer Research Laboratories, University of California, San Francisco, CA, USA
    Biochem Biophys Res Commun 322:355-63. 2004
  8. ncbi request reprint Alcoholism and neuro-immune-endocrine interactions: physiochemical aspects
    John J Haddad
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Biochem Biophys Res Commun 323:361-71. 2004
  9. ncbi request reprint Nuclear factor (NF)-kappa B blockade attenuates but does not abrogate LPS-mediated interleukin (IL)-1 beta biosynthesis in alveolar epithelial cells
    John J Haddad
    Oxygen Signaling Group, Center for Research into Human Development, Tayside Institute of Child Health, Faculty of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK corrected
    Biochem Biophys Res Commun 293:252-7. 2002
  10. ncbi request reprint N-methyl-D-aspartate (NMDA) and the regulation of mitogen-activated protein kinase (MAPK) signaling pathways: a revolving neurochemical axis for therapeutic intervention?
    John J Haddad
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Lebanon
    Prog Neurobiol 77:252-82. 2005

Detail Information

Publications41

  1. ncbi request reprint Nuclear factor-kappa B-independent regulation of lipopolysaccharide-mediated interleukin-6 biosynthesis
    John J Haddad
    Oxygen Signaling Group, Center for Research into Human Development, Tayside Institute of Child Health, Faculty of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK corrected
    Biochem Biophys Res Commun 291:1045-51. 2002
    ..These data indicate a NF-kappa B-independent pathway mediating LPS-dependent regulation of IL-6 biosynthesis in the airway epithelium...
  2. ncbi request reprint Hypoxia and the regulation of mitogen-activated protein kinases: gene transcription and the assessment of potential pharmacologic therapeutic interventions
    John J Haddad
    Severinghaus Radiometer Research Laboratories, University of California, San Francisco, CA, USA
    Int Immunopharmacol 4:1249-85. 2004
    ....
  3. ncbi request reprint Oxygen sensing and oxidant/redox-related pathways
    John J Haddad
    Severinghaus Radiometer Research Laboratories, University of California, San Francisco, CA, USA
    Biochem Biophys Res Commun 316:969-77. 2004
    ....
  4. ncbi request reprint Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment
    John J Haddad
    Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
    Int Immunopharmacol 4:475-93. 2004
    ..ROS/redox modifications, therefore, may disrupt signal transduction pathways, can be perceived as abnormal and, under some conditions, may trigger apoptosis...
  5. ncbi request reprint Redox regulation of pro-inflammatory cytokines and IkappaB-alpha/NF-kappaB nuclear translocation and activation
    John J Haddad
    Oxygen Signaling Group, Center for Research into Human Development, Tayside Institute of Child Health, Faculty of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK corrected
    Biochem Biophys Res Commun 296:847-56. 2002
    ....
  6. ncbi request reprint Mitogen-activated protein kinases and the evolution of Alzheimer's: a revolutionary neurogenetic axis for therapeutic intervention?
    John J Haddad
    Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
    Prog Neurobiol 73:359-77. 2004
    ..MAPKs, therefore, may constitute a neurogenetic, therapeutic target for the diagnosis and evolution of a preventative medical strategy for early detection, and likely treatment, of Alzheimer's...
  7. ncbi request reprint On the antioxidant mechanisms of Bcl-2: a retrospective of NF-kappaB signaling and oxidative stress
    John J Haddad
    Severinghaus Radiometer Research Laboratories, University of California, San Francisco, CA, USA
    Biochem Biophys Res Commun 322:355-63. 2004
    ....
  8. ncbi request reprint Alcoholism and neuro-immune-endocrine interactions: physiochemical aspects
    John J Haddad
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Biochem Biophys Res Commun 323:361-71. 2004
    ....
  9. ncbi request reprint Nuclear factor (NF)-kappa B blockade attenuates but does not abrogate LPS-mediated interleukin (IL)-1 beta biosynthesis in alveolar epithelial cells
    John J Haddad
    Oxygen Signaling Group, Center for Research into Human Development, Tayside Institute of Child Health, Faculty of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK corrected
    Biochem Biophys Res Commun 293:252-7. 2002
    ..It is concluded that the NF-kapp B pathway is partially implicated and its blockade attenuates but does not abrogate LPS-dependent IL-1 beta biosynthesis in alveolar epithelial cells...
  10. ncbi request reprint N-methyl-D-aspartate (NMDA) and the regulation of mitogen-activated protein kinase (MAPK) signaling pathways: a revolving neurochemical axis for therapeutic intervention?
    John J Haddad
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Lebanon
    Prog Neurobiol 77:252-82. 2005
    ..Given the versatility of the NMDA-MAPK interactions, the NMDA-MAPK axis will likely form a neurochemical target for therapeutic interventions...
  11. ncbi request reprint Cytokines and neuro-immune-endocrine interactions: a role for the hypothalamic-pituitary-adrenal revolving axis
    John J Haddad
    Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California at San Francisco, School of Medicine, Medical Sciences, San Francisco, CA 94143 0542, USA
    J Neuroimmunol 133:1-19. 2002
    ..In addition, we elaborate on HPA/cytokine interactions in oxidative stress within the context of nuclear factor-kappaB transcriptional regulation and the role of oxidative markers and related gaseous transmitters...
  12. ncbi request reprint L-gamma-Glutamyl-L-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)?
    John J Haddad
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Mol Immunol 42:987-1014. 2005
    ....
  13. ncbi request reprint Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha
    John J Haddad
    Department of Biology and Biomedical Sciences corrected Faculty of Arts and Sciences, Lebanese International University corrected Beirut, Lebanon
    Int Immunopharmacol 5:461-83. 2005
    ....
  14. pmc Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology
    John J Haddad
    Severinghaus Radiometer Research Laboratories, Molecular Neuroscience Research Division, Department of Anesthesia and Perioperative Care, University of California at San Francisco, School of Medicine, 94143 0542, USA
    Respir Res 3:26. 2002
    ..An association is established between oxidative stress conditions and the augmentation of an inflammatory state in pathophysiology, regulated by the oxygen- and redox-sensitive pleiotropic cytokines...
  15. ncbi request reprint Amiloride and the regulation of NF-kappaB: an unsung crosstalk and missing link between fluid dynamics and oxidative stress-related inflammation--controversy or pseudo-controversy?
    John J Haddad
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Biochem Biophys Res Commun 327:373-81. 2005
    ....
  16. ncbi request reprint Inhibition of glutathione-related enzymes augments LPS-mediated cytokine biosynthesis: involvement of an IkappaB/NF-kappaB-sensitive pathway in the alveolar epithelium
    John J Haddad
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, School of Medicine, 94143 0542, USA
    Int Immunopharmacol 2:1567-83. 2002
    ....
  17. ncbi request reprint Immunopharmacological potential of selective phosphodiesterase inhibition. II. Evidence for the involvement of an inhibitory-kappaB/nuclear factor-kappaB-sensitive pathway in alveolar epithelial cells
    John J Haddad
    Neuroscience Research Laboratory, Department of Anesthesia and Perioperative Care, University of California Medical Center, San Francisco, California 94143, USA
    J Pharmacol Exp Ther 300:567-76. 2002
    ....
  18. ncbi request reprint Amiloride blockades lipopolysaccharide-induced proinflammatory cytokine biosynthesis in an IkappaB-alpha/NF-kappaB-dependent mechanism. Evidence for the amplification of an antiinflammatory pathway in the alveolar epithelium
    John J Haddad
    Oxygen Signaling Group, Center for Research into Human Development, Tayside Institute of Child Health, Faculty of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Am J Respir Cell Mol Biol 26:114-26. 2002
    ..This biphasic effect is IL-10 sensitive and is associated with the selective targeting of the IkappaB-alpha/NF-kappaB signaling transduction pathway...
  19. ncbi request reprint The involvement of L-gamma-glutamyl-L-cysteinyl-glycine (glutathione/GSH) in the mechanism of redox signaling mediating MAPK(p38)-dependent regulation of pro-inflammatory cytokine production
    John J Haddad
    Oxygen Signaling Group, Tayside Institute of Child Health, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Biochem Pharmacol 63:305-20. 2002
    ....
  20. ncbi request reprint Redox regulation of TNF-alpha biosynthesis: augmentation by irreversible inhibition of gamma-glutamylcysteine synthetase and the involvement of an IkappaB-alpha/NF-kappaB-independent pathway in alveolar epithelial cells
    John J Haddad
    Oxygen Signalling Group, Center for Research into Human Development, Tayside Institute of Child Health, Faculty of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, Dundee, UK
    Cell Signal 14:211-8. 2002
    ....
  21. ncbi request reprint Redox signaling-mediated regulation of lipopolysaccharide-induced proinflammatory cytokine biosynthesis in alveolar epithelial cells
    John J Haddad
    Oxygen Signaling Group, Center for Research into Human Development, Tayside Institute of Child Health, Faculty of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Antioxid Redox Signal 4:179-93. 2002
    ....
  22. pmc Science review: redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for hypoxia-inducible factor-1alpha
    John J Haddad
    Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California at San Francisco, School of Medicine, San Francisco, California, USA
    Crit Care 7:47-54. 2003
    ..Changes in the pattern of gene expression through regulatory transcription factors are therefore crucial components of the machinery that determines cellular responses to oxidative/redox stress...
  23. doi request reprint Thymulin and zinc (Zn2+)-mediated inhibition of endotoxin-induced production of proinflammatory cytokines and NF-kappaB nuclear translocation and activation in the alveolar epithelium: unraveling the molecular immunomodulatory, anti-inflammatory effect of
    John J Haddad
    Cellular and Molecular Signaling Research Group, Department of Clinical Laboratory Science, Faculty of Health Sciences, American University of Science and Technology, Aschrafieh, Beirut, Lebanon
    Mol Immunol 47:205-14. 2009
    ..The molecular regulation of thymulin via a NF-kappaB-dependent pathway is critical to understanding the anti-inflammatory alleviating role of this nonapeptide in regulating proinflammatory signals...
  24. ncbi request reprint Recombinant human interleukin (IL)-1 beta-mediated regulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism
    John J Haddad
    Neuroscience Research Laboratory, Department of Anesthesia and Perioperative Care, University of California at San Francisco, Medical Sciences Building S 261, San Francisco, California 94143, USA
    Eur Cytokine Netw 13:250-60. 2002
    ..These results indicate that a non-hypoxic pathway mediates cytokine-dependent regulation of HIF-1 alpha translocation and activation in a ROS-sensitive mechanism...
  25. ncbi request reprint Redox- and oxidant-mediated regulation of interleukin-10: an anti-inflammatory, antioxidant cytokine?
    John J Haddad
    Severinghaus Radiometer Research Laboratories, Molecular Neuroscience Research Division, Department of Anesthesia and Perioperative Care, University of California at San Francisco, School of Medicine, 94143 0542, USA
    Biochem Biophys Res Commun 297:163-76. 2002
    ..The association between IL-10, an anti-inflammatory antioxidant, with redox- and oxidant-related pathways governing the regulation of inflammatory and closely dependent processes is thereafter discussed...
  26. ncbi request reprint Immunopharmacological potential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide-mediated proinflammatory cytokine (interleukin-6 and tumor necrosis factor-alpha) biosynthesis in alveolar epithelial cells
    John J Haddad
    Neuroscience Research Laboratory, Department of Anesthesia and Perioperative Care, University of California Medical Center, San Francisco, California 94143, USA
    J Pharmacol Exp Ther 300:559-66. 2002
    ....
  27. ncbi request reprint Recombinant TNF-alpha mediated regulation of the I kappa B-alpha/NF-kappa B signaling pathway: evidence for the enhancement of pro- and anti-inflammatory cytokines in alveolar epithelial cells
    John J Haddad
    Neuroscience Research Laboratory, Department of Anesthesia and Perioperative Care, University of California, Medical Center S 261, San Francisco, California 94143 0542, USA
    Cytokine 17:301-10. 2002
    ..These results indicate a novel involvement of an I kappa B-alpha/NF-kappa B-sensitive pathway mediating the effect of TNF-alpha, which is associated with an autocrine, endogenous mechanism mediating the regulation of cytokine signaling...
  28. doi request reprint A redox microenvironment is essential for MAPK-dependent secretion of pro-inflammatory cytokines: modulation by glutathione (GSH/GSSG) biosynthesis and equilibrium in the alveolar epithelium
    John J Haddad
    Cellular and Molecular Signaling Research Group, Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon
    Cell Immunol 270:53-61. 2011
    ..These results indicate that a redox microenvironment plays a major role in regulating MAPK-dependent production of cytokines in the alveolar epithelium...
  29. ncbi request reprint Oxygen homeostasis, thiol equilibrium and redox regulation of signalling transcription factors in the alveolar epithelium
    John J Haddad
    Neuroscience Research Laboratory, Department of Anesthesia and Perioperative Care, University of California at San Francisco, Medical Sciences Building S 261, San Francisco, CA 94143 0542, USA
    Cell Signal 14:799-810. 2002
    ....
  30. ncbi request reprint Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors
    John J Haddad
    Molecular Neuroscience Research Division, Department of Anesthesia and Perioperative Care, University of California at San Francisco, School of Medicine, San Francisco, CA 94143 0542, USA
    Cell Signal 14:879-97. 2002
    ..Here, I describe the basic components of the intracellular oxidative/redox control machinery and its crucial regulation of oxygen- and redox-sensitive transcription factors such as NF-kappaB and HIF-1alpha...
  31. pmc Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for nuclear factor-kappaB
    John J Haddad
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, School of Medicine, San Francisco, California, USA
    Crit Care 6:481-90. 2002
    ....
  32. ncbi request reprint Cytokines in the central nervous system: targets for therapeutic intervention
    Bared Safieh-Garabedian
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, 1107 2020, Lebanon
    Curr Drug Targets CNS Neurol Disord 3:271-80. 2004
    ....
  33. ncbi request reprint Interleukin-10 and the regulation of mitogen-activated protein kinases: are these signalling modules targets for the anti-inflammatory action of this cytokine?
    John J Haddad
    Severinghaus Radiometer Research Laboratories, Molecular Neuroscience Research Division, Department of Anesthesia and Perioperative Care, University of California at San Francisco, School of Medicine, 94143 0542, USA
    Cell Signal 15:255-67. 2003
    ..The biochemistry and molecular biology of cytokine actions, particularly IL-10, explain some well known and sometimes also some of the more obscure clinical aspects of the evolution of diseases...
  34. ncbi request reprint Discordant tissue-specific expression of SAPK/MAPK(JNK)-related cofactors in hypoxia and hypoxia/reoxygenation in a model of anoxia-tolerance
    John J Haddad
    Molecular Signaling Research Group, Division of Biological Sciences, Department of Biology, Faculty of Arts and Sciences, Lebanese International University, Beirut, Lebanon
    Protein Pept Lett 14:373-80. 2007
    ..Changes in the phosphorylation state of MAPKs may occur during anoxia, thereby reversible protein phosphorylation could be a critical factor and major mechanism of metabolic reorganization for enduring anaerobiosis...
  35. ncbi request reprint On the enigma of pain and hyperalgesia: A molecular perspective
    John J Haddad
    Molecular Signaling Research Group, Division of Biological Sciences, Department of Biology and Biomedical Sciences, Faculty of Arts and Sciences, Lebanese International University, Beirut, Lebanon
    Biochem Biophys Res Commun 353:217-24. 2007
    ..Understanding the mechanisms of pain continue to make nociception and hyperalgesia a burgeoning field of research...
  36. ncbi request reprint The role of Bax/Bcl-2 and pro-caspase peptides in hypoxia/reperfusion-dependent regulation of MAPK(ERK): discordant proteomic effect of MAPK(p38)
    John J Haddad
    Molecular Signaling Research Group, Division of Biological Sciences, Department of Biology, Faculty of Arts and Sciences, Lebanese International University, Beirut, Lebanon
    Protein Pept Lett 14:361-71. 2007
    ....
  37. doi request reprint On the mechanisms and putative pathways involving neuroimmune interactions
    John J Haddad
    Cellular and Molecular Signaling Research Group, Department of Biology, Faculty of Arts and Sciences, Lebanese International University, Beirut, Lebanon
    Biochem Biophys Res Commun 370:531-5. 2008
    ....
  38. doi request reprint The role of inflammatory cytokines and NF-kappaB/MAPK signaling pathways in the evolution of familial Mediterranean fever: current clinical perspectives and potential therapeutic approaches
    John J Haddad
    Cellular and Molecular Signaling Research Group, Department of Clinical Laboratory Science, Faculty of Health Sciences, American University of Science and Technology, Aschrafieh, Beirut, Lebanon
    Cell Immunol 260:6-13. 2009
    ..Furthermore, I summarize current advances for the clinical treatments available for FMF...
  39. ncbi request reprint Pharmaco-redox regulation of cytokine-related pathways: from receptor signaling to pharmacogenomics
    John J Haddad
    Severinghaus Radiometer Research Labs, Molecular Neuroscience Research Division, Dept of Anesthesia and Perioperative Care, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0542, USA
    Free Radic Biol Med 33:907-26. 2002
    ..This fact, therefore, may have crucial significance in the development of therapeutic strategies for biopharmacologic intervention in cytokine-mediated inflammatory processes and infections...
  40. ncbi request reprint Cytokines and related receptor-mediated signaling pathways
    John J Haddad
    Severinghaus Radiometer Research Labs, Molecular Neuroscience Research Division, School of Medicine, University of California San Francisco, Medical Sciences Building S 261, 513 Parnassus Avenue, San Francisco, CA 94143 0542, USA
    Biochem Biophys Res Commun 297:700-13. 2002
    ..This fact therefore may have crucial significance in the development of therapeutic strategies for bio-pharmacologic intervention in cytokine-mediated inflammatory processes and infections...
  41. doi request reprint NF-κB cellular and molecular regulatory mechanisms and pathways: therapeutic pattern or pseudoregulation?
    John J Haddad
    Cellular and Molecular Signaling Research Group, Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon
    Cell Immunol 271:5-14. 2011
    ....