David Michael Wood

Summary

Affiliation: Guy's and St Thomas' NHS Foundation Trust
Country: UK

Publications

  1. pmc Recreational use of mephedrone (4-methylmethcathinone, 4-MMC) with associated sympathomimetic toxicity
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    J Med Toxicol 6:327-30. 2010
  2. pmc Putting cocaine use and cocaine-associated cardiac arrhythmias into epidemiological and clinical perspective
    David M Wood
    Guy s and St Thomas NHS Foundation Trust and Kings Health Partners, London, UK
    Br J Clin Pharmacol 69:443-7. 2010
  3. doi request reprint Five-year trends in self-reported recreational drugs associated with presentation to a UK emergency department with suspected drug-related toxicity
    David M Wood
    Department of Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    Eur J Emerg Med 20:263-7. 2013
  4. doi request reprint Internet survey of home storage of paracetamol by individuals in the UK
    A D Shah
    Medical Toxicology Office, 2nd Floor, Bermondsey Wing, Guy s Hospital, Great Maze Pond, London, UK
    QJM 106:253-9. 2013
  5. doi request reprint Emergency department presentations in determining the effectiveness of drug control in the United Kingdom: mephedrone (4-methylmethcathinone) control appears to be effective using this model
    David M Wood
    Medical Toxicology Office, 2nd Floor, Bermondsey Wing, Guy s Hospital, Great Maze Pond, London SE1 9RT, UK
    Emerg Med J 30:70-1. 2013
  6. doi request reprint Management of acute paracetamol (acetaminophen) toxicity: a standardised proforma improves risk assessment and overall risk stratification by emergency medicine doctors
    David J McQuade
    Emergency Department, Guy s and St Thomas NHS Foundation Trust, London, UK
    Emerg Med J 29:961-4. 2012
  7. doi request reprint Use and acute toxicity associated with the novel psychoactive substances diphenylprolinol (D2PM) and desoxypipradrol (2-DPMP)
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    Clin Toxicol (Phila) 50:727-32. 2012
  8. doi request reprint Mephedrone (4-methylmethcathinone): what is new in our understanding of its use and toxicity
    David M Wood
    Guy s and St Thomas NHS Foundation Trust, London, UK
    Prog Neuropsychopharmacol Biol Psychiatry 39:227-33. 2012
  9. ncbi request reprint Limited use of novel psychoactive substances in South London nightclubs
    D M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and Kings Health Partners, London, UK
    QJM 105:959-64. 2012
  10. doi request reprint Intravenous fluid use in the acutely unwell adult medical inpatient: improving practice through a clinical audit process
    G E Walker
    ACCS Training Programme, London, UK
    J R Coll Physicians Edinb 42:211-5. 2012

Collaborators

Detail Information

Publications42

  1. pmc Recreational use of mephedrone (4-methylmethcathinone, 4-MMC) with associated sympathomimetic toxicity
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    J Med Toxicol 6:327-30. 2010
    ..There are discrepancies in the legal status of both the khat plant and its extracted alkaloids between the UK and the USA...
  2. pmc Putting cocaine use and cocaine-associated cardiac arrhythmias into epidemiological and clinical perspective
    David M Wood
    Guy s and St Thomas NHS Foundation Trust and Kings Health Partners, London, UK
    Br J Clin Pharmacol 69:443-7. 2010
    ..We will discuss the acute cardiac and non-cardiac toxicity associated with cocaine and highlight the lack of data on the true UK prevalence of acute cocaine toxicity and on the incidence of cocaine-related cardiac arrhythmias...
  3. doi request reprint Five-year trends in self-reported recreational drugs associated with presentation to a UK emergency department with suspected drug-related toxicity
    David M Wood
    Department of Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    Eur J Emerg Med 20:263-7. 2013
    ..This study aims to determine whether there have been similar trends in the drug(s) used by individuals presenting to the emergency department (ED) with acute recreational drug toxicity...
  4. doi request reprint Internet survey of home storage of paracetamol by individuals in the UK
    A D Shah
    Medical Toxicology Office, 2nd Floor, Bermondsey Wing, Guy s Hospital, Great Maze Pond, London, UK
    QJM 106:253-9. 2013
    ..This may be because people have large amounts of paracetamol stored at home, but no previous studies have explored this question...
  5. doi request reprint Emergency department presentations in determining the effectiveness of drug control in the United Kingdom: mephedrone (4-methylmethcathinone) control appears to be effective using this model
    David M Wood
    Medical Toxicology Office, 2nd Floor, Bermondsey Wing, Guy s Hospital, Great Maze Pond, London SE1 9RT, UK
    Emerg Med J 30:70-1. 2013
    ..This suggests that the control of mephedrone in the United Kingdom may have been effective in reducing the acute harm associated with the drug...
  6. doi request reprint Management of acute paracetamol (acetaminophen) toxicity: a standardised proforma improves risk assessment and overall risk stratification by emergency medicine doctors
    David J McQuade
    Emergency Department, Guy s and St Thomas NHS Foundation Trust, London, UK
    Emerg Med J 29:961-4. 2012
    ..Patients deemed to be at 'high risk' of hepatotoxicity have lower treatment thresholds than those deemed to be at 'normal risk'. Errors in this process can lead to harmful or potentially fatal under or over treatment...
  7. doi request reprint Use and acute toxicity associated with the novel psychoactive substances diphenylprolinol (D2PM) and desoxypipradrol (2-DPMP)
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    Clin Toxicol (Phila) 50:727-32. 2012
    ..This review will discuss the pharmacology and mechanisms of action of these two compounds, available data on their sources and prevalence of use and reports of acute toxicity and fatalities associated with their use...
  8. doi request reprint Mephedrone (4-methylmethcathinone): what is new in our understanding of its use and toxicity
    David M Wood
    Guy s and St Thomas NHS Foundation Trust, London, UK
    Prog Neuropsychopharmacol Biol Psychiatry 39:227-33. 2012
    ..This demonstrates that mephedrone has a pattern of acute toxicity that is similar to other stimulant drugs such as MDMA, amphetamine and cocaine...
  9. ncbi request reprint Limited use of novel psychoactive substances in South London nightclubs
    D M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and Kings Health Partners, London, UK
    QJM 105:959-64. 2012
    ..However, most surveys of recreational drug use focus on classical drugs such as cocaine and ecstasy, and there is limited information on how commonly emerging novel psychoactive substances are used...
  10. doi request reprint Intravenous fluid use in the acutely unwell adult medical inpatient: improving practice through a clinical audit process
    G E Walker
    ACCS Training Programme, London, UK
    J R Coll Physicians Edinb 42:211-5. 2012
    ..We audited the effect of targeted interventions to improve performance against this guideline...
  11. pmc Understanding how data triangulation identifies acute toxicity of novel psychoactive drugs
    D M Wood
    Clinical Toxicology Service, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    J Med Toxicol 8:300-3. 2012
    ..We will then describe how pattern of acute toxicity associated with the use of the cathinone mephedrone (4-methylmethcathinone) was established using triangulation of these different data sources...
  12. doi request reprint Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and Kings Health Partners, London, UK
    Eur J Clin Pharmacol 68:853-6. 2012
    ..We report here a case series of three individuals with acute toxicity related to the analytically confirmed use of methoxetamine...
  13. doi request reprint A case series of individuals with analytically confirmed acute diphenyl-2-pyrrolidinemethanol (D2PM) toxicity
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and Kings Health Partners, London, UK
    Eur J Clin Pharmacol 68:349-53. 2012
    ..There is limited information on the acute toxicity related to both D2PM and 2-DPMP. We report here a case series of five individuals with acute toxicity related to the use of D2PM...
  14. doi request reprint ICD-10 coding: poor identification of recreational drug presentations to a large emergency department
    David M Wood
    Guy s and St Thomas NHS Foundation Trust and King s Healthcare Partners, Medical Toxicology Office, 2nd Floor, Bermondsey Wing, Guy s Hospital, Great Maze Pond, London SE1 9RT, UK
    Emerg Med J 28:387-9. 2011
    ..No previous studies have reported the validity of clinical coding in identifying patients who present with acute recreational drug toxicity...
  15. doi request reprint Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone
    D M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust, London, UK
    Emerg Med J 28:280-2. 2011
    ..However, there have only two single case reports of mephedrone toxicity. The aim of this study is to report the pattern of clinical toxicity seen with mephedrone use...
  16. doi request reprint Analysis of recreational drug samples obtained from patients presenting to a busy inner-city emergency department: a pilot study adding to knowledge on local recreational drug use
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust, and King s Health Partners, London, UK
    Emerg Med J 28:11-3. 2011
    ..The pilot study described here looks at the analysis of presumed recreational drugs in the possession of individuals presenting to the ED with acute recreational drug toxicity...
  17. doi request reprint Variability in the 3,4-methylenedioxymethamphetamine content of 'ecstasy' tablets in the UK
    David Michael Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust, and King s Health Partners, London, UK
    Emerg Med J 28:764-5. 2011
    ..Although work has shown this variation in other areas of the world, no studies have reported on the variation of MDMA content in UK ecstasy tablets...
  18. doi request reprint Case series of individuals with analytically confirmed acute mephedrone toxicity
    David M Wood
    Department of Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust, Guy s Hospital, Great Maze Pond, London, UK
    Clin Toxicol (Phila) 48:924-7. 2010
    ..Previous reports of acute toxicity/harm associated with mephedrone use have been based on self-reported mephedrone use; toxicological screening has not been undertaken in these cases to determine whether mephedrone has been used...
  19. doi request reprint Acute toxicity and withdrawal syndromes related to γ-hydroxybutyrate (GHB) and its analogues γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD)
    David M Wood
    Guy s and St Thomas NHS Foundation Trust, London, UK
    Drug Test Anal 3:417-25. 2011
    ....
  20. doi request reprint Energy-1 ('NRG-1'): don't believe what the newspapers say about it being legal
    David M Wood
    Clinical Toxicology Service, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    Emerg Med J 28:1068-70. 2011
    ..Future educational campaigns aimed at recreational drug and legal high users should include reference to the potential legal implications of buying these substances...
  21. pmc Is cocaine use recognised as a risk factor for acute coronary syndrome by doctors in the UK?
    David M Wood
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
    Postgrad Med J 83:325-8. 2007
    ..The management of cocaine-induced ACS/AMI is different to classical atheromatous ACS/MI, because the mechanisms are different...
  22. doi request reprint Patient knowledge of the paracetamol content of over-the-counter (OTC) analgesics, cough/cold remedies and prescription medications
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    Emerg Med J 27:829-33. 2010
    ....
  23. doi request reprint Factitiously elevated blood chromium
    David M Wood
    Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    Clin Toxicol (Phila) 48:388-9. 2010
    ..Chromium toxicity is rare in individuals who do not have a history of occupational or deliberate exposure to chromium or chromium-containing compounds...
  24. pmc Fatality after deliberate ingestion of sustained-release ibuprofen: a case report
    David Michael Wood
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
    Crit Care 10:R44. 2006
    ..Although there have been nine other reported fatalities, co-existent factors have probably contributed to all of these deaths. We report here a fatality from isolated toxicity following self-poisoning with sustained-release ibuprofen...
  25. ncbi request reprint Collapse, reported seizure--and an unexpected pill
    David M Wood
    Department of Clinical Toxicology, Guy s and St Thomas Poisons Unit, London SE14 5ER, UK
    Lancet 369:1490. 2007
  26. ncbi request reprint Status epilepticus following intentional overdose of fluvoxamine: a case report with serum fluvoxamine concentration
    David M Wood
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
    Clin Toxicol (Phila) 45:791. 2007
    ..We report a patient with status epilepticus requiring quadruple anti-convulsant treatment following a fluvoxamine overdose...
  27. pmc Gut decontamination of acutely poisoned patients: what do doctors really know about it?
    David Michael Wood
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, London, SE14 5ER, UK
    Emerg Med J 24:774-5. 2007
    ..Future guidelines should be published in journals more widely read by those doctors treating poisoned patients...
  28. doi request reprint Medical and legal confusion surrounding gamma-hydroxybutyrate (GHB) and its precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4BD)
    D M Wood
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, Avonley Road, London, UK
    QJM 101:23-9. 2008
    ..However, its precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4BD) remain legally available despite having similar clinical effects...
  29. doi request reprint What evidence is there that the UK should tackle the potential emerging threat of methamphetamine toxicity rather than established recreational drugs such as MDMA ('ecstasy')?
    D M Wood
    Guy s and St Thomas Poisons Unit, Avonley Road, London SE14 5ER, UK
    QJM 101:207-13. 2008
    ..There is increasing interest in whether methamphetamine is an emerging recreational drug in the UK...
  30. pmc Improvement in the pre-hospital care of recreational drug users through the development of club specific ambulance referral guidelines
    David M Wood
    Guy s and St, Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, Avonley Road, London, SE14 5ER, UK
    Subst Abuse Treat Prev Policy 3:14. 2008
    ....
  31. doi request reprint Management of cocaine-induced cardiac arrhythmias due to cardiac ion channel dysfunction
    David M Wood
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
    Clin Toxicol (Phila) 47:14-23. 2009
    ..In particular, we review the evidence concerning the controversies relating to the use of lidocaine in comparison with sodium bicarbonate, in terms of QRS prolongation secondary to sodium channel blockade...
  32. doi request reprint Epidemiology of recreational drug toxicity in a nightclub environment
    David M Wood
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
    Subst Use Misuse 44:1495-502. 2009
    ..Limitations related to data collection are discussed. Further studies are needed to investigate the use brief interventions in those with problem recreational drug use within the nightclub environment...
  33. pmc Dissociative and sympathomimetic toxicity associated with recreational use of 1-(3-trifluoromethylphenyl) piperazine (TFMPP) and 1-benzylpiperzine (BZP)
    David M Wood
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
    J Med Toxicol 4:254-7. 2008
    ..In addition, there are very few "user reports" of effects when TFMPP is taken alone or in combination with BZP [1-benzylpiperazine]...
  34. pmc Significant pregabalin toxicity managed with supportive care alone
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust and King s Health Partners, London, UK
    J Med Toxicol 6:435-7. 2010
    ....
  35. pmc Delayed onset of seizures and toxicity associated with recreational use of Bromo-dragonFLY
    David M Wood
    Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust, London, UK
    J Med Toxicol 5:226-9. 2009
    ..These are often not covered under current legislation, despite the fact that they often have both similar chemical structures and/or clinical effects to controlled recreational drugs...
  36. pmc Fatality after deliberate ingestion of the pesticide rotenone: a case report
    David Michael Wood
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London, UK
    Crit Care 9:R280-4. 2005
    ..However, no animal studies have been reported that confirm these findings, and there are no previous reports of attempted use of these agents in patients with acute rotenone-induced toxicity...
  37. pmc Poisoned patients as potential organ donors: postal survey of transplant centres and intensive care units
    David Michael Wood
    National Poisons Information Service London, Guy s and St Thomas Hospital, London, UK
    Crit Care 7:147-54. 2003
    ..Patients who die from drug and poison intoxication tend to have similar characteristics but are less frequently offered as potential organ donors...
  38. doi request reprint Mephedrone use and associated adverse effects in school and college/university students before the UK legislation change
    P I Dargan
    Clinical Toxicology, Guy s Hospital, Great Maze Pond, London, SE1 9RT, UK
    QJM 103:875-9. 2010
    ..The aim of this study was to determine the prevalence and frequency of use of mephedrone among school and college/university aged individuals and to collect data on the sources of mephedrone and acute harm related to its use...
  39. ncbi request reprint Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child
    David Michael Wood
    Department of General Medicine, St George s University of London, London, UK
    Ther Drug Monit 27:405-8. 2005
    ..Because the maximum tolerated dose and pharmacokinetics of intravenous iron preparations are not known, their use in both adults and children should still be undertaken with caution...
  40. doi request reprint Doctors' knowledge of the appropriate use and route of administration of antidotes in the management of recreational drug toxicity
    S Lidder
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, London SE14 5ER, UK
    Emerg Med J 25:820-3. 2008
    ..Some controversies surround the use of some of these antidotes, especially flumazenil in benzodiazepine toxicity. There are no previously published data on doctors' knowledge of the use of these specific antidotes...
  41. doi request reprint Survey of ICD-10 coding of hospital admissions in the UK due to recreational drug toxicity
    A D Shah
    Department of Clinical Toxicology, Guy s and St Thomas NHS Foundation Trust, London, UK
    QJM 104:779-84. 2011
    ..It is unclear how these admissions are coded, as often there are no specific ICD-10 codes for the drug(s) involved. This study was undertaken to determine how acute recreational drug toxicity admissions are routinely coded...
  42. doi request reprint Can medical students identify recreational drugs by name?
    P I Dargan
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, Avonley Road, London, SE14 5ER, UK
    QJM 101:979-82. 2008
    ..Recreational drug toxicity is a common reason for presentation to the Emergency Department. Knowledge of recreational drug names is important to allow targeted assessment of patients presenting with recreational drug toxicity...