Frances M K Williams
Affiliation: Guy's and St Thomas' NHS Foundation Trust
- The effect of moderate alcohol consumption on bone mineral density: a study of female twinsF M K Williams
Department of Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, United Kingdom
Ann Rheum Dis 64:309-10. 2005..Osteoporosis is associated with morbidity and mortality, particularly in postmenopausal women. The effect of moderate alcohol intake on bone mineral density (BMD) and fracture risk remains unclear...
- A common genetic factor underlies hypertension and other cardiovascular disordersFrances M K Williams
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, UK
BMC Cardiovasc Disord 4:20. 2004..This study used a classical twin design to examine whether these conditions are linked through shared environmental exposures or by a common underlying genetic propensity to vasospasm...
- The heritable determinants of cartilage oligomeric matrix proteinFrances M K Williams
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
Arthritis Rheum 54:2147-51. 2006..An association between COMP and OA has been shown, yet the precise factors governing serum levels of COMP remain unclear. The aim of this study was to determine whether genetic factors influence serum levels of COMP...
- Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT studyFrances M K Williams
Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
Arterioscler Thromb Vasc Biol 29:600-5. 2009..The aims of the current study from the EU consortium EuroCLOT were to (1) determine the heritability of fibrin phenotypes and (2) identify QTLs associated with fibrin phenotypes...
- Pain reporting at different body sites is explained by a single underlying genetic factorFrances M K Williams
Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital Campus, London SE1 7EH, UK
Rheumatology (Oxford) 49:1753-5. 2010....
- The UK Adult Twin Registry (TwinsUK)Tim D Spector
Twin Research and Genetic Epidemiology Unit, Kings College London, St Thomas Hospital Campus, London, UK
Twin Res Hum Genet 9:899-906. 2006..The resource has led to many successful and innovative research projects particularly in common age-related diseases, and has led to collaborations with over 80 groups worldwide...
- The genetics of osteoporosisFrances M K Williams
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
Acta Reumatol Port 32:231-40. 2007..Cost-effective large scale genetic testing is becoming available and lends itself to combining large multi-national populations for candidate gene analysis, meta-analyses, DNA pooling studies and gene expression studies...
- Reduced telomere length in rheumatoid arthritis is independent of disease activity and durationSophia E Steer
Department of Rheumatology, Twin Research and Genetic Epidemiology Unit, Kings College London School of Medicine at Guy s, King s and St Thomas, London SE1 7EH, UK
Ann Rheum Dis 66:476-80. 2007..Telomere loss in white blood cells (WBC) is accelerated by oxidative stress and inflammation in vitro. It was postulated that the accelerated WBC telomere shortening in RA occurs as a result of exposure to chronic inflammation...
- Genomewide linkage scan of hand osteoarthritis in female twin pairs showing replication of quantitative trait loci on chromosomes 2 and 19Gregory Livshits
Tel Aviv University, Tel Aviv, Israel
Ann Rheum Dis 66:623-7. 2007..The purpose of this study was to conduct a whole-genome linkage scan to identify susceptibility loci for idiopathic hand OA in a large, population-based sample of females...
- Biomarkers in osteoarthritisFrances M K Williams
Arthritis Res Ther 10:101. 2008..Precisely what role it plays in OA pathogenesis remains unclear and elucidating this may be key to defining, and then targeting, the cellular pathways involved in OA...