Martin J Shearer

Summary

Affiliation: Guy's and St Thomas' NHS Foundation Trust
Country: UK

Publications

  1. doi request reprint Vitamin K deficiency bleeding (VKDB) in early infancy
    Martin J Shearer
    The Centre for Haemostasis and Thrombosis, St Thomas Hospital, Westminster Bridge Road, London, UK
    Blood Rev 23:49-59. 2009
  2. ncbi request reprint Metabolism and cell biology of vitamin K
    Martin J Shearer
    Centre for Haemostasis and Thrombosis, St Thomas Hospital, Westminster Bridge Road, London, UK
    Thromb Haemost 100:530-47. 2008
  3. pmc Vitamin K nutrition, metabolism, and requirements: current concepts and future research
    Martin J Shearer
    Haemostasis Research Unit, Centre for Haemostasis and Thrombosis, Guy s and St Thomas NHS Foundation Trust, London, UK
    Adv Nutr 3:182-95. 2012
  4. doi request reprint Vitamin K in parenteral nutrition
    Martin J Shearer
    Centre for Haemostasis and Thrombosis, St Thomas Hospital, London, United Kingdom
    Gastroenterology 137:S105-18. 2009
  5. doi request reprint Erythrocyte folate and 5-methyltetrahydrofolate levels decline during 6 months of oral anticoagulation with warfarin
    Agata Sobczyńska-Malefora
    Centre for Haemostasis and Thrombosis, St Thomas Hospital, London, UK
    Blood Coagul Fibrinolysis 20:297-302. 2009
  6. ncbi request reprint Excretion of the urinary 5C- and 7C-aglycone metabolites of vitamin K by young adults responds to changes in dietary phylloquinone and dihydrophylloquinone intakes
    Dominic J Harrington
    The Centre for Haemostasis and Thrombosis, St Thomas Hospital, London SE1 7EH, UK
    J Nutr 137:1763-8. 2007
  7. ncbi request reprint Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K1) in severe acute liver disease
    Stephen P Pereira
    Institute of Liver Studies, King s College Hospital, London, UK
    J Hepatol 42:365-70. 2005
  8. doi request reprint The external quality assurance of phylloquinone (vitamin K(1)) analysis in human serum
    David J Card
    The Centre for Haemostasis and Thrombosis Nutristasis Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
    Biomed Chromatogr 23:1276-82. 2009
  9. doi request reprint The role of dietary vitamin K in the management of oral vitamin K antagonists
    Michael V Holmes
    Department of Clinical Pharmacology, Guy s and St Thomas NHS Foundation Trust, London, UK
    Blood Rev 26:1-14. 2012
  10. doi request reprint Urinary excretion of vitamin K metabolites in term and preterm infants: relationship to vitamin K status and prophylaxis
    Dominic Jon Harrington
    The Nutristasis Unit, St Thomas Hospital, London SE1 7EH, United Kingdom
    Pediatr Res 68:508-12. 2010

Collaborators

Detail Information

Publications14

  1. doi request reprint Vitamin K deficiency bleeding (VKDB) in early infancy
    Martin J Shearer
    The Centre for Haemostasis and Thrombosis, St Thomas Hospital, Westminster Bridge Road, London, UK
    Blood Rev 23:49-59. 2009
    ..Targeted surveillance of high-risk groups (e.g. biliary atresia) offers a novel approach to assess efficacy of prophylaxis...
  2. ncbi request reprint Metabolism and cell biology of vitamin K
    Martin J Shearer
    Centre for Haemostasis and Thrombosis, St Thomas Hospital, Westminster Bridge Road, London, UK
    Thromb Haemost 100:530-47. 2008
    ..In humans, MK-7 has a greater efficacy than phylloquinone in carboxylating both liver and bone Gla proteins. A daily supplement of phylloquinone has shown potential for improving anticoagulation control...
  3. pmc Vitamin K nutrition, metabolism, and requirements: current concepts and future research
    Martin J Shearer
    Haemostasis Research Unit, Centre for Haemostasis and Thrombosis, Guy s and St Thomas NHS Foundation Trust, London, UK
    Adv Nutr 3:182-95. 2012
    ..In contrast, there is still a lack of suitable biomarkers or clinical endpoints that can be used to determine vitamin K requirements among adults...
  4. doi request reprint Vitamin K in parenteral nutrition
    Martin J Shearer
    Centre for Haemostasis and Thrombosis, St Thomas Hospital, London, United Kingdom
    Gastroenterology 137:S105-18. 2009
    ..Natural forms of vitamin K have no proven toxicity...
  5. doi request reprint Erythrocyte folate and 5-methyltetrahydrofolate levels decline during 6 months of oral anticoagulation with warfarin
    Agata Sobczyńska-Malefora
    Centre for Haemostasis and Thrombosis, St Thomas Hospital, London, UK
    Blood Coagul Fibrinolysis 20:297-302. 2009
    ..The majority of patients had intakes of folate and phylloquinone below the national average or UK guidelines. The study highlights the need for improved dietary management of patients taking oral anticoagulants...
  6. ncbi request reprint Excretion of the urinary 5C- and 7C-aglycone metabolites of vitamin K by young adults responds to changes in dietary phylloquinone and dihydrophylloquinone intakes
    Dominic J Harrington
    The Centre for Haemostasis and Thrombosis, St Thomas Hospital, London SE1 7EH, UK
    J Nutr 137:1763-8. 2007
    ..699, P < 0.001). We conclude that the urinary excretion of vitamin K metabolites reflects dietary phylloquinone intake and offers the first candidate marker of global vitamin K status...
  7. ncbi request reprint Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K1) in severe acute liver disease
    Stephen P Pereira
    Institute of Liver Studies, King s College Hospital, London, UK
    J Hepatol 42:365-70. 2005
    ..However, there have been no studies of the pharmacokinetics or efficacy of i.v. or oral K1 in such patients...
  8. doi request reprint The external quality assurance of phylloquinone (vitamin K(1)) analysis in human serum
    David J Card
    The Centre for Haemostasis and Thrombosis Nutristasis Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
    Biomed Chromatogr 23:1276-82. 2009
    ..The high proportion of false positive results suggest that poor assay specificity at low phylloquinone concentrations is a common problem, which in the clinical setting could lead to underreporting of vitamin K deficiency...
  9. doi request reprint The role of dietary vitamin K in the management of oral vitamin K antagonists
    Michael V Holmes
    Department of Clinical Pharmacology, Guy s and St Thomas NHS Foundation Trust, London, UK
    Blood Rev 26:1-14. 2012
    ....
  10. doi request reprint Urinary excretion of vitamin K metabolites in term and preterm infants: relationship to vitamin K status and prophylaxis
    Dominic Jon Harrington
    The Nutristasis Unit, St Thomas Hospital, London SE1 7EH, United Kingdom
    Pediatr Res 68:508-12. 2010
    ..Measurement of the 5C- and 7C-aglycones may facilitate longitudinal studies of vitamin K status in neonates and aid the development of improved prophylactic regimens...
  11. ncbi request reprint Determination of the urinary aglycone metabolites of vitamin K by HPLC with redox-mode electrochemical detection
    Dominic J Harrington
    Centre for Haemostasis and Thrombosis, The Haemophilia Reference Centre, St Thomas Hospital, London, UK
    J Lipid Res 46:1053-60. 2005
    ..We propose that the measurement of urinary vitamin K metabolite excretion is a candidate noninvasive marker of total vitamin K status...
  12. ncbi request reprint Hyperhomocysteinemia and B-vitamin status after discontinuation of oral anticoagulation therapy in patients with a history of venous thromboembolism
    Agata Sobczyńska-Malefora
    The Haemophilia Reference Centre, Centre for Thrombosis and Haemostasis, St Thomas Hospital, London, UK
    Clin Chem Lab Med 41:1493-7. 2003
    ..On the basis of this study we suggest that homocysteine screening should be carried out at the time that patients begin warfarin therapy...
  13. ncbi request reprint Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1
    Dominic J Harrington
    The Centre for Haemostasis and Thrombosis, St Thomas Hospital, London, United Kingdom
    Thromb Haemost 93:23-6. 2005
    ....
  14. ncbi request reprint The uptake of lipoprotein-borne phylloquinone (vitamin K1) by osteoblasts and osteoblast-like cells: role of heparan sulfate proteoglycans and apolipoprotein E
    Paul Newman
    The Haemophilia Centre, St Thomas s Hospital, London, United Kingdom
    J Bone Miner Res 17:426-33. 2002
    ..The inhibition by heparin of lipoprotein-mediated carriage of vitamin K and possibly other lipids to bone may provide a basis for the future understanding of heparin-induced osteoporosis...