Paul Veys

Summary

Affiliation: Great Ormond Street
Country: UK

Publications

  1. ncbi request reprint Stem cell transplantation for congenital immunodeficiencies using reduced-intensity conditioning
    P Veys
    Great Ormond Street Hospital GOSH for Children NHS Trust, London, UK
    Bone Marrow Transplant 35:S45-7. 2005
  2. ncbi request reprint Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis
    Nichola Cooper
    Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Blood 107:1233-6. 2006
  3. pmc Reduced intensity transplantation for primary immunodeficiency disorders
    Paul Veys
    Department of BMT, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Pediatr Rep 3:e11. 2011
  4. doi request reprint Reduced intensity transplantation for primary immunodeficiency disorders
    Paul Veys
    Department of BMT, Level 4 Westlink, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
    Immunol Allergy Clin North Am 30:103-24. 2010
  5. ncbi request reprint The role of haploidentical stem cell transplantation in the management of children with haematological disorders
    Paul Veys
    Department of Blood and Marrow Transplantation, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Br J Haematol 123:193-206. 2003
  6. ncbi request reprint Improved survival and preserved antiviral responses after combination therapy with daclizumab and infliximab in steroid-refractory graft-versus-host disease
    Kanchan Rao
    Department of Blood and Marrow Transplantation, Great Ormond Street Hospital for Sick Children, Great Ormond Street, London WC1N 3JH, UK
    J Pediatr Hematol Oncol 31:456-61. 2009
  7. ncbi request reprint EBV-related disease following haematopoietic stem cell transplantation with reduced intensity conditioning
    Jonathan M Cohen
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital, NHS Trust, London, UK
    Leuk Lymphoma 48:256-69. 2007
  8. doi request reprint Pulmonary hypertension following haematopoietic stem cell transplantation for primary haemophagocytic lymphohistiocytosis
    Ulrike Zeilhofer
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Pediatr Blood Cancer 60:521-3. 2013
  9. doi request reprint Reduced-intensity conditioning for allogeneic stem cell transplant in primary immune deficiencies
    Robert Chiesa
    Bone Marrow Transplantation Department, Great Ormond Street Hospital, London, UK
    Expert Rev Clin Immunol 8:255-66; quiz 267. 2012
  10. doi request reprint Pre-emptive rituximab based on viraemia and T cell reconstitution: a highly effective strategy for the prevention of Epstein-Barr virus-associated lymphoproliferative disease following stem cell transplantation
    Austen Worth
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, UK
    Br J Haematol 155:377-85. 2011

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Stem cell transplantation for congenital immunodeficiencies using reduced-intensity conditioning
    P Veys
    Great Ormond Street Hospital GOSH for Children NHS Trust, London, UK
    Bone Marrow Transplant 35:S45-7. 2005
    ..Findings suggest a significant survival advantage in the unrelated donor setting for RIC compared to conventional SCT...
  2. ncbi request reprint Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis
    Nichola Cooper
    Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Blood 107:1233-6. 2006
    ..Three of 9 survivors have mixed chimerism but remain free of disease. In summary, RIC compares favorably to conventional SCT with long-term disease control in surviving patients despite a significant incidence of mixed chimerism...
  3. pmc Reduced intensity transplantation for primary immunodeficiency disorders
    Paul Veys
    Department of BMT, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Pediatr Rep 3:e11. 2011
    ....
  4. doi request reprint Reduced intensity transplantation for primary immunodeficiency disorders
    Paul Veys
    Department of BMT, Level 4 Westlink, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
    Immunol Allergy Clin North Am 30:103-24. 2010
    ..This article addresses modifications in the conditioning regimen that might lead to further improvement in HCT outcomes...
  5. ncbi request reprint The role of haploidentical stem cell transplantation in the management of children with haematological disorders
    Paul Veys
    Department of Blood and Marrow Transplantation, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Br J Haematol 123:193-206. 2003
    ..The relative merits of a haploidentical family donor versus mismatched unrelated bone marrow or cord blood donation needs to be assessed in prospective, randomized clinical trials...
  6. ncbi request reprint Improved survival and preserved antiviral responses after combination therapy with daclizumab and infliximab in steroid-refractory graft-versus-host disease
    Kanchan Rao
    Department of Blood and Marrow Transplantation, Great Ormond Street Hospital for Sick Children, Great Ormond Street, London WC1N 3JH, UK
    J Pediatr Hematol Oncol 31:456-61. 2009
    ....
  7. ncbi request reprint EBV-related disease following haematopoietic stem cell transplantation with reduced intensity conditioning
    Jonathan M Cohen
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital, NHS Trust, London, UK
    Leuk Lymphoma 48:256-69. 2007
    ....
  8. doi request reprint Pulmonary hypertension following haematopoietic stem cell transplantation for primary haemophagocytic lymphohistiocytosis
    Ulrike Zeilhofer
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Pediatr Blood Cancer 60:521-3. 2013
    ..PHT may be an association with HLH and physicians treating HLH should be aware of this potential association...
  9. doi request reprint Reduced-intensity conditioning for allogeneic stem cell transplant in primary immune deficiencies
    Robert Chiesa
    Bone Marrow Transplantation Department, Great Ormond Street Hospital, London, UK
    Expert Rev Clin Immunol 8:255-66; quiz 267. 2012
    ..Here we discuss the most recent data on the use of different reduced-intensity conditioning protocols in children with primary immunodeficiency disorders, highlighting significant clinical lessons and areas that need additional study...
  10. doi request reprint Pre-emptive rituximab based on viraemia and T cell reconstitution: a highly effective strategy for the prevention of Epstein-Barr virus-associated lymphoproliferative disease following stem cell transplantation
    Austen Worth
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, UK
    Br J Haematol 155:377-85. 2011
    ..This strategy is safe and highly effective in preventing PTLD following T cell depleted SCT, and directs rituximab therapy to patients at highest risk of this complication...
  11. doi request reprint Stem cell transplantation for primary immune deficiency
    Austen J J Worth
    aDepartment of Paediatric Immunology, Great Ormond Street Hospital NHS Foundation Trust bMolecular Immunology Unit, Institute of Child Health, University College London cDepartment of Bone Marrow Transplantation, Great Ormond Street Hospital NHS Foundation Trust, London, UK
    Curr Opin Hematol 20:501-8. 2013
    ....
  12. doi request reprint Omission of in vivo T-cell depletion promotes rapid expansion of naïve CD4+ cord blood lymphocytes and restores adaptive immunity within 2 months after unrelated cord blood transplant
    Robert Chiesa
    Bone Marrow Transplantation Department, Great Ormond Street Hospital, London, UK
    Br J Haematol 156:656-66. 2012
    ..We postulate that this relates to the specific immunological and ontological qualities of fetal-derived lymphocytes...
  13. doi request reprint Neonatal diagnosis of severe combined immunodeficiency leads to significantly improved survival outcome: the case for newborn screening
    Lucinda Brown
    Department of Clinical Immunology, Great Ormond Street Hospital National Health Service Trust, London, UK
    Blood 117:3243-6. 2011
    ..Neonatal screening for SCID would significantly improve the outcome in this otherwise potentially devastating condition...
  14. ncbi request reprint Improved outcome for children with disseminated adenoviral infection following allogeneic stem cell transplantation
    B Kampmann
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Br J Haematol 130:595-603. 2005
    ..Mortality from disseminated AdV infection was 5/26 (19%) in this study, which is significantly lower than previously reported...
  15. doi request reprint Allogeneic haemopoietic stem cell transplantation in children: what alternative donor should we choose when no matched sibling is available?
    Rachael Hough
    University College Hospital, London, UK
    Br J Haematol 147:593-613. 2009
    ....
  16. ncbi request reprint Early pediatric anthracycline cardiotoxicity: managed by serial heart and bone marrow transplantation
    Jasveer S Mangat
    Department of Paediatric Cardiology, Great Ormond Street Hospital, London, UK
    J Heart Lung Transplant 26:658-60. 2007
    ..This case is unique in the literature. We believe it offers an alternative strategy for children with hematologic malignancies, where severe early post-anthracycline cardiotoxicity might preclude bone marrow transplantation...
  17. ncbi request reprint Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus, and Epstein-Barr virus: an approach for adoptive immunotherapy of multiple pathogens
    Helen Karlsson
    Molecular Immunology Unit, Institute of Child Health, Great Ormond Street Children s Hospital, London, UK
    J Immunother 30:544-56. 2007
    ..In summary, we have developed a protocol for the generation of CTL with trivirus specificity, enabling adoptive transfer of CTL recognizing multiple viruses to restore cellular immunity after SCT...
  18. pmc Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation
    Persis J Amrolia
    Department of Bone Marrow Transplantation, Great Ormond St Childrens Hospital, London WC1N 3JH, United Kingdom
    Blood 108:1797-808. 2006
    ..These data demonstrate that allodepleted donor T cells can be safely used to improve T-cell recovery after haploidentical SCT and may broaden the applicability of this approach...
  19. ncbi request reprint Increased incidence of EBV-related disease following paediatric stem cell transplantation with reduced-intensity conditioning
    Jonathan Cohen
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital NHS Trust, London, UK
    Br J Haematol 129:229-39. 2005
    ..This probably reflects the profound immunosuppression following RIC SCT, together with the incomplete ablation of recipient-derived B cells...
  20. doi request reprint Pulmonary hypertension in children with Evans syndrome
    Philip Connor
    Department of Haematology, Great Ormond Street Hospital, London, UK
    Pediatr Hematol Oncol 25:93-8. 2008
    ..However, they suggest a vasculitic process as the main cause...
  21. doi request reprint The current role of T cell depletion in paediatric stem cell transplantation
    Claire Booth
    Molecular Immunology Unit, Institute of Child Health, University College London, London, UK
    Br J Haematol 162:177-90. 2013
    ..Translational work building on megadose CD34(+) selected grafts, including pathogen-specific immunotherapy, suicide gene therapy and other adoptive cellular immunotherapies, has also offered improved outcomes for such patients...
  22. ncbi request reprint Evolution in the management of acute liver failure-associated aplastic anaemia in children: a single centre experience
    Nedim Hadzic
    Institute of Liver Studies, King s College London School of Medicine at King s College, London, UK
    J Hepatol 48:68-73. 2008
    ..Bone marrow failure (BMF) is a potentially life-threatening complication of acute liver failure (ALF)...
  23. ncbi request reprint Respiratory infections following haemopoietic stem cell transplantation in children
    Paul Veys
    Bone Marrow Transplant Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Br Med Bull 61:151-74. 2002
    ....
  24. ncbi request reprint Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia
    Judith M Chessells
    Department of Haematology Oncology, Great Ormond Street Hospital, London, UK
    Br J Haematol 123:396-405. 2003
    ..Only a small number of children can be treated effectively in third remission...
  25. ncbi request reprint Outcome of children requiring admission to an intensive care unit after bone marrow transplantation
    Stephen J Jacobe
    Pediatric Intensive Care Unit, Great Ormond Street Hospital for Children, London, UK
    Crit Care Med 31:1299-305. 2003
    ..To review the outcome of bone marrow transplant (BMT) recipients admitted to a pediatric intensive care unit (ICU) and attempt to identify admission characteristics that might accurately predict a poor outcome...
  26. ncbi request reprint Successful treatment of lymphoproliferative disease complicating primary immunodeficiency/immunodysregulatory disorders with reduced-intensity allogeneic stem-cell transplantation
    Jonathan M Cohen
    Department of Clinical Immunology, Great Ormond Street Hospital, London, United Kingdom
    Blood 110:2209-14. 2007
    ..With careful monitoring and pre-emptive therapy, we advocate this RIC SCT approach to patients with PID who have pre-existing EBV-LPD...
  27. ncbi request reprint Serial transplantation of mismatched donor hematopoietic cells between HLA-identical sibling pairs with congenital immunodeficiency: in vivo tolerance permits rapid immune reconstitution following T-replete transplantation without GVHD in the secondary re
    Jonathan M Cohen
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, United Kingdom
    Blood 108:2124-6. 2006
    ....
  28. ncbi request reprint Haematopoietic stem cell transplantation for Shwachman-Diamond disease: a study from the European Group for blood and marrow transplantation
    Simone Cesaro
    Department of Pediatrics, Clinic of Paediatric Haematology Oncology, University of Padova, Italy
    Br J Haematol 131:231-6. 2005
    ..Further improvements would be anticipated by a better definition of the optimum time in the course of disease to transplant and by the adoption of less toxic conditioning regimens...
  29. ncbi request reprint Hematopoietic stem cell transplantation for complete IFN-gamma receptor 1 deficiency: a multi-institutional survey
    Joachim Roesler
    Department of Pediatrics and the Department of Internal Medicine, University Clinic Carl Gustav Carus, Dresden, Germany
    J Pediatr 145:806-12. 2004
    ..To evaluate the outcome of hematopoietic stem cell transplantation (HSCT) in a series of patients with inherited complete IFN-gamma receptor 1 (IFNgammaR1) deficiency...
  30. ncbi request reprint Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968-99
    Corinne Antoine
    Service de Biostatistique et Service d Immunologie et d Hématologie Pédiatrique, Hopital Necker Enfants Malades, Paris, France
    Lancet 361:553-60. 2003
    ..This European report focuses on the long-term results of such procedures done between 1968 and December, 1999, for primary immunodeficiencies...
  31. ncbi request reprint Successful treatment of juvenile myelomonocytic leukemia relapsing after stem cell transplantation using donor lymphocyte infusion
    Austen Worth
    Great Ormond Street Hospital for Children, London, United Kingdom
    Blood 101:1713-4. 2003
    ..This is the first report that describes the successful treatment of relapsed JMML with DLI in the absence of further chemotherapy and provides definite proof of a GVL effect in JMML...
  32. ncbi request reprint Treatment of CD40 ligand deficiency by hematopoietic stem cell transplantation: a survey of the European experience, 1993-2002
    Andrew R Gennery
    Newcastle General Hospital, Westgate Rd, Newcastle upon Tyne, NE4 6BE United Kingdom
    Blood 103:1152-7. 2004
    ..Preexisting lung damage was the most important adverse risk factor. Further studies will determine optimal timing and type of HSCT...
  33. ncbi request reprint Liver disease in children with primary immunodeficiencies
    Fernanda Rodrigues
    Department of Child Health, Institute of Liver Studies and Department of Radiology and King s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom
    J Pediatr 145:333-9. 2004
    ..Study design A retrospective analysis of medical records of 147 children with PID who presented with abnormal liver tests to a tertiary center...
  34. doi request reprint Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responses
    Helen Karlsson
    Molecular Immunology Unit, Institute of Child Health, London, United Kingdom
    Blood 112:532-41. 2008
    ..These data have major implications for immunotherapy of GVHD with MSCs and suggest that the effector functions of virus-specific T cells may be retained after MSC infusion...
  35. ncbi request reprint Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation
    Hulya Ozsahin
    Department of Pediatrics, Geneva University Hospital, Geneva, Switzerland
    Blood 111:439-45. 2008
    ....