Research Topics
| Paul VeysSummaryAffiliation: Great Ormond Street Country: UK Publications
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Detail Information
Publications
Stem cell transplantation for congenital immunodeficiencies using reduced-intensity conditioningP Veys
Great Ormond Street Hospital GOSH for Children NHS Trust, London, UK
Bone Marrow Transplant 35:S45-7. 2005..Findings suggest a significant survival advantage in the unrelated donor setting for RIC compared to conventional SCT...
Reduced intensity transplantation for primary immunodeficiency disordersPaul Veys
Department of BMT, Level 4 Westlink, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
Immunol Allergy Clin North Am 30:103-24. 2010..This article addresses modifications in the conditioning regimen that might lead to further improvement in HCT outcomes...- The role of haploidentical stem cell transplantation in the management of children with haematological disordersPaul Veys
Department of Blood and Marrow Transplantation, Great Ormond Street Hospital for Children NHS Trust, London, UK
Br J Haematol 123:193-206. 2003..The relative merits of a haploidentical family donor versus mismatched unrelated bone marrow or cord blood donation needs to be assessed in prospective, randomized clinical trials... - EBV-related disease following haematopoietic stem cell transplantation with reduced intensity conditioningJonathan M Cohen
Department of Bone Marrow Transplantation, Great Ormond Street Hospital, NHS Trust, London, UK
Leuk Lymphoma 48:256-69. 2007.... - Improved survival and preserved antiviral responses after combination therapy with daclizumab and infliximab in steroid-refractory graft-versus-host diseaseKanchan Rao
Department of Blood and Marrow Transplantation, Great Ormond Street Hospital for Sick Children, Great Ormond Street, London WC1N 3JH, UK
J Pediatr Hematol Oncol 31:456-61. 2009.... - Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosisNichola Cooper
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
Blood 107:1233-6. 2006..Three of 9 survivors have mixed chimerism but remain free of disease. In summary, RIC compares favorably to conventional SCT with long-term disease control in surviving patients despite a significant incidence of mixed chimerism... - Pulmonary hypertension following haematopoietic stem cell transplantation for primary haemophagocytic lymphohistiocytosisUlrike Zeilhofer
Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
Pediatr Blood Cancer 60:521-3. 2013..PHT may be an association with HLH and physicians treating HLH should be aware of this potential association... - Reduced-intensity conditioning for allogeneic stem cell transplant in primary immune deficienciesRobert Chiesa
Bone Marrow Transplantation Department, Great Ormond Street Hospital, London, UK
Expert Rev Clin Immunol 8:255-66; quiz 267. 2012..Here we discuss the most recent data on the use of different reduced-intensity conditioning protocols in children with primary immunodeficiency disorders, highlighting significant clinical lessons and areas that need additional study... - Pre-emptive rituximab based on viraemia and T cell reconstitution: a highly effective strategy for the prevention of Epstein-Barr virus-associated lymphoproliferative disease following stem cell transplantationAusten Worth
Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, UK
Br J Haematol 155:377-85. 2011..This strategy is safe and highly effective in preventing PTLD following T cell depleted SCT, and directs rituximab therapy to patients at highest risk of this complication... - Omission of in vivo T-cell depletion promotes rapid expansion of naïve CD4+ cord blood lymphocytes and restores adaptive immunity within 2 months after unrelated cord blood transplantRobert Chiesa
Bone Marrow Transplantation Department, Great Ormond Street Hospital, London, UK
Br J Haematol 156:656-66. 2012..We postulate that this relates to the specific immunological and ontological qualities of fetal-derived lymphocytes... - Neonatal diagnosis of severe combined immunodeficiency leads to significantly improved survival outcome: the case for newborn screeningLucinda Brown
Department of Clinical Immunology, Great Ormond Street Hospital National Health Service Trust, London, UK
Blood 117:3243-6. 2011..Neonatal screening for SCID would significantly improve the outcome in this otherwise potentially devastating condition... - Improved outcome for children with disseminated adenoviral infection following allogeneic stem cell transplantationB Kampmann
Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children NHS Trust, London, UK
Br J Haematol 130:595-603. 2005..Mortality from disseminated AdV infection was 5/26 (19%) in this study, which is significantly lower than previously reported... - Allogeneic haemopoietic stem cell transplantation in children: what alternative donor should we choose when no matched sibling is available?Rachael Hough
University College Hospital, London, UK
Br J Haematol 147:593-613. 2009.... - Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus, and Epstein-Barr virus: an approach for adoptive immunotherapy of multiple pathogensHelen Karlsson
Molecular Immunology Unit, Institute of Child Health, Great Ormond Street Children s Hospital, London, UK
J Immunother 30:544-56. 2007..In summary, we have developed a protocol for the generation of CTL with trivirus specificity, enabling adoptive transfer of CTL recognizing multiple viruses to restore cellular immunity after SCT... - Early pediatric anthracycline cardiotoxicity: managed by serial heart and bone marrow transplantationJasveer S Mangat
Department of Paediatric Cardiology, Great Ormond Street Hospital, London, UK
J Heart Lung Transplant 26:658-60. 2007..This case is unique in the literature. We believe it offers an alternative strategy for children with hematologic malignancies, where severe early post-anthracycline cardiotoxicity might preclude bone marrow transplantation... 
Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantationPersis J Amrolia
Department of Bone Marrow Transplantation, Great Ormond St Childrens Hospital, London WC1N 3JH, United Kingdom
Blood 108:1797-808. 2006..These data demonstrate that allodepleted donor T cells can be safely used to improve T-cell recovery after haploidentical SCT and may broaden the applicability of this approach...- Increased incidence of EBV-related disease following paediatric stem cell transplantation with reduced-intensity conditioningJonathan Cohen
Department of Bone Marrow Transplantation, Great Ormond Street Hospital NHS Trust, London, UK
Br J Haematol 129:229-39. 2005..This probably reflects the profound immunosuppression following RIC SCT, together with the incomplete ablation of recipient-derived B cells... - Pulmonary hypertension in children with Evans syndromePhilip Connor
Department of Haematology, Great Ormond Street Hospital, London, UK
Pediatr Hematol Oncol 25:93-8. 2008..However, they suggest a vasculitic process as the main cause... - Evolution in the management of acute liver failure-associated aplastic anaemia in children: a single centre experienceNedim Hadzic
Institute of Liver Studies, King s College London School of Medicine at King s College, London, UK
J Hepatol 48:68-73. 2008..Bone marrow failure (BMF) is a potentially life-threatening complication of acute liver failure (ALF)... - Respiratory infections following haemopoietic stem cell transplantation in childrenPaul Veys
Bone Marrow Transplant Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK
Br Med Bull 61:151-74. 2002.... - Outcome of children requiring admission to an intensive care unit after bone marrow transplantationStephen J Jacobe
Pediatric Intensive Care Unit, Great Ormond Street Hospital for Children, London, UK
Crit Care Med 31:1299-305. 2003..Decisions regarding treatment options and limitation of care in this group of patients should be based on ongoing outcome research in this field... - Long-term follow-up of relapsed childhood acute lymphoblastic leukaemiaJudith M Chessells
Department of Haematology/Oncology, Great Ormond Street Hospital, London, UK
Br J Haematol 123:396-405. 2003..Only a small number of children can be treated effectively in third remission... - Successful treatment of lymphoproliferative disease complicating primary immunodeficiency/immunodysregulatory disorders with reduced-intensity allogeneic stem-cell transplantationJonathan M Cohen
Department of Clinical Immunology, Great Ormond Street Hospital, London, United Kingdom
Blood 110:2209-14. 2007..With careful monitoring and pre-emptive therapy, we advocate this RIC SCT approach to patients with PID who have pre-existing EBV-LPD... - Hematopoietic stem cell transplantation for complete IFN-gamma receptor 1 deficiency: a multi-institutional surveyJoachim Roesler
Department of Pediatrics and the Department of Internal Medicine, University Clinic Carl Gustav Carus, Dresden, Germany
J Pediatr 145:806-12. 2004..To evaluate the outcome of hematopoietic stem cell transplantation (HSCT) in a series of patients with inherited complete IFN-gamma receptor 1 (IFNgammaR1) deficiency... - Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968-99Corinne Antoine
, , Paris, France
Lancet 361:553-60. 2003..For non-SCID, stem-cell transplantation can provide a cure, and grafts from unrelated donors are almost as beneficial as those from genetically HLA-identical relatives... - Serial transplantation of mismatched donor hematopoietic cells between HLA-identical sibling pairs with congenital immunodeficiency: in vivo tolerance permits rapid immune reconstitution following T-replete transplantation without GVHD in the secondary reJonathan M Cohen
Department of Bone Marrow Transplantation, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, United Kingdom
Blood 108:2124-6. 2006.... - Haematopoietic stem cell transplantation for Shwachman-Diamond disease: a study from the European Group for blood and marrow transplantationSimone Cesaro
Department of Pediatrics, Clinic of Paediatric Haematology Oncology, University of Padova, Italy
Br J Haematol 131:231-6. 2005..Further improvements would be anticipated by a better definition of the optimum time in the course of disease to transplant and by the adoption of less toxic conditioning regimens... - Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow TransplantationHulya Ozsahin
Department of Pediatrics, Geneva University Hospital, Geneva, Switzerland
Blood 111:439-45. 2008.... - Treatment of CD40 ligand deficiency by hematopoietic stem cell transplantation: a survey of the European experience, 1993-2002Andrew R Gennery
Newcastle General Hospital, Westgate Rd, Newcastle upon Tyne, NE4 6BE United Kingdom
Blood 103:1152-7. 2004..Preexisting lung damage was the most important adverse risk factor. Further studies will determine optimal timing and type of HSCT... - Successful treatment of juvenile myelomonocytic leukemia relapsing after stem cell transplantation using donor lymphocyte infusionAusten Worth
Great Ormond Street Hospital for Children, London, United Kingdom
Blood 101:1713-4. 2003..This is the first report that describes the successful treatment of relapsed JMML with DLI in the absence of further chemotherapy and provides definite proof of a GVL effect in JMML... - Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responsesHelen Karlsson
Molecular Immunology Unit, Institute of Child Health, London, United Kingdom
Blood 112:532-41. 2008..These data have major implications for immunotherapy of GVHD with MSCs and suggest that the effector functions of virus-specific T cells may be retained after MSC infusion... - Liver disease in children with primary immunodeficienciesFernanda Rodrigues
Department of Child Health, Institute of Liver Studies and Department of Radiology and King's College Hospital, Denmark Hill, London SE5 9RS, United Kingdom
J Pediatr 145:333-9. 2004..CONCLUSION: SC is the most common hepatic complication of PID. Mild liver involvement could be arrested by early nonmyeloablative HSCT, whereas advanced disease may warrant combined liver and HSCT...