Rukshana C Shroff

Summary

Affiliation: Great Ormond Street
Country: UK

Publications

  1. ncbi request reprint The vascular biology of calcification
    Rukshana C Shroff
    Paediatric Nephrology Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Semin Dial 20:103-9. 2007
  2. ncbi request reprint Mineral metabolism and vascular damage in children on dialysis
    Rukshana C Shroff
    Department of Nephrourology, Great Ormond Street Hospital and Institute of Child Health, London, United Kingdom
    J Am Soc Nephrol 18:2996-3003. 2007
  3. ncbi request reprint Long-term outcome of paediatric renal transplantation: follow-up of 300 children from 1973 to 2000
    Lesley Rees
    Department of Nephro urology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Nephron Clin Pract 105:c68-76. 2007
  4. ncbi request reprint Monitoring cardiovascular risk factors in children on dialysis
    Rukshana Shroff
    Great Ormond Street Hospital for Children NHS Trust, London, UK
    Perit Dial Int 29:S173-5. 2009
  5. doi request reprint The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis
    Rukshana C Shroff
    Nephrourology Unit, Great Ormond Street Hospital and UCL Institute of Child Health, London WC1N 1EH, UK
    Nephrol Dial Transplant 23:3263-71. 2008
  6. pmc A bimodal association of vitamin D levels and vascular disease in children on dialysis
    Rukshana Shroff
    Department of Nephrourology, Great Ormond Street Hospital for Children, London, UK
    J Am Soc Nephrol 19:1239-46. 2008
  7. ncbi request reprint The virtues of vitamin D--but how much is too much?
    Rukshana Shroff
    Department of Nephrology, Great Ormond Street Hospital for Children, NHS Trust, Great Ormond Street, London WC1N 3JH, UK
    Pediatr Nephrol 25:1607-20. 2010
  8. doi request reprint Uraemic vasculopathy in children with chronic kidney disease: prevention or damage limitation?
    Rukshana Shroff
    Department of Nephrourology, Great Ormond Street Hospital for Children, NHS Trust, Great Ormond Street, London, WC1N 3JH, United Kingdom
    Pediatr Nephrol 26:853-65. 2011
  9. doi request reprint Dysregulated mineral metabolism in children with chronic kidney disease
    Rukshana Shroff
    Renal Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Curr Opin Nephrol Hypertens 20:233-40. 2011
  10. doi request reprint Vitamin D deficiency is associated with short stature and may influence blood pressure control in paediatric renal transplant recipients
    Rukshana Shroff
    Renal Unit, Great Ormond Street Hospital for Children NHS Trust and Institute of Child Health London, London, WC1N 3JH, UK
    Pediatr Nephrol 26:2227-33. 2011

Detail Information

Publications19

  1. ncbi request reprint The vascular biology of calcification
    Rukshana C Shroff
    Paediatric Nephrology Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Semin Dial 20:103-9. 2007
    ..A better understanding of the complex mechanisms regulating tissue calcification may have therapeutic potential in reducing the cardiovascular disease-associated morbidity and mortality in patients with renal disease...
  2. ncbi request reprint Mineral metabolism and vascular damage in children on dialysis
    Rukshana C Shroff
    Department of Nephrourology, Great Ormond Street Hospital and Institute of Child Health, London, United Kingdom
    J Am Soc Nephrol 18:2996-3003. 2007
    ..In conclusion, both iPTH level and dosage of vitamin D are associated with vascular damage and calcification in children on dialysis...
  3. ncbi request reprint Long-term outcome of paediatric renal transplantation: follow-up of 300 children from 1973 to 2000
    Lesley Rees
    Department of Nephro urology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Nephron Clin Pract 105:c68-76. 2007
    ..To report our experience of paediatric renal transplantation at Great Ormond Street and Royal Free Hospitals since the inception of the programme...
  4. ncbi request reprint Monitoring cardiovascular risk factors in children on dialysis
    Rukshana Shroff
    Great Ormond Street Hospital for Children NHS Trust, London, UK
    Perit Dial Int 29:S173-5. 2009
    ....
  5. doi request reprint The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis
    Rukshana C Shroff
    Nephrourology Unit, Great Ormond Street Hospital and UCL Institute of Child Health, London WC1N 1EH, UK
    Nephrol Dial Transplant 23:3263-71. 2008
    ....
  6. pmc A bimodal association of vitamin D levels and vascular disease in children on dialysis
    Rukshana Shroff
    Department of Nephrourology, Great Ormond Street Hospital for Children, London, UK
    J Am Soc Nephrol 19:1239-46. 2008
    ..For optimization of strategies to protect the vasculature of dialysis patients, careful monitoring of 1,25(OH)(2)D levels may be required...
  7. ncbi request reprint The virtues of vitamin D--but how much is too much?
    Rukshana Shroff
    Department of Nephrology, Great Ormond Street Hospital for Children, NHS Trust, Great Ormond Street, London WC1N 3JH, UK
    Pediatr Nephrol 25:1607-20. 2010
    ....
  8. doi request reprint Uraemic vasculopathy in children with chronic kidney disease: prevention or damage limitation?
    Rukshana Shroff
    Department of Nephrourology, Great Ormond Street Hospital for Children, NHS Trust, Great Ormond Street, London, WC1N 3JH, United Kingdom
    Pediatr Nephrol 26:853-65. 2011
    ..In this review we focus on the role of calcium, phosphate, parathyroid hormone and vitamin D in ectopic vascular calcification, and discuss the role of screening, early intervention and management of established vascular calcification...
  9. doi request reprint Dysregulated mineral metabolism in children with chronic kidney disease
    Rukshana Shroff
    Renal Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Curr Opin Nephrol Hypertens 20:233-40. 2011
    ..Mechanisms of CVD development are poorly understood. This review focuses on the role of dysregulated homeostasis of calcium (Ca), phosphorus (P), parathyroid hormone (PTH) and vitamin D in ectopic vascular calcification...
  10. doi request reprint Vitamin D deficiency is associated with short stature and may influence blood pressure control in paediatric renal transplant recipients
    Rukshana Shroff
    Renal Unit, Great Ormond Street Hospital for Children NHS Trust and Institute of Child Health London, London, WC1N 3JH, UK
    Pediatr Nephrol 26:2227-33. 2011
    ..Further studies are required to test if routine supplementation with ergo or cholecalciferol is safe and effective in children after renal transplantation...
  11. pmc Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification
    Rukshana C Shroff
    Great Ormond Street Hospital and University College London Institute of Child Health, London, UK
    J Am Soc Nephrol 21:103-12. 2010
    ..These adaptations may initially promote survival but ultimately culminate in VSMC apoptosis and overt calcification, especially with continued exposure to elevated calcium...
  12. doi request reprint Phosphate binders in CKD: chalking out the differences
    Lesley Rees
    Department of Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Pediatr Nephrol 25:385-94. 2010
    ..In this review, the role of phosphate as a uraemic toxin and the advantages and disadvantages of the currently available phosphate binders are discussed...
  13. pmc Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis
    Rukshana C Shroff
    Nephro Urology Unit, UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    PLoS ONE 8:e56273. 2013
    ..The possibility that the release of angiopoietin-2 from endothelia is mediated by urate should be explored further...
  14. doi request reprint A phase I trial of epstein-barr virus gp350 vaccine for children with chronic kidney disease awaiting transplantation
    Lesley Rees
    Paediatric Nephrology, Great Ormond Street Hospital for Sick Children NHS Trust, London, United Kingdom
    Transplantation 88:1025-9. 2009
    ..DISCUSSION.: The vaccine was immunogenic but a prolonged vaccine schedule up to time of transplantation or improved adjuvants are required in future trials to reduce posttransplant EBV load and risk of lymphoproliferative disease...
  15. pmc Long-term outcome of chronic dialysis in children
    Rukshana Shroff
    Department of Nephrourology, Great Ormond Street Hospital for Children NHS Trust London, London, WC1 N3JH, UK
    Pediatr Nephrol 24:463-74. 2009
    ..The multiple factors that may influence outcome, and, particularly, those that can potentially be modified, are discussed...
  16. ncbi request reprint Renal transplantation or bladder augmentation first? A comparison of complications and outcomes in children
    Arash K Taghizadeh
    Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, UK
    BJU Int 100:1365-70. 2007
    ..To identify whether the order of performing transplant and bladder reconstruction operations in children who need both operations affects outcome of either operation...
  17. doi request reprint Renal complications following lung and heart-lung transplantation
    Paul D Robinson
    Department of Pediatric Heart and Lung Transplant, Great Ormond Street Hospital, London, England, UK
    Pediatr Nephrol 28:375-86. 2013
    ..Multicentre studies of CNI minimisation strategies are required to guide future therapy that aims to minimise CKD development and progression in this vulnerable population...
  18. ncbi request reprint Long-term outcome of chronic dialysis in children
    Rukshana Shroff
    Department of Nephrourology, Great Ormond Street Hospital for Children NHS Trust London, London WC1 N3JH, UK
    Pediatr Nephrol 21:257-64. 2006
    ..In conclusion, both a younger age at the start of renal replacement therapy and comorbidity are significant risk factors for death. The number of returnees to dialysis highlights the importance of conserving dialysis access...
  19. doi request reprint Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis
    Rukshana C Shroff
    Nephrology Unit, Great Ormond Street Hospital, University College London Institute of Child Health, King s College London, London SE5 9NU
    Circulation 118:1748-57. 2008
    ..To address this, we quantified the calcium (Ca) load in arteries from children (10 predialysis, 24 dialysis) and correlated it with clinical, biochemical, and vascular measures...