Neil James Sebire

Summary

Affiliation: Great Ormond Street
Country: UK

Publications

  1. pmc Trial protocol OPPTIMUM-- does progesterone prophylaxis for the prevention of preterm labour improve outcome?
    Jane E Norman
    University of Edinburgh MRC Centre for Reproductive Health, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TY, UK
    BMC Pregnancy Childbirth 12:79. 2012
  2. doi request reprint Minimally invasive perinatal autopsies using magnetic resonance imaging and endoscopic postmortem examination ("keyhole autopsy"): feasibility and initial experience
    Neil J Sebire
    Department of Paediatric Pathology, Clinical Molecular Genetics, Great Ormond Street Hospital For Children and UCL Institute of Child Health, London, UK
    J Matern Fetal Neonatal Med 25:513-8. 2012
  3. pmc A molecular map of mesenchymal tumors
    Stephen R Henderson
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Gower Street, University College London, London, WC1E 6BT, UK
    Genome Biol 6:R76. 2005
  4. pmc Post mortem magnetic resonance imaging in the fetus, infant and child: a comparative study with conventional autopsy (MaRIAS Protocol)
    Sudhin Thayyil
    Institute for Women s Health, University College London, London, UK
    BMC Pediatr 11:120. 2011
  5. ncbi request reprint Pathophysiological significance of abnormal umbilical cord coiling index
    N J Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK
    Ultrasound Obstet Gynecol 30:804-6. 2007
  6. ncbi request reprint Epstein-Barr virus-associated lymphoproliferative disorder presenting as apparently isolated gastrointestinal lesions in childhood
    N J Sebire
    Department of Paediatric Pathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, United Kingdom
    Pediatr Dev Pathol 8:88-91. 2005
  7. ncbi request reprint Persistent gestational trophoblastic disease is rarely, if ever, derived from non-molar first-trimester miscarriage
    N J Sebire
    Trophoblastic Disease Unit, Charing Cross Hospital, London WC1N 3JH, UK
    Med Hypotheses 64:689-93. 2005
  8. pmc Pathology of astrovirus associated diarrhoea in a paediatric bone marrow transplant recipient
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    J Clin Pathol 57:1001-3. 2004
  9. ncbi request reprint Alveolar septal collapse in the transitional infant lung: a possible common mechanism in sudden unexpected death in infancy
    N J Sebire
    Department of Paediatric Pathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    Med Hypotheses 63:485-93. 2004
  10. ncbi request reprint p57(KIP2) immunohistochemical staining of gestational trophoblastic tumours does not identify the type of the causative pregnancy
    N J Sebire
    Department of Histopathology, Charing Cross Hospital, London, UK
    Histopathology 45:135-41. 2004

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. pmc Trial protocol OPPTIMUM-- does progesterone prophylaxis for the prevention of preterm labour improve outcome?
    Jane E Norman
    University of Edinburgh MRC Centre for Reproductive Health, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TY, UK
    BMC Pregnancy Childbirth 12:79. 2012
    ....
  2. doi request reprint Minimally invasive perinatal autopsies using magnetic resonance imaging and endoscopic postmortem examination ("keyhole autopsy"): feasibility and initial experience
    Neil J Sebire
    Department of Paediatric Pathology, Clinical Molecular Genetics, Great Ormond Street Hospital For Children and UCL Institute of Child Health, London, UK
    J Matern Fetal Neonatal Med 25:513-8. 2012
    ....
  3. pmc A molecular map of mesenchymal tumors
    Stephen R Henderson
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Gower Street, University College London, London, WC1E 6BT, UK
    Genome Biol 6:R76. 2005
    ..Histological diagnosis is challenging due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over prognosis and appropriate therapy...
  4. pmc Post mortem magnetic resonance imaging in the fetus, infant and child: a comparative study with conventional autopsy (MaRIAS Protocol)
    Sudhin Thayyil
    Institute for Women s Health, University College London, London, UK
    BMC Pediatr 11:120. 2011
    ....
  5. ncbi request reprint Pathophysiological significance of abnormal umbilical cord coiling index
    N J Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK
    Ultrasound Obstet Gynecol 30:804-6. 2007
  6. ncbi request reprint Epstein-Barr virus-associated lymphoproliferative disorder presenting as apparently isolated gastrointestinal lesions in childhood
    N J Sebire
    Department of Paediatric Pathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, United Kingdom
    Pediatr Dev Pathol 8:88-91. 2005
    ..The patient responded to therapy with targeted anti-CD20 immunotherapy. PTLD may manifest as apparently isolated gastrointestinal tract lesions in childhood...
  7. ncbi request reprint Persistent gestational trophoblastic disease is rarely, if ever, derived from non-molar first-trimester miscarriage
    N J Sebire
    Trophoblastic Disease Unit, Charing Cross Hospital, London WC1N 3JH, UK
    Med Hypotheses 64:689-93. 2005
    ....
  8. pmc Pathology of astrovirus associated diarrhoea in a paediatric bone marrow transplant recipient
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    J Clin Pathol 57:1001-3. 2004
    ..Electron microscopic examination demonstrated viral particles within the cytoplasm of enterocytes, focally forming paracrystalline arrays...
  9. ncbi request reprint Alveolar septal collapse in the transitional infant lung: a possible common mechanism in sudden unexpected death in infancy
    N J Sebire
    Department of Paediatric Pathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    Med Hypotheses 63:485-93. 2004
    ..Many epidemiological risk factors for SUDI could influence such a mechanism, leading to the proposal that Alveolar Septal Collapse in Infancy (ASCI) is a core mechanism via which these factors act...
  10. ncbi request reprint p57(KIP2) immunohistochemical staining of gestational trophoblastic tumours does not identify the type of the causative pregnancy
    N J Sebire
    Department of Histopathology, Charing Cross Hospital, London, UK
    Histopathology 45:135-41. 2004
    ....
  11. ncbi request reprint Indoleamine 2,3-dioxygenase expression in gestational trophoblastic disease: implications for development of immunotherapeutic approaches
    Neil James Sebire
    Trophoblastic Disease Unit, Department of Cancer Medicine, Charing Cross Hospital, London, UK
    J Reprod Med 53:789-92. 2008
    ..To examine the immunoexpression of indoleamine 2,3-dioxygenase (IDO) in gestational trophoblastic neoplasia (GTN), including hydatidiform moles and gestational trophoblastic tumors...
  12. ncbi request reprint The dynamic placenta: II. Hypothetical model of a fetus driven transplacental water balance mechanism producing low apparent permeability in a highly permeable placenta
    N J Sebire
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    Med Hypotheses 62:520-8. 2004
    ..This may shed new light on disorders such as polyhydramnios and fetal hydrops...
  13. doi request reprint Histopathological diagnosis of hydatidiform mole: contemporary features and clinical implications
    N J Sebire
    Trophoblastic Disease Unit, Department of Medical Oncology, Charing Cross Hospital, London, UK
    Fetal Pediatr Pathol 29:1-16. 2010
    ....
  14. ncbi request reprint Immunohistochemical findings in embryonal small round cell tumors with molecular diagnostic confirmation
    Neil J Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, United Kingdom
    Appl Immunohistochem Mol Morphol 13:1-5. 2005
    ..Embryonal pediatric malignancies can demonstrate apparently nonspecific expression patterns for several antigens, which may reflect developmental immaturity rather than specific differentiation pathways...
  15. ncbi request reprint Term preeclampsia is associated with minimal histopathological placental features regardless of clinical severity
    N J Sebire
    Department of Histopathology, St Mary s Hospital Paddington, London, UK
    J Obstet Gynaecol 25:117-8. 2005
    ....
  16. ncbi request reprint Pathological diagnosis of paediatric tumours from image-guided needle core biopsies: a systematic review
    Neil J Sebire
    Department of Paediatric Histopathology, Great Ormond Street Hospital for Children, Great Ormond Street, London, WC1N 3JH, UK
    Pediatr Radiol 36:426-31. 2006
    ..Image-guided core needle biopsy is widely used in paediatric oncology, but many protocols continue to discourage this practice. No published randomized studies compare image-guided needle biopsy with surgical techniques...
  17. ncbi request reprint Towards a new era of tissue-based diagnosis and research
    N J Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    Chronic Illn 3:301-9. 2007
    ..Nonetheless, ensuring confidence and trust in tissue-banking will remain an important objective, and the possibilities of novel governance structures should be explored...
  18. ncbi request reprint Posttransplant de novo membranous nephropathy in childhood
    N J Sebire
    Department of Paediatric Histopathology, Great Ormond Street Hospital, London, United Kingdom
    Fetal Pediatr Pathol 24:95-103. 2005
    ..The presence of posttransplant de novo membranous nephropathy may be associated with an increased risk of graft loss...
  19. ncbi request reprint Intraplacental choriocarcinoma: experience from a tertiary referral center and relationship with infantile choriocarcinoma
    N J Sebire
    Department of Histopathology, Trophoblastic Disease Unit, Charing Cross Hospital, London, UK
    Fetal Pediatr Pathol 24:21-9. 2005
    ....
  20. ncbi request reprint Massive cardiac chondroma presenting with heart failure and superior vena cava obstruction in a teenage boy
    N J Sebire
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London, UK WC1N 3JH
    Fetal Pediatr Pathol 23:325-31. 2004
    ..Primary cardiac chondromas are exceptionally rare in patients of any age although cardiac chondrosarcoma, both primary and metastatic, is well reported. We present a case of a teenage boy with a fatal cardiac chondroma..
  21. ncbi request reprint Sacrococcygeal tumors in infancy and childhood; a retrospective histopathological review of 85 cases
    N J Sebire
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    Fetal Pediatr Pathol 23:295-303. 2004
    ..59, p = .08). The median age in the group of non-germ-cell sacrococcygeal masses was 3 years (range 5 months to 13 years)...
  22. ncbi request reprint Histopathological features of open lung biopsies in children treated with extracorporeal membrane oxygenation (ECMO)
    N J Sebire
    Department of Paediatric Pathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, Great Ormond Street, London WC1N 3JH, United Kingdom
    Early Hum Dev 81:455-60. 2005
    ..This study describes the histopathological features in a series of 22 children receiving ECMO therapy in whom open lung biopsy was carried out...
  23. doi request reprint Correlation of placental pathology with prenatal ultrasound findings
    N J Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital Institute of Child Health, London, UK
    J Clin Pathol 61:1276-84. 2008
    ....
  24. doi request reprint Current issues in the histopathology of gestational trophoblastic tumors
    N J Sebire
    Trophoblastic Disease Unit, Charing Cross Hospital, London, and Department of Paediatric Pathology, Great Ormond Street Hospital, London WC1N 3JH, United Kingdom
    Fetal Pediatr Pathol 29:30-44. 2010
    ..Current issues regarding the clinical and histological features of CC and PSTT/ETT are discussed...
  25. ncbi request reprint Anaplastic large cell lymphoma with ALK expression and presence of the t(2;5) translocation in a 5-month-old infant
    N J Sebire
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London, UK
    Fetal Pediatr Pathol 24:63-70. 2005
    ..This is the youngest case of ALCL thus far reported and hence expands the spectrum of infantile lymphoproliferative disorders...
  26. ncbi request reprint Immunohistochemical staining for diagnosis and prognostic assessment of hydatidiform moles: current evidence and future directions
    Neil J Sebire
    Trophoblastic Disease Unit, Department of Cancer Medicine, Charing Cross Hospital, London, UK
    J Reprod Med 55:236-46. 2010
    ..To review the published data on studies examining immunohistochemical markers of hydatidiform moles for determination of diagnosis or prognosis, with regard to whether such investigations can provide clinically relevant information...
  27. ncbi request reprint The role of intraplacental vascular smooth muscle in the dynamic placenta: a conceptual framework for understanding uteroplacental disease
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital, London, UK
    Med Hypotheses 58:347-51. 2002
    ....
  28. ncbi request reprint Placental pathology, antiphospholipid antibodies, and pregnancy outcome in recurrent miscarriage patients
    N J Sebire
    Department of Histopathology, Imperial College School of Medicine at St Mary s, London, United Kingdom
    Obstet Gynecol 101:258-63. 2003
    ....
  29. ncbi request reprint Pseudo-partial moles: placental stem vessel hydrops and the association with Beckwith-Wiedemann syndrome and complete moles
    F J Paradinas
    Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, London, UK
    Histopathology 39:447-54. 2001
    ....
  30. ncbi request reprint Histopathological features of pretreatment neuroblastoma are of limited clinical significance following adjustment for clinical and biological marker status
    N J Sebire
    Consultant in Paediatric Pathology, Great Ormond Street Hospital, London, UK
    Med Hypotheses 66:1078-81. 2006
    ....
  31. ncbi request reprint The dynamic placenta: I. Hypothetical model of a placental mechanism matching local fetal blood flow to local intervillus oxygen delivery
    D Talbert
    Institute of Reproduction and Developmental Biology, ICSM, Hammersmith Hospital, Du Cane Road, London, UK
    Med Hypotheses 62:511-9. 2004
    ..Intervillus/villus flow matching is likely in the human placenta and this study suggests probable biologically plausible mechanisms for such a phenomenon...
  32. doi request reprint Virological investigations in sudden unexpected deaths in infancy (SUDI)
    M A Weber
    Department of Paediatric Histopathology, Great Ormond Street Hospital For Children and UCL Institute of Child Health, Great Ormond Street, London WC1N 3JH, UK
    Forensic Sci Med Pathol 6:261-7. 2010
    ..Application of a broader panel using more sensitive detection techniques may reveal more viruses, although their contribution to the final cause of death requires further exploration...
  33. pmc Histopathological features of gastrointestinal mucosal biopsy specimens in children with epidermolysis bullosa
    N Shah
    Department of Paediatric Gastroenterology, Great Ormond Street Hospital, London, UK
    J Clin Pathol 60:843-4. 2007
  34. ncbi request reprint Histomorphometric features of hydatidiform moles in early pregnancy: relationship to detectability by ultrasound examination
    D J Fowler
    Trophoblastic Disease Unit, Department of Cancer Medicine, Charing Cross Hospital, London, UK
    Ultrasound Obstet Gynecol 29:76-80. 2007
    ..We measured a microscopic parameter, average villus diameter, of evacuated PHMs and CHMs to ascertain the cause of non-detection on ultrasound...
  35. ncbi request reprint Apparent diffusion coefficient maps of pediatric mass lesions with free-breathing diffusion-weighted magnetic resonance: feasibility study
    O E Olsen
    Department of Haematology Oncology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Acta Radiol 47:198-204. 2006
    ..To assess the technical feasibility of apparent diffusion coefficient (ADC) mapping based on free-breathing diffusion-weighted magnetic resonance (DW-MR) outside the CNS in children...
  36. ncbi request reprint Aberrant immunohistochemical expression in nonrhabdomyosarcoma soft tissue sarcomas of infancy: retrospective review of clinical material
    Neil James Sebire
    Department of Histopathology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    Pediatr Dev Pathol 5:579-86. 2002
    ....
  37. ncbi request reprint Sclerosing rhabdomyosarcoma in childhood: case report and review of the literature
    Bhumita Vadgama
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital for Children, London WC1N 3JH, UK
    Pediatr Dev Pathol 7:391-6. 2004
    ..This is the first case report, to our knowledge, of this rare tumor arising in the pediatric age group, and we compare the features with those reported in adult sclerosing rhabdomyosarcoma...
  38. ncbi request reprint Intravascular inflammatory myofibroblastic tumors in infancy
    Neil James Sebire
    Department of Histopathology, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK
    Pediatr Dev Pathol 5:400-4. 2002
    ..IMT should be considered in the differential diagnosis of unusual pediatric intravascular spindle cell lesions...
  39. doi request reprint Fetal and placental malignancies: prenatal diagnosis and management
    N J Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol 33:235-44. 2009
    ..Placental malignancy is most commonly in the form of gestatational trophoblastic disease, which requires assessment and management in specialist centers...
  40. ncbi request reprint 'Cor placentale': placental intervillus/intravillus blood flow mismatch is the pathophysiological mechanism in severe intrauterine growth restriction due to uteroplacental disease
    N J Sebire
    Department of Pathology, St Mary's Hospital, Paddington, London, UK
    Med Hypotheses 57:354-7. 2001
    ....
  41. ncbi request reprint The diagnostic implications of routine ultrasound examination in histologically confirmed early molar pregnancies
    N J Sebire
    Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, Fulham Palace Road, London, UK
    Ultrasound Obstet Gynecol 18:662-5. 2001
    ..Early ultrasound examination is being used increasingly in the diagnosis of molar pregnancy. The aim of this study was to examine the diagnostic implications of routine ultrasound examination for histologically confirmed molar pregnancies...
  42. doi request reprint Capillary apposition and density in the diagnosis of alveolar capillary dysplasia
    L Melly
    Department of Histopathology, Royal Free Hospital, London, UK
    Histopathology 53:450-7. 2008
    ..The aim was to characterise further the histological features of patients suspected of having ACD and to correlate histopathological features with outcome...
  43. ncbi request reprint Megacystis at 10-14 weeks of gestation: chromosomal defects and outcome according to bladder length
    A W Liao
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Ultrasound Obstet Gynecol 21:338-41. 2003
    ..To examine the prevalence of chromosomal defects and outcome of fetuses with megacystis at 10-14 weeks of gestation...
  44. ncbi request reprint Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy
    N J Sebire
    Trophoblastic Disease Screening and Treatment Centre, Department of Cancer Medicine, Imperial College School of Medicine at Charing Cross Hospital, London, UK
    BJOG 110:22-6. 2003
    ..To determine pregnancy outcome, including the rate of repeat molar pregnancy, following histologically confirmed complete or partial hydatidiform mole...
  45. ncbi request reprint Routine pre-evacuation ultrasound diagnosis of hydatidiform mole: experience of more than 1000 cases from a regional referral center
    D J Fowler
    Trophoblastic Disease Unit, Department of Cancer Medicine, Charing Cross Hospital, London, UK
    Ultrasound Obstet Gynecol 27:56-60. 2006
    ....
  46. ncbi request reprint Shortened duration of human chorionic gonadotrophin surveillance following complete or partial hydatidiform mole: evidence for revised protocol of a UK regional trophoblastic disease unit
    N J Sebire
    Trophoblastic Disease Unit, Department of Cancer Medicine, Charing Cross Hospital, London, UK
    BJOG 114:760-2. 2007
    ..Therefore, the current revised protocol comprises hCG follow up for 6 months after spontaneous return of hCG levels to normal for all women...
  47. ncbi request reprint Routine uterine artery Doppler screening in twin pregnancies?
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol 20:532-4. 2002
  48. ncbi request reprint Massive perivillous fibrin deposition associated with discordant fetal growth in a dichorionic twin pregnancy
    N Gupta
    Department of Histopathology, Charing Cross Hospital, London, UK
    J Obstet Gynaecol 24:579-80. 2004
  49. pmc Isolated EBV lymphoproliferative disease in a child with Wiskott-Aldrich syndrome manifesting as cutaneous lymphomatoid granulomatosis and responsive to anti-CD20 immunotherapy
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK Department of Immunology, Great Ormond Street Hospital for Children
    J Clin Pathol 56:555-7. 2003
    ..Biopsy revealed an EBV related LPD with the histological features of LyG. This cutaneous lesion responded dramatically to treatment with specific anti-CD20 immunotherapy and the patient remains clinically free of LPD at 18 months...
  50. ncbi request reprint Increased first-trimester fetal nuchal translucency thickness in association with chondroectodermal dysplasia (Ellis-Van Creveld syndrome)
    N Venkat-Raman
    Fetal Medicine Unit, St Mary s Hospital, Praed Street, London, UK
    Ultrasound Obstet Gynecol 25:412-4. 2005
    ..The acetabular roofs were horizontal with medial and lateral spurs. This case adds a further type of severe skeletal dysplasia to the list of genetic syndromes which may present as increased fetal NT in the late first trimester...
  51. pmc Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas
    N J Sebire
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London GU21 2FB, UK
    J Clin Pathol 56:412-6. 2003
    ..This review examines the use of the immunohistochemical markers, MyoD1 and myogenin, in the diagnosis of paediatric rhabdomyosarcoma, including its subtypes...
  52. doi request reprint Gestational trophoblastic disease: current management of hydatidiform mole
    N J Sebire
    Trophoblastic Disease Centre, Department of Medical Oncology, Charing Cross Hospital, London W6 8RF
    BMJ 337:a1193. 2008
  53. ncbi request reprint Testicular and paratesticular pathology in infants and children: the histopathological experience of a tertiary paediatric unit over a 17 year period
    F L Murphy
    Department of Paediatric Urology, Great Ormond Street Children s Hospital, Great Ormond Street, London WC1N 3JH, UK
    Pediatr Surg Int 23:867-72. 2007
    ..Neoplasms represented >20% of the pathology, but the largest clinical group of pathological specimens in this patient population is associated with clinically impalpable or the palpably abnormal testis...
  54. doi request reprint Prospective parental consent for autopsy research following sudden unexpected childhood deaths: a successful model
    S Thayyil
    UCL Institute of Child Health, London, UK
    Arch Dis Child 94:354-8. 2009
    ..Organ retention issues, recent changes in the Coroners' (Amendment) Rules 2005 and the Human Tissue Act have resulted in pessimism regarding prospective consent for paediatric autopsy research in the UK...
  55. ncbi request reprint Risks of miscarriage and early preterm birth in trichorionic triplet pregnancies with embryo reduction versus expectant management: new data and systematic review
    A T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Hum Reprod 21:1912-7. 2006
    ..Triplet pregnancies are associated with a high risk of miscarriage and early preterm birth. It is uncertain if the outcome is improved by embryo reduction (ER)...
  56. ncbi request reprint Familial Currarino syndrome presenting with peripheral primitive neuroectodermal tumour arising with a sacral teratoma
    G Sen
    Department of Paediatric Oncology and Haematology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Pediatr Blood Cancer 50:172-5. 2008
    ..Detailed family history taken at time of initial presentation may have prevented delay in diagnosis and averted the need for intensive treatment, which may well cause late sequelae...
  57. ncbi request reprint Updated diagnostic criteria for partial and complete hydatidiform moles in early pregnancy
    N J Sebire
    Trophoblastic Disease Unit, Department of Histopathology, Charing Cross Hospital, Fulham Palace Road, London, U K
    Anticancer Res 23:1723-8. 2003
    ..Diagnosis of both complete and partial hydatidiform mole at this early stage of pregnancy requires the use of appropriate, updated histopathological features which are different from those described in later pregnancy...
  58. doi request reprint Salvage chemotherapy of relapsed or high-risk gestational trophoblastic neoplasia (GTN) with paclitaxel/cisplatin alternating with paclitaxel/etoposide (TP/TE)
    J Wang
    Department of Health, Charing Cross Hospital Gestational Trophoblastic Disease Centre, Imperial College School of Medicine, Charing Cross Hospital, London, UK
    Ann Oncol 19:1578-83. 2008
    ..To evaluate the efficacy and toxicity of paclitaxel and cisplatin alternating with paclitaxel and etoposide doublet regimen (TP/TE), for salvage of patients with high-risk gestational trophoblastic neoplasia (GTN)...
  59. ncbi request reprint Twin-to-twin transfusion syndrome results from dynamic asymmetrical reduction in placental anastomoses: a hypothesis
    N J Sebire
    Centre for Fetal Care, Department of Maternal-Fetal Medicine, Imperial College School of Medicine at Queen Charlotte's, Hammersmith Hospital Site, Du Cane Road, London, UK
    Placenta 22:383-91. 2001
    ....
  60. doi request reprint Intrauterine growth in multiple pregnancies in relation to fetal number, chorionicity and gestational age
    A T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London, UK
    Ultrasound Obstet Gynecol 32:890-3. 2008
    ..To examine birth weight in dichorionic and monochorionic twins and trichorionic triplets, and to estimate the relative independent importance on growth of fetal number, chorionicity and gestational age...
  61. doi request reprint Minimally invasive fetal postmortem examination using magnetic resonance imaging and computerised tomography: current evidence and practical issues
    S Thayyil
    Department of Radiology, Institute of Child Health, University College London, London, UK
    Prenat Diagn 30:713-8. 2010
    ..Here, we review the case for the development of less invasive autopsy using combined investigations including imaging techniques, in particular, magnetic resonance imaging and computerised tomography...
  62. doi request reprint Rhabdomyosarcoma subtyping by immunohistochemical assessment of myogenin: tissue array study and review of the literature
    D A Morgenstern
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, UK
    Pathol Oncol Res 14:233-8. 2008
    ..0001). This data is consistent with previously published studies identifying strong nuclear myogenin staining in a high proportion of cells as a marker of alveolar histology...
  63. ncbi request reprint Trichorionic triplet pregnancies at 10-14 weeks: outcome after embryo reduction compared to expectant management
    A T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    J Matern Fetal Neonatal Med 11:307-12. 2002
    ..To compare the outcome of trichorionic triplet pregnancies managed expectantly with those reduced to twins or singletons...
  64. ncbi request reprint Placental site trophoblastic tumour derived from an oocyte donation pregnancy
    S Khan
    Department of Health Gestational Trophoblastic Disease Centre, Charing Cross Hospital, London, UK
    BJOG 113:344-6. 2006
  65. ncbi request reprint Biology and pathology of the placenta in relation to antiphospholipid antibody-associated pregnancy failure
    N J Sebire
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Imperial College School of Medicine, St Mary s Hospital, London, UK
    Lupus 11:641-3. 2002
    ....
  66. ncbi request reprint Extravillus endovascular implantation site trophoblast invasion is abnormal in complete versus partial molar pregnancies
    N J Sebire
    Department of Histopathology, Trophoblastic Disease Surveillance Unit, Charing Ross Hospital, London, UK
    Placenta 22:725-8. 2001
    ..These findings may provide some explanation regarding the mechanism of clinical findings in molar pregnancy...
  67. doi request reprint Clinicopathological features of paediatric deaths due to myocarditis: an autopsy series
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, Great Ormond Street, London, UK
    Arch Dis Child 93:594-8. 2008
    ..Myocarditis is a recognised cause of cardiac failure in childhood but the frequency of myocarditis as a cause of sudden unexpected death across the paediatric age range is uncertain...
  68. ncbi request reprint Melanotic neuroectodermal tumor of infancy: clinical, radiological, and pathological features
    D J Fowler
    Department of Pediatric Histopathology, Great Ormond Street Hospital, London, UK
    Fetal Pediatr Pathol 25:59-72. 2006
    ..At present, the optimal management includes complete surgical excision with clear margins, but there are no reliable histopathological or molecular features to predict the biological behavior in individual cases...
  69. doi request reprint EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A
    D M Gascoyne
    Molecular Haematology and Cancer Biology Unit, University College London Institute of Child Health, London, UK
    Oncogene 29:3134-45. 2010
    ..These results extend the hypothesis that EWS/ETS proteins induce expression of neuronal markers such as BRN3A in EFT by showing that the function of those same markers may be restricted or controlled in an EWS/ETS-dependent manner...
  70. ncbi request reprint Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London
    N J Sebire
    Department of Obstetrics and Gynaecology, Imperial College School of Medicine at St Mary's Hospital, London, UK
    Int J Obes Relat Metab Disord 25:1175-82. 2001
    ..The basis of many of the complications is likely to be related to the altered metabolic state associated with morbid obesity...
  71. ncbi request reprint Is maternal underweight really a risk factor for adverse pregnancy outcome? A population-based study in London
    N J Sebire
    Department of Obstetrics and Gynaecology, Imperial College School of Medicine, St Mary s Hospital, Paddington, London, UK
    BJOG 108:61-6. 2001
    ..To determine the maternal and fetal risk of adverse outcome during pregnancy in relation to low maternal body mass index in an unselected population...
  72. ncbi request reprint Pathology teach and tell: pediatric gastrointestinal stromal tumor
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital, London, United Kingdom
    Pediatr Pathol Mol Med 22:259-64. 2003
  73. ncbi request reprint Risk of partial and complete hydatidiform molar pregnancy in relation to maternal age
    N J Sebire
    Department of Cancer Medicine, Imperial College School of Medicine at Charing Cross Hospital, London, UK
    BJOG 109:99-102. 2002
    ..This study provides, for the first time, data regarding specific risk of partial versus complete hydatidiform mole with maternal age...
  74. ncbi request reprint Histopathological diagnosis of partial and complete hydatidiform mole in the first trimester of pregnancy
    Neil J Sebire
    Department of Histopathology, Trophoblastic Disease Unit, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
    Pediatr Dev Pathol 6:69-77. 2003
    ..Pathophysiological issues relevant to molar pregnancies, such as genetic abnormalities, will be briefly summarized, but nonhistopathological aspects of molar disease will not be covered in detail in this review...
  75. ncbi request reprint Kaiser Wilhelm syndrome: obstetric trauma or placental insult in a historical case mimicking Erb's palsy
    Venu Jain
    Institute of Reproductive and Developmental Biology, Imperial College London, Obstetrics and Gynaecology, Hammersmith Campus, Room 4009, IRDB, Du Cane Road, London, Middx W12 0NN, UK
    Med Hypotheses 65:185-91. 2005
    ..We further suggest that such a mechanism be called Kaiser Wilhelm syndrome to distinguish it from Erb's palsy originating from obstetric trauma...
  76. doi request reprint Variable antigen expression in hepatoblastomas
    Alan D Ramsay
    Great Ormond Street Hospital for Children, London WC1N 3JH, UK
    Appl Immunohistochem Mol Morphol 16:140-7. 2008
    ..In the clinical setting of the differential diagnosis of childhood abdominal mass, hepatoblastoma shows no distinct immunohistochemical profile, and the diagnosis requires a combination of the clinical, imaging, and pathologic findings...
  77. doi request reprint Glomerular tip changes in childhood minimal change nephropathy
    Alexander J Howie
    Department of Pathology, University College London, London, UK
    Pediatr Nephrol 23:1281-6. 2008
    ..This should make little difference in clinical practice, because the clinical course should resemble that of minimal change nephropathy...
  78. ncbi request reprint Placental site trophoblastic tumour arising from a partial hydatidiform mole
    Carlo Palmieri
    Department of Cancer Medicine, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
    Lancet 366:688. 2005
  79. ncbi request reprint Placental-site trophoblastic tumour: an unusual presentation with bilateral ovarian involvement
    Carlo Palmieri
    Department of Cancer Medicine, Charing Cross Hospital, London, UK
    Lancet Oncol 6:59-61. 2005
  80. ncbi request reprint Posttransplant lymphoproliferative disorder presenting as CD30+, ALK+, anaplastic large cell lymphoma in a child
    Neil J Sebire
    Department of Histopathology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    Pediatr Dev Pathol 7:290-3. 2004
    ..This is the first reported case, to our knowledge, of PTLPD occurring in childhood with an ALK+, CD30+ anaplastic large cell lymphoma phenotype...
  81. ncbi request reprint Changes in computed tomography features following preoperative chemotherapy for nephroblastoma: relation to histopathological classification
    Øystein E Olsen
    Department of Radiology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK
    Eur Radiol 14:990-4. 2004
    ..Volume change following chemotherapy did not relate to histopathological risk group. Changes in subjectively assessed qualitative CT features were more strongly related to histopathological risk group...
  82. ncbi request reprint Risk factors for macrosomia and its clinical consequences: a study of 350,311 pregnancies
    Matthew C Jolly
    Section of Endocrinology and Metabolic Medicine, The Mint Wing, Imperial College of Science Technology and Medicine, St Mary s Campus, London W2 1PG, UK
    Eur J Obstet Gynecol Reprod Biol 111:9-14. 2003
    ..To identify demographic risk factors for either birthweight >4kg or over the 90th centile and to quantify the obstetric risks...
  83. ncbi request reprint Chronic pneumonitis of infancy: high-resolution CT findings
    Øystein E Olsen E
    Radiology Department, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
    Pediatr Radiol 34:86-8. 2004
    ..An accurate diagnosis is crucial for correct management; however, several entities with the same HRCT findings are recognized...
  84. ncbi request reprint Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin
    Neil J Sebire
    Trophoblastic Disease Unit, Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, London W6 8RF, UK
    Lancet 359:2165-6. 2002
    ..CHM and healthy co-twin pregnancies have a high risk of spontaneous abortion, but about 40% result in livebirths, without significantly increasing the risk of pGTD...
  85. ncbi request reprint The maternally transcribed gene p57(KIP2) (CDNK1C) is abnormally expressed in both androgenetic and biparental complete hydatidiform moles
    Rosemary A Fisher
    Department of Cancer Medicine, Imperial College of Science Technology and Medicine, London W6 8RF, UK
    Hum Mol Genet 11:3267-72. 2002
    ..In addition we provide further evidence for a major control gene on 19q13.3-13.4 which regulates expression of imprinted genes on other chromosomes...
  86. ncbi request reprint Neonatal death due to transposition in association with premature closure of the oval foramen
    Michael Ashworth
    Department of Paediatric Histopathology, Great Ormond Street Hospital, London, UK
    Cardiol Young 16:586-9. 2006
    ..Premature closure of the oval foramen is rare in the setting of transposition. As far as we know, there have been only three previously reported cases...
  87. ncbi request reprint Radiological-pathological correlation in lipoblastoma and lipoblastomatosis
    Shruti Moholkar
    Department of Radiology, Great Ormond Street Hospital, London, WC1N 3JH, UK
    Pediatr Radiol 36:851-6. 2006
    ..Lipoblastoma and lipoblastomatosis are uncommon benign mesenchymal lesions that predominantly occur in infancy and early childhood...
  88. ncbi request reprint Third trimester intrauterine fetal death caused by arterial aneurysm of the umbilical cord
    Martin A Weber
    Department of Histopathology, Great Ormond Street Hospital for Children, London, UK
    Pediatr Dev Pathol 10:305-8. 2007
    ..Cytogenetic analysis should be performed in all cases diagnosed with this unusual lesion, and placental mosaicism for trisomy 18 should be excluded...
  89. ncbi request reprint Clinicopathological correlations of paediatric lupus nephritis
    Stephen D Marks
    Nephro Urology Unit, Institute of Child Health, London, UK
    Pediatr Nephrol 22:77-83. 2007
    ..73 m(2) in patients with diffuse global sclerosing [class IV-G(C)] LN. The new classification allows expanded histopathological grading of LN with further delineation of classes III and IV with activity and chronicity indices...
  90. ncbi request reprint Unsuspected rejection episodes on routine surveillance endomyocardial biopsy post-heart transplant in paediatric patients
    Viktoria Dixon
    Department of Paediatric Cardiology, Great Ormond Street Hospital, London, UK
    Pediatr Transplant 11:286-90. 2007
    ..More frequent surveillance appears needed in children treated with sirolimus, but less frequent surveillance may be possible in infants...
  91. pmc Hydatidiform mole and medical management of miscarriage
    Neil J Sebire
    BMJ 332:1454. 2006
  92. ncbi request reprint Evaluation of deletions in 7q11.2 and 8p12-p21 as prognostic indicators of tumour development following molar pregnancy
    Beverley Burke
    Department of Oncology, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London, UK
    Gynecol Oncol 103:642-8. 2006
    ..Our objectives were to refine the regions of loss and evaluate these deletions as prognostic indicators of trophoblastic tumour development following molar pregnancy...
  93. ncbi request reprint Successful treatment of lymphoproliferative disease complicating primary immunodeficiency/immunodysregulatory disorders with reduced-intensity allogeneic stem-cell transplantation
    Jonathan M Cohen
    Department of Clinical Immunology, Great Ormond Street Hospital, London, United Kingdom
    Blood 110:2209-14. 2007
    ..With careful monitoring and pre-emptive therapy, we advocate this RIC SCT approach to patients with PID who have pre-existing EBV-LPD...
  94. ncbi request reprint Assessment of extrahepatic abdominal extension in primary malignant liver tumours of childhood
    Derek J Roebuck
    Department of Radiology, Great Ormond Street Hospital, London, WC1N 3JH, UK
    Pediatr Radiol 37:1096-100. 2007
    ..This article reviews the imaging findings of two of these criteria: direct extrahepatic extension of the tumour (E1, E1a, E2, E2a) and tumour rupture at diagnosis (H1)...
  95. ncbi request reprint Routine terminations of pregnancy--should we screen for gestational trophoblastic neoplasia?
    Michael J Seckl
    Gestational Trophoblastic Disease Unit, Department of Medical Oncology, Charing Cross and Hammersmith Hospitals Campus, Imperial College London, Fulham Palace Road, London W6 8RF, UK
    Lancet 364:705-7. 2004
    ..003), and to require surgical intervention (15 of 15 vs one of 36; p<0.0001) and chemotherapy (nine of 15 vs two of 36; p<0.0001). All women should be screened for gestational trophoblastic neoplasia after termination of pregnancy...
  96. ncbi request reprint Value of whole body 18FDG-PET to identify the active site of gestational trophoblastic neoplasia
    Tony Dhillon
    Department of Medical Oncology, Charing Cross Hospital Campus of Imperial College, Fulham Palace Road, London W6 8RF, UK
    J Reprod Med 51:879-87. 2006
    ..To evaluate the usefulness of positron emission tomography with 18-fluorodeoxyglucose (18FDG-PET) in locating residual or relapsed gestational trophoblastic neoplasia (GTN)...
  97. ncbi request reprint Predictors of long-term outcome of children with idiopathic focal segmental glomerulosclerosis
    Asiri S Abeyagunawardena
    Nephro Urology Unit, Great Ormond Street Hospital NHS Trust, London, WC1N 3JH, UK
    Pediatr Nephrol 22:215-21. 2007
    ..005) as the independent predictors of favourable response to cytotoxic therapy and the presence of renal impairment (p=0.008) and extensive focal segmental sclerosis (p=0.025) as independent predictors of unfavourable response...
  98. ncbi request reprint Part I: Primary malignant non-Wilms' renal tumours in children
    Hashim Uddin Ahmed
    Institute of Urology and Nephrology, University College London Hospitals NHS Foundation Trust, London, UK
    Lancet Oncol 8:730-7. 2007
    ..This review is the first of two parts, and provides an updated review of the clinical presentation, imaging, and pathology of these tumours...
  99. ncbi request reprint Extensive posttreatment ganglioneuromatous differentiation of rhabdomyosarcoma: malignant ectomesenchymoma in an infant
    Neil J Sebire
    Pediatr Dev Pathol 6:94-6. 2003
  100. ncbi request reprint Autosomal dominant inheritance of non-syndromic renal hypoplasia and dysplasia: dramatic variation in clinical severity in a single kindred
    Larissa Kerecuk
    Nephro Urology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Nephrol Dial Transplant 22:259-63. 2007
  101. ncbi request reprint Portopulmonary hypertension in childhood presenting as sudden death
    Martin A Weber
    Deapartment of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital for Children, Great Ormond Street, London, UK WC1N 3JH
    Pediatr Dev Pathol 9:65-71. 2006
    ....