Lesley Rees

Summary

Affiliation: Great Ormond Street
Country: UK

Publications

  1. ncbi request reprint Long-term peritoneal dialysis in infants
    Lesley Rees
    Great Ormond Street Hospital for Children, London, United Kingdom
    Perit Dial Int 27:S180-4. 2007
  2. ncbi request reprint Long-term outcome of paediatric renal transplantation: follow-up of 300 children from 1973 to 2000
    Lesley Rees
    Department of Nephro urology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Nephron Clin Pract 105:c68-76. 2007
  3. pmc Growth in very young children undergoing chronic peritoneal dialysis
    Lesley Rees
    Renal Office, Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, United Kingdom
    J Am Soc Nephrol 22:2303-12. 2011
  4. ncbi request reprint Management of the neonate with chronic renal failure
    Lesley Rees
    Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, UK
    Semin Fetal Neonatal Med 13:181-8. 2008
  5. pmc What parathyroid hormone levels should we aim for in children with stage 5 chronic kidney disease; what is the evidence?
    Lesley Rees
    Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
    Pediatr Nephrol 23:179-84. 2008
  6. doi request reprint Tube feeding in children with chronic kidney disease: technical and practical issues
    Lesley Rees
    Department of Nephrology, Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, UK
    Pediatr Nephrol 25:699-704. 2010
  7. ncbi request reprint Management of the infant with end-stage renal failure
    Lesley Rees
    Department of Nephrourology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Nephrol Dial Transplant 17:1564-7. 2002
  8. ncbi request reprint Phosphate binders in CKD: chalking out the differences
    Lesley Rees
    Department of Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Pediatr Nephrol 25:385-94. 2010
  9. doi request reprint Ergocalciferol supplementation in children with CKD delays the onset of secondary hyperparathyroidism: a randomized trial
    Rukshana Shroff
    Renal Unit, Ormond Street Hospital for Children NHS Trust and Institute of Child Health, London WC1N 3JH, UK
    Clin J Am Soc Nephrol 7:216-23. 2012
  10. ncbi request reprint Catch-up growth with normal parathyroid hormone levels in chronic renal failure
    Simon Waller
    Department of Nephro urology, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, 30 Guilford Street, London WC1N 1EH, UK
    Pediatr Nephrol 18:1236-41. 2003

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Long-term peritoneal dialysis in infants
    Lesley Rees
    Great Ormond Street Hospital for Children, London, United Kingdom
    Perit Dial Int 27:S180-4. 2007
    ..Mortality is high in infants with comorbidities, complications of dialysis are common, and most of these infants need enteral feeding. However, the long-term outcome for otherwise healthy infants is comparable to that for older children...
  2. ncbi request reprint Long-term outcome of paediatric renal transplantation: follow-up of 300 children from 1973 to 2000
    Lesley Rees
    Department of Nephro urology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Nephron Clin Pract 105:c68-76. 2007
    ..To report our experience of paediatric renal transplantation at Great Ormond Street and Royal Free Hospitals since the inception of the programme...
  3. pmc Growth in very young children undergoing chronic peritoneal dialysis
    Lesley Rees
    Renal Office, Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, United Kingdom
    J Am Soc Nephrol 22:2303-12. 2011
    ..The use of gastrostomy feeding, biocompatible dialysis fluid, and growth hormone therapy associate with improved linear growth...
  4. ncbi request reprint Management of the neonate with chronic renal failure
    Lesley Rees
    Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, UK
    Semin Fetal Neonatal Med 13:181-8. 2008
    ..Commitment from the family and medical team is crucial for success. However, the long-term outcome for otherwise healthy infants is comparable to that of older children...
  5. pmc What parathyroid hormone levels should we aim for in children with stage 5 chronic kidney disease; what is the evidence?
    Lesley Rees
    Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
    Pediatr Nephrol 23:179-84. 2008
    ..This editorial takes a critical look at the evidence upon which these recommendations are based...
  6. doi request reprint Tube feeding in children with chronic kidney disease: technical and practical issues
    Lesley Rees
    Department of Nephrology, Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, UK
    Pediatr Nephrol 25:699-704. 2010
    ..This review discusses the indications for enteral feeding in children with chronic kidney disease, the types of feeding tubes that can be used, methods of insertion and their benefits and complications...
  7. ncbi request reprint Management of the infant with end-stage renal failure
    Lesley Rees
    Department of Nephrourology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Nephrol Dial Transplant 17:1564-7. 2002
  8. ncbi request reprint Phosphate binders in CKD: chalking out the differences
    Lesley Rees
    Department of Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Pediatr Nephrol 25:385-94. 2010
    ..In this review, the role of phosphate as a uraemic toxin and the advantages and disadvantages of the currently available phosphate binders are discussed...
  9. doi request reprint Ergocalciferol supplementation in children with CKD delays the onset of secondary hyperparathyroidism: a randomized trial
    Rukshana Shroff
    Renal Unit, Ormond Street Hospital for Children NHS Trust and Institute of Child Health, London WC1N 3JH, UK
    Clin J Am Soc Nephrol 7:216-23. 2012
    ..The hypothesis was that nutritional vitamin D (ergocalciferol) supplementation in children with CKD stages 2-4 delays the onset of secondary hyperparathyroidism...
  10. ncbi request reprint Catch-up growth with normal parathyroid hormone levels in chronic renal failure
    Simon Waller
    Department of Nephro urology, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, 30 Guilford Street, London WC1N 1EH, UK
    Pediatr Nephrol 18:1236-41. 2003
    ..Our results indicate that catch-up growth can occur in infants and children with CRF when medical therapy is aimed at normalizing PTH levels...
  11. doi request reprint Nephrectomy for the failed renal allograft in children: predictors and outcomes
    Susan Minson
    Renal Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London, WC1N 3JH, UK
    Pediatr Nephrol 28:1299-305. 2013
    ..There are no guidelines for the removal of a failed renal allograft, and its impact on subsequent dialysis and retransplantation has not yet been described...
  12. ncbi request reprint Bone mineral density in children with chronic renal failure
    Simon Waller
    Department of Nephro urology, Institute of Child Health and The Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
    Pediatr Nephrol 22:121-7. 2007
    ..Further investigation of the underlying bone by the use of biopsy and histomorphometry is required to determine actual bone health...
  13. pmc Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification
    Rukshana C Shroff
    Great Ormond Street Hospital and University College London Institute of Child Health, London, UK
    J Am Soc Nephrol 21:103-12. 2010
    ..These adaptations may initially promote survival but ultimately culminate in VSMC apoptosis and overt calcification, especially with continued exposure to elevated calcium...
  14. doi request reprint Vitamin D deficiency is associated with short stature and may influence blood pressure control in paediatric renal transplant recipients
    Rukshana Shroff
    Renal Unit, Great Ormond Street Hospital for Children NHS Trust and Institute of Child Health London, London, WC1N 3JH, UK
    Pediatr Nephrol 26:2227-33. 2011
    ..Further studies are required to test if routine supplementation with ergo or cholecalciferol is safe and effective in children after renal transplantation...
  15. doi request reprint Urinary and dialysate losses of vitamin D-binding protein in children on chronic peritoneal dialysis
    Agnieszka Prytuła
    Renal Unit, Great Ormond Street Hospital for Children NHS, Trust and Institute of Child Health, London, United Kingdom
    Pediatr Nephrol 27:643-9. 2012
    ..The aim of our study was to determine whether losses of vitamin D binding protein [VDBP] in urine and dialysate contribute to circulating 25-hydroxyvitamin D [25OHD] levels in chronic peritoneal dialysis [PD] patients...
  16. pmc A bimodal association of vitamin D levels and vascular disease in children on dialysis
    Rukshana Shroff
    Department of Nephrourology, Great Ormond Street Hospital for Children, London, UK
    J Am Soc Nephrol 19:1239-46. 2008
    ..For optimization of strategies to protect the vasculature of dialysis patients, careful monitoring of 1,25(OH)(2)D levels may be required...
  17. ncbi request reprint Effect of haemodialysis on markers of bone turnover in children
    Simon Waller
    Department of Nephro urology, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Pediatr Nephrol 22:586-92. 2007
    ..The relationship between BALP and CTx and bone histology requires investigation to determine whether they are more useful markers of bone turnover in this patient group...
  18. doi request reprint Fibroblast growth factor 23 and soluble klotho in children with chronic kidney disease
    Mandy Wan
    Renal Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
    Nephrol Dial Transplant 28:153-61. 2013
    ..There are scarce data on the levels of its essential co-receptor klotho, and longitudinal changes in FGF23 levels are also unknown...
  19. ncbi request reprint Parathyroid hormone and growth in children with chronic renal failure
    Simon C Waller
    Nephro Urology Unit, Insitute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Kidney Int 67:2338-45. 2005
    ..The purpose of this study was to investigate the relationship between PTH, the 1-84 PTH:C-PTH ratio and growth rate in children with CRF...
  20. ncbi request reprint Differences between "intact" PTH and 1-84 PTH assays in chronic renal failure and dialysis
    Simon Waller
    Department of Nephro urology, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Pediatr Nephrol 20:197-9. 2005
    ..Studies investigating the correlation between newer assays and bone histology are required to determine whether these more-specific PTH assays are superior surrogate markers of bone turnover...
  21. ncbi request reprint Mineral metabolism and vascular damage in children on dialysis
    Rukshana C Shroff
    Department of Nephrourology, Great Ormond Street Hospital and Institute of Child Health, London, United Kingdom
    J Am Soc Nephrol 18:2996-3003. 2007
    ..In conclusion, both iPTH level and dosage of vitamin D are associated with vascular damage and calcification in children on dialysis...
  22. ncbi request reprint Long-term outcome of chronic dialysis in children
    Rukshana Shroff
    Department of Nephrourology, Great Ormond Street Hospital for Children NHS Trust London, London WC1 N3JH, UK
    Pediatr Nephrol 21:257-64. 2006
    ..In conclusion, both a younger age at the start of renal replacement therapy and comorbidity are significant risk factors for death. The number of returnees to dialysis highlights the importance of conserving dialysis access...
  23. ncbi request reprint The effect of heparin on graft thrombosis in pediatric renal allografts
    Arvind Nagra
    Renal Unit, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, WCIN 3JH, London, UK
    Pediatr Nephrol 19:531-5. 2004
    ..009), increasing CIT ( P=0.007), and surgical complications ( P=0.002) increased the risk of graft thrombosis. A reduction in the incidence of early renal allograft thrombosis upon introduction of heparin was not demonstrated...
  24. ncbi request reprint Chronic hemodialysis in infants and children under 2 years of age
    Rokshana Shroff
    Department of Nephrourology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK
    Pediatr Nephrol 18:378-83. 2003
    ..None of the deaths occurred on HD or resulted from its complications. In conclusion, HD in infants and small children is an effective and safe form of renal replacement therapy, but problems with vascular access limit its long-term use...
  25. doi request reprint Hemodialysis-induced acute myocardial dyssynchronous impairment in children
    Daljit K Hothi
    Department of Nephro urology, Great Ormond Street Hospital for Children, London, UK
    Nephron Clin Pract 123:83-92. 2013
    ..The aim of this study was, to assess the impact of HD on left ventricular (LV) myocardial function in children...
  26. pmc Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis
    Rukshana C Shroff
    Nephro Urology Unit, UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    PLoS ONE 8:e56273. 2013
    ..The possibility that the release of angiopoietin-2 from endothelia is mediated by urate should be explored further...
  27. doi request reprint Nutritional management and growth in children with chronic kidney disease
    Lesley Rees
    Department of Nephrology, Gt Ormond St Hospital for Children Foundation Trust, Gt Ormond St, London, WC1N 3JH, UK
    Pediatr Nephrol 28:527-36. 2013
    ....
  28. pmc Long-term outcome of infants with severe chronic kidney disease
    Djalila Mekahli
    Renal Office, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK
    Clin J Am Soc Nephrol 5:10-7. 2010
    ..In 2000, we reported the outcome of 101 children with a GFR <20 ml/min per 1.73 m2 at 0.3 yr of age (range 0.0 to 1.5 yr). Long-term data on such young children are scarce...
  29. ncbi request reprint A fatal case of cerebral oedema with hyponatraemia and massive polyuria after renal transplantation
    Janette Cansick
    Department of Nephrology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
    Pediatr Nephrol 24:1231-4. 2009
    ..45% saline solution for urine output replacement. The case highlights the dangers of massive fluid therapy in the context of polyuria and, therefore, the need for intensive monitoring...
  30. ncbi request reprint Gastrostomy feeding in infants and children on peritoneal dialysis
    Sarah E Ledermann
    Renal Unit, Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, UK
    Pediatr Nephrol 17:246-50. 2002
    ..We recommend placement of a PEG or OG if an anti-reflux procedure is necessary prior to starting PD. Placement of a PEG while on PD is contraindicated, but an OG is a safe alternative procedure...
  31. ncbi request reprint The virtues of vitamin D--but how much is too much?
    Rukshana Shroff
    Department of Nephrology, Great Ormond Street Hospital for Children, NHS Trust, Great Ormond Street, London WC1N 3JH, UK
    Pediatr Nephrol 25:1607-20. 2010
    ....
  32. ncbi request reprint Growth and PTH in prepubertal children on long-term dialysis
    Janette Cansick
    Department of Nephrology, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK
    Pediatr Nephrol 22:1349-54. 2007
    ..In some children under 2 years of age catch-up growth can be observed in the first dialysis year...
  33. doi request reprint Can vitamin D slow down the progression of chronic kidney disease?
    Rukshana Shroff
    Renal Unit, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
    Pediatr Nephrol 27:2167-73. 2012
    ....
  34. ncbi request reprint An association of tubular dysfunction, cortical macrocysts and chronic kidney disease
    Detlef Bockenhauer
    Paediatric Nephrology, Great Ormond Street Hospital, Great Ormond Street, London, WC1 3JH, UK
    Pediatr Nephrol 21:580-3. 2006
    ..The association of initial tubular dysfunction followed by the development of multiple cysts may represent a new form of kidney disease...
  35. pmc Nutrition in children with CRF and on dialysis
    Lesley Rees
    Department of Nephrourology, Gt Ormond St Hospital for Children NHS Trust, Gt Ormond St, London, WC1N 3JH, UK
    Pediatr Nephrol 22:1689-702. 2007
    ....
  36. pmc Long-term outcome after renal transplantation in childhood
    Lesley Rees
    Department of Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Pediatr Nephrol 24:475-84. 2009
    ..Final height and obesity 5. Psycho-social outcome...
  37. ncbi request reprint The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis
    Rukshana C Shroff
    Nephrourology Unit, Great Ormond Street Hospital and UCL Institute of Child Health, London WC1N 1EH, UK
    Nephrol Dial Transplant 23:3263-71. 2008
    ....
  38. ncbi request reprint Evaluation of quality of life by young adult survivors of severe chronic kidney disease in infancy
    Djalila Mekahli
    Renal Unit, Great Ormond St Hospital for Children NHS Trust, Great Ormond St, London, WC1N 3JH, UK
    Pediatr Nephrol 29:1387-93. 2014
    ..The health related quality of life (HRQoL) of young adults treated for chronic kidney disease (CKD) stage 4/5 from infancy is unknown...
  39. doi request reprint A comparison of arteriovenous fistulas and central venous lines for long-term chronic haemodialysis
    Alison Ma
    Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, WC1N 3JH, UK
    Pediatr Nephrol 28:321-6. 2013
    ..Our aim was to compare outcomes of AVFs and central venous lines (CVL) in children on chronic HD in a centre where AVF is the primary choice for vascular access...
  40. ncbi request reprint A phase I trial of epstein-barr virus gp350 vaccine for children with chronic kidney disease awaiting transplantation
    Lesley Rees
    Paediatric Nephrology, Great Ormond Street Hospital for Sick Children NHS Trust, London, United Kingdom
    Transplantation 88:1025-9. 2009
    ..DISCUSSION.: The vaccine was immunogenic but a prolonged vaccine schedule up to time of transplantation or improved adjuvants are required in future trials to reduce posttransplant EBV load and risk of lymphoproliferative disease...
  41. ncbi request reprint Predictors of long-term outcome of children with idiopathic focal segmental glomerulosclerosis
    Asiri S Abeyagunawardena
    Nephro Urology Unit, Great Ormond Street Hospital NHS Trust, London, WC1N 3JH, UK
    Pediatr Nephrol 22:215-21. 2007
    ..005) as the independent predictors of favourable response to cytotoxic therapy and the presence of renal impairment (p=0.008) and extensive focal segmental sclerosis (p=0.025) as independent predictors of unfavourable response...
  42. pmc Pediatric myocardial stunning underscores the cardiac toxicity of conventional hemodialysis treatments
    Daljit K Hothi
    Department of Nephro urology, Great Ormond Street Hospital for Children, London, UK
    Clin J Am Soc Nephrol 4:790-7. 2009
    ....
  43. ncbi request reprint The post-transplant lymphoproliferative disorder-a literature review
    Rokshana Shroff
    Department of Nephrourology, Great Ormond Street Hospital for Children, WC1 N 3JH, London, UK
    Pediatr Nephrol 19:369-77. 2004
    ..In this review, we have presented the current knowledge of this increasingly common complication in renal transplant recipients...
  44. ncbi request reprint Parathyroid hormone and its fragments in children with chronic renal failure
    Simon Waller
    Department of Nephro urology, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Pediatr Nephrol 18:1242-8. 2003
    ..Maintenance of normal PTH levels throughout the course of CRF permits the maintenance of a normal 1-84 PTH/C-PTH ratio, the clinical significance of which requires further investigation in children...
  45. ncbi request reprint Eosinophilic peritonitis in children on chronic peritoneal dialysis
    Catherine Quinlan
    Department of Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, WC1N 3JH, UK
    Pediatr Nephrol 25:517-22. 2010
    ..Despite recurrent episodes, there were no adverse outcomes, although a raised peritoneal eosinophil count persisted in most cases. Eosinophilic peritonitis is under-diagnosed and may lead to unnecessary antibiotic therapy...
  46. ncbi request reprint A sporadic case of paraganglioma undetected by urine metabolite screening
    Detlef Bockenhauer
    Department of Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, WC1N 3JH, UK
    Pediatr Nephrol 23:1889-91. 2008
    ..Postoperatively, the patient developed renal vein thrombosis. Appropriate screening tests for phaeochromocytomas, peri-operative management, and the high incidence of an underlying genetic basis, even in sporadic cases, are discussed...
  47. ncbi request reprint Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure
    Katy J Bennett-Richards
    Departments of Nephrourology and Vascular Physiology, Great Ormond Street Hospital for Children NHS Trust, 34 Great Ormond Street, London WC1 3JH, England, United Kingdom
    Kidney Int 62:1372-8. 2002
    ..We examined whether dietary L-arginine supplementation improved endothelial function in children with CRF...
  48. ncbi request reprint Growth hormone for children with chronic renal failure and on dialysis
    Jameela A Kari
    Pediatrics Department, King Abdulaziz University Hospital, PO Box 80215, 21589, Jeddah, Saudi Arabia
    Pediatr Nephrol 20:618-21. 2005
    ..0 years and for 1 year in children on dialysis. Discontinuation of rhGH after transplantation resulted in little change in Ht SDS...
  49. ncbi request reprint Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis
    Rukshana C Shroff
    Nephrology Unit, Great Ormond Street Hospital, University College London Institute of Child Health, King s College London, London SE5 9NU
    Circulation 118:1748-57. 2008
    ..To address this, we quantified the calcium (Ca) load in arteries from children (10 predialysis, 24 dialysis) and correlated it with clinical, biochemical, and vascular measures...
  50. doi request reprint Bone histomorphometry in children prior to commencing renal replacement therapy
    Simon Waller
    Royal Sick Children s Hospital, Yorkhill, Dalnair St, Glasgow, G3 8SJ, UK
    Pediatr Nephrol 23:1523-9. 2008
    ..The presence of ROD was universal in these children with severe CKD. Low bone turnover was associated with normal-range mean PTH levels, and high bone turnover occurred at lower PTH levels than current guidelines would suggest...
  51. ncbi request reprint The use of steroid-sparing agents in steroid-sensitive nephrotic syndrome
    Asiri S Abeyagunawardena
    Nephro Urology Unit, Institute of Child Health, 30 Guilford Street, London WC1 N 1EH, UK
    Pediatr Nephrol 18:919-24. 2003
    ..Levamisole and cyclosporin A have emerged as attractive steroid-sparing agents. Complications and major side effects of treatment are infrequent but occasionally fatal...
  52. ncbi request reprint Severe hyperglycemia after renal transplantation in a pediatric patient with a mutation of the hepatocyte nuclear factor-1beta gene
    Simon C Waller
    Nephro Urology Unit, Institute of Child Health, University College London and the Department of Diabetes and Vascular Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, England
    Am J Kidney Dis 40:1325-30. 2002
    ....