Karl A Bettelheim

Summary

Affiliation: Great Ormond Street
Country: UK

Publications

  1. ncbi request reprint The non-O157 shiga-toxigenic (verocytotoxigenic) Escherichia coli; under-rated pathogens
    Karl A Bettelheim
    Crit Rev Microbiol 33:67-87. 2007
  2. pmc Treatment of enterohemorrhagic Escherichia coli (EHEC) infection and hemolytic uremic syndrome (HUS)
    Paul N Goldwater
    Microbiology and Infectious Diseases, SA Pathology at the Women s and Children s Hospital, and Discipline of Paediatrics, University of Adelaide, 72 King William Road, North Adelaide, South Australia, Australia
    BMC Med 10:12. 2012
  3. ncbi request reprint Emergence and spread of two distinct clonal groups of multidrug-resistant Escherichia coli in a veterinary teaching hospital in Australia
    Hanna E Sidjabat
    School of Veterinary Science, University of Queensland, Brisbane, QLD 4072, Australia
    J Med Microbiol 55:1125-34. 2006
  4. pmc Comparison of virulence gene profiles of Escherichia coli strains isolated from healthy and diarrheic swine
    Toni A Chapman
    Immunology and Molecular Diagnostic Research Unit, Elizabeth Macarthur Agriculture Institute, PMB 8, Camden, NSW 2570, Australia
    Appl Environ Microbiol 72:4782-95. 2006
  5. pmc Bovine feces from animals with gastrointestinal infections are a source of serologically diverse atypical enteropathogenic Escherichia coli and Shiga toxin-producing E. coli strains that commonly possess intimin
    Michael A Hornitzky
    Elizabeth Macarthur Agricultural Institute, New South Wales Department of Primary Industries, Private Mail Bag 8, Camden, New South Wales 2570, Australia
    Appl Environ Microbiol 71:3405-12. 2005
  6. pmc Escherichia coli and community-acquired gastroenteritis, Melbourne, Australia
    Roy M Robins-Browne
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Emerg Infect Dis 10:1797-805. 2004
  7. pmc Serotypes and virulence gene profiles of shiga toxin-producing Escherichia coli strains isolated from feces of pasture-fed and lot-fed sheep
    Steven P Djordjevic
    Elizabeth Macarthur Agricultural Institute, NSW Agriculture, Camden, New South Wales 2570, Australia
    Appl Environ Microbiol 70:3910-7. 2004
  8. pmc Distribution of intimin subtypes among Escherichia coli isolates from ruminant and human sources
    Vidiya Ramachandran
    Elizabeth Macarthur Agricultural Institute, Camden, New South Wales, 2570, Australia
    J Clin Microbiol 41:5022-32. 2003
  9. pmc Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates commonly possess stx2-EDL933 and/or stx2vhb subtypes
    Kim N Brett
    Elizabeth Macarthur Agricultural Institute, Camden, New South Wales, Australia 2570
    J Clin Microbiol 41:2716-22. 2003
  10. ncbi request reprint Non-O157 verotoxin-producing Escherichia coli: a problem, paradox, and paradigm
    Karl A Bettelheim
    National Escherichia coli Reference Laboratory, Microbiological Diagnostic Unit, Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3052, Australia
    Exp Biol Med (Maywood) 228:333-44. 2003

Collaborators

  • S P Djordjevic
  • P N Goldwater
  • M A Hornitzky
  • Kari S Gobius
  • Herbert Schmidt
  • M E Hellard
  • L Beutin
  • Darren J Trott
  • Narelle Fegan
  • Kim N Brett
  • Mark J Walker
  • Vidiya Ramachandran
  • Toni A Chapman
  • Hanna E Sidjabat
  • James J C Chin
  • Catriona McLean
  • Roy M Robins-Browne
  • Jane L Pearce
  • Hemant Kulkarni
  • Nancy D Hanson
  • Steven Driesen
  • Xi Yang Wu
  • Michael Lorentzen
  • Mark Wilson
  • Idris Barchia
  • Kirsty M Townsend
  • John C Bensink
  • Alexander Kuzevski
  • Linda Falconer
  • Anne Marie Bordun
  • Nicole A Lister
  • Christopher K Fairley
  • Vicki R Bennett-Wood
  • Jacinta Russell
  • Marija Tauschek
  • Richard K J Luke
  • Frances Oppedisano
  • Martha I Sinclair
  • Mark Dowton
  • Kim Brett
  • Anne Martin

Detail Information

Publications22

  1. ncbi request reprint The non-O157 shiga-toxigenic (verocytotoxigenic) Escherichia coli; under-rated pathogens
    Karl A Bettelheim
    Crit Rev Microbiol 33:67-87. 2007
    ..The animal host-specificity of these STEC is also reviewed. In conclusion some methods of improving isolation of these pathogens is addressed...
  2. pmc Treatment of enterohemorrhagic Escherichia coli (EHEC) infection and hemolytic uremic syndrome (HUS)
    Paul N Goldwater
    Microbiology and Infectious Diseases, SA Pathology at the Women s and Children s Hospital, and Discipline of Paediatrics, University of Adelaide, 72 King William Road, North Adelaide, South Australia, Australia
    BMC Med 10:12. 2012
    ..Due to the complexity of pathogenesis, it is likely a multitargeted approach is warranted. Developments in terms of these treatments are discussed...
  3. ncbi request reprint Emergence and spread of two distinct clonal groups of multidrug-resistant Escherichia coli in a veterinary teaching hospital in Australia
    Hanna E Sidjabat
    School of Veterinary Science, University of Queensland, Brisbane, QLD 4072, Australia
    J Med Microbiol 55:1125-34. 2006
    ..These results confirm that in this particular outbreak, canine MDREC were highly clonal and CG 2 MDREC may colonize both humans and dogs...
  4. pmc Comparison of virulence gene profiles of Escherichia coli strains isolated from healthy and diarrheic swine
    Toni A Chapman
    Immunology and Molecular Diagnostic Research Unit, Elizabeth Macarthur Agriculture Institute, PMB 8, Camden, NSW 2570, Australia
    Appl Environ Microbiol 72:4782-95. 2006
    ..coli strains have evolved and are engaged in the dynamic process of losing or acquiring VGs within the pig population...
  5. pmc Bovine feces from animals with gastrointestinal infections are a source of serologically diverse atypical enteropathogenic Escherichia coli and Shiga toxin-producing E. coli strains that commonly possess intimin
    Michael A Hornitzky
    Elizabeth Macarthur Agricultural Institute, New South Wales Department of Primary Industries, Private Mail Bag 8, Camden, New South Wales 2570, Australia
    Appl Environ Microbiol 71:3405-12. 2005
    ..1% of samples), and direct culture on BVCC agar was the most successful method for the isolation of EPEC (14.1% samples). These studies show that diarrheagenic calves and cattle represent important reservoirs of eae-positive E. coli...
  6. pmc Escherichia coli and community-acquired gastroenteritis, Melbourne, Australia
    Roy M Robins-Browne
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Emerg Infect Dis 10:1797-805. 2004
    ..Apart from the surface protein, intimin, no virulence determinant or phenotype was uniformly present in atypical EPEC strains. This study shows that atypical EPEC are an important cause of gastroenteritis in Melbourne...
  7. pmc Serotypes and virulence gene profiles of shiga toxin-producing Escherichia coli strains isolated from feces of pasture-fed and lot-fed sheep
    Steven P Djordjevic
    Elizabeth Macarthur Agricultural Institute, NSW Agriculture, Camden, New South Wales 2570, Australia
    Appl Environ Microbiol 70:3910-7. 2004
    ..Collectively, our data show that Australian sheep are colonized by diverse cSTEC serotypes that are rarely isolated from healthy Australian cattle...
  8. pmc Distribution of intimin subtypes among Escherichia coli isolates from ruminant and human sources
    Vidiya Ramachandran
    Elizabeth Macarthur Agricultural Institute, Camden, New South Wales, 2570, Australia
    J Clin Microbiol 41:5022-32. 2003
    ..Our data confirm that ruminants are an important source of serologically and genetically diverse intimin-containing E. coli strains...
  9. pmc Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates commonly possess stx2-EDL933 and/or stx2vhb subtypes
    Kim N Brett
    Elizabeth Macarthur Agricultural Institute, Camden, New South Wales, Australia 2570
    J Clin Microbiol 41:2716-22. 2003
    ..Three of the four were from separate sporadic cases of HUS, and one was from an unknown source...
  10. ncbi request reprint Non-O157 verotoxin-producing Escherichia coli: a problem, paradox, and paradigm
    Karl A Bettelheim
    National Escherichia coli Reference Laboratory, Microbiological Diagnostic Unit, Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3052, Australia
    Exp Biol Med (Maywood) 228:333-44. 2003
    ..The VTEC and their toxicity are considered as a paradigm for emerging pathogens. The question on how such pathogens could arise from a basic commensal population is also addressed...
  11. ncbi request reprint Escherichia coli 'O' group serological responses and clinical correlations in epidemic HUS patients
    Hemant Kulkarni
    Department of Nephrology, Women s and Children s Hospital, North Adelaide, SA, Australia
    Comp Immunol Microbiol Infect Dis 25:249-68. 2002
    ..This study indicates that co-infection with different VTEC serogroups may affect clinical outcome...
  12. ncbi request reprint Verocytotoxigenic Escherichia coli serologic responses in patients with hemolytic uremic syndrome
    Paul N Goldwater
    J Infect Dis 186:582; author reply 582-3. 2002
  13. pmc Virulence properties and serotypes of Shiga toxin-producing Escherichia coli from healthy Australian cattle
    Michael A Hornitzky
    Elizabeth Macarthur Agricultural Institute, New South Wales Agriculture, Camden, Australia
    Appl Environ Microbiol 68:6439-45. 2002
    ..The second, a longitudinal study of three feedlots and five pasture beef properties, resulted in the recovery of 118 cSTEC isolates from 104 animals. Of the 70 serotypes identified, 38 had not previously been reported...
  14. ncbi request reprint Antibiotic resistance among verocytotoxigenic Escherichia coli (VTEC) and non-VTEC isolated from domestic animals and humans
    Karl A Bettelheim
    Microbiological Diagnostic Unit, Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne, Royal Parade, Parkville, Victoria, Australia 3052
    J Med Microbiol 52:155-62. 2003
    ....
  15. pmc stx1c Is the most common Shiga toxin 1 subtype among Shiga toxin-producing Escherichia coli isolates from sheep but not among isolates from cattle
    Kim N Brett
    Cooperative Research Centre for Cattle and Beef Quality, Elizabeth Macarthur Agricultural Institute, Camden, New South Wales 2570, Australia
    J Clin Microbiol 41:926-36. 2003
    ....
  16. ncbi request reprint Infection and food: a factor in sudden infant death syndrome?
    Jane L Pearce
    Department of Agricultural Sciences, Faculty of Science, Technology and Engineering, La Trobe University, Victoria 3086, Australia
    FEMS Immunol Med Microbiol 42:66-75. 2004
    ..In this ecological study, we demonstrated significant correlations between SIDS rates and exposure to meat from some sources, and we propose that more detailed studies be carried out...
  17. ncbi request reprint Outbreak of Shiga toxin-producing Escherichia coli O111:H8 infection
    Karl A Bettelheim
    Clin Infect Dis 39:148; author reply 148-9. 2004
  18. ncbi request reprint Isolation of Escherichia coli O5 :H-, possessing genes for Shiga toxin 1, intimin-beta and enterohaemolysin, from an intestinal biopsy from an adult case of bloody diarrhoea: evidence for two distinct O5 :H- pathotypes
    Catriona McLean
    Department of Pathology, Alfred Hospital, Prahran, Victoria 3181, Australia
    J Med Microbiol 54:605-7. 2005
    ..Both were biochemically typical Escherichia coli O5 :H(-), apart from producing urease. Such O5 isolates represent a human pathogenic E. coli lineage...
  19. ncbi request reprint Curliated Escherichia coli, soluble curlin and the sudden infant death syndrome (SIDS)
    Paul N Goldwater
    J Med Microbiol 51:1009-12. 2002
  20. ncbi request reprint First isolation outside Europe of sorbitol-fermenting verocytotoxigenic Escherichia coli (VTEC) belonging to O group O157
    Karl A Bettelheim
    J Med Microbiol 51:713-4. 2002
  21. pmc HEp-2 cell adherence, actin aggregation, and intimin types of attaching and effacing Escherichia coli strains isolated from healthy infants in Germany and Australia
    Lothar Beutin
    Division of Emerging Bacterial Pathogens, Department of Biological Safety, Robert Koch Institute, 13353 Berlin, Germany
    Infect Immun 71:3995-4002. 2003
    ..Our finding indicates that atypical EPEC strains could play a double role as strains that naturally immunize against intimin in humans and as reservoirs for new emerging human pathogenic EPEC strains...
  22. ncbi request reprint Role of Non-O157:H7 Escherichia coli in hemolytic uremic syndrome
    Paul N Goldwater
    Clin Infect Dis 35:346-7. 2002