Phil J Ancliff

Summary

Affiliation: Great Ormond Street
Country: UK

Publications

  1. ncbi Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia
    Phil J Ancliff
    Department of Haematology and Immunology, University College London and Great Ormond Street Children s Hospital, London, United Kingdom
    Blood 100:707-9. 2002
  2. ncbi Neutrophil elastase mutations in congenital neutropenia
    Phil J Ancliff
    Department of Haematology, Geat Ormond Street Hospital, Great Ormond Street, London, UK
    Hematology 8:165-71. 2003
  3. ncbi Congenital neutropenia
    Philip James Ancliff
    Department of Haematology, Great Ormond Street Hospital, London WC1N 3JH, UK
    Blood Rev 17:209-16. 2003
  4. ncbi Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia
    Phil J Ancliff
    Department of Haematology, Great Ormond Street Hospital, London, WC1N 3JH, United Kingdom
    Blood 108:2182-9. 2006
  5. pmc Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia
    Dale A Moulding
    Wolfson Centre for Gene Therapy of Childhood Disease, UCL Institute of Child Health, University College London, London, UK
    J Exp Med 204:2213-24. 2007
  6. ncbi Long-term follow-up of granulocyte colony-stimulating factor receptor mutations in patients with severe congenital neutropenia: implications for leukaemogenesis and therapy
    Phil J Ancliff
    Department of Haematology, University College London, London, UK
    Br J Haematol 120:685-90. 2003
  7. doi Homozygous HAX1 mutations in severe congenital neutropenia patients with sporadic disease: a novel mutation in two unrelated British kindreds
    Bradley N Smith
    Department of Haematology, University College London, London, UK
    Br J Haematol 144:762-70. 2009
  8. ncbi Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia
    Marc R Mansour
    Department of Haematology, University College London, UK
    Clin Cancer Res 13:6964-9. 2007
  9. doi Recent advances in the understanding of genetic defects of neutrophil number and function
    Gerben Bouma
    Molecular Immunology Unit, UCL Institute of Child Health, Great Ormond Street Hospital NHS Trust, London, UK
    Br J Haematol 151:312-26. 2010

Collaborators

Detail Information

Publications9

  1. ncbi Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia
    Phil J Ancliff
    Department of Haematology and Immunology, University College London and Great Ormond Street Children s Hospital, London, United Kingdom
    Blood 100:707-9. 2002
    ..This is the first in vivo confirmation of the pathogenic nature of elastase mutations in humans. The normal neutrophil count in the father suggests that the mutant elastase does not have paracrine effects...
  2. ncbi Neutrophil elastase mutations in congenital neutropenia
    Phil J Ancliff
    Department of Haematology, Geat Ormond Street Hospital, Great Ormond Street, London, UK
    Hematology 8:165-71. 2003
    ..Clinically to date, the discovery of an elastase mutation has been of limited value to individual patients. However, it is hoped that further genotype/phenotype studies may improve assessment of patient prognosis...
  3. ncbi Congenital neutropenia
    Philip James Ancliff
    Department of Haematology, Great Ormond Street Hospital, London WC1N 3JH, UK
    Blood Rev 17:209-16. 2003
    ..Shwachman-Diamond Syndrome and other less common causes of congenital neutropenia will also be reviewed. Finally, an approach to the child with potential congenital neutropenia will be presented...
  4. ncbi Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia
    Phil J Ancliff
    Department of Haematology, Great Ormond Street Hospital, London, WC1N 3JH, United Kingdom
    Blood 108:2182-9. 2006
    ..Furthermore, these results also suggest a novel cause of myelodysplasia and that male children with myelodysplasia and disturbance of immunologic function should be screened for such mutations...
  5. pmc Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia
    Dale A Moulding
    Wolfson Centre for Gene Therapy of Childhood Disease, UCL Institute of Child Health, University College London, London, UK
    J Exp Med 204:2213-24. 2007
    ..These findings reveal a novel mechanism for inhibition of myelopoiesis through defective mitosis and cytokinesis due to hyperactivation and mislocalization of actin polymerization...
  6. ncbi Long-term follow-up of granulocyte colony-stimulating factor receptor mutations in patients with severe congenital neutropenia: implications for leukaemogenesis and therapy
    Phil J Ancliff
    Department of Haematology, University College London, London, UK
    Br J Haematol 120:685-90. 2003
    ..Furthermore, the low frequency of G-CSFR mutations in SCN and the importance of regular screening and close clinical and laboratory follow-up if a mutation is found were demonstrated...
  7. doi Homozygous HAX1 mutations in severe congenital neutropenia patients with sporadic disease: a novel mutation in two unrelated British kindreds
    Bradley N Smith
    Department of Haematology, University College London, London, UK
    Br J Haematol 144:762-70. 2009
    ..The low incidence of HAX1 mutations in our study suggests that the frequency may vary between racial groups but suggests that irrespective of inheritance or racial origin, SCN patients should be screened for HAX1 mutations...
  8. ncbi Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia
    Marc R Mansour
    Department of Haematology, University College London, UK
    Clin Cancer Res 13:6964-9. 2007
    ..Whether acquisition of Notch-1 mutations is an early initiating event or a secondary event in the pathogenesis of human T-ALL is unclear...
  9. doi Recent advances in the understanding of genetic defects of neutrophil number and function
    Gerben Bouma
    Molecular Immunology Unit, UCL Institute of Child Health, Great Ormond Street Hospital NHS Trust, London, UK
    Br J Haematol 151:312-26. 2010
    ..In this review we discuss recent advances in our understanding of the genetic and molecular basis of human neutrophil disorders...