Persis J Amrolia

Summary

Affiliation: Great Ormond Street
Country: UK

Publications

  1. ncbi request reprint Allorestricted cytotoxic T cells specific for human CD45 show potent antileukemic activity
    Persis J Amrolia
    Department of Haematology, Imperial College School of Medicine, London, United Kingdom
    Blood 101:1007-14. 2003
  2. ncbi request reprint Therapeutic challenges in childhood sickle cell disease. Part 2: a problem-orientated approach
    Persis J Amrolia
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Sick Children, London, UK
    Br J Haematol 120:737-43. 2003
  3. ncbi request reprint Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses
    Persis J Amrolia
    Department of Bone Marrow Transplantation, Great Ormond Street Children s Hospital, London, United Kingdom
    Blood 102:2292-9. 2003
  4. ncbi request reprint Increased incidence of EBV-related disease following paediatric stem cell transplantation with reduced-intensity conditioning
    Jonathan Cohen
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital NHS Trust, London, UK
    Br J Haematol 129:229-39. 2005
  5. ncbi request reprint Therapeutic challenges in childhood sickle cell disease. Part 1: current and future treatment options
    Persis J Amrolia
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Sick Children, London, UK
    Br J Haematol 120:725-36. 2003
  6. pmc Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation
    Persis J Amrolia
    Department of Bone Marrow Transplantation, Great Ormond St Childrens Hospital, London WC1N 3JH, United Kingdom
    Blood 108:1797-808. 2006
  7. ncbi request reprint Successful treatment of lymphoproliferative disease complicating primary immunodeficiency/immunodysregulatory disorders with reduced-intensity allogeneic stem-cell transplantation
    Jonathan M Cohen
    Department of Clinical Immunology, Great Ormond Street Hospital, London, United Kingdom
    Blood 110:2209-14. 2007
  8. doi request reprint Optimization of methodology for production of CD25/CD71 allodepleted donor T cells for clinical use
    Sarah J Albon
    Molecular Immunology Unit, UCL Institute of Child Health, London, UK
    Cytotherapy 15:109-21. 2013
  9. ncbi request reprint Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease
    Jennifer Brewin
    Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom
    Blood 114:4792-803. 2009
  10. ncbi request reprint Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy
    Sujith Samarasinghe
    Department of Molecular Immunology, Institute of Child Health, London, United Kingdom
    Blood 115:396-407. 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Allorestricted cytotoxic T cells specific for human CD45 show potent antileukemic activity
    Persis J Amrolia
    Department of Haematology, Imperial College School of Medicine, London, United Kingdom
    Blood 101:1007-14. 2003
    ..Further, because P1218-specific CTLs also recognize healthy HLA-A2(+) progenitors, such CTLs could also contribute to host myeloablation and enhance donor cell engraftment...
  2. ncbi request reprint Therapeutic challenges in childhood sickle cell disease. Part 2: a problem-orientated approach
    Persis J Amrolia
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Sick Children, London, UK
    Br J Haematol 120:737-43. 2003
  3. ncbi request reprint Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses
    Persis J Amrolia
    Department of Bone Marrow Transplantation, Great Ormond Street Children s Hospital, London, United Kingdom
    Blood 102:2292-9. 2003
    ..Based on these data, we have embarked on a phase 1 clinical trial of addback of allo-LCL-depleted donor T cells in the haplo-identical setting...
  4. ncbi request reprint Increased incidence of EBV-related disease following paediatric stem cell transplantation with reduced-intensity conditioning
    Jonathan Cohen
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital NHS Trust, London, UK
    Br J Haematol 129:229-39. 2005
    ..This probably reflects the profound immunosuppression following RIC SCT, together with the incomplete ablation of recipient-derived B cells...
  5. ncbi request reprint Therapeutic challenges in childhood sickle cell disease. Part 1: current and future treatment options
    Persis J Amrolia
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Sick Children, London, UK
    Br J Haematol 120:725-36. 2003
  6. pmc Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation
    Persis J Amrolia
    Department of Bone Marrow Transplantation, Great Ormond St Childrens Hospital, London WC1N 3JH, United Kingdom
    Blood 108:1797-808. 2006
    ..These data demonstrate that allodepleted donor T cells can be safely used to improve T-cell recovery after haploidentical SCT and may broaden the applicability of this approach...
  7. ncbi request reprint Successful treatment of lymphoproliferative disease complicating primary immunodeficiency/immunodysregulatory disorders with reduced-intensity allogeneic stem-cell transplantation
    Jonathan M Cohen
    Department of Clinical Immunology, Great Ormond Street Hospital, London, United Kingdom
    Blood 110:2209-14. 2007
    ..With careful monitoring and pre-emptive therapy, we advocate this RIC SCT approach to patients with PID who have pre-existing EBV-LPD...
  8. doi request reprint Optimization of methodology for production of CD25/CD71 allodepleted donor T cells for clinical use
    Sarah J Albon
    Molecular Immunology Unit, UCL Institute of Child Health, London, UK
    Cytotherapy 15:109-21. 2013
    ..Combined depletion of these cells yields a pool of allodepleted donor T cells with antiviral properties with minimal capacity to cause graft-versus-host disease...
  9. ncbi request reprint Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease
    Jennifer Brewin
    Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom
    Blood 114:4792-803. 2009
    ....
  10. ncbi request reprint Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy
    Sujith Samarasinghe
    Department of Molecular Immunology, Institute of Child Health, London, United Kingdom
    Blood 115:396-407. 2010
    ..39% vs third-party response of 62%, n = 5). This strategy enables further clinical studies of adoptive immunotherapy with larger doses of ADTs to enhance immune reconstitution after T cell-depleted stem cell transplantation...
  11. ncbi request reprint EBV-related disease following haematopoietic stem cell transplantation with reduced intensity conditioning
    Jonathan M Cohen
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital, NHS Trust, London, UK
    Leuk Lymphoma 48:256-69. 2007
    ....
  12. ncbi request reprint Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responses
    Helen Karlsson
    Molecular Immunology Unit, Institute of Child Health, London, United Kingdom
    Blood 112:532-41. 2008
    ..These data have major implications for immunotherapy of GVHD with MSCs and suggest that the effector functions of virus-specific T cells may be retained after MSC infusion...
  13. ncbi request reprint Improved survival and preserved antiviral responses after combination therapy with daclizumab and infliximab in steroid-refractory graft-versus-host disease
    Kanchan Rao
    Department of Blood and Marrow Transplantation, Great Ormond Street Hospital for Sick Children, Great Ormond Street, London WC1N 3JH, UK
    J Pediatr Hematol Oncol 31:456-61. 2009
    ....
  14. ncbi request reprint Serial transplantation of mismatched donor hematopoietic cells between HLA-identical sibling pairs with congenital immunodeficiency: in vivo tolerance permits rapid immune reconstitution following T-replete transplantation without GVHD in the secondary re
    Jonathan M Cohen
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, United Kingdom
    Blood 108:2124-6. 2006
    ....
  15. doi request reprint The many faces of Artemis-deficient combined immunodeficiency - Two patients with DCLRE1C mutations and a systematic literature review of genotype-phenotype correlation
    Pamela P Lee
    Department of Immunology, Great Ormond Street Hospital NHS Foundation Trust, London, UK
    Clin Immunol 149:464-74. 2013
    ..The progressive nature of immunodeficiency and genomic instability accounts for poor survival, and early HSCT should be considered. ..
  16. doi request reprint Simultaneous generation of multivirus-specific and regulatory T cells for adoptive immunotherapy
    Gertjan Lugthart
    Department of Molecular Immunology, Institute of Child Health, Great Ormond Street Hospital for Children NHS Trust, London, UK
    J Immunother 35:42-53. 2012
    ..Owing to the speed and simplicity of this methodology, this approach may significantly broaden the applicability of adoptive immunotherapy...
  17. doi request reprint Omission of in vivo T-cell depletion promotes rapid expansion of naïve CD4+ cord blood lymphocytes and restores adaptive immunity within 2 months after unrelated cord blood transplant
    Robert Chiesa
    Bone Marrow Transplantation Department, Great Ormond Street Hospital, London, UK
    Br J Haematol 156:656-66. 2012
    ..We postulate that this relates to the specific immunological and ontological qualities of fetal-derived lymphocytes...
  18. ncbi request reprint Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus, and Epstein-Barr virus: an approach for adoptive immunotherapy of multiple pathogens
    Helen Karlsson
    Molecular Immunology Unit, Institute of Child Health, Great Ormond Street Children s Hospital, London, UK
    J Immunother 30:544-56. 2007
    ..In summary, we have developed a protocol for the generation of CTL with trivirus specificity, enabling adoptive transfer of CTL recognizing multiple viruses to restore cellular immunity after SCT...
  19. doi request reprint Pre-emptive rituximab based on viraemia and T cell reconstitution: a highly effective strategy for the prevention of Epstein-Barr virus-associated lymphoproliferative disease following stem cell transplantation
    Austen Worth
    Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, UK
    Br J Haematol 155:377-85. 2011
    ..This strategy is safe and highly effective in preventing PTLD following T cell depleted SCT, and directs rituximab therapy to patients at highest risk of this complication...
  20. doi request reprint Successful treatment of central nervous system PTLD with rituximab and cranial radiotherapy
    Valerie Said-Conti
    Department of Paediatric Nephrology, Great Ormond Street Hospital NHS Trust, London, UK
    Pediatr Nephrol 28:2053-6. 2013
    ..The modalities of treatment include reduction in immunosuppression, cranial radiotherapy (CRT), intravenous and intrathecal rituximab when CD20 is expressed on B-lymphocytes and PTLD cells, and chemotherapy...
  21. ncbi request reprint Improved survival after unrelated donor bone marrow transplantation in children with primary immunodeficiency using a reduced-intensity conditioning regimen
    Kanchan Rao
    Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, United Kingdom
    Blood 105:879-85. 2005
    ....
  22. ncbi request reprint Bystander transfer of functional human CD40 ligand from gene-modified fibroblasts to B-chronic lymphocytic leukemia cells
    Ettore Biagi
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Gene Ther 14:545-59. 2003
    ..This approach does not use any direct gene transfer to primary leukemia cells and can readily be scaled up for production of clinical B-CLL vaccines...