Research Topics
| Persis J AmroliaSummaryAffiliation: Great Ormond Street Country: UK Publications
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Detail Information
Publications
Allorestricted cytotoxic T cells specific for human CD45 show potent antileukemic activityPersis J Amrolia
Department of Haematology, Imperial College School of Medicine, London, United Kingdom
Blood 101:1007-14. 2003..Further, because P1218-specific CTLs also recognize healthy HLA-A2(+) progenitors, such CTLs could also contribute to host myeloablation and enhance donor cell engraftment...- Therapeutic challenges in childhood sickle cell disease. Part 2: a problem-orientated approachPersis J Amrolia
Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Sick Children, London, UK
Br J Haematol 120:737-43. 2003 - Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responsesPersis J Amrolia
Department of Bone Marrow Transplantation, Great Ormond Street Children s Hospital, London, United Kingdom
Blood 102:2292-9. 2003..Based on these data, we have embarked on a phase 1 clinical trial of addback of allo-LCL-depleted donor T cells in the haplo-identical setting... - Therapeutic challenges in childhood sickle cell disease. Part 1: current and future treatment optionsPersis J Amrolia
Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Sick Children, London, UK
Br J Haematol 120:725-36. 2003 
Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantationPersis J Amrolia
Department of Bone Marrow Transplantation, Great Ormond St Childrens Hospital, London WC1N 3JH, United Kingdom
Blood 108:1797-808. 2006..These data demonstrate that allodepleted donor T cells can be safely used to improve T-cell recovery after haploidentical SCT and may broaden the applicability of this approach...- Successful treatment of lymphoproliferative disease complicating primary immunodeficiency/immunodysregulatory disorders with reduced-intensity allogeneic stem-cell transplantationJonathan M Cohen
Department of Clinical Immunology, Great Ormond Street Hospital, London, United Kingdom
Blood 110:2209-14. 2007..With careful monitoring and pre-emptive therapy, we advocate this RIC SCT approach to patients with PID who have pre-existing EBV-LPD... 
Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative diseaseJennifer Brewin
Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom
Blood 114:4792-803. 2009....- Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategySujith Samarasinghe
Department of Molecular Immunology, Institute of Child Health, London, United Kingdom
Blood 115:396-407. 2010..39% vs third-party response of 62%, n = 5). This strategy enables further clinical studies of adoptive immunotherapy with larger doses of ADTs to enhance immune reconstitution after T cell-depleted stem cell transplantation... - Increased incidence of EBV-related disease following paediatric stem cell transplantation with reduced-intensity conditioningJonathan Cohen
Department of Bone Marrow Transplantation, Great Ormond Street Hospital NHS Trust, London, UK
Br J Haematol 129:229-39. 2005..This probably reflects the profound immunosuppression following RIC SCT, together with the incomplete ablation of recipient-derived B cells... - EBV-related disease following haematopoietic stem cell transplantation with reduced intensity conditioningJonathan M Cohen
Department of Bone Marrow Transplantation, Great Ormond Street Hospital, NHS Trust, London, UK
Leuk Lymphoma 48:256-69. 2007.... - Improved survival and preserved antiviral responses after combination therapy with daclizumab and infliximab in steroid-refractory graft-versus-host diseaseKanchan Rao
Department of Blood and Marrow Transplantation, Great Ormond Street Hospital for Sick Children, Great Ormond Street, London WC1N 3JH, UK
J Pediatr Hematol Oncol 31:456-61. 2009.... - Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responsesHelen Karlsson
Molecular Immunology Unit, Institute of Child Health, London, United Kingdom
Blood 112:532-41. 2008..These data have major implications for immunotherapy of GVHD with MSCs and suggest that the effector functions of virus-specific T cells may be retained after MSC infusion... - Serial transplantation of mismatched donor hematopoietic cells between HLA-identical sibling pairs with congenital immunodeficiency: in vivo tolerance permits rapid immune reconstitution following T-replete transplantation without GVHD in the secondary reJonathan M Cohen
Department of Bone Marrow Transplantation, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, United Kingdom
Blood 108:2124-6. 2006.... - Optimization of methodology for production of CD25/CD71 allodepleted donor T cells for clinical useSarah J Albon
Molecular Immunology Unit, UCL Institute of Child Health, London, UK
Cytotherapy 15:109-21. 2013..Combined depletion of these cells yields a pool of allodepleted donor T cells with antiviral properties with minimal capacity to cause graft-versus-host disease... - Simultaneous generation of multivirus-specific and regulatory T cells for adoptive immunotherapyGertjan Lugthart
Department of Molecular Immunology, Institute of Child Health, Great Ormond Street Hospital for Children NHS Trust, London, UK
J Immunother 35:42-53. 2012..Owing to the speed and simplicity of this methodology, this approach may significantly broaden the applicability of adoptive immunotherapy... - Omission of in vivo T-cell depletion promotes rapid expansion of naïve CD4+ cord blood lymphocytes and restores adaptive immunity within 2 months after unrelated cord blood transplantRobert Chiesa
Bone Marrow Transplantation Department, Great Ormond Street Hospital, London, UK
Br J Haematol 156:656-66. 2012..We postulate that this relates to the specific immunological and ontological qualities of fetal-derived lymphocytes... - Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus, and Epstein-Barr virus: an approach for adoptive immunotherapy of multiple pathogensHelen Karlsson
Molecular Immunology Unit, Institute of Child Health, Great Ormond Street Children s Hospital, London, UK
J Immunother 30:544-56. 2007..In summary, we have developed a protocol for the generation of CTL with trivirus specificity, enabling adoptive transfer of CTL recognizing multiple viruses to restore cellular immunity after SCT... - Pre-emptive rituximab based on viraemia and T cell reconstitution: a highly effective strategy for the prevention of Epstein-Barr virus-associated lymphoproliferative disease following stem cell transplantationAusten Worth
Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, UK
Br J Haematol 155:377-85. 2011..This strategy is safe and highly effective in preventing PTLD following T cell depleted SCT, and directs rituximab therapy to patients at highest risk of this complication... - Improved survival after unrelated donor bone marrow transplantation in children with primary immunodeficiency using a reduced-intensity conditioning regimenKanchan Rao
Department of Bone Marrow Transplant, Great Ormond Street Hospital, London, United Kingdom
Blood 105:879-85. 2005.... - Bystander transfer of functional human CD40 ligand from gene-modified fibroblasts to B-chronic lymphocytic leukemia cellsEttore Biagi
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Hum Gene Ther 14:545-59. 2003..This approach does not use any direct gene transfer to primary leukemia cells and can readily be scaled up for production of clinical B-CLL vaccines...