S P Vickers

Summary

Affiliation: Granta Park
Country: UK

Publications

  1. ncbi request reprint Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors
    S P Vickers
    Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh RG41 5UA, UK
    Neuropharmacology 41:200-9. 2001
  2. ncbi request reprint Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists
    S P Vickers
    Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, RG41 5UA, UK
    Pharmacol Biochem Behav 69:643-52. 2001
  3. ncbi request reprint Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats
    S P Vickers
    Vernalis Research Limited, Oakdene Court, 613 Reading Road, RG41 5UA, Winnersh, Wokingham, UK
    Psychopharmacology (Berl) 167:103-11. 2003
  4. ncbi request reprint Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia
    S P Vickers
    Vernalis Research Limited, Oakdene Court, Winnersh, Wokingham, UK
    Psychopharmacology (Berl) 167:274-80. 2003
  5. pmc Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats
    S P Vickers
    Cerebrus, Oakdene Court, Winnersh, Wokingham
    Br J Pharmacol 130:1305-14. 2000
  6. ncbi request reprint Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists
    S Röver
    Vernalis Research Ltd, Oakdene Court, 613 Reading Road, Wokingham RG41 5UA, UK
    Bioorg Med Chem Lett 15:3604-8. 2005
  7. ncbi request reprint Indoline derivatives as 5-HT(2C) receptor agonists
    J M Bentley
    Vernalis Research Ltd, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, Berkshire RG41 5UA, UK
    Bioorg Med Chem Lett 14:2367-70. 2004
  8. ncbi request reprint Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant mice
    S P Vickers
    Laboratory of Experimental Psychology, University of Sussex, Brighton, East Sussex, UK
    Psychopharmacology (Berl) 143:309-14. 1999
  9. ncbi request reprint Cannabinoids and the regulation of ingestive behaviour
    S P Vickers
    RenaSci Consultancy Ltd, BioCity Nottingham, Pennyfoot Street, Nottingham NG1 1GF, UK
    Curr Drug Targets 6:215-23. 2005

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors
    S P Vickers
    Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh RG41 5UA, UK
    Neuropharmacology 41:200-9. 2001
    ..These data provide unequivocal evidence for an important role of the 5-HT2C receptor in the mediation of d-fenfluramine and d-norfenfluramine-induced hypophagia in the rat and do not support the involvement of 5-HT1A/1B/2A/2B receptors...
  2. ncbi request reprint Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists
    S P Vickers
    Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, RG41 5UA, UK
    Pharmacol Biochem Behav 69:643-52. 2001
    ..Both the in vivo and in vitro data suggest that for some ligands, previous reports have overestimated their in vivo selectivity for the 5-HT(2C) receptor...
  3. ncbi request reprint Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats
    S P Vickers
    Vernalis Research Limited, Oakdene Court, 613 Reading Road, RG41 5UA, Winnersh, Wokingham, UK
    Psychopharmacology (Berl) 167:103-11. 2003
    ..The selective CB(1) receptor antagonist, SR 141716, has been demonstrated to reduce food consumption in a range of animal species...
  4. ncbi request reprint Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia
    S P Vickers
    Vernalis Research Limited, Oakdene Court, Winnersh, Wokingham, UK
    Psychopharmacology (Berl) 167:274-80. 2003
    ..The 5-HT(2C) receptor subtype has been implicated extensively in the regulation of ingestive behaviour...
  5. pmc Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats
    S P Vickers
    Cerebrus, Oakdene Court, Winnersh, Wokingham
    Br J Pharmacol 130:1305-14. 2000
    ..5. These data suggest tolerance does not develop to the effects of d-fenfluramine, mCPP and Ro 60-0175 on rat body weight gain...
  6. ncbi request reprint Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists
    S Röver
    Vernalis Research Ltd, Oakdene Court, 613 Reading Road, Wokingham RG41 5UA, UK
    Bioorg Med Chem Lett 15:3604-8. 2005
    ..Selectivity was improved for several compounds versus the lead 1, increasing the therapeutic interest in this series of 5-HT(2C) receptor agonists...
  7. ncbi request reprint Indoline derivatives as 5-HT(2C) receptor agonists
    J M Bentley
    Vernalis Research Ltd, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, Berkshire RG41 5UA, UK
    Bioorg Med Chem Lett 14:2367-70. 2004
    ..The functional efficacy and radioligand binding data for all of the compounds at 5-HT(2) receptor subtypes are reported. A number of compounds were found to reduce food intake in rats after oral administration...
  8. ncbi request reprint Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant mice
    S P Vickers
    Laboratory of Experimental Psychology, University of Sussex, Brighton, East Sussex, UK
    Psychopharmacology (Berl) 143:309-14. 1999
    ..d-Fenfluramine stimulates the release of serotonin (5-HT) and is a potent inhibitor of the re-uptake of 5-HT into nerve terminals. Administration of d-fenfluramine suppresses food intake in both animals and humans...
  9. ncbi request reprint Cannabinoids and the regulation of ingestive behaviour
    S P Vickers
    RenaSci Consultancy Ltd, BioCity Nottingham, Pennyfoot Street, Nottingham NG1 1GF, UK
    Curr Drug Targets 6:215-23. 2005
    ..Accordingly, the cannabinoid system appears to have an important role in the regulation of ingestive behaviour in man and animals...