David Felmingham

Summary

Affiliation: GR Micro Ltd
Country: UK

Publications

  1. ncbi request reprint Instrumentation in antimicrobial susceptibility testing
    D Felmingham
    GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 48:81-5. 2001
  2. ncbi request reprint Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and compatative in vitro activity of the ketolide, telithromycin
    David Felmingham
    GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 50:25-37. 2002
  3. ncbi request reprint Regional trends in beta-lactam, macrolide, fluoroquinolone and telithromycin resistance among Streptococcus pneumoniae isolates 2001-2004
    David Felmingham
    G R Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Infect 55:111-8. 2007
  4. ncbi request reprint Surveillance of resistance in bacteria causing community-acquired respiratory tract infections
    David Felmingham
    GR Micro Ltd, London, UK
    Clin Microbiol Infect 8:12-42. 2002
  5. ncbi request reprint Tigecyclin--the first glycylcycline to undergo clinical development: an overview of in vitro activity compared to tetracycline
    D Felmingham
    GR Micro, London, UK
    J Chemother 17:5-11. 2005
  6. ncbi request reprint The Alexander Project: the benefits from a decade of surveillance
    David Felmingham
    GR Micro, Limited, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 56:ii3-ii21. 2005
  7. ncbi request reprint Antibacterial resistance among children with community-acquired respiratory tract infections (PROTEKT 1999-2000)
    D Felmingham
    GR Micro Ltd, London, UK
    J Infect 48:39-55. 2004
  8. ncbi request reprint In vitro activity of telithromycin against Gram-negative bacterial pathogens
    D Felmingham
    G R Micro Ltd, London NW1 3ER, UK
    J Infect 52:178-80. 2006
  9. ncbi request reprint Comparative antimicrobial susceptibility of respiratory tract pathogens
    David Felmingham
    G R Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    Chemotherapy 50:3-10. 2004
  10. ncbi request reprint The need for antimicrobial resistance surveillance
    David Felmingham
    GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 50:1-7. 2002

Detail Information

Publications43

  1. ncbi request reprint Instrumentation in antimicrobial susceptibility testing
    D Felmingham
    GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 48:81-5. 2001
    ....
  2. ncbi request reprint Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and compatative in vitro activity of the ketolide, telithromycin
    David Felmingham
    GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 50:25-37. 2002
    ..pneumoniae and demonstrate the potential of telithromycin as a therapeutic option for the treatment of community-acquired respiratory tract infections caused by this organism...
  3. ncbi request reprint Regional trends in beta-lactam, macrolide, fluoroquinolone and telithromycin resistance among Streptococcus pneumoniae isolates 2001-2004
    David Felmingham
    G R Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Infect 55:111-8. 2007
    ..To determine global antibacterial resistance rates among community-acquired isolates of Streptococcus pneumoniae...
  4. ncbi request reprint Surveillance of resistance in bacteria causing community-acquired respiratory tract infections
    David Felmingham
    GR Micro Ltd, London, UK
    Clin Microbiol Infect 8:12-42. 2002
    ..If disseminated effectively these data can be used to guide empiric antibiotic therapy, and to support-and monitor the impact of-interventions on antibiotic resistance...
  5. ncbi request reprint Tigecyclin--the first glycylcycline to undergo clinical development: an overview of in vitro activity compared to tetracycline
    D Felmingham
    GR Micro, London, UK
    J Chemother 17:5-11. 2005
    ..including vancomycin-resistant strains) and some extended-spectrum, beta-lactamase producing isolates of species of the Enterobacteriaceae, is particularly noteworthy...
  6. ncbi request reprint The Alexander Project: the benefits from a decade of surveillance
    David Felmingham
    GR Micro, Limited, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 56:ii3-ii21. 2005
    ..This paper reviews the 10 years of the Alexander Project and the benefits it has brought to an understanding of the evolution of antibacterial resistance in community respiratory bacteria...
  7. ncbi request reprint Antibacterial resistance among children with community-acquired respiratory tract infections (PROTEKT 1999-2000)
    D Felmingham
    GR Micro Ltd, London, UK
    J Infect 48:39-55. 2004
    ..To determine the susceptibility of bacterial respiratory tract pathogens, isolated from children (0-12 years) as part of the global PROTEKT surveillance study (1999-2000), to a range of antibacterials, including the ketolide telithromycin...
  8. ncbi request reprint In vitro activity of telithromycin against Gram-negative bacterial pathogens
    D Felmingham
    G R Micro Ltd, London NW1 3ER, UK
    J Infect 52:178-80. 2006
    ..To investigate the in vitro activity of the ketolide anti-bacterial telithromycin against a range of commensal bacteria and common aerobic Gram-negative respiratory and non-respiratory pathogens...
  9. ncbi request reprint Comparative antimicrobial susceptibility of respiratory tract pathogens
    David Felmingham
    G R Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    Chemotherapy 50:3-10. 2004
    ..catarrhalis. However, respiratory fluoroquinolones, of which levofloxacin has been available for the longest time, currently remain active against the great majority of common bacterial respiratory pathogens, including atypicals...
  10. ncbi request reprint The need for antimicrobial resistance surveillance
    David Felmingham
    GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 50:1-7. 2002
    ....
  11. ncbi request reprint Evolving resistance patterns in community-acquired respiratory tract pathogens: first results from the PROTEKT global surveillance study. Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin
    D Felmingham
    GR Micro Ltd, London, UK
    J Infect 44:3-10. 2002
    ..These data justify the assertion that telithromycin is a promising new candidate for the empirical treatment of community-acquired RTIs, particularly in the face of increasing antibacterial resistance...
  12. ncbi request reprint Activity of the ketolide antibacterial telithromycin against typical community-acquired respiratory pathogens
    D Felmingham
    GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 48:33-42. 2001
    ..This review covers the potent in vitro activity of telithromycin against the most common community-acquired RTI pathogens compared with other currently available antimicrobial agents...
  13. ncbi request reprint Microbiological profile of telithromycin, the first ketolide antimicrobial
    D Felmingham
    GR Micro Ltd, London, UK
    Clin Microbiol Infect 7:2-10. 2001
    ..These characteristics indicate that telithromycin will have an important clinical role in the empirical treatment of community-acquired respiratory tract infections...
  14. doi request reprint Non-susceptibility trends among Haemophilus influenzae and Moraxella catarrhalis from community-acquired respiratory tract infections in the UK and Ireland, 1999-2007
    Ian Morrissey
    Quotient Bioresearch Limited, Microbiology, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 62:ii97-103. 2008
    ..To determine the antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis causing community-acquired respiratory tract infections in the UK and Ireland from 1999/2000 to 2006/07...
  15. pmc In vitro activities of telithromycin, linezolid, and quinupristin-dalfopristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutations
    David J Farrell
    GR Micro Ltd, London, United Kingdom
    Antimicrob Agents Chemother 48:3169-71. 2004
    ..Six isolates were resistant to quinupristin-dalfopristin and two were resistant to linezolid, while telithromycin demonstrated good activities against all isolates...
  16. ncbi request reprint Antimicrobial susceptibility of community-acquired lower respiratory tract bacterial pathogens isolated in the UK during the 1995-1996 cold season
    D Felmingham
    GR Micro Ltd, London, UK
    J Antimicrob Chemother 41:411-5. 1998
    ..3%) of the isolates of S. pneumoniae were susceptible to amoxycillin (MIC < or = 0.5 mg/L), 96% to cefaclor (MIC < or = 8 mg/L), 90.7% to clarithromycin (MIC < or = 0.25 mg/L) and 89% to ciprofloxacin (MIC < or = 1 mg/L)...
  17. doi request reprint Non-susceptibility trends and serotype distributions among Streptococcus pneumoniae from community-acquired respiratory tract infections and from bacteraemias in the UK and Ireland, 1999 to 2007
    David J Farrell
    Quotient Bioresearch, Microbiology, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 62:ii87-95. 2008
    ....
  18. ncbi request reprint The Alexander Project 1996-1997: latest susceptibility data from this international study of bacterial pathogens from community-acquired lower respiratory tract infections
    D Felmingham
    GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 45:191-203. 2000
    ..1%, 28.9%). Of H. influenzae from the USA, 30.4% were beta-lactamase producers in 1996 and 23.3% in 1997. beta-Lactamase production among isolates of Moraxella catarrhalis was observed in >90% of the isolates tested in 1996 and 1997...
  19. ncbi request reprint Trends in the antimicrobial susceptibility of bacterial respiratory tract pathogens--findings of the Alexander Project 1992-1996
    D Felmingham
    GR Micro Ltd, London, UK
    J Chemother 11:5-21. 1999
    ..influenzae were generally very uncommon, with only Barcelona, Spain consistently associated with rates in excess of 1%. beta-lactamase production in Moraxella catarrhalis was observed in over 90% of isolates tested in 1996...
  20. pmc Activities of telithromycin against 13,874 Streptococcus pneumoniae isolates collected between 1999 and 2003
    David J Farrell
    GR Micro Limited, London, United Kingdom
    Antimicrob Agents Chemother 48:1882-4. 2004
    ..The telithromycin MICs for 10 isolates (0.07%) were >/=4 micro g/ml, and these 10 isolates contained erm(B); there was no evidence of reproducible clonal spread between centers...
  21. pmc Molecular epidemiology of multiresistant Streptococcus pneumoniae with both erm(B)- and mef(A)-mediated macrolide resistance
    David J Farrell
    GR Micro Limited, London, United Kingdom
    J Clin Microbiol 42:764-8. 2004
    ..Telithromycin demonstrated high levels of activity (MIC for 90% of the strains tested, 0.5 micro g/ml; MIC range, 0.06 to 1 micro g/ml) against all isolates...
  22. ncbi request reprint Detection of macrolide resistance mechanisms in Streptococcus pneumoniae and Streptococcus pyogenes using a multiplex rapid cycle PCR with microwell-format probe hybridization
    D J Farrell
    GR Micro Limited, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 48:541-4. 2001
    ..2%) negative for all mechanisms tested. For 56 strains of macrolide-resistant S. pyogenes tested, 33 (58.9%) were positive for erm(A) subclass erm(TR), 18 (32.1%) mef(A) and five (8.9%) erm(B)...
  23. ncbi request reprint Molecular characterization of macrolide resistance mechanisms among Streptococcus pneumoniae and Streptococcus pyogenes isolated from the PROTEKT 1999-2000 study
    D J Farrell
    GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 50:39-47. 2002
    ..pneumoniae, respectively. It also exhibited potent activity against S. pyogenes that had become resistant to macrolides via either mef(A), (MIC(90 )0.5 mg/L) or erm(TR), (MIC(90) 0.03 mg/L)...
  24. pmc Macrolide resistance by ribosomal mutation in clinical isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 study
    D J Farrell
    GR Micro Limited, London, United Kingdom
    Antimicrob Agents Chemother 47:1777-83. 2003
    ..Despite their high levels of macrolide resistance, all 16 isolates remained susceptible to the ketolide telithromycin (MICs, 0.015 to 0.25 microg/ml)...
  25. ncbi request reprint Global distribution of TEM-1 and ROB-1 beta-lactamases in Haemophilus influenzae
    D J Farrell
    GR Micro Limited, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 56:773-6. 2005
    ..To investigate the activities of commonly used antibiotics against these isolates...
  26. ncbi request reprint Respiratory pathogens: assessing resistance patterns in Europe and the potential role of grepafloxacin as treatment of patients with infections caused by these organisms
    D Felmingham
    GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
    J Antimicrob Chemother 45:1-8. 2000
    ....
  27. ncbi request reprint A UK multicentre study of the antimicrobial susceptibility of bacterial pathogens causing urinary tract infection
    D J Farrell
    GR Micro Limited, London, UK
    J Infect 46:94-100. 2003
    ..To determine the prevalence of resistance amongst urinary tract pathogens against antimicrobials used to treat urinary tract infections (UTIs) in the UK to provide data to help direct empirical therapy...
  28. pmc Molecular characterization and antimicrobial susceptibility of fluoroquinolone-resistant or -susceptible Streptococcus pneumoniae from Hong Kong
    Ian Morrissey
    GR Micro Ltd, London, United Kingdom
    Antimicrob Agents Chemother 47:1433-5. 2003
    ..The Spain(23F)-1 clone also occurred among antimicrobial-susceptible isolates, which suggests that the primary source of this clone may have been Asia rather than Iberia...
  29. ncbi request reprint Tigecycline: an expanded broad-spectrum intravenous antibiotic. Preface and summary
    D Felmingham
    G R Micro, 7 9 William Road, London NW1 3ER, UK
    J Chemother 17:3-4. 2005
  30. ncbi request reprint The in vitro activity of some 14-, 15- and 16- membered macrolides against Staphylococcus spp., Legionella spp., Mycoplasma spp. and Ureaplasma urealyticum
    D Felmingham
    Department of Clinical Microbiology, University College Hospital, London, UK
    Drugs Exp Clin Res 17:91-9. 1991
    ..However, erythromycin, roxithromycin, clarithromycin and azithromycin were poorly active against isolates of Mycoplasma hominis. By contrast, the same isolates were susceptible (MIC range: 0.008-0.12 mg/l) to midecamycin acetate...
  31. ncbi request reprint BSAC Respiratory Resistance Surveillance Programme (2002-2003): comparative susceptibility of Streptococcus pneumoniae, cultured from patients in Great Britain and Ireland with community-acquired lower respiratory tract infection, to gemifloxacin
    David Felmingham
    J Antimicrob Chemother 54:698-9. 2004
  32. pmc Effects of various test media on the activities of 21 antimicrobial agents against Haemophilus influenzae
    Michael R Jacobs
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Microbiol 40:3269-76. 2002
    ..Reproducible susceptibility results were obtained for a wide range of agents against H. influenzae in three laboratories using a variety of media that support the growth of this fastidious species...
  33. doi request reprint The British Society for Antimicrobial Chemotherapy Resistance Surveillance Project: a successful collaborative model
    Anthony R White
    Tony White Ltd, Newport, Essex, UK
    J Antimicrob Chemother 62:ii3-14. 2008
    ..The Project satisfies the requirement for sustainable defined-protocol high-quality resistance surveillance across the UK and Ireland...
  34. ncbi request reprint The PROTEKT surveillance study: antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis from community-acquired respiratory tract infections
    Daryl Hoban
    Health Sciences Centre, Clinical Microbiology, MS673 820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9, Canada
    J Antimicrob Chemother 50:49-59. 2002
    ..influenzae and M. catarrhalis, although these pathogens generally remain susceptible to macrolides, fluoroquinolones and the new ketolide telithromycin...
  35. ncbi request reprint Trends in penicillin and macrolide resistance among pneumococci in the UK and the Republic of Ireland in relation to antibiotic sales to pharmacies and dispensing doctors
    David M Livermore
    Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5HT, UK
    Int J Antimicrob Agents 28:273-9. 2006
    ..Stabilisation or decline in penicillin resistance has occurred in Ireland despite stable or increasing oral beta-lactam sales...
  36. ncbi request reprint Antimicrobial susceptibility of community-acquired respiratory tract pathogens in North America in 1999-2000: findings of the PROTEKT surveillance study
    Daryl Hoban
    Health Sciences Centre, Winnipeg, Manitoba, Canada
    Diagn Microbiol Infect Dis 45:251-9. 2003
    ....
  37. ncbi request reprint The Alexander Project 1998-2000: susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents
    Michael R Jacobs
    Department of Pathology, Case Western Reserve University of Cleveland, 11100 Euclid Ave, Cleveland, OH 44106, USA
    J Antimicrob Chemother 52:229-46. 2003
    ..The Alexander Project is a continuing surveillance study, begun in 1992, examining the susceptibility of pathogens involved in adult community-acquired respiratory tract infections (CARTI) to a range of antimicrobial agents...
  38. ncbi request reprint Antimicrobial susceptibility of lower respiratory tract pathogens in Great Britain and Ireland 1999-2001 related to demographic and geographical factors: the BSAC Respiratory Resistance Surveillance Programme
    Rosy Reynolds
    Department of Medical Microbiology, North Bristol NHS Trust, Southmead Hospital, Bristol BS10 5NB, UK
    J Antimicrob Chemother 52:931-43. 2003
    ....
  39. ncbi request reprint The PROTEKT global study (year 4) demonstrates a continued lack of resistance development to telithromycin in Streptococcus pneumoniae
    David J Farrell
    J Antimicrob Chemother 56:795-7. 2005
  40. ncbi request reprint PROTEKT 1999-2000: a multicentre study of the antibiotic susceptibility of respiratory tract pathogens in Hong Kong, Japan and South Korea
    Matsuhisa Inoue
    Department of Microbiology, Kitasato University School of Medicine, 1 15 1 Kitasato Sagamihara, Kanagawa 228 8555, Japan
    Int J Antimicrob Agents 23:44-51. 2004
    ..Resistance to antibacterials, particularly penicillin and macrolides, has reached high but stable levels in the Far East and the presence of multiply-resistant pneumococci is well established...
  41. ncbi request reprint Comparison of BSAC agar dilution and NCCLS broth microdilution MIC methods for in vitro susceptibility testing of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis: the BSAC Respiratory Resistance Surveillance Programme
    Rosy Reynolds
    Department of Medical Microbiology, North Bristol NHS Trust, Southmead Hospital, Bristol BS10 5NB, UK
    J Antimicrob Chemother 52:925-30. 2003
    ..The aim of this study was to establish the degree of comparability between the NCCLS broth microdilution and BSAC agar dilution MIC methods of antimicrobial susceptibility testing...
  42. ncbi request reprint Activity of telithromycin against key pathogens associated with community-acquired respiratory tract infections
    Donald E Low
    Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ont, Canada
    J Infect 49:115-25. 2004
    ..To investigate the correlation between in vitro susceptibility of isolates and clinical outcomes with telithromycin in respiratory tract infections...
  43. ncbi request reprint Demographic analysis of antimicrobial resistance among Streptococcus pneumoniae: worldwide results from PROTEKT 1999-2000
    Daryl Hoban
    Health Sciences Centre, Department of Clinical Microbiology, Winnipeg, Man, Canada
    Int J Infect Dis 9:262-73. 2005
    ..The influence of demographic factors upon antimicrobial resistance among 3362 isolates of Streptococcus pneumoniae from 25 countries was investigated, using univariate comparison and multivariate logistic regression...