Research Topics
| David FelminghamSummaryAffiliation: GR Micro Ltd Country: UK Publications
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Detail Information
Publications
Instrumentation in antimicrobial susceptibility testingD Felmingham
GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
J Antimicrob Chemother 48:81-5. 2001....- Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and compatative in vitro activity of the ketolide, telithromycinDavid Felmingham
GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
J Antimicrob Chemother 50:25-37. 2002..pneumoniae and demonstrate the potential of telithromycin as a therapeutic option for the treatment of community-acquired respiratory tract infections caused by this organism... - Regional trends in beta-lactam, macrolide, fluoroquinolone and telithromycin resistance among Streptococcus pneumoniae isolates 2001-2004David Felmingham
G R Micro Ltd, 7 9 William Road, London NW1 3ER, UK
J Infect 55:111-8. 2007..To determine global antibacterial resistance rates among community-acquired isolates of Streptococcus pneumoniae... - Surveillance of resistance in bacteria causing community-acquired respiratory tract infectionsDavid Felmingham
GR Micro Ltd, London, UK
Clin Microbiol Infect 8:12-42. 2002..If disseminated effectively these data can be used to guide empiric antibiotic therapy, and to support-and monitor the impact of-interventions on antibiotic resistance... - Tigecyclin--the first glycylcycline to undergo clinical development: an overview of in vitro activity compared to tetracyclineD Felmingham
GR Micro, London, UK
J Chemother 17:5-11. 2005..including vancomycin-resistant strains) and some extended-spectrum, beta-lactamase producing isolates of species of the Enterobacteriaceae, is particularly noteworthy... - The Alexander Project: the benefits from a decade of surveillanceDavid Felmingham
GR Micro, Limited, 7 9 William Road, London NW1 3ER, UK
J Antimicrob Chemother 56:ii3-ii21. 2005..This paper reviews the 10 years of the Alexander Project and the benefits it has brought to an understanding of the evolution of antibacterial resistance in community respiratory bacteria... - Antibacterial resistance among children with community-acquired respiratory tract infections (PROTEKT 1999-2000)D Felmingham
GR Micro Ltd, London, UK
J Infect 48:39-55. 2004..To determine the susceptibility of bacterial respiratory tract pathogens, isolated from children (0-12 years) as part of the global PROTEKT surveillance study (1999-2000), to a range of antibacterials, including the ketolide telithromycin... - In vitro activity of telithromycin against Gram-negative bacterial pathogensD Felmingham
G R Micro Ltd, London NW1 3ER, UK
J Infect 52:178-80. 2006..To investigate the in vitro activity of the ketolide anti-bacterial telithromycin against a range of commensal bacteria and common aerobic Gram-negative respiratory and non-respiratory pathogens... - Comparative antimicrobial susceptibility of respiratory tract pathogensDavid Felmingham
G R Micro Ltd, 7 9 William Road, London NW1 3ER, UK
Chemotherapy 50:3-10. 2004..catarrhalis. However, respiratory fluoroquinolones, of which levofloxacin has been available for the longest time, currently remain active against the great majority of common bacterial respiratory pathogens, including atypicals... - The need for antimicrobial resistance surveillanceDavid Felmingham
GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
J Antimicrob Chemother 50:1-7. 2002.... - Evolving resistance patterns in community-acquired respiratory tract pathogens: first results from the PROTEKT global surveillance study. Prospective Resistant Organism Tracking and Epidemiology for the Ketolide TelithromycinD Felmingham
GR Micro Ltd, London, UK
J Infect 44:3-10. 2002..These data justify the assertion that telithromycin is a promising new candidate for the empirical treatment of community-acquired RTIs, particularly in the face of increasing antibacterial resistance... - Activity of the ketolide antibacterial telithromycin against typical community-acquired respiratory pathogensD Felmingham
GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
J Antimicrob Chemother 48:33-42. 2001..This review covers the potent in vitro activity of telithromycin against the most common community-acquired RTI pathogens compared with other currently available antimicrobial agents... - Microbiological profile of telithromycin, the first ketolide antimicrobialD Felmingham
GR Micro Ltd, London, UK
Clin Microbiol Infect 7:2-10. 2001..These characteristics indicate that telithromycin will have an important clinical role in the empirical treatment of community-acquired respiratory tract infections... 
Non-susceptibility trends among Haemophilus influenzae and Moraxella catarrhalis from community-acquired respiratory tract infections in the UK and Ireland, 1999-2007Ian Morrissey
Quotient Bioresearch Limited, Microbiology, 7 9 William Road, London NW1 3ER, UK
J Antimicrob Chemother 62:ii97-103. 2008..To determine the antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis causing community-acquired respiratory tract infections in the UK and Ireland from 1999/2000 to 2006/07...
In vitro activities of telithromycin, linezolid, and quinupristin-dalfopristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutationsDavid J Farrell
GR Micro Ltd, London, United Kingdom
Antimicrob Agents Chemother 48:3169-71. 2004..Six isolates were resistant to quinupristin-dalfopristin and two were resistant to linezolid, while telithromycin demonstrated good activities against all isolates...- Antimicrobial susceptibility of community-acquired lower respiratory tract bacterial pathogens isolated in the UK during the 1995-1996 cold seasonD Felmingham
GR Micro Ltd, London, UK
J Antimicrob Chemother 41:411-5. 1998..3%) of the isolates of S. pneumoniae were susceptible to amoxycillin (MIC < or = 0.5 mg/L), 96% to cefaclor (MIC < or = 8 mg/L), 90.7% to clarithromycin (MIC < or = 0.25 mg/L) and 89% to ciprofloxacin (MIC < or = 1 mg/L)... - Non-susceptibility trends and serotype distributions among Streptococcus pneumoniae from community-acquired respiratory tract infections and from bacteraemias in the UK and Ireland, 1999 to 2007David J Farrell
Quotient Bioresearch, Microbiology, 7 9 William Road, London NW1 3ER, UK
J Antimicrob Chemother 62:ii87-95. 2008.... - The Alexander Project 1996-1997: latest susceptibility data from this international study of bacterial pathogens from community-acquired lower respiratory tract infectionsD Felmingham
GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
J Antimicrob Chemother 45:191-203. 2000..1%, 28.9%). Of H. influenzae from the USA, 30.4% were beta-lactamase producers in 1996 and 23.3% in 1997. beta-Lactamase production among isolates of Moraxella catarrhalis was observed in >90% of the isolates tested in 1996 and 1997... - Trends in the antimicrobial susceptibility of bacterial respiratory tract pathogens--findings of the Alexander Project 1992-1996D Felmingham
GR Micro Ltd, London, UK
J Chemother 11:5-21. 1999..influenzae were generally very uncommon, with only Barcelona, Spain consistently associated with rates in excess of 1%. beta-lactamase production in Moraxella catarrhalis was observed in over 90% of isolates tested in 1996... - Activities of telithromycin against 13,874 Streptococcus pneumoniae isolates collected between 1999 and 2003David J Farrell
GR Micro Limited, London, United Kingdom
Antimicrob Agents Chemother 48:1882-4. 2004..The telithromycin MICs for 10 isolates (0.07%) were >/=4 micro g/ml, and these 10 isolates contained erm(B); there was no evidence of reproducible clonal spread between centers... - Molecular epidemiology of multiresistant Streptococcus pneumoniae with both erm(B)- and mef(A)-mediated macrolide resistanceDavid J Farrell
GR Micro Limited, London, United Kingdom
J Clin Microbiol 42:764-8. 2004..Telithromycin demonstrated high levels of activity (MIC for 90% of the strains tested, 0.5 micro g/ml; MIC range, 0.06 to 1 micro g/ml) against all isolates... - Detection of macrolide resistance mechanisms in Streptococcus pneumoniae and Streptococcus pyogenes using a multiplex rapid cycle PCR with microwell-format probe hybridizationD J Farrell
GR Micro Limited, 7 9 William Road, London NW1 3ER, UK
J Antimicrob Chemother 48:541-4. 2001..2%) negative for all mechanisms tested. For 56 strains of macrolide-resistant S. pyogenes tested, 33 (58.9%) were positive for erm(A) subclass erm(TR), 18 (32.1%) mef(A) and five (8.9%) erm(B)... - Molecular characterization of macrolide resistance mechanisms among Streptococcus pneumoniae and Streptococcus pyogenes isolated from the PROTEKT 1999-2000 studyD J Farrell
GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
J Antimicrob Chemother 50:39-47. 2002..pneumoniae, respectively. It also exhibited potent activity against S. pyogenes that had become resistant to macrolides via either mef(A), (MIC(90 )0.5 mg/L) or erm(TR), (MIC(90) 0.03 mg/L)... - Macrolide resistance by ribosomal mutation in clinical isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 studyD J Farrell
GR Micro Limited, London, United Kingdom
Antimicrob Agents Chemother 47:1777-83. 2003..Despite their high levels of macrolide resistance, all 16 isolates remained susceptible to the ketolide telithromycin (MICs, 0.015 to 0.25 microg/ml)... - Global distribution of TEM-1 and ROB-1 beta-lactamases in Haemophilus influenzaeD J Farrell
GR Micro Limited, 7 9 William Road, London NW1 3ER, UK
J Antimicrob Chemother 56:773-6. 2005..To investigate the activities of commonly used antibiotics against these isolates... - Respiratory pathogens: assessing resistance patterns in Europe and the potential role of grepafloxacin as treatment of patients with infections caused by these organismsD Felmingham
GR Micro Ltd, 7 9 William Road, London NW1 3ER, UK
J Antimicrob Chemother 45:1-8. 2000.... - A UK multicentre study of the antimicrobial susceptibility of bacterial pathogens causing urinary tract infectionD J Farrell
GR Micro Limited, London, UK
J Infect 46:94-100. 2003..To determine the prevalence of resistance amongst urinary tract pathogens against antimicrobials used to treat urinary tract infections (UTIs) in the UK to provide data to help direct empirical therapy... - Molecular characterization and antimicrobial susceptibility of fluoroquinolone-resistant or -susceptible Streptococcus pneumoniae from Hong KongIan Morrissey
GR Micro Ltd, London, United Kingdom
Antimicrob Agents Chemother 47:1433-5. 2003..The Spain(23F)-1 clone also occurred among antimicrobial-susceptible isolates, which suggests that the primary source of this clone may have been Asia rather than Iberia... - Tigecycline: an expanded broad-spectrum intravenous antibiotic. Preface and summaryD Felmingham
G.R. Micro, 7-9 William Road, London NW1 3ER, UK
J Chemother 17:3-4. 2005 - The in vitro activity of some 14-, 15- and 16- membered macrolides against Staphylococcus spp., Legionella spp., Mycoplasma spp. and Ureaplasma urealyticumD Felmingham
Department of Clinical Microbiology, University College Hospital, London, UK
Drugs Exp Clin Res 17:91-9. 1991..However, erythromycin, roxithromycin, clarithromycin and azithromycin were poorly active against isolates of Mycoplasma hominis. By contrast, the same isolates were susceptible (MIC range: 0.008-0.12 mg/l) to midecamycin acetate... - BSAC Respiratory Resistance Surveillance Programme (2002-2003): comparative susceptibility of Streptococcus pneumoniae, cultured from patients in Great Britain and Ireland with community-acquired lower respiratory tract infection, to gemifloxacinDavid Felmingham
J Antimicrob Chemother 54:698-9. 2004 - Effects of various test media on the activities of 21 antimicrobial agents against Haemophilus influenzaeMichael R Jacobs
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
J Clin Microbiol 40:3269-76. 2002..Reproducible susceptibility results were obtained for a wide range of agents against H. influenzae in three laboratories using a variety of media that support the growth of this fastidious species... - The British Society for Antimicrobial Chemotherapy Resistance Surveillance Project: a successful collaborative modelAnthony R White
Tony White Ltd, Newport, Essex, UK
J Antimicrob Chemother 62:ii3-14. 2008..The Project satisfies the requirement for sustainable defined-protocol high-quality resistance surveillance across the UK and Ireland... - The PROTEKT surveillance study: antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis from community-acquired respiratory tract infectionsDaryl Hoban
Health Sciences Centre, Clinical Microbiology, MS673 820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9, Canada
J Antimicrob Chemother 50:49-59. 2002..influenzae and M. catarrhalis, although these pathogens generally remain susceptible to macrolides, fluoroquinolones and the new ketolide telithromycin... - Trends in penicillin and macrolide resistance among pneumococci in the UK and the Republic of Ireland in relation to antibiotic sales to pharmacies and dispensing doctorsDavid M Livermore
Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5HT, UK
Int J Antimicrob Agents 28:273-9. 2006..Stabilisation or decline in penicillin resistance has occurred in Ireland despite stable or increasing oral beta-lactam sales... - Antimicrobial susceptibility of community-acquired respiratory tract pathogens in North America in 1999-2000: findings of the PROTEKT surveillance studyDaryl Hoban
Health Sciences Centre, Winnipeg, Manitoba, Canada
Diagn Microbiol Infect Dis 45:251-9. 2003.... - The Alexander Project 1998-2000: susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agentsMichael R Jacobs
Department of Pathology, Case Western Reserve University of Cleveland, 11100 Euclid Ave, Cleveland, OH 44106, USA
J Antimicrob Chemother 52:229-46. 2003..The Alexander Project is a continuing surveillance study, begun in 1992, examining the susceptibility of pathogens involved in adult community-acquired respiratory tract infections (CARTI) to a range of antimicrobial agents... - Antimicrobial susceptibility of lower respiratory tract pathogens in Great Britain and Ireland 1999-2001 related to demographic and geographical factors: the BSAC Respiratory Resistance Surveillance ProgrammeRosy Reynolds
Department of Medical Microbiology, North Bristol NHS Trust, Southmead Hospital, Bristol BS10 5NB, UK
J Antimicrob Chemother 52:931-43. 2003.... - The PROTEKT global study (year 4) demonstrates a continued lack of resistance development to telithromycin in Streptococcus pneumoniaeDavid J Farrell
J Antimicrob Chemother 56:795-7. 2005 - PROTEKT 1999-2000: a multicentre study of the antibiotic susceptibility of respiratory tract pathogens in Hong Kong, Japan and South KoreaMatsuhisa Inoue
Department of Microbiology, Kitasato University School of Medicine, 1 15 1 Kitasato Sagamihara, Kanagawa 228 8555, Japan
Int J Antimicrob Agents 23:44-51. 2004..Resistance to antibacterials, particularly penicillin and macrolides, has reached high but stable levels in the Far East and the presence of multiply-resistant pneumococci is well established... - Comparison of BSAC agar dilution and NCCLS broth microdilution MIC methods for in vitro susceptibility testing of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis: the BSAC Respiratory Resistance Surveillance ProgrammeRosy Reynolds
Department of Medical Microbiology, North Bristol NHS Trust, Southmead Hospital, Bristol BS10 5NB, UK
J Antimicrob Chemother 52:925-30. 2003..The aim of this study was to establish the degree of comparability between the NCCLS broth microdilution and BSAC agar dilution MIC methods of antimicrobial susceptibility testing... - Activity of telithromycin against key pathogens associated with community-acquired respiratory tract infectionsDonald E Low
Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ont, Canada
J Infect 49:115-25. 2004..To investigate the correlation between in vitro susceptibility of isolates and clinical outcomes with telithromycin in respiratory tract infections... - Demographic analysis of antimicrobial resistance among Streptococcus pneumoniae: worldwide results from PROTEKT 1999-2000Daryl Hoban
Health Sciences Centre, Department of Clinical Microbiology, Winnipeg, Man, Canada
Int J Infect Dis 9:262-73. 2005..The influence of demographic factors upon antimicrobial resistance among 3362 isolates of Streptococcus pneumoniae from 25 countries was investigated, using univariate comparison and multivariate logistic regression...